hsp90 - Robuta Search

https://www.jci.org/assets/240366/powerpoint JCI - The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau... https://www.rcsb.org/structure/6GPR RCSB PDB - 6GPR: Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) in... Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) in complex with cAMP https://www.rcsb.org/structure/6GR5 RCSB PDB - 6GR5: Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD)... Structure of human Heat shock protein 90-alpha N-terminal domain (Hsp90-NTD) variant K112R in complex with ADP https://www.thermofisher.com/antibody/product/HSP90-Antibody-clone-MBH90AB-Monoclonal/MA1-10372 HSP90 Monoclonal Antibody (MBH90AB) | Invitrogen (MA1-10372) Detect HSP90 in WB, ICC/IF, IP, IHC (P), ELISA. Reacts with Mouse, Rabbit, Chicken, Llama. Cited in 4 publications. Catalog # MA1-10372 monoclonal antibody hsp90 invitrogen ma1 10372 https://www.rcsb.org/structure/2FWY RCSB PDB - 2FWY: Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-H64 Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-H64 https://www.rcsb.org/structure/1US7 RCSB PDB - 1US7: Complex of Hsp90 and P50 Complex of Hsp90 and P50 rcsb pdb complex hsp90 p50 https://www.mskcc.org/news/out-lab-and-world-chaperone-protein-hsp90?_subsite=research-ski Out of the Lab and into the World: Hsp90 Inhibitor, a New Cancer Drug | Sloan Kettering Institute A dynamic mix of experts in biology, chemistry, and medicine come together in the Sloan Kettering Institute lab of chemical biologist Gabriella Chiosis to... https://www.ncbi.nlm.nih.gov/protein/16800010?report=GenPept Record removed: HSP90 family protein [Listeria innocua Clip11262] - Protein - NCBI listeria innocua record removed hsp90 family https://www.ncbi.nlm.nih.gov/protein/269795606?report=GenPept Record removed: molecular chaperone of HSP90 family [Sanguibacter keddieii DSM 10542] - Protein -... molecular chaperone https://www.rcsb.org/structure/1UYK RCSB PDB - 1UYK: Human Hsp90-alpha with... Human Hsp90-alpha with 8-Benzo[1,3]dioxol-,5-ylmethyl-9-butyl-2-fluoro-9H-purin-6-ylamine rcsb pdb human hsp90 alpha https://www.rcsb.org/structure/5J64 RCSB PDB - 5J64: Crystal Structure of Hsp90-alpha N-domain in complex with... Crystal Structure of Hsp90-alpha N-domain in complex with 5-(2,4-Dihydroxy-phenyl)-4-(2-fluoro-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one https://www.rcsb.org/structure/2YKE RCSB PDB - 2YKE: Tricyclic series of Hsp90 inhibitors Tricyclic series of Hsp90 inhibitors rcsb pdb series of tricyclic hsp90 inhibitors https://www.easychair.org/publications/keyword/17WR Keyword: Hsp90 keyword hsp90 https://www.thermofisher.com/antibody/product/HSP90-Antibody-clone-D7A-Monoclonal/MA5-45158 HSP90 Monoclonal Antibody (D7A), FITC | Invitrogen (MA5-45158) Detect HSP90 in WB, ICC/IF, IP, IHC (P), ELISA. Reacts with Mouse, Rabbit, Chicken, Llama. Catalog # MA5-45158 monoclonal antibody hsp90 d7a fitc invitrogen https://www.science20.com/news_articles/hsp90_is_a_potential_target_for_ameliorating_skeletal_muscle_abnormalities_in_pd-137146 HSP90 Is A Potential Target For Ameliorating Skeletal Muscle Abnormalities In PD | Science 2.0 Heat shock protein (HSP90) has been suggested to be involved in neuronal protein misfolding and accumulation in Parkinson's disease (PD) brains leading to... https://www.jci.org/assets/240367/powerpoint JCI - The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau... https://www.ncbi.nlm.nih.gov/Structure/pdb/2CGE 2CGE: Crystal structure of an Hsp90-Sba1 closed chaperone complex ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 crystal structure hsp90 closed chaperone complex https://www.ncbi.nlm.nih.gov/Structure/pdb/3H80 3H80: Crystal structure of the amino-terminal domain