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https://elifesciences.org/articles/21330/figures Figures and data in Glycolysis and glutaminolysis cooperatively control T cell function by limiting... Metabolic switches between oxidative phosphorylation and aerobic glycolysis plus glutaminolysis direct T cell function by altering the flux of glucose and... figures and data https://elifesciences.org/articles/96281/figures Figures and data in Chronic activation of a negative engram induces behavioral and cellular... Repeatedly activating negative memory-bearing cells produces cellular and behavioral abnormalities. figures and data https://elifesciences.org/articles/89889/figures Figures and data in Choline supplementation in early life improves and low levels of choline can... Supplementing the diet in early life with choline improved memory, neuronal morphology, and neuronal activity in mice with a genetic form of Alzheimer's... figures and data https://elifesciences.org/articles/68693/figures Figures and data in Rolling controls sperm navigation in response to the dynamic rheological... Rheological properties of the environment regulate sperm swimming and navigational behavior through suppression or reactivation of sperm rolling around its... figures and data https://elifesciences.org/articles/06604/figures Figures and data in Visual processing of informative multipoint correlations arises primarily in V2... Building on recent findings that central sensory processing allocates resources according to the informativeness of statistical features (Hermundstad et al.,... figures and data https://elifesciences.org/articles/25782/figures Figures and data in Crosstalk within a functional INO80 complex dimer regulates nucleosome sliding... Regulation of the INO80 chromatin remodelling complex differs from those identified in other chromatin remodellers and involves a C-terminal domain of the... figures and data https://elifesciences.org/articles/05401/figures Figures and data in Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the... Two membrane proteins that belong to a new type of cell-surface receptor mediate the transmembrane signaling for a secreted factor that has broad therapeutic... figures and data https://elifesciences.org/articles/58061/figures Figures and data in Primary and promiscuous functions coexist during evolutionary innovation... The coexistence of ancestral and innovative functions is possible and fosters evolutionary innovation in events involving the acquisition of whole protein... figures and data primary https://elifesciences.org/articles/71069/figures Figures and data in Simplifying the development of portable, scalable, and reproducible workflows |... Descriptions, examples, and tools to enable biologists to use the Common Workflow Language for data processing and to facilitate computational reproducibility. figures and data the development https://elifesciences.org/articles/17180/figures Figures and data in Tetherin is an exosomal tether | eLife Blocking acidification causes endosomes to fuse with the plasma membrane, releasing exosomes that remain attached to the cell surface via the anti-viral... figures and data tether elife https://elifesciences.org/articles/22451/figures Figures and data in Oncometabolite D-2-Hydroxyglutarate enhances gene silencing through inhibition... Mutations in budding yeast modeled after cancer-associated isocitrate dehydrogenase mutations lead to stabilization of heterochromatin and enhanced gene... figures and data https://elifesciences.org/articles/30107v2/figures Figures and data in Identification and functional characterization of muscle satellite cells in... Modeling adult muscle homeostasis, maintenance and repair will now be possible in Drosophila with the discovery of satellite cells equivalents in flight... figures and data identification https://elifesciences.org/articles/23136/figures Figures and data in Bacterial flagella grow through an injection-diffusion mechanism | eLife Single cell, fluorescent microscopy and mathematical modeling reveal how bacterial flagella dynamically assemble outside the cell. figures and data https://elifesciences.org/articles/04380v1/figures Figures and data in Homeostasis in C. elegans sleep is characterized by two behaviorally and... figures and data https://elifesciences.org/articles/44306/figures Figures and data in PAX8 regulon in human ovarian cancer links lineage dependency with epigenetic... A functional ovarian-specific PAX8-centric regulon is susceptible to FDA-approved HDAC inhibitors, providing the rationale to target human cancers driven by... figures and data https://elifesciences.org/articles/54275/figures Figures and data in Dual orexin and MCH neuron-ablated mice display severe sleep attacks and... New transgenic mice, which can be ablated both orexin neurons and MCH neurons, showed new brain state and revealed functional interaction that MCH neurons have... figures and data https://elifesciences.org/articles/58825/figures Figures and data in Cell-cycle-gated feedback control mediates desensitization to interferon... Cell cycle gating enables a temporal compartmentalization of negative vs positive