Robuta

https://www.rcsb.org/structure/4MQ1 RCSB PDB - 4MQ1: The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor https://www.rcsb.org/structure/7AJ8 RCSB PDB - 7AJ8: Structure of DYRK1A in complex with compound 25 Structure of DYRK1A in complex with compound 25 rcsb pdb structure https://sites.google.com/view/dyrk1afrance/contact Association DYRK1A France - Contact association dyrk1a france https://www.jci.org/articles/view/199108/pdf JCI - DYRK1A enhances antitumor immunity in type 1 conventional dendritic cells via mTORC1... https://pmc.ncbi.nlm.nih.gov/articles/PMC11153725/ Targeting the DYRK1A kinase prevents cancer progression and metastasis and promotes cancer cells... Metastatic cancer remains incurable as patients eventually loose sensitivity to targeted therapies and chemotherapies, further leading to poor clinical... cancer progression targeting dyrk1a kinase prevents https://elifesciences.org/articles/24502/figures Figures and data in Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent... Small molecule inhibition of stem cell differentiation in vitro provides novel insight into how DYRK1A loss disrupts human nervous system development. https://www.rcsb.org/structure/6T6A RCSB PDB - 6T6A: Crystal structure of DYRK1A complexed with KuFal319 (compound 11) Crystal structure of DYRK1A complexed with KuFal319 (compound 11) rcsb pdb crystal structure https://www.rcsb.org/structure/7A4R RCSB PDB - 7A4R: Structure of DYRK1A in complex with compound 1 Structure of DYRK1A in complex with compound 1 rcsb pdb structure https://www.ncbi.nlm.nih.gov/Structure/pdb/7Z5N 7Z5N: Crystal structure of DYRK1A in complex with CX-4945 Dual specificity tyrosine-phosphorylation-regulated kinase 1A1,2-ETHANEDIOL5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic... crystal structure dyrk1a complex cx 4945 https://www.rcsb.org/structure/7AK2 RCSB PDB - 7AK2: Structure of DYRK1A in complex with compound 53 Structure of DYRK1A in complex with compound 53 rcsb pdb structure