https://elifesciences.org/
Latest research | eLife
eLife works to improve research communication through open science and open technology innovation
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https://elifesciences.org/articles/87930
De novo identification of universal cell mechanics gene signatures | eLife
A computational systems biology approach identifies a gene network module associated with single-cell mechanical phenotype changes across diverse mouse and...
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https://elifesciences.org/articles/56844v1
A microscopy-based kinetic analysis of yeast vacuolar protein sorting | eLife
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https://elifesciences.org/articles/80923
Flexible specificity of memory in Drosophila depends on a comparison between choices | eLife
Flies can optimally recall a memory with high specificity by comparing options close in time, or default to generalization when they cannot.
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Arquivos Bots - Elife Brasil
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https://elifesciences.org/articles/13876
VEGFR-2 conformational switch in response to ligand binding | eLife
A receptor for vascular endothelial growth factor forms dimers in the absence of its ligand, and ligand-binding leads to structural changes that result in...
in responsevegfrswitchligandbinding
https://elifesciences.org/articles/68648
Phosphoproteomics of ATR signaling in mouse testes | eLife
An in-depth map of ATR signaling during mouse meiosis is revealed using a combination of genetic and pharmacological approaches coupled to quantitative mass...
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https://elifesciences.org/articles/54612
Regulation of nerve growth and patterning by cell surface protein disulphide isomerase | eLife
The nerve growth-repellent activity that generates spinal nerve repeat-patterning in birds and mammals is identified at the molecular level, and a similar...
https://cordis.europa.eu/project/id/13032
European Lipidomics Initiative | ELIFE | Project | Fact Sheet | FP6 | CORDIS | European Commission
Over the past ten years, technological developments have caused a revolution in the fields of genomics and proteomics. Suitable technologies are now emerging...
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https://lens.elifesciences.org/48198/
Area 2 of primary somatosensory cortex encodes kinematics of the whole arm | eLife Lens
https://elifesciences.org/articles/04353/peer-reviews
Peer review in Structural basis of diverse membrane target recognitions by ankyrins | eLife
The 24 ankyrin repeats of ankyrin proteins form an extended solenoid that provides an extremely conserved groove for binding to numerous targets via...
https://www.mcb.harvard.edu/department/news/how-does-the-brain-orchestrate-learning-from-reward-uchida-lab/elife-62390-v2/
elife-62390-v2 - Harvard University - Department of Molecular & Cellular Biology
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https://lens.elifesciences.org/70283/
Novel insights from a multiomics dissection of the Hayflick limit | eLife Lens
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https://elifesciences.org/articles/12352
Cascade of neural processing orchestrates cognitive control in human frontal cortex | eLife
A dynamic and hierarchical sequence of steps in human frontal cortex orchestrates cognitive control.
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https://elifesciences.org/articles/100674
The dominance of large-scale phase dynamics in human cortex, from delta to gamma | eLife
The phase of cortical activity, measured in the gray matter, is organized at multiple spatial scales, with the largest scales explaining most variance in phase...
https://elifesciences.org/articles/15023
Active suppression of a leaf meristem orchestrates determinate leaf growth | eLife
A meristem acting at the margins of Arabidopsis leaves is suppressed by factors acting primarily in leaves and other determinate organs.
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https://elifesciences.org/articles/75373/figures
Figures and data in Oligogenic heterozygous inheritance of sperm abnormalities in mouse | eLife
This first evidence of oligogenic inheritance in failed spermatogenesis strongly suggests that oligogenic heterozygosity could explain a significant proportion...
figures and data
https://elifesciences.org/articles/24100
Coordinated control of terminal differentiation and restriction of cellular plasticity | eLife
Transcription factors that specify the identity of individual neuron types via activating terminal differentiation gene batteries also restrict cellular...
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https://elifesciences.org/articles/83073
Cell-intrinsic ceramides determine T cell function during melanoma progression | eLife
Cell-intrinsic ceramide concentrations are involved in T cell differentiation and function.