feedback control processes, leading to differential responses to repetitive... figures and data https://elifesciences.org/articles/92426/figures Figures and data in Human DDX6 regulates translation and decay of inefficiently translated mRNAs |... DDX6 triggers inefficiently translated mRNA decay by interacting with the ribosome through its FDF motif via the 5'-3' mRNA decay pathway. figures and data https://elifesciences.org/articles/89023/figures Figures and data in Modulation of RNA processing genes during sleep-dependent memory | eLife RNA processing genes regulated during sleep-dependent memory may contribute to sleep and memory. figures and data https://elifesciences.org/articles/11285/figures Figures and data in Evaluating probabilistic dengue risk forecasts from a prototype early warning... The evaluation of a dengue early warning system demonstrates its potential to assist dengue prevention and control up to three months ahead of future epidemics. figures and data https://elifesciences.org/articles/88799/figures Figures and data in Distinct states of nucleolar stress induced by anticancer drugs | eLife Anticancer compound library screen identified many types of nucleolar stress and revealed an essential role of transcriptional cyclin-dependent kinases in... figures and data https://elifesciences.org/articles/05007v1/figures Figures and data in Heritable capture of heterochromatin dynamics in Saccharomyces cerevisiae |... figures and data heritable https://elifesciences.org/articles/00422/figures Figures and data in ER-associated mitochondrial division links the distribution of mitochondria and... Sites at which mitochondria contact the endoplasmic reticulum co-localize the replication of mitochondria and their DNA to help ensure that DNA is distributed... figures and data https://elifesciences.org/articles/64395/figures Figures and data in Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the... Structural, biochemical, and cell biology study revealed that Rsu1, through binding to PINCH1, inhibits the actin bundling ability of ILK/PINCH/Parvin to... figures and data https://elifesciences.org/articles/83005/figures Figures and data in Coronary artery established through amniote evolution | eLife During the evolution of amniotes, the transformation of branchial arches coincided with the drastic remodeling of the ancestral extrinsic cardiac arteries,... figures and data coronary artery https://elifesciences.org/articles/47549v1/figures Figures and data in A genetic selection reveals functional metastable structures embedded in a... figures and data genetic selection https://elifesciences.org/articles/80277/figures Figures and data in A selective LIS1 requirement for mitotic spindle assembly discriminates... Mouse deficiencies for the dynein-binding protein LIS1 reveal different cell division mechanisms across T-cell subsets. figures and data https://elifesciences.org/articles/35322v1/figures Figures and data in The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler... figures and data https://elifesciences.org/articles/40841/figures Figures and data in Natural variation in sugar tolerance associates with changes in signaling and... The optimal macronutrient composition, macronutrient space, varies strongly between closely related species and is determined by genetic changes in regulatory... figures and data https://elifesciences.org/articles/27345/figures Figures and data in Light reintroduction after dark exposure reactivates plasticity in adults via... Light reintroduction (LRx) after dark exposure reactivates structural and functional plasticity in the adult mouse visual cortex by increasing the activity of... figures and data https://elifesciences.org/articles/04790v1/figures Figures and data in Death following traumatic brain injury in Drosophila is associated with... figures and data traumatic brain injury https://elifesciences.org/articles/62455/figures Figures and data in Highly redundant neuropeptide volume co-transmission underlying episodic... The arcuate nucleus kisspeptin neurons express multiple transmitters but use only the neuropeptide kisspeptin to drive the episodic secretion of... figures and data https://elifesciences.org/articles/42528/figures Figures and data in Venous endothelin modulates responsiveness of cardiac sympathetic axons to... Second-order guidance, a novel mechanism by which an initial guidance cue controls expression of a second guidance receptor, is required for precise refinement... figures and data https://elifesciences.org/articles/90623v1/figures Figures and data in Science Forum: Best practices to promote rigor and reproducibility in the era... Guidelines are presented to help researchers comply with sex-inclusive research mandates while upholding high standards of rigor. figures and data https://elifesciences.org/articles/98552/figures Figures and data in Streamlining segmentation of cryo-electron tomography datasets with Ais | eLife The software package Ais simplifies automated segmentation in cryo-electron tomography, enabling users to segment, detect particles, and visualize data in a... figures and data https://elifesciences.org/articles/04599v2/figures