klotho - Robuta Search

https://pmc.ncbi.nlm.nih.gov/articles/PMC4060456/ Skeletal muscle as a regulator of the longevity protein, Klotho - PMC Klotho is a powerful longevity protein that has been linked to the prevention of muscle atrophy, osteopenia, and cardiovascular disease. Similar anti-aging... skeletal muscle of the regulator https://www.ncbi.nlm.nih.gov/search/all/?term=Klotho Search: Klotho - NLM search klotho nlm https://researchfestival.nih.gov/2015/posters/serum-25-hydroxyvitamin-d-plasma-klotho-and-lower-extremity-physical Serum 25-hydroxyvitamin D, plasma klotho, and lower-extremity physical performance among older... https://pubmed.ncbi.nlm.nih.gov/22419041/ KLOTHO methylation is linked to uremic toxins and chronic kidney disease Epigenetic regulation plays a major role in uremic toxin-induced chronic kidney disease (CKD) progression. The KLOTHO protein is a key modulator of homeostasis... chronic kidney klotho methylation linked https://pmc.ncbi.nlm.nih.gov/articles/PMC4399270/ Molecular Basis of Klotho: From Gene to Function in Aging - PMC The discovery of the Klotho (KL) gene, which was originally identified as a putative aging-suppressor gene, has generated tremendous interest and has advanced... molecular basis klotho https://pubmed.ncbi.nlm.nih.gov/9363890/ Mutation of the mouse klotho gene leads to a syndrome resembling ageing A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the... of the https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.755366/full Frontiers | Klotho as Potential Autophagy Regulator and Therapeutic Target The protein Klotho can significantly delay aging, so it has attracted widespread attention. Abnormal downregulation of Klotho has been detected in several ag... frontiers klotho potential autophagy regulator https://scholars.lib.ntu.edu.tw/entities/publication/b7efcdf0-ca1a-43d7-b2d1-c981cc353b29 Suppressed Klotho expression induced by protein-bound uremic toxins is mediated by DNA... by protein https://pubmed.ncbi.nlm.nih.gov/23212367/ Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart Klotho is a membrane protein predominantly produced in the kidney that exerts some antiageing effects. Ageing is associated with an increased risk of heart... https://publikationen.uni-tuebingen.de/xmlui/handle/10900/93306 Therapeutic Interference With Vascular Calcification-Lessons From Klotho-Hypomorphic Mice and Beyond https://pmc.ncbi.nlm.nih.gov/articles/PMC2536606/ Suppression of Aging in Mice by the Hormone Klotho - PMC A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression of Klotho in mice... by the suppression aging mice hormone https://pmc.ncbi.nlm.nih.gov/articles/PMC3780390/ SECRETED KLOTHO AND CHRONIC KIDNEY DISEASE - PMC Soluble Klotho (sKl) in the circulation can be generated directly by alterative splicing of the Klotho transcript or the extracellular domain of membrane... chronic kidney disease secreted klotho pmc https://scholars.cityu.edu.hk/en/publications/klotho-in-the-kidney-distal-convolution-regulates-urinary-klotho-/ Klotho in the kidney distal convolution regulates urinary Klotho excretion and kidney calcium... in the klotho kidney distal https://pure.psu.edu/en/publications/life-extension-factor-klotho-enhances-cognition/ Life Extension Factor Klotho Enhances Cognition - Penn State life extension factor klotho enhances cognition https://pubmed.ncbi.nlm.nih.gov/40118264/ Klotho senses mechanical stimuli and modulates tension-induced osteogenesis Delicate external mechanosensing, efficient intracellular mechanotransduction and effective alveolar bone remodeling lay the foundation of orthodontic tooth... klotho senses mechanical stimuli tension https://pmc.ncbi.nlm.nih.gov/articles/PMC9952437/ Klotho, Oxidative Stress, and Mitochondrial Damage in Kidney Disease - PMC Reducing oxidative stress stands at the center of a prevention and control strategy for mitigating cellular senescence and aging. Kidney disease is... oxidative stress kidney disease klotho mitochondrial damage https://pmc.ncbi.nlm.nih.gov/articles/PMC5816951/ Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging,... Cognitive dysfunction and decreased mobility from aging and neurodegenerative conditions, such as Parkinson and Alzheimer diseases, are major biomedical... https://researchprofiles.ku.dk/da/publications/klotho-and-activin-a-in-kidney-injury-plasma-klotho-is-maintained/ Klotho and activin A in kidney injury: plasma Klotho is maintained in unilateral obstruction... kidney injury https://www.sciencedaily.com/releases/2014/07/140724172108.htm Klotho: neuroprotective against Alzheimer's disease | ScienceDaily Researchers may have found a way to delay or even prevent Alzheimer's disease. They discovered that pre-treatment of neurons with the anti-aging protein Klotho... klotho neuroprotective alzheimer disease sciencedaily https://pubmed.ncbi.nlm.nih.gov/14528024/ Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative... The klotho gene encodes a novel type I membrane protein of beta-glycosidase family and is expressed principally in distal tubule cells of the kidney and... https://www.ucsf.edu/news/2018/01/409711/could-protein-called-klotho-block-dementia-and-aging Archive: Could a Protein Called Klotho Block Dementia and Aging? | UC San Francisco Denal Dubal, an associate professor of neurology at UCSF, thinks we can use the science of aging to help stave off these neurodegenerative diseases. https://pmc.ncbi.nlm.nih.gov/articles/PMC3911771/ Klotho and Chronic Kidney Disease - PMC Through alternative splicing, Klotho protein exists both as a secreted and a membrane form whose extracellular domain could be shed from the cell surface by... chronic kidney disease klotho pmc https://pubmed.ncbi.nlm.nih.gov/28793260/ Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging,... Cognitive dysfunction and decreased mobility from aging and neurodegenerative conditions, such as Parkinson and Alzheimer diseases, are major biomedical... https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1497224/full Frontiers | Dietary caffeine and its negative link to serum Klotho concentrations: evidence from... BackgroundThis is the initial investigation assessing the association between caffeine consumption through diet and circulating Klotho concentrations, with K...