of HSP90 from Leishmania major,... Heat shock protein 83-11,2-ETHANEDIOLMAGNESIUM IONPHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER crystal structure of the amino terminal https://www.rcsb.org/structure/2VW5 RCSB PDB - 2VW5: Structure Of The Hsp90 Inhibitor 7-O-carbamoylpremacbecin Bound To The N- Terminus... Structure Of The Hsp90 Inhibitor 7-O-carbamoylpremacbecin Bound To The N- Terminus Of Yeast Hsp90 https://www.ncbi.nlm.nih.gov/gene/55664 CDC37L1 cell division cycle 37 like 1, HSP90 cochaperone [Homo sapiens (human)] - Gene - NCBI https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2022.947078/full Frontiers | In silico analysis of the HSP90 chaperone system from the African trypanosome,... African Trypanosomiasis is a neglected tropical disease caused by Trypanosoma brucei (T. brucei) and spread by the tsetse fly in sub-Saharan Africa. The tryp... frontiers in of the https://www.rcsb.org/structure/2YKB RCSB PDB - 2YKB: Tricyclic series of Hsp90 inhibitors Tricyclic series of Hsp90 inhibitors rcsb pdb series of tricyclic hsp90 inhibitors https://www.mdpi.com/1422-0067/23/13/7150 Triiodothyronine Acts as a Smart Influencer on Hsp90 via a Triiodothyronine Binding Site Microarray-based experiments revealed that thyroid hormone triiodothyronine (T3) enhanced the binding of Cy5-labeled ATP on heat shock protein 90 (Hsp90). By... as a triiodothyronine acts smart https://www.mskcc.org/news/hsp90-very-promising-target-therapy Hsp90: A Very Promising Target for Cancer Therapy | Memorial Sloan Kettering Cancer Center A small molecule discovered at MSK called PU-H71 blocks the growth of cancer cells and enables doctors to image tumors. memorial sloan kettering https://www.rcsb.org/structure/3HJC RCSB PDB - 3HJC: Crystal structure of the carboxy-terminal domain of HSP90 from Leishmania major,... Crystal structure of the carboxy-terminal domain of HSP90 from Leishmania major, LmjF33.0312 https://www.rcsb.org/structure/8U1N RCSB PDB - 8U1N: Cryo-EM structure of the cross-linked HSP90 dimer (NTD-MD) in the semi-open state Cryo-EM structure of the cross-linked HSP90 dimer (NTD-MD) in the semi-open state https://pmc.ncbi.nlm.nih.gov/articles/PMC11897633/ Potential benefits of combined treatment with Hsp90 inhibitor AUY922 and cisplatin for overcoming... Nasopharyngeal carcinoma (NPC) initially responds well to platinum-based therapy but often develops resistance. Combining therapies may offer a viable approach... https://www.ncbi.nlm.nih.gov/gene/10598 AHSA1 activator of HSP90 ATPase activity 1 [Homo sapiens (human)] - Gene - NCBI activity 1 https://www.rcsb.org/structure/2YEC RCSB PDB - 2YEC: HSP90 inhibitors and drugs from fragment and virtual screening HSP90 inhibitors and drugs from fragment and virtual screening rcsb pdb hsp90 inhibitors https://www.rcsb.org/structure/4O07 RCSB PDB - 4O07: Identification of novel HSP90/isoform selective inhibitors using structure-based... Identification of novel HSP90/isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such... https://pmc.ncbi.nlm.nih.gov/articles/PMC10447550/ Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the... Heat shock protein 90 (Hsp90) and its co-chaperones promote cancer, and targeting Hsp90 holds promise for cancer treatment. Most of the efforts to harness this... https://www.easychair.org/publications/preprint/HMm1 Targeting Cancer's Achilles Heel: Pharmacophore Insights into Hsp90 Alpha Inhibition achilles heel targeting cancer https://elifesciences.org/articles/39925/figures Figures and data in Glucose intake hampers PKA-regulated HSP90 chaperone activity | eLife Food overconsumption impairs cellular protein folding through a novel aging-related signaling pathway. https://www.mskcc.org/news/hsp90-very-promising-target-therapy?