Figures and data in Side-binding proteins modulate actin filament dynamics | eLife The kinetics of actin polymerization are strongly influenced by the binding of proteins to the lateral filament surface. figures and data in side https://elifesciences.org/articles/45181/figures Figures and data in Thyroid hormone regulates distinct paths to maturation in pigment cell lineages... Single-cell transcriptomics combined with genetic analyses identify post-embryonic neural crest subpopulations and thyroid hormone dependencies in zebrafish... figures and data https://elifesciences.org/articles/90992/figures Figures and data in Mechanistic target of rapamycin (mTOR) pathway in Sertoli cells regulates... For the first time, a molecular mechanism is identified, for experimental acceleration and deceleration (rejuvenation) of sperm epigenetic aging. figures and data https://elifesciences.org/articles/69444/figures Figures and data in Towards novel herbicide modes of action by inhibiting lysine biosynthesis in... Proof-of-principle for a new herbicide mode of action through the identification of novel inhibitors of lysine biosynthesis with in planta efficacy. figures and data https://elifesciences.org/articles/89570/figures Figures and data in Neural correlates of perceptual similarity masking in primate V1 | eLife Optical imaging from macaque monkeys performing a detection task reveals the contribution of neural populations in V1 to the phenomenon of camouflage, where... figures and data https://elifesciences.org/articles/07304/figures Figures and data in A conserved histidine modulates HSPB5 structure to trigger chaperone activity... Small decreases in pH associated with cellular stress conditions unleash a cryptic mode of client binding in a ubiquitously expressed human small heat shock... figures and data https://elifesciences.org/articles/81051/figures Figures and data in Transparency of research practices in cardiovascular literature | eLife Based on a standardized screening process, the simple majority of reviewed cardiovascular research publications lack sufficient information needed for the... figures and data research practices transparency https://elifesciences.org/articles/85246/figures Figures and data in Dalpiciclib partially abrogates ER signaling activation induced by pyrotinib in... Dalpiciclib could partially abrogate ER nuclear transportation induced by pyrotinib in HER2+HR+ breast cancer and CALML5 could serve as a potential risk factor... figures and data https://elifesciences.org/articles/83107/figures Figures and data in The evolutionary mechanism of non-carbapenemase carbapenem-resistant phenotypes... Genetic, phenotypic, and evolutionary analysis of a clinical isolate provides an explanation of the intricate genetic factors behind non-carbapenemase... figures and data https://elifesciences.org/articles/03842v1/figures Figures and data in Flattop regulates basal body docking and positioning in mono- and multiciliated... figures and data https://elifesciences.org/articles/63524/figures Figures and data in Molecular structures of the eukaryotic retinal importer ABCA4 | eLife The structures of ABCA4 in two conformations provide a framework to understand its transport mechanism. figures and data https://elifesciences.org/articles/74970/figures Figures and data in The missing link between genetic association and regulatory function | eLife A common conceptual model exists in which trait-associated genetic variants that do not alter protein structure act by changing gene expression, but, in the... figures and data the missing link https://elifesciences.org/articles/32696/figures Figures and data in Large-scale network integration in the human brain tracks temporal fluctuations... Graph analysis revealed that spontaneous fluctuations of episodic-memory encoding performance associate with time-varying brain connectivity networks. figures and data https://elifesciences.org/articles/61287/figures Figures and data in Characterization of the mechanism by which the RB/E2F pathway controls... The antiviral and genomic DNA deaminase APOBEC3B is repressed in normal cells by PRC1.6/E2F6 and DREAM/E2F4 complexes and deregulation of this axis provides a... figures and data https://elifesciences.org/articles/53447/figures Figures and data in Suppressing proteasome mediated processing of topoisomerase II DNA-protein... Analysis of genome integrity in primary murine B-cells reveals how depleting 26S proteasome activity enhanced cell survival following treatment with... figures and data https://elifesciences.org/articles/18904/figures Figures and data in Oxytocin improves behavioral and electrophysiological deficits in a novel... The production, validation and study of a novel rat model for Phelan McDermid Syndrome shows an ameliorative effect of oxytocin on both social and attentional... figures and data oxytocin https://elifesciences.org/articles/64919v1/figures Figures and data in Tissue-autonomous immune response regulates stress signalling during... figures and data https://elifesciences.org/articles/26371/figures Figures and data in Essential roles of Caspase-3 in facilitating Myc-induced genetic instability... Myc