https://www.pennmedicine.org/news/knockout-of-cd5-on-car-t-cells-boosts-anti-tumor-efficacy
Knockout of CD5 on CAR T cells boosts anti-tumor efficacy | Penn Medicine
Researchers have identified CD5 as an immune checkpoint protein and a potential target of future cancer therapies.
car t cells
https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1121020/full
Frontiers | Anti-ROR1 CAR-T cells: Architecture and performance
The Receptor Tyrosine Kinase Like-Orphan Receptor 1 (ROR1) is a membrane receptor that plays a key role in development. It is highly expressed during the emb...
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https://www.cancer.gov/research/participate/clinical-trials/intervention/autologous-anti-cd19-cd20-cd22-car-t-cells
Clinical Trials Using Autologous Anti-CD19/CD20/CD22 CAR T-cells - NCI
NCI supports clinical trials that test new and more effective ways to treat cancer. Find clinical trials studying autologous anti-cd19/cd20/cd22 car t-cells.
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https://www.corning.com/emea/de/products/life-sciences/resources/stories/the-cutting-edge/cat-t-cells-immunotherapy-and-3d-models-are-paving-the-way-in-cancer-research.html
CAR-T Cells, Immunotherapy, and 3D Models in Cancer Research | Immunotherapy | Corning
This article explores the role of immunotherapy in cancer treatment: What are CAR-T cells? How are in vivo-like environments and CAR-T cells innovating cancer...
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https://www.plutonet.com.my/
CAR T-Cells Treatment in Malaysia
Sep 24, 2025 - Our expertise lies in cell and gene-based immunotherapy, spearheading healthcare innovation through research-driven treatment.
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https://www.cancer.gov/research/participate/clinical-trials/intervention/anti-cd19-cd20-cd22-car-t-cells
Clinical Trials Using Anti-CD19/CD20/CD22 CAR T-Cells - NCI
NCI supports clinical trials that test new and more effective ways to treat cancer. Find clinical trials studying anti-cd19/cd20/cd22 car t-cells.
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https://www.cancer.gov/publications/dictionaries/cancer-drug/def/autologous-cd138-specific-car-t-cells?redirect=true
Definition of autologous CD138-specific CAR T cells - NCI Drug Dictionary - NCI
Find technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. Each entry includes...
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https://medcraveonline.com/GHOA/stab-car-t-cells-pioneering-precision-in-cancer-immunotherapy.html
STAb CAR-T Cells: pioneering precision in cancer immunotherapy - MedCrave online
Chimeric Antigen Receptor (CAR) T cell therapy has revolutionized cancer treatment, particularly for hematologic malignancies. However, challenges such as...
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https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-cldn182-car-t-cells-ly011
Definition of anti-CLDN18.2 CAR T cells LY011 - NCI Drug Dictionary - NCI
Find technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. Each entry includes...
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https://www.cancer.gov/publications/dictionaries/cancer-drug/def/autologous-baff-expressing-car-t-cells-lmy-920
Definition of autologous BAFF-expressing CAR T cells LMY-920 - NCI Drug Dictionary - NCI
Find technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. Each entry includes...
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https://www.cancer.gov/publications/dictionaries/cancer-drug/def/autologous-anti-cd7-car-t-cells-senl101
Definition of autologous anti-CD7 CAR T cells SENL101 - NCI Drug Dictionary - NCI
Find technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. Each entry includes...
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https://www.biospace.com/promab-presents-promising-results-in-humanized-cd19-car-t-cells-trial
ProMab Presents Promising Results in Humanized CD19 CAR-T Cells Trial - BioSpace
Jul 27, 2020 - ProMab Biotechnology, Inc., a leading developer of CAR-T/NK cell technology for global life sciences, announced today it has successfully completed an...
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https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1411393/full
Frontiers | Engineering strategies to safely drive CAR T-cells into the future
Chimeric antigen receptor (CAR) T-cell therapy has proven a breakthrough in cancer treatment in the last decade, giving unprecedented results against hematol...
car t cellsengineering strategies
https://www.fiercebiotech.com/research/car-ts-turn-back-clock-age-related-metabolic-disease-mice-and-even-prevent-it
CAR-T cells prevent and reverse signs of metabolic age in mice
Jan 30, 2024 - A one-time CAR-T therapy was enough to slow signs of aging in young mice and reverse them in old ones.
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https://pmc.ncbi.nlm.nih.gov/articles/PMC5909636/
Trivalent CAR T cells overcome interpatient antigenic variability in glioblastoma - PMC
Glioblastoma (GBM) is the most common primary malignant brain cancer, and is currently incurable. Chimeric antigen receptor (CAR) T cells have shown promise in...
