Robuta

https://elifesciences.org/articles/75373/figures Figures and data in Oligogenic heterozygous inheritance of sperm abnormalities in mouse | eLife This first evidence of oligogenic inheritance in failed spermatogenesis strongly suggests that oligogenic heterozygosity could explain a significant proportion... figures and data https://elifesciences.org/articles/42646/figures Figures and data in Retinal stem cells modulate proliferative parameters to coordinate... 3D niche topology imposes a spatially biased random stem cell loss, which is differentially fine-tuned in neural retina and retinal pigmented epithelium to... figures and datastem cells https://elifesciences.org/articles/07789/figures Figures and data in Longitudinal analysis of Plasmodium sporozoite motility in the dermis reveals... Malaria parasites enter the host via the skin, where they are inoculated by an infected mosquito as it probes for blood: the inoculation site is a bottleneck... figures and data https://elifesciences.org/articles/48943/figures Figures and data in Cytoplasmic retention and degradation of a mitotic inducer enable plant... Degradation of a mitotic inducer coordinates the transition of two successive cell cycle arrests during the infective process of a plant pathogenic fungus. figures and data https://elifesciences.org/articles/89004/figures Figures and data in Sex-biased regulatory changes in the placenta of native highlanders contribute... Comparative transcriptome analyses of human placenta reveal regulatory divergence between native highlanders and lowland immigrants living at high altitude,... figures and data https://elifesciences.org/articles/44219/figures Figures and data in Expression of WIPI2B counteracts age-related decline in autophagosome... The dynamic phosphorylation of autophagy component WIPI2B is critical to maintain autophagosome biogenesis in neurons, and ectopic expression of WIPI2B can... figures and data https://elifesciences.org/articles/87356/figures Figures and data in A dynamical computational model of theta generation in hippocampal circuits to... Combining biophysically realistic hippocampal neurons with coupled phase oscillators that represent theta inputs enables probing the phase-dependent effects of... figures and data https://elifesciences.org/articles/09580/figures Figures and data in Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis |... The Munc18-1 protein promotes formation of the t-SNARE complex and the half-zippered SNARE complex, two rate-limiting steps of SNARE assembly, to enhance... figures and data https://elifesciences.org/articles/52983/figures Figures and data in The structure of the endogenous ESX-3 secretion system | eLife The structure of the endogenous ESX-3 secretion system reveals a highly coordinated inner membrane complex and suggests a mechanism for the regulated secretion... figures and data https://elifesciences.org/articles/90820/figures Figures and data in Interplay between charge distribution and DNA in shaping HP1 paralog phase... Despite highly conserved sequences, subtle variations in HP1 paralog charge distribution influence distinct liquid-liquid phase separation behaviors,... figures and data https://elifesciences.org/articles/66657/figures Figures and data in Structure-guided microbial targeting of antistaphylococcal prodrugs | eLife Prodrug antibiotics can be designed that are serum-stable but readily cleaved inside bacterial pathogens. figures and data https://elifesciences.org/articles/41228/figures Figures and data in Plant diversity maintains multiple soil functions in future environments | eLife Empirical evidence shows that conserving local plant diversity is a robust strategy to maintain multiple valuable ecosystem services provided by soils in both... figures and data https://elifesciences.org/articles/63703/figures Figures and data in To lie or not to lie: Super-relaxing with myosins | eLife A perspective of the energy-sparing super-relaxed state of myosin and its evolutionary role in modulating skeletal and cardiac muscle power under different... figures and data https://elifesciences.org/articles/63102/figures Figures and data in Stable transplantation of human mitochondrial DNA by high-throughput,... Applied pressure enables efficient isolated mitochondrial transfer and stable mitochondrial DNA (mtDNA) transplantation into a range of mtDNA-depleted cell... figures and data https://elifesciences.org/articles/30233/figures Figures and data in Time-gated detection of protein-protein interactions with transcriptional... A light-dependent two-hybrid tool with transcriptional readout detects multiple protein-protein interactions in living mammalian cells with high... figures and datain time https://elifesciences.org/articles/66466/figures Figures and data in The genetic organization