expression is shown to cause sublethal activation of Caspase-3 and downstream endonuclease G, which causes DNA double strand breaks and oncogenic... figures and data https://elifesciences.org/articles/77241/figures Figures and data in VE-cadherin enables trophoblast endovascular invasion and spiral artery... VE-cadherin is required for trophoblast invasion of the maternal decidua and spiral arteries. figures and data https://elifesciences.org/articles/21253/figures Figures and data in Replication Study: BET bromodomain inhibition as a therapeutic strategy to... Editors' Summary: This Replication Study has reproduced important parts of the original paper. figures and data https://elifesciences.org/articles/18937/figures Figures and data in Autocorrelation structure at rest predicts value correlates of single neurons... Variability in individual neurons' temporal receptive fields of integration is found to explain the heterogeneity of neuronal responses observed in prefrontal... figures and data https://elifesciences.org/articles/14012v2/figures Figures and data in Epidermal RAF prevents allergic skin disease | eLife In keratinocytes, the BRAF and RAF1 proteins work independently to balance the activity of mitogenic and stress kinase cascades and uphold the mechanical and... figures and data allergic skin disease epidermal https://elifesciences.org/articles/17681v3/figures Figures and data in Isoform-specific subcellular localization and function of protein kinase A... High-resolution, large-scale immunohistochemical mouse brain images showing global views of different brain regions, as well as cellular and subcellular... figures and data https://elifesciences.org/articles/82563v1/figures Figures and data in The RAM signaling pathway links morphology, thermotolerance, and CO2 tolerance... figures and data https://elifesciences.org/articles/75419/figures Figures and data in Key features of the genetic architecture and evolution of host-microbe... Genetic variation influencing the gut microbiome is abundant among incipient mammalian host species, and cospeciating bacterial taxa display a unique genetic... figures and data https://elifesciences.org/articles/87992/figures Figures and data in Multimodal neural correlates of childhood psychopathology | eLife A multivariate approach identifying structural and functional factors underpinning dimensions of psychopathology in over 5000 children. figures and data multimodal https://elifesciences.org/articles/81716/figures Figures and data in Microcephaly-associated protein WDR62 shuttles from the Golgi apparatus to the... Microcephaly-associated mutations disrupt microtubule-dependent WDR62 translocation from the Golgi complex to the mitotic spindle poles, impair mitotic... figures and data https://elifesciences.org/articles/45506/figures Figures and data in Cooperation of mitochondrial and ER factors in quality control of tail-anchored... The endoplasmic reticulum E3 ubiquitin ligase Doa10 and the mitochondrial AAA-ATPase Msp1 govern targeting fidelity of outer mitochondrial tail-anchored... figures and data https://elifesciences.org/articles/54868v1/figures Figures and data in Pattern regulation in a regenerating jellyfish | eLife figures and data pattern regulation regenerating jellyfish https://elifesciences.org/articles/44478/figures Figures and data in KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D | eLife Both VEGF-C and VEGF-D can be activated by KLK3/PSA and Cathepsin D, producing two novel VEGF-C forms and the known VEGFR-2-specific form of VEGF-D. figures and data https://elifesciences.org/articles/55813v1/figures Figures and data in Diversity-decomposition relationships in forests worldwide | eLife figures and data diversity decomposition relationships forests https://elifesciences.org/articles/84077/figures Figures and data in Vitamin B2 enables regulation of fasting glucose availability | eLife The dietary vitamin riboflavin provides the chemical backbone to generate essential substrates that support liver glucose metabolism during low-nutrient... figures and data https://elifesciences.org/articles/67554/figures Figures and data in CTP promotes efficient ParB-dependent DNA condensation by facilitating... Single-molecule methods reveal that cytidine triphosphate promotes DNA condensation specifically at bacterial centromeres by facilitating one-dimensional... figures and data https://elifesciences.org/articles/21221v2/figures Figures and data in Pharmacological targeting of the transcription factor SOX18 delays breast... A novel molecular strategy to block transcription factor activity using small molecule interference of multiple protein-protein interactions is reported. figures and data https://elifesciences.org/articles/62875v1/figures Figures and data in Three-dimensional reconstruction of a whole insect reveals its phloem... figures and data https://elifesciences.org/articles/06327/figures Figures and data in Palmitoylation of LIM Kinase-1 ensures spine-specific actin polymerization and... The protein-lipid modification palmitoylation targets the kinase LIMK1 to dendritic spines to ensure precise control of the size of individual spines