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The first high-resolution structure of a bacterial flagellar cap protein, FliD, reveals new insights into the assembly of bacterial flagella.
bacterialflagellarcappingproteinsadopt
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The parabrachial nucleus-thalamic paraventricular nucleus pathway is critical for modulating affective states in mice.
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Lumen extension in intracellular tubes relies on a molecular pathway involving Rho GTPase signaling, cell polarity, and vesicle-tethering proteins.
polaritypathwayexocystdependentintracellular
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Surgical weight loss treatments reduce breast cancer growth in obese mice, but not as well as dietary interventions.
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Resolving parallel and concurrent cytokine secretion is essential to studying polyfunctional cytokine-secreting cells, and to differentiating immune response...
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The transmembrane helices forming the pore determine the conductance of the selectivity filter through allosteric interactions.
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The photoreceptor tetraspanin protein ROM1 contributes to the formation of light-sensitive 'disc' membranes, but it can be functionally replaced by an excess...
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Active dendritic processing enables an individual neuron to discriminate the spatial pattern of synaptic inputs, increasing neural and behavioral selectivity...
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The host transmembrane protein MARCH8, previously known as an expression regulator of host proteins, is a powerful antiviral host factor with a potentially...
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A new method for developing biosensors from ligand binding domains that have concentration-dependent and selective responses to small molecules in yeast,...
in afiguresdatageneralstrategy
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People with a PhD in the life sciences answer questions about their life and work.
a seriesworkinglivesinterviewscollections
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Slow and fast movements are controlled by distinct sets of spinal V2a neurons with matching properties and connections.
the rhythmgoing toget youlocomotionelife
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MR1T cells are human polyclonal T cells endowed with diverse effector functions in response to endogenous antigens presented by MHC-class 1-related molecule,...
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Development of a new tool to control the activity of the GAL4 in Drosophila allows researchers to switch transgene expression on in specific cell types by...
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Ring-like structures made up of caveolae appear to drive the development of membrane invaginations called T-tubules which are important for muscle contraction.
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A statistical model rescues multi-mapping reads with high accuracy and demonstrates their impact in all facets of the analysis of genome-wide high throughput...
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When the neuropeptide orexin is peripherally administered in mice with septic shock, it penetrates the blood-brain barrier and acts in the brain to improve...
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The new open-access journal eLife has launched, making its first content available in PubMed Central. In addition to publishing science of the highest quality,...
scientific publishinglaunchingelifepart
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Comprehensive 3D electron tomography reconstructions of metaphase spindles in human tissue culture cells reveal that kinetochore-fibers broaden as they extend...
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Environmental conditions strongly impact the fitness effects of Hsp90, resulting in the selection of Hsp90 sequences in nature that are robust to a variety of...
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Why does protein kinase A respond to purine nucleosides in certain pathogens, but not to the cyclic nucleotides that activate this kinase in most other...
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The increasing knowledge of barrier tissue-resident memory macrophages and trained innate immunity (TII) will help develop both nontarget-specific and...
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A model is proposed to estimate the nuclear export rate of mRNAs produced in a transcription burst, using the spatial distribution of mRNAs determined by...
nuclear exportstatisticalframeworkrate
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The pulsatile activities of kisspeptin neurons, the central pacemaker activities of reproductive functions, show unexpected robustness in terms of frequency,...
dynamicspulsatileactivitiesarcuatekisspeptin
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A young group leader reflects on academic culture and working while going through cancer treatments.
strikes twicescientistcancerelife
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Discovery of a novel neuropeptide signalling system in a deuterostome invertebrate reveals the evolutionary origin of prolactin-releasing peptide and its...
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The sensory nerves that carry sensations from the taste buds to the brain induce the formation of the taste buds in the embryo.
peer reviewtaste budformationdependsnerves
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Chronic exposure to a potent chemical contact sensitizer drives a self-limiting expansion of a polyclonal population of T cells recognizing a small number of...
structure and dynamicsclonalhumancell
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The serine phosphorylated and inhibited KdpFABC complex (KdpFABS162-PC) adopts an off-cycle E1P tight state, due to an impaired E1P/E2P transition.
figuresdatainhibitedtransitions
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Treatment with a JAK inhibitor normalizes multiple biomarkers of autoinflammation and provides therapeutic benefit for diverse immune skin conditions in...
in jakfiguresdatainhibitionautoimmune
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Quantitative super resolution imaging, in live mammalian cells, reveals a direct relationship between protein clustering dynamics and the number of mRNA...
rna polymerase iipeer reviewclusterdynamicspredict
https://elifesciences.org/podcast/episode31
In this episode we hear about human height, fish joints, colour vision, chimpanzees using tools and open science.
episodeaugustpodcastelife
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The evolution of hunting behavior in fish larvae has arrived at different, species-specific solutions, recombining a shared repertoire of locomotor and eye...