of longitudinal subcortical volumetric change is... Volumetric lifespan change in subcortical structures follows fundamental principles of brain development, lifespan continuity, genetic organization, and... figures and data https://elifesciences.org/articles/88863/figures Figures and data in Leveraging inter-individual transcriptional correlation structure to infer... A population resource to investigate mechanisms of organ communication. figures and data https://elifesciences.org/articles/15600/figures Figures and data in Multisensory integration in the developing tectum is constrained by the balance... During development, the Xenopus brain improves its ability to discern specific time intervals between sensory inputs of different modalities via the maturation... figures and data https://elifesciences.org/articles/44278/figures Figures and data in Anatomical basis and physiological role of cerebrospinal fluid transport... Chemical ablation of olfactory sensory neurons blocks cerebrospinal fluid outflow into the nasal epithelium, leading to alterations of cerebrospinal fluid... figures and data https://elifesciences.org/articles/47733/figures Figures and data in Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane... Silencing the acyl-coA synthethase ACSL1 protects against saturated fat lipotoxicity by preventing the degradation of polyunsaturated fatty acids, allowing... figures and data https://elifesciences.org/articles/34896/figures Figures and data in The dual role of chloride in synaptic vesicle glutamate transport | eLife Whole endosome recording shows that chloride interacts with vesicular glutamate transporters as both allosteric activator and permeant ion, and although the... figures and data https://elifesciences.org/articles/46994/figures Figures and data in The Natural History of Model Organisms: The untapped potential of medaka and... Studies of medaka and other ricefishes in the wild could provide insights in fields such as evolutionary biology, development and cancer research. figures and datathe natural history https://elifesciences.org/articles/71858/figures Figures and data in Synaptic targets of photoreceptors specialized to detect color and skylight... The fly connectome reveals dedicated cell types for processing specific kinds of visual information such as color or skylight polarization. figures and data https://elifesciences.org/articles/87523/figures Figures and data in An important role for triglyceride in regulating spermatogenesis | eLife Triglyceride plays an important role in regulating sperm development. figures and data https://elifesciences.org/articles/44360/figures Figures and data in Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and... A subset of EC/VCs have CD4+T cells with resistance specific to R5-tropic HIV infection associated with transcriptional down-regulation of ccr5, a phenotype... figures and data https://elifesciences.org/articles/71980/figures Figures and data in Structure and function of the ROR2 cysteine-rich domain in vertebrate... Structure-function analysis of the ROR2 cysteine-rich domain reveals a new mechanism of WNT5A reception at the cell surface and provides new insights into the... figures and data https://elifesciences.org/articles/59566v2/figures Figures and data in Extensive and diverse patterns of cell death sculpt neural networks in insects... Developmental cell death plays a key role during insect neurogenesis and is increased in specific neuronal populations in flies that have evolved... figures and data https://elifesciences.org/articles/00425/figures Figures and data in Decoding the neural mechanisms of human tool use | eLife Imaging experiments reveal that some brain regions do not distinguish between actions performed using tools and those performed using the hands, while others... figures and data https://elifesciences.org/articles/88750/figures Figures and data in Yeast cell responses and survival during periodic osmotic stress are controlled... Microfluidic methods are used to quantitatively probe single yeast cells' response to either simultaneous or sequential stresses, revealing the dynamic... figures and data https://elifesciences.org/articles/42866/figures Figures and data in The human gut chemical landscape predicts microbe-mediated biotransformation of... A network of the gut chemical landscape predicts microbe-mediated biotransformation of foods and drugs and supports the generation of mechanistic hypotheses of... figures and data https://elifesciences.org/articles/49672v1/figures Figures and data in The HCN domain couples voltage gating and cAMP response in... figures and datain the https://elifesciences.org/articles/80965/figures Figures and data in Convergence of two global regulators to coordinate expression of essential... The two global regulators CRP