_subsite=research-ski Hsp90: A Very Promising Target for Cancer Therapy | Sloan Kettering Institute A small molecule discovered at MSK called PU-H71 blocks the growth of cancer cells and enables doctors to image tumors. cancer therapy sloan kettering hsp90 promising target https://www.ncbi.nlm.nih.gov/Structure/pdb/6KSQ 6KSQ: Middle Domain of Human HSP90 Alpha Heat shock protein HSP 90-alpha middle domain human hsp90 alpha https://www.spandidos-publications.com/10.3892/or.2018.6250/abstract The targeted inhibition of Hsp90 by a synthetic small molecule, DPide offers an effective treatment... Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. https://www.thermofisher.com/antibody/product/HSP90-Antibody-clone-AC-16-Monoclonal/MA5-45115 HSP90 Monoclonal Antibody (AC-16), APC | Invitrogen (MA5-45115) Detect HSP90 in WB, ICC/IF, IP, IHC (P), ELISA. Reacts with Mouse, Rabbit, Chicken, Llama. Catalog # MA5-45115 monoclonal antibody hsp90 ac 16 apc https://www.ncbi.nlm.nih.gov/Structure/pdb/3RLR 3RLR: Co-crystal structure of the HSP90 ATP binding domain in complex with... Heat shock protein HSP 90-alpha4-(2,4-dichloro-5-methoxyphenyl)-2,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrilePHOSPHATE ION atp binding domain https://www.news-medical.net/news/20100331/Hsp90-inhibitors-may-help-fight-cardiovascular-disease-say-researchers.aspx Hsp90 inhibitors may help fight cardiovascular disease, say researchers Jun 19, 2019 - New drugs that are helping fight a multi-front war on cancer may do the same for cardiovascular disease, Medical College of Georgia researchers said. hsp90 inhibitors cardiovascular disease may help fight https://www.rcsb.org/structure/5T21 RCSB PDB - 5T21: CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR148019. CRYSTAL STRUCTURE OF HSP90 IN COMPLEX WITH SAR148019. rcsb pdb crystal structure https://www.rcsb.org/structure/2WI5 RCSB PDB - 2WI5: Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone https://www.ncbi.nlm.nih.gov/Structure/pdb/2YGE 2YGE: E88G-N92L Mutant of N-Term HSP90 complexed with Geldanamycin ATP-DEPENDENT MOLECULAR CHAPERONE HSP82GELDANAMYCINGLYCEROL n term mutant https://www.ncbi.nlm.nih.gov/Structure/pdb/2YEE 2YEE: HSP90 inhibitors and drugs from fragment and virtual screening HEAT SHOCK PROTEIN HSP 90-ALPHA9-ETHYL-9H-PURIN-6-YLAMINESULFATE ION hsp90 inhibitors drugs fragment virtual screening https://pmc.ncbi.nlm.nih.gov/articles/PMC19060/ Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence - PMC The abundant molecular chaperone Hsp90 is a key regulator of protein structure in the cytosol of eukaryotic cells. Although under physiological conditions a... https://pmc.ncbi.nlm.nih.gov/articles/PMC41959/ Heat shock protein hsp90 regulates dioxin receptor function in vivo - PMC The dioxin (aryl hydrocarbon) receptor is a ligand-dependent basic helix-loop-helix (bHLH) factor that binds to xenobiotic response elements of target... heat shock protein dioxin receptor hsp90 https://www.jci.org/assets/240368/powerpoint JCI - The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau... https://www.rcsb.org/structure/3T1K RCSB PDB - 3T1K: HSP90 N-terminal domain bound to ANP HSP90 N-terminal domain bound to ANP n terminal domain rcsb pdb hsp90 bound anp https://www.rcsb.org/structure/5LO6 RCSB PDB - 5LO6: HSP90 WITH indazole derivative HSP90 WITH indazole derivative rcsb pdb hsp90 indazole derivative https://www.ncbi.nlm.nih.gov/Structure/pdb/2GQ0 2GQ0: Crystal Structure of the Middle Domain of HtpG, the E. coli Hsp90 Chaperone protein htpG crystal structure of the https://www.rcsb.org/structure/5LO5 RCSB PDB - 5LO5: HSP90 WITH indole derivative HSP90 WITH indole derivative rcsb pdb hsp90 indole derivative