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https://elifesciences.org/labs/8de87c33/texture-an-open-science-manuscript-editor
Substance invite the community to use and contribute to a new XML-first text editor.
open sciencetexturemanuscripteditorlabs
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A group of neurons in the medulla expressing the tachykinin precursor 1 promote rhythmic breathing, but also elicit substantial motor behaviors, suggesting a...
figuresdatamedullarytachykininprecursor
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SUMO-dependent pathway is responsible for selective repression of damaged rDNA and silencing of intact surplus units revealing an epigenetic mechanism that...
sumo pathwayrepressioninterruptedintactrdna
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Bats' uniquely robust innate antiviral immune defenses select for faster transmitting viruses likely to generate extreme virulence upon spillover to secondary...
viral dynamicscell linesbatimplications
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Oxytocin neuron projections from two brain regions involved in parental care regulate both parental care and infanticidal behaviors in virgin mandarin voles.
a fine linevoleparentingattackcare
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From July 2021 eLife will only review manuscripts already published as preprints, and will focus its editorial process on producing public reviews to be posted...
peer reviewpublishmodel
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Neuronal activity in the primate orbitofrontal cortex reveals different choice biases observed when offers are presented sequentially originate at different...
neuronaloriginsreducedaccuracybiases
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Engineered T cell receptors enable targeted immunotherapy with a reduced risk of harmful autoimmunity.
t celldomainswappedreceptorsimprove
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Ultherapy - Finesse - Cfu Elife sono dispositivi medici che permettono rigenerazione del collagene endogeno e producono lifting.
finessecfuelife
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Novel human iPS cell derived and primary skeletal muscle stem cells show that abnormal ACVR1 activation increases osteogenic/ECM gene expression and impairs...
figuresdatamodelingmutationhuman
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Discovery of a novel long non-coding RNA overlapping the distal SOX17 enhancer (eSOX17) that plays an essential role in human endoderm development.
non coding rnaexpressedessential
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Complementary structural biology approaches reveal how an agonist and a covalent inhibitor simultaneously bind to a nuclear receptor.
nuclear receptorsnewmodeinhibitionelife
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The conformation of an isoleucine gate located along the TM6 segment on the intracellular side below the selectivity filter is a critical component leading to...
in cisoleucinegateblocksconduction
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The inhibition of EPAC1, a cAMP-binding protein, appears as a potential therapeutic strategy to limit doxorubicin-induced cardiotoxicity without interfering...
peer reviewthe heartinhibitionprotectsdoxorubicin
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A combination of single molecule fluorescence with DMD simulations and disulfide mapping resolved the multistate structural landscape of the PSG supramodule...
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A novel mechanism of gene regulation is discovered wherein a specific long non-coding RNA abolishes the blocking activity of chromatin insulator in the...
peer reviewread throughthe bxlncrna
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The cells in our inner ear commonly believed to provide fast mechanical feedback are too sluggish to follow the vibrations evoked by high-frequency sounds.
in thefiguresdatafrequencylimit
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A real-time genomic surveillance approach based on mutation analysis of SARS-CoV-2 proteins has enabled a priori prediction of surge in number of COVID19...
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The eLife Ambassadors programme provides a solid foundation for scientists to learn and apply open science principles in their work and communities, with...
elifeambassadorsprogrammeapplicationswelcomed
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The well-studied Kv1.2 potassium ion channel is observed in a variety of states and conditions, to understand mechanisms of ion permeation, gating and block.
peer reviewpotassium channelscryoemstructures
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Population output variability in a motor control system varies across levels (CPG, motor neurons, muscles) and can be ascribed to life history differences...
in amotor systemoutputvariabilityacross
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High-profile news coverage that eLife papers generated in February 2020, including The Times, Sky News and National Geographic.
in the newsmedia coveragefebruaryroundupelife
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Psychophysical measurement and computational modeling show that sensory information cannot contribute directly to a cognitive judgment, but must first be...
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Targeted optogenetic activation of small ensembles of neurons is sufficient to trigger a behavioral report while recruiting matched network suppression,...
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Older US adults die at higher rates in the winter, while seasonal differences in mortality have disappeared or declined for other age groups.
wintermonthsremainolderus
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eLife is making changes to its policies on peer review in response to the impact of COVID-19 on the scientific community.
peer reviewin thepublishingtimecovid
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eLife works to improve research communication through open science and open technology innovation
latestresearchelife
https://elifesciences.org/articles/42728v2
Parvalbumin positive GABAergic neurons in the ventral zona incerta receive input from somatosensory cortex and enhance sound-induced flight behavior, which...
crossmodalityenhancementdefensiveflight
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Antigen Ki-67, which is widely used as a cell proliferation marker, controls heterochromatin organisation and gene expression.
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Lattice light-sheet single-molecule imaging shows 3D Sox2 enhancer clusters in live embryonic stem cells and reveals a model linking 3D spatial distribution of...
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