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https://www.aacr.org/blog/2025/08/15/harnessing-car-t-cells-for-children-with-brain-cancers/
Harnessing CAR T Cells for Children With Brain Cancers | Blog | AACR
Sep 29, 2025 - New clinical trials are exploring an array of CAR T-cell approaches for children with cancers of the brain and central nervous system.
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https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-cd22-car-t-cells-preparation
Definition of anti-CD22 CAR T cells preparation - NCI Drug Dictionary - NCI
Find technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. Each entry includes...
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https://www.pennmedicine.org/news/penn-developed-car-t-cells-suppress-gi-solid-tumor-cells-without-toxicity-to-healthy-tissue
CAR T cells suppress GI solid tumor cells without damage | Penn Medicine
Early research shows that targeting the molecule CDH17 with CAR T cells represents a new approach to treat solid cancers.
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https://www.news-medical.net/news/20250402/EchoBack-CAR-T-cells-could-be-a-game-changer-in-cancer-immunotherapy.aspx
EchoBack CAR T-cells could be a game changer in cancer immunotherapy
Apr 2, 2025 - Imagine a super-charged immune cell that can launch a focused attack on stubborn solid tumors - a smart fighter that destroys cancer cells for days without...
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https://www.fraunhofer.de/en/press/research-news/2025/september-2025/car-t-cells-fight-solid-tumors.html
Advances in Cancer Treatment: CAR T Cells Fight Solid Tumors
A new generation of CAR T cell therapy is bringing hope in the fight against cancer, targeting not only blood cancers but also solid tumors such as ovarian and...
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https://www.cancer.gov/research/participate/clinical-trials/intervention/anti-cd19-cd20-cd22-car-t-cells?pn=1
Clinical Trials Using Anti-CD19/CD20/CD22 CAR T-Cells - NCI
NCI supports clinical trials that test new and more effective ways to treat cancer. Find clinical trials studying anti-cd19/cd20/cd22 car t-cells.
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https://www.sciencedaily.com/releases/2024/12/241207194223.htm
Keto diet metabolite may power up CAR T cells to kill cancer | ScienceDaily
A simple dietary supplement may provide a new approach to boost CAR T cell function, according to a new study.
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https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01109/full
Frontiers | CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape
Chimeric antigen receptor (CAR) T cell therapies have demonstrated remarkable efficacy for the treatment of hematological malignancies. However, in patients ...
car t cells
https://www.cancer.gov/news-events/cancer-currents-blog/2022/nhl-car-t-cells-belinda-transform-zuma7
CAR T Cells: Second-Line Treatment Option for NHL? - NCI
Recent trial results suggest that CAR T cells may be superior to standard treatments for B-cell NHL that has not responded or has returned after treatment.
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https://www.cancer.gov/research/participate/clinical-trials-search/v?id=NCI-2025-02214
Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing...
Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma
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https://www.jci.org/articles/view/153204
JCI - HIV-specific CAR T cells return to the clinic
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https://www.aacr.org/blog/2025/02/27/unleashing-the-power-of-car-t-cells-insights-from-day-3-of-aacr-io/
Unleashing the Power of CAR T Cells: Insights from AACR IO | Blog | AACR
Mar 4, 2025 - On day three of AACR IO, Crystal Mackall and Carl June unveiled cutting-edge advances in CAR T-cell therapy, including for solid cancers.
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https://www.cancer.gov/publications/dictionaries/cancer-drug/def/autologous-pd1-knockout-cd19-specific-car-t-cells
Definition of autologous PD1-knockout CD19-specific CAR T cells - NCI Drug Dictionary - NCI
Find technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. Each entry includes...
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https://www.cancer.gov/publications/dictionaries/cancer-drug/def/autologous-anti-gpc2-car-t-cells
Definition of autologous anti-GPC2-CAR T cells - NCI Drug Dictionary - NCI
Find technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. Each entry includes...
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https://www.cancer.gov/publications/dictionaries/cancer-drug/def/allogeneic-hypoimmune-anti-cd19-car-t-cells-sc291
Definition of allogeneic hypoimmune anti-CD19 CAR T cells SC291 - NCI Drug Dictionary - NCI
Find technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. Each entry includes...
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https://pmc.ncbi.nlm.nih.gov/articles/PMC10999258/
Latent human herpesvirus 6 is reactivated in CAR T cells - PMC
Cell therapies have yielded durable clinical benefits for patients with cancer, but the risks associated with the development of therapies from manipulated...
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https://www.cancer.gov/publications/dictionaries/cancer-drug/def/autologous-anti-cd79a-anti-cd20-car-t-cells-bbt369
Definition of autologous anti-CD79a/anti-CD20 CAR T cells bbT369 - NCI Drug Dictionary - NCI
Find technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. Each entry includes...