in... figures and data https://elifesciences.org/articles/74708/figures Figures and data in Distance estimation from monocular cues in an ethological visuomotor task |... Mice accurately perform an ethological distance estimation task based on gap jumping and can use monocular cues to estimate distance in addition to binocular... figures and data https://elifesciences.org/articles/98834/figures Figures and data in Bidirectional dysregulation of synaptic glutamate signaling after transient... Synaptic glutamate release is potentiated by short metabolic failure whereas longer durations of energy depletion lead to a postsynaptic failure of synaptic... figures and data https://elifesciences.org/articles/06369/figures Figures and data in Evolution of alternative biosynthetic pathways for vitamin C following plastid... Genomic evidence suggests that L-gulonolactone oxidase-the terminal enzyme in vitamin C synthesis, which has been repeatedly lost throughout animal... figures and data https://elifesciences.org/articles/09849/figures Figures and data in Rhythmic coordination of hippocampal neurons during associative memory... Different rhythms uniquely contribute to task-related processing in the hippocampus, and changes in the rhythmic profile of the hippocampus reflect dynamic... figures and data https://elifesciences.org/articles/51085/figures Figures and data in CytoCensus, mapping cell identity and division in tissues and organs using... Easy-to-use image analysis software enables single cell quantitation of cell types and division rates in complex 3D tissues including living Drosophila brains,... figures and data https://elifesciences.org/articles/53664v1/figures Figures and data in A circuit mechanism for decision-making biases and NMDA receptor hypofunction |... Ketamine, an NMDA receptor antagonist and experimental model for schizophrenia, produces decision-making deficits in monkeys, which are predicted by a lowering... figures and data https://elifesciences.org/articles/64988/figures Figures and data in The structure of behavioral variation within a genotype | eLife Multidimensional analysis of data from high-throughput behavioral assays reveals many independent axes of behavioral variation among inbred animals reared in... figures and data https://elifesciences.org/articles/52677v1/figures Figures and data in Brain aging comprises many modes of structural and functional change with... figures and data https://elifesciences.org/articles/40907v1/figures Figures and data in Bid maintains mitochondrial cristae structure and protects against cardiac... figures and data https://elifesciences.org/articles/30094/figures Figures and data in Dissection of affinity captured LINE-1 macromolecular complexes | eLife The range of molecular forms adopted by L1 retrotransposons reflect a tapestry of lifecycle-permissive and -restrictive host-parasite interactions occurring... figures and data https://elifesciences.org/articles/69603/figures Figures and data in Modelling the impact of decidual senescence on embryo implantation in human... The study of embryo-endometrial interactions in assembloid co-cultures identifies novel mechanisms of reproductive failure. figures and data https://elifesciences.org/articles/09345/figures Figures and data in Matrix metalloproteinase 14 is required for fibrous tissue expansion | eLife The membrane type I-matrix metalloproteinase is essential for the release of collagen fibrils from plasma membrane fibripositors, which is required for the... figures and data https://elifesciences.org/articles/64175/figures Figures and data in scAAVengr, a transcriptome-based pipeline for quantitative ranking of... A transcriptome-based pipeline (scAAVengr) quantifies and ranks competing adeno-associated viral vectors in primate retina, and mouse brain, heart, and liver,... figures and data https://elifesciences.org/articles/90133/figures Figures and data in Homeodomain proteins hierarchically specify neuronal diversity and synaptic... The homeodomain protein Bsh increases lamina neuron types and visual function. figures and data homeodomain proteins https://elifesciences.org/articles/49998/figures Figures and data in Defining murine monocyte differentiation into colonic and ileal macrophages |... Detailed analysis of the sequence of monocyte differentiation into distinct gut tissue macrophages provides insights into monocyte biology and can serve as a... figures and data https://elifesciences.org/articles/05438/figures Figures and data in CAPS-1 promotes fusion competence of stationary dense-core vesicles in... Stationary dense-core vesicles depend on the CAPS-1 protein to fuse with the presynaptic membrane. figures and data https://elifesciences.org/articles/52135v1/figures Figures and data in PCK1 and DHODH drive colorectal cancer liver metastatic colonization and... figures and data https://elifesciences.org/articles/07000/figures Figures and data in Norepinephrine is required to promote wakefulness and for hypocretin-induced... Experiments in genetically modified zebrafish that are unable to produce norepinephrine show that this neurotransmitter promotes wakefulness by mediating the... figures and data