and PhoP interact with each other to coordinate expression of essential virulence determinants of Mycobacterium tuberculosis. figures and data https://elifesciences.org/articles/91722/figures Figures and data in Brain state and cortical layer-specific mechanisms underlying perception at... States of elevated arousal and stable retinal images allow enhanced processing of threshold stimuli in the laminar microcircuits of area V4. figures and data https://elifesciences.org/articles/50253/figures Figures and data in Asymmetrical diversification of the receptor-ligand interaction controlling... In-planta ancestral protein resurrection of the female determinant of self-incompatibility specificity in Arabidopsis halleri demonstrates that two allelic... figures and data https://elifesciences.org/articles/58237/figures Figures and data in Meta-Research: Questionable research practices may have little effect on... Although questionable research practices inflate false positive rates, they have little effect on replicability because they also increase power. figures and data https://elifesciences.org/articles/57637v1/figures Figures and data in Fine-scale computations for adaptive processing in the human brain | eLife figures and data https://elifesciences.org/articles/75163/figures Figures and data in Regional opportunities for tundra conservation in the next 1000 years | eLife The treeline follows climate warming with a severe time lag, but migration rates are increasing so that only under ambitious mitigation efforts will 30% of... figures and data https://elifesciences.org/articles/17101/figures Figures and data in Hemi-methylated DNA regulates DNA methylation inheritance through allosteric... Epigenetic modifications to DNA can regulate E3 ubiquitin ligase activity in human cells. figures and data https://elifesciences.org/articles/05290/figures Figures and data in A recurrent regulatory change underlying altered expression and Wnt response of... An identical DNA base pair change has occurred in divergent sticklebacks to alter the expression of a major developmental gene controlling armor plates, thus... figures and data https://elifesciences.org/articles/40385/figures Figures and data in Molecular mechanisms that stabilize short term synaptic plasticity during... Genetic and electrophysiological experiments define how homeostatic signaling stabilizes both the gain and short-term dynamic properties of neurotransmitter... figures and data https://elifesciences.org/articles/93223/figures Figures and data in OpenNucleome for high-resolution nuclear structural and dynamical modeling |... An open-source tool for computational simulations of the human genome has been introduced, enabling the characterization of complex nuclear environments and... figures and data https://elifesciences.org/articles/10067v1/figures Figures and data in Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming... figures and data https://elifesciences.org/articles/66686/figures Figures and data in Insula to mPFC reciprocal connectivity differentially underlies novel taste... aIC to mPFC connections are correlative and necessary both for taste novelty behavior and learning while the reciprocal connection from mPFC to aIC is... figures and data https://elifesciences.org/articles/02687/figures Figures and data in Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5 | eLife The GEF activity of Rabex-5 is weakly autoinhibited by its CC domain and activated by Rabaptin-5 and the two proteins work concertedly to activate Rab5. figures and data https://elifesciences.org/articles/61056/figures Figures and data in Antibody escape by polyomavirus capsid mutation facilitates neurovirulence |... Cryo EM and a custom subvolume refinement approach applied to mouse polyomavirus revealed the in vivo impact of polyomavirus capsid mutations on antiviral... figures and data https://elifesciences.org/articles/56554/figures Figures and data in Cytotoxic T cells swarm by homotypic chemokine signalling | eLife Killer T cells swarm around tumour targets by accelerating the recruitment of distant T cells, which upon arrival and target engagement augment the chemotactic... figures and data https://elifesciences.org/articles/63756/figures Figures and data in Action potential-coupled Rho GTPase signaling drives presynaptic plasticity |... Proteomic and genetic analysis discovers a new cytoskeletal mechanism of presynaptic short-term plasticity common across neuronal cell types. figures and data https://elifesciences.org/articles/23539/figures Figures and data in The cyanobacterial circadian clock follows midday in vivo and in vitro | eLife The cyanobacterial core clock tracks midday regardless of day length, which can be understood in terms of a model for how the environment alters the clock... figures and data