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https://elifesciences.org/articles/62021/peer-reviews
Peer review in Structural basis for SARM1 inhibition and activation under energetic stress | eLife
Cryo-EM shows that the NADase activity of SARM1 is allosterically inhibited by physiological concentrations of NAD+ that stabilizes an auto-inhibited...
https://elifesciences.org/articles/104439v1
SFSWAP is a negative regulator of OGT intron detention and global pre-mRNA splicing | eLife
SFSWAP was identified in a genetic screen to negatively regulate splicing of OGT and other mRNAs primarily by regulating intron retention and exon skipping.
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https://blog.elifelimo.com/en/page/2
Elife's Your Best Guide & Tips for Travel (2)
The best place for your wanderlust! We want to share our best recommendations for you to enjoy your next adventure in the best way. And if you need a ride...
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https://elifesciences.org/articles/03727
Interpretive monitoring in the caudate nucleus | eLife
The caudate region of the brain signals the context in which sensory evidence is evaluated, helping animals to adapt their behavior to changing conditions.
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https://elifesciences.org/inside-elife/961cb4ad/elife-community-ten-simple-rules-for-successful-and-sustainable-african-research-collaboration
eLife Community: Ten simple rules for successful and sustainable African research collaboration |...
Learn how you can engage in true collaboration in this guide from African eLife Community Ambassadors
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https://elifesciences.org/articles/18425
Nucleophile sensitivity of Drosophila TRPA1 underlies light-induced feeding deterrence | eLife
Electron-donating nucleophilic compounds activate TRPA1 ion channels in fruit flies and mosquitoes, but not humans, making TRPA1 a promising target for insect...
sensitivitydrosophila
https://elifesciences.org/articles/96402
Nonlinear feedback modulation contributes to the optimization of flexible decision-making | eLife
Precise feedback connections in posterior parietal cortex enable iterative computation between decision processes, optimizing flexible decision-making...
to the
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https://elifesciences.org/articles/59295v1
4-hydroxy-2-nonenal antimicrobial toxicity is neutralized by an intracellular pathogen | eLife
https://elifesciences.org/articles/32323v1
An incoherent feedforward loop facilitates adaptive tuning of gene expression | eLife
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https://lens.elifesciences.org/18447/
Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells | eLife Lens
https://elifesciences.org/articles/10955
The evolution of distributed sensing and collective computation in animal populations | eLife
A computational model shows that natural selection can cause populations to evolve a distinctive population-level phenotype: the ability to transition between...
the evolution
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https://elifesciences.org/podcast/episode63
Episode 63: January 2020 | Podcast | eLife
In this episode we hear about a fall in average body temperature over time, how our brain encodes seasons, why members of underrepresented communities leave...
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Polypyrimidine tract-binding proteins are essential for B cell development | eLife Lens
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https://elifesciences.org/articles/29586
Virus Evolution: A new twist in measuring mutation rates | eLife
The influenza virus mutates faster than we previously thought.
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https://elifesciences.org/articles/78092
Differentiation signals from glia are fine-tuned to set neuronal numbers during development | eLife
Extrinsic signals establish an invariant and stereotyped pattern of neuronal differentiation and programmed cell death in the Drosophila visual system.
https://elifesciences.org/articles/09305
Point of View: Strategies from UW-Madison for rescuing biomedical research in the US | eLife
A cross-campus, cross-career stage and cross-disciplinary series of discussions at a large public university has produced a series of recommendations for...
https://elifesciences.org/interviews/521a51ee/daniel-mansur
Interview: Catching up | Interviews | eLife
Daniel Mansur explains the challenges he faces as a Group Leader in Brazil.
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https://lens.elifesciences.org/72289/
microRNA-mediated regulation of microRNA machinery controls cell fate decisions | eLife Lens
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https://lens.elifesciences.org/00306/
Time line of redox events in aging postmitotic cells | eLife Lens
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https://elifesciences.org/articles/69883
A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive endosomal recycling | eLife
PX-BAR Mvp1 and dynamin-like GTPase Vps1 drive retromer-independent endosomal recycling.
