https://www.rcsb.org/structure/3INM
Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase R132H mutant in complex with NADPH, ALPHA-KETOGLUTARATE and CALCIUM(2+)
crystal structurercsbpdbhumancytosolic
https://pubmed.ncbi.nlm.nih.gov/25271760/
Mutations of isocitrate dehydrogenase 1 (IDH1) are frequently found in certain cancers such as glioma. Different from the wild-type (WT) IDH1, the mutant...
inhibitioncancerassociatedmutantisocitrate