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https://www.wikidata.org/wiki/Q36078653 Leukocytic proteases and the immunologic release of lysosomal enzymes - Wikidata lysosomal enzymes proteases immunologic release wikidata https://esgld.org/ European Study Group on Lysosomal Diseases study group european lysosomal diseases https://www.jci.org/articles/view/110414/pdf JCI - Apolipoprotein C-III-1 activates lysosomal sphingomyelinase in vitro. apolipoprotein c iii jci 1 activates lysosomal https://www.ncbi.nlm.nih.gov/protein/6V7N_A Chain A, Lysosomal acid lipase/cholesteryl ester hydrolase - Protein - NCBI lysosomal acid lipase cholesteryl ester chain hydrolase protein https://ldn.rarediseasesnetwork.org/ Home | Lysosomal Disease Network lysosomal disease network https://www.ncbi.nlm.nih.gov/gene?term=26258 BLOC1S6 biogenesis of lysosomal organelles complex 1 subunit 6 [Homo sapiens (human)] - Gene - NCBI https://www.spandidos-publications.com/10.3892/ijmm.2012.1187/abstract New strategies for the treatment of lysosomal storage diseases (Review) International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease. lysosomal storage diseases new strategies for the treatment review https://www.rcsb.org/structure/6V7N RCSB PDB - 6V7N: Crystal Structure of a human Lysosome Resident Glycoprotein, Lysosomal Acid... Crystal Structure of a human Lysosome Resident Glycoprotein, Lysosomal Acid Lipase, and its Implications in Cholesteryl Ester Storage Disease (CESD) https://lysosomaldiseasesummit.org/ Lysosomal Disease Summit 2026 | Melbourne, Australia - Lysosomal Disease Summit Apr 20, 2026 - Advancing Research and Treatment Across APAC. Join the Lysosomal Disease Summit, the leading event for metabolic and lysosomal disease professionals in the... lysosomal disease summit 2026 melbourne australia https://elifesciences.org/articles/61590 Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments... Cellular etiology of a human WASH complex mutation in mice reveals its specific roles in neuronal organelle trafficking and a surprising role in motor... https://elifesciences.org/articles/85214v1/peer-reviews Peer review in Organelle proteomic profiling reveals lysosomal heterogeneity in association with... peer review proteomic profiling organelle https://elifesciences.org/articles/53430 Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175 | eLife Structures of the non-canonical potassium channel TMEM175 in open and closed states reveal unique mechanisms for channel gating and the selective permeation of... for the k channel gating selectivity mechanisms https://www.massgeneral.org/children/genetics/lysosomal-disorder-patient-resources Patient Resources from the Lysosomal Disorders Clinic View the full collection of patient resources from the Lysosomal Disorders Clinic at MGfC. patient resources from the lysosomal disorders clinic https://medlineplus.gov/genetics/condition/lysosomal-acid-lipase-deficiency/ Lysosomal acid lipase deficiency: MedlinePlus Genetics Lysosomal acid lipase deficiency is an inherited condition characterized by problems with the breakdown and use of fats and cholesterol in the body (lipid... lysosomal acid lipase deficiency medlineplus genetics https://www.pearson.com/channels/cell-biology/exam-prep/intracellular-protein-transport/lysosomal-and-degradation-pathways Lysosomal and Degradation Pathways | Test Your Skills with Real Questions Explore Lysosomal and Degradation Pathways with interactive practice questions. Get instant answer verification, watch video solutions, and gain a deeper... test your skills lysosomal degradation pathways real https://elifesciences.org/reviewed-preprints/99913 Loss of SPNS1, a lysosomal transporter, in the nervous system causes dysmyelination and white... https://www.marketresearch.com/Maia-Research-v4212/Global-Lysosomal-Acid-Lipase-LAL-44132990/ Global Lysosomal Acid Lipase (LAL) Deficiency Treatment Industry Trends Analysis Report 2025,... Global Lysosomal Acid Lipase (LAL) Deficiency Treatment Industry Trends Analysis Report 2025, Forecast to 2033 (Broken Down by Type, End User, Regional... lysosomal acid lipase lal deficiency