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https://elifesciences.org/articles/23743
Sequential sensory and decision processing in posterior parietal cortex | eLife
Comparison of feature encoding and top-down cognitive signals gives insight into the role of parietal cortex in mediating decision making.
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https://elifesciences.org/articles/02419
The GTPase IFT27 is involved in both anterograde and retrograde intraflagellar transport | eLife
A small GTPase within the flagellum can participate in the control of transport from the base to the tip of the flagellum, and back again.
https://elifesciences.org/articles/52983/figures
Figures and data in The structure of the endogenous ESX-3 secretion system | eLife
The structure of the endogenous ESX-3 secretion system reveals a highly coordinated inner membrane complex and suggests a mechanism for the regulated secretion...
figures and data
https://elifesciences.org/articles/108748
Are peer reviewers influenced by their work being cited? | eLife
Some requests by reviewers to cite their own publications are coercive and can unnecessarily delay indexation and publication.
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https://elifesciences.org/articles/43231
Molecular mechanisms of gating in the calcium-activated chloride channel bestrophin | eLife
Cryo-EM structures of the gating cycle of bestrophin reveal the molecular underpinnings of activation and inactivation gating in this calcium-activated...
in the
https://elifesciences.org/articles/13065
Spatial organization shapes the turnover of a bacterial transcriptome | eLife
Transcriptome-scale RNA imaging and lifetime measurements reveal that the E. coli transcriptome is spatially organized and that this organization modulates the...
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Figures and data in Adaptor linked K63 di-ubiquitin activates Nedd4/Rsp5 E3 ligase | eLife
Arrestin-related trafficking adaptors (ARTs) undergo a K63 linked di-ubiquitin modification to promote Rsp5 E3 ligase recruitment and enhance cargo protein...
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https://elifesciences.org/articles/16409
Engineering vanilloid-sensitivity into the rat TRPV2 channel | eLife
Vanilloid sensitivity has been introduced into the TRPV2 channel, revealing that the gating and permeation properties of this enigmatic TRP channel are...
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https://www.mcb.harvard.edu/department/news/foresight-fish-physical-intelligence-3d-prey-capture-engert-lab/elife-51975-v1/
elife-51975-v1 - Harvard University - Department of Molecular & Cellular Biology
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https://elifesciences.org/articles/07074v2/peer-reviews
Peer review in Experimental evolution reveals hidden diversityin evolutionary pathways | eLife
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BERLINALE 2017 - Women eLife
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https://elifesciences.org/articles/102335v1
Criterion placement threatens the construct validity of neural measures of consciousness | eLife
The neural basis of consciousness is confounded by the mismatch between what participants report about their experience versus what they actually experience.
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https://elifesciences.org/articles/22089
The golden mimicry complex uses a wide spectrum of defence to deter a community of predators | eLife
A mimetic complex composed of at least 140 species of ants, wasps, spiders, true bugs and treehoppers, all with conspicuous golden bodies, has been discovered.
https://elifesciences.org/articles/51493v1
Bacterial interspecies interactions modulate pH-mediated antibiotic tolerance | eLife
bacterialinterspeciesinteractionsmodulateph
https://elifesciences.org/articles/66657/figures
Figures and data in Structure-guided microbial targeting of antistaphylococcal prodrugs | eLife
Prodrug antibiotics can be designed that are serum-stable but readily cleaved inside bacterial pathogens.
figures and data
https://hub.stenci.la/elife/
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Reproducibility of in vivo electrophysiological measurements in mice | eLife
An electrophysiology dataset generated by 10 laboratories from mice during perceptual decision-making reveals that reproducibility of systems neuroscience data...
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https://elifesciences.org/articles/30094v4
Dissection of affinity captured LINE-1 macromolecular complexes | eLife
The range of molecular forms adopted by L1 retrotransposons reflect a tapestry of lifecycle-permissive and -restrictive host-parasite interactions occurring...
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MicroRNA-mediated repression of nonsense mRNAs | eLife
microRNAs can serve as a surveillance system to repress nonsense mRNAs by recognizing miRNA-responsive elements in the open reading frame region downstream of...