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https://www.mskcc.org/event/microenvironment-actuated-car-cells-improve-solid-tumor-efficacy-without-toxicity
Microenvironment actuated CAR T cells improve solid tumor efficacy without toxicity | Memorial...
View the Daniel Heller Lab page for Microenvironment actuated CAR T cells improve solid tumor efficacy without toxicity.
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https://www.jci.org/articles/view/153204/pdf
JCI - HIV-specific CAR T cells return to the clinic
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https://pmc.ncbi.nlm.nih.gov/articles/PMC9218214/
The Past, Present, and Future of Non-Viral CAR T Cells - PMC
Adoptive transfer of chimeric antigen receptor (CAR) T lymphocytes is a powerful technology that has revolutionized the way we conceive immunotherapy. The...
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https://www.mskcc.org/news/car-cells-get-invisibility-cloak
CAR T Cells Get an Invisibility Cloak | Memorial Sloan Kettering Cancer Center
Research is focusing on ways to help cancer-fighting immune cells stick around longer, boosting their effectiveness.
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https://www.mendeley.com/catalogue/cfda09a6-fbc0-3fbd-9dbb-1c9c4bd4e4e3/
CAR-T cells and allogeneic hemato... preview & related info | Mendeley
(2017) Liu et al. Immunotherapy. Relapsed/refractory acute lymphoblastic leukemia (ALL) has a low remission rate after chemotherapy, a high relapse rate and...
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https://www.cancer.gov/publications/dictionaries/cancer-drug/def/autologous-anti-cd30-car-t-cells-hsp-car30
Definition of autologous anti-CD30 CAR T cells HSP-CAR30 - NCI Drug Dictionary - NCI
Find technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. Each entry includes...
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https://www.cancer.gov/publications/dictionaries/cancer-drug/def/autologous-anti-egfr-anti-il13ralpha2-car-t-cells
Definition of autologous anti-EGFR/anti-IL13Ralpha2 CAR T cells - NCI Drug Dictionary - NCI
Find technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. Each entry includes...
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https://www.news-medical.net/news/20260429/Scientists-redesign-CAR-T-cells-to-fight-more-than-cancer.aspx
Scientists redesign CAR-T cells to fight more than cancer
Apr 29, 2026 - This review examines how CAR-T cell therapy is expanding beyond blood cancers into solid tumors, autoimmune diseases, chronic viral infections, and...
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https://www.news-medical.net/news/20251002/Engineered-CAR-T-cells-show-promise-against-solid-tumors.aspx
Engineered CAR T cells show promise against solid tumors
Oct 2, 2025 - Chimeric antigen receptor (CAR) T cell therapy, which uses a patient's own immune cells to fight cancer, has emerged as a powerful way to treat lymphoma and...
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https://pmc.ncbi.nlm.nih.gov/articles/PMC11874698/
Mesothelin-targeted CAR-T cells secreting NKG2D-BiTEs exhibit potent efficacy against...
Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis and limited treatment options. Chimeric antigen receptor (CAR)-T cell therapy...
car t cells
https://www.cancer.gov/publications/dictionaries/cancer-drug/def/autologous-pd-1-antibody-expressing-mesothelin-specific-car-t-cells
Definition of autologous PD-1 antibody-expressing mesothelin-specific CAR-T cells - NCI Drug...
Find technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. Each entry includes...
https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-interleukin-13-receptor-alpha-2-car-t-cells-yyb-103
Definition of anti-interleukin-13 receptor alpha 2 allogeneic CAR T cells YYB-103 - NCI Drug...
Find technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. Each entry includes...
https://www.mskcc.org/news/msk-scientists-fine-tune-car-cells-improve-their-performance
MSK Scientists Fine-Tune CAR T Cells to Improve Their Performance | Memorial Sloan Kettering Cancer...
The updated versions can survive longer in the body while still packing a punch against cancer.
https://www.cancer.gov/research/participate/clinical-trials-search/v?id=NCI-2022-02972&r=1
Genetically Engineered Cells (Anti-CD19/CD20/CD22 CAR T-cells) for the Treatment of Relapsed or...
Genetically Engineered Cells (Anti-CD19/CD20/CD22 CAR T-cells) for the Treatment of Relapsed or Refractory Lymphoid Malignancies
https://pmc.ncbi.nlm.nih.gov/articles/PMC11779983/
A CAR enhancer increases the activity and persistence of CAR T cells - PMC
Although chimeric antigen receptor (CAR) T cell therapies have demonstrated promising clinical outcomes, durable remissions remain limited. To extend the...
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