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https://elifesciences.org/articles/76409v1
The importance of intermediate filaments in the shape maintenance of myoblast model tissues | eLife
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https://elifesciences.org/podcast/episode66
Episode 66: May 2020 | Podcast | eLife
In this episode we hear about sparrows, cave-dwelling fish, COVID-19 in hospital staff, anti-fungal drugs and lack of insect diversity in soil.
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https://elifesciences.org/articles/46156/peer-reviews
Peer review in Network-wide abnormalities explain memory variability in hippocampal amnesia | eLife
Hippocampal damage is associated with changes across the extended hippocampal system, and these may explain variability in memory between patients presenting...
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https://elifesciences.org/about/people/biochemistry-chemical-biology
Editors for Biochemistry and Chemical Biology | About | eLife
We aim to review studies that provide new insights into the structure, function, and regulation of biological molecules including proteins, nucleic acids,...
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https://elifesciences.org/articles/55429
Evolution: Mapping the ancestry of primates | eLife
Structures in the inner ear can help determine the evolutionary relationship between extinct and living primates.
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https://elifesciences.org/articles/41228/figures
Figures and data in Plant diversity maintains multiple soil functions in future environments | eLife
Empirical evidence shows that conserving local plant diversity is a robust strategy to maintain multiple valuable ecosystem services provided by soils in both...
figures and data
https://www.elife.co.jp/en/ec_column-sa3/
What is Shopify? Why it is suitable for cross-border e-commerce| eLife Inc.
Jul 5, 2023 - INTRODUCTION HELLO. MY NAME IS SAITO, AND I AM A CONSULTANT. IN TODAY'S DIGITIZED WORLD, COMPANIES HAVE A WIDE VARIETY OF WAYS TO SELL THEIR PRODUCTS AND...
https://elifesciences.org/articles/03579
Structure and substrate ion binding in the sodium/proton antiporter PaNhaP | eLife
The X-ray structure of the PaNhaP provides a unique view of substrate-ion binding and release in electroneutral sodium/proton antiporters.
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Saccade suppression depends on context | eLife
The ability to smoothly perceive the environment across saccades without disturbing retinal motion sensations is generated by eye movement contingent...
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https://elifesciences.org/articles/53618/peer-reviews
Peer review in Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth | eLife
In lung adenocarcinoma, deleting one glucose transporter, whether it is Glut1 or Glut3 is insufficient, whereas their dual deletion reduces tumor growth.
https://elifesciences.org/articles/31649
Hedgehog signaling via Gli2 prevents obesity induced by high-fat diet in adult mice | eLife
Targeted activation of Hedgehog signalling via Gli2 facilitated the reduction of high-fat-diet-induced obesity and improvement of whole-body glucose tolerance...
https://elifesciences.org/subjects/chromosomes-gene-expression
Chromosomes and Gene Expression | eLife
eLife reviews research ranging from transcription and RNA processing to epigenetics and chromatin biology. Learn more about what we review and sign up for the...
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https://elifesciences.org/articles/23661v1
Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells | eLife
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Community Archives | Page 2 of 62 eLife Inc.
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Figures and data in To lie or not to lie: Super-relaxing with myosins | eLife
A perspective of the energy-sparing super-relaxed state of myosin and its evolutionary role in modulating skeletal and cardiac muscle power under different...
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RNA polymerase III is involved in regulating Plasmodium falciparum virulence | eLife
RNA polymerase III plays a crucial role in controlling virulence in response to environmental changes and provides a new molecular perspective into the...
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The insulin receptor cellular IRES confers resistance to eIF4A inhibition | eLife
Utilizing a conserved mechanism, a ribosome can initiate translation from a site within the insulin receptor mRNA to maintain protein synthesis even when...
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Unified bursting strategies in ectopic and endogenous even-skipped expression patterns | eLife
Drosophila melanogastereven-skipped enhancers control transcriptional bursting by modulating frequency and amplitude, regardless of varying transcription...
https://elifesciences.org/subjects/immunology-inflammation
Immunology and Inflammation | eLife
eLife reviews research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we review and sign...
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