https://www.stjude.org/research/why-st-jude/shared-resources/technology-licensing/technologies/improved-method-to-produce-proteins-to-treat-lysosomal-storage-disorders-sj-01-0020.html Improvement producing proteins to treat lysosomal storage disorders (SJ-01-0020) | St. Jude Research Improved Method to Produce Proteins to Treat Lysosomal Storage Disorders (SJ-01-0020) https://www.ncbi.nlm.nih.gov/nuccore/NM_007509.2 Mus musculus ATPase, H+ transporting, lysosomal V1 subunit B2 (Atp6v1b - Nucleotide - NCBI mus musculus https://www.cincinnatichildrens.org/research/divisions/e/ex-hem/labs/pan/lysosomal-storage-disease Lysosomal Storage Diseases | Pan Lab Lysosomal storage diseases (LSDs) are a group of inherited metabolic disorders with defects in lysosomal function. lysosomal storage diseases pan lab https://www.takeda.com/newsroom/shire-news-releases/2018/ao383f/ Shire and NanoMedSyn Enter Into Research Agreement for Potential Lysosomal Storage Disorder... Shire and NanoMedSyn Enter Into Research Agreement for Potential Lysosomal Storage Disorder Treatment https://www.mdpi.com/2077-0383/9/6/1923 The Effect of Cellular Coenzyme Q10 Deficiency on Lysosomal Acidification Coenzyme Q10 (CoQ10) deficiency currently represents the only treatable mitochondrial disorder, however, little is known about how it may affect other... coenzyme q10 deficiency the effect cellular lysosomal acidification https://www.takeda.com/newsroom/shire-news-releases/2018/teokje/ Shire to Highlight Advancements in Diagnosis, Treatment and Management of Rare Lysosomal Diseases... Shire to Highlight Advancements in Diagnosis, Treatment and Management of Rare Lysosomal Diseases at Global Conference treatment and management https://www.wikidata.org/wiki/Q42508761 Inhibition of lysosomal protein degradation inhibits the basal degradation of... protein degradation inhibition lysosomal basal https://www.chop.edu/centers-programs/lysosomal-storage-disease-lsd-center/why-choose-us-lsd-care Why Choose Us for Lysosomal Storage Disease Care | Children's Hospital of Philadelphia Our center combines excellent clinical care with access to active clinical research and new drug trials. We have been recognized as an LSD Center for... why choose us lysosomal storage disease https://www.thermofisher.com/antibody/primary/panther/lysosomal%20transport lysosomal transport Antibodies | Invitrogen Antibodies for proteins involved in lysosomal transport pathways, according to their Panther/Gene Ontology Classification lysosomal transport antibodies invitrogen https://www.doccheck.com/en/detail/photos/42087-the-lysosomal-degradation-pathway-pei-2021 The lysosomal degradation pathway (Pei, 2021) - DocCheck IntroductionLysosomes play an important role in protein degradation. Protein degradation drugs targeting the lysosomal degradation pathway can directly... lysosomal degradation pathway pei 2021 https://polaryx.com/ Polaryx Therapeutics | Combating Lysosomal Storage Disorders therapeutics lysosomal storage disorders https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2023.1209760/full Frontiers | Disruption of mitochondrial and lysosomal functions by human CACNA1C variants expressed... Objective: To investigate the pathogenesis of 3 novel, de novo CACNA1C variants (p.E411D, p.V622G and p.A272V) in causing neurodevelopmental disorders and ar... https://www.spandidos-publications.com/10.3892/or.1.4.849/abstract THE VALUE OF THE LYSOSOMAL PROTEASE CATHEPSIN-D IN EGYPTIAN BLADDER-CANCER Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. the value lysosomal protease cathepsin d https://www.rcsb.org/structure/5NN8 RCSB PDB - 5NN8: Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with... Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with acarbose https://pmc.ncbi.nlm.nih.gov/articles/PMC43441/ Mutations at the lysosomal acid cholesteryl ester hydrolase gene locus in Wolman disease - PMC The genomic sequences encoding the human lysosomal acid lipase/cholesteryl esterase (sterol esterase; EC 3.1.1.13) have been isolated and sequenced, and the... https://www.rcsb.org/structure/8K7H RCSB PDB - 8K7H: Crystal structure of human lysosomal alpha-galactosidase A in complex with... Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3S,4R)-2-(hydroxymethyl)-1-methylpyrrolidine-3,4-diol https://www.thermofisher.com/antibody/primary/panther/lysosomal%20membrane%20organization lysosomal membrane organization Antibodies | Invitrogen Antibodies for proteins involved in lysosomal membrane organization pathways, according to their Panther/Gene Ontology Classification lysosomal membrane organization antibodies invitrogen https://www.mdpi.com/2218-273X/10/5/761 High Levels of ROS Impair Lysosomal Acidity and Autophagy Flux in Glucose-Deprived Fibroblasts by... Under glucose deprivation, cells heavily mobilize oxidative phosphorylation to maintain energy homeostasis. This leads to the generation of high levels of ATP,... https://pmc.ncbi.nlm.nih.gov/articles/PMC10447550/ Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the... Heat shock protein 90 (Hsp90) and its co-chaperones promote cancer, and targeting Hsp90 holds promise for cancer treatment. Most of the efforts to harness this... https://pmc.ncbi.nlm.nih.gov/articles/PMC9903130/ Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative... Tumour cells under hypoxia tend to modulate the number and contents of extracellular vesicles (EVs) to regulate the tumour microenvironment (TME) and thus... https://www.stjude.org/research/why-st-jude/shared-resources/technology-licensing/success-stories/success-story-lysosomal-drugs.html Lysosomal Drugs May Also Hold Promise for Cancer | St. Jude Research St. Jude licensed the patent rights for using PPCA and Neurominidase to treat neurodegenerative diseases in 2015. Additional fields remain available.. st jude lysosomal drugs may also https://elifesciences.org/articles/31268v1 Metformin extends C. elegans lifespan through lysosomal pathway | eLife c elegans metformin extends lifespan lysosomal https://elifesciences.org/articles/19360v1 Regulation of mTORC1 by lysosomal calcium and calmodulin | eLife regulation mtorc1 lysosomal calcium calmodulin https://elifesciences.org/articles/19360/figures Figures and data in Regulation of mTORC1 by lysosomal calcium and calmodulin | eLife The multipronged chemical biology approach unraveled a novel mechanism by which mTOR is regulated by the second messenger calcium. https://www.rcsb.org/structure/2XPK RCSB PDB - 2XPK: Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal... Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases rcsb pdb https://elifesciences.org/articles/98020v1 Unraveling the link between Neuropathy Target Esterase NTE/SWS, lysosomal storage diseases,... neuropathy target esterase the link https://www.wikidata.org/wiki/Q43888113 Electron microscopic studies of the rickettsia Coxiella burneti: entry, lysosomal response, and... scientific article published in February 1971 of the https://pmc.ncbi.nlm.nih.gov/articles/PMC4059147/ The Phytoestrogen Genistein Modulates Lysosomal Metabolism and Transcription Factor EB (TFEB)... Background: Genistein is a potential drug for certain inherited lysosomal disorders. Results: Genistein influences molecular cross-talk in the cell responsible... transcription factor phytoestrogen genistein lysosomal https://elifesciences.org/articles/73812 Low doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid... The organic insecticide spinosad severely impacts metabolism, the cell biology, and the visual system of the model insect Drosophila, suggesting that it poses... https://pmc.ncbi.nlm.nih.gov/articles/PMC34647/ Identification and characterization of a lysosomal transporter for small neutral amino acids - PMC In eukaryotic cells, lysosomes represent a major site for macromolecule degradation. Hydrolysis products are eventually exported from this acidic organelle... https://www.muni.cz/vyzkum/publikace/1124558 TRAIL-induced lysosomal cell death pathway in breast carcinoma cells is upregulated by Cathepsin D... https://www.fiercebiotech.com/biotech/abeona-bags-rights-to-regenxbio-aav9-vector-rare-lysosomal-storage-disorders Abeona bags rights to Regenxbio AAV9 vector in rare lysosomal storage disorders | Fierce Biotech Nov 5, 2018 - Regenxbio has granted Abeona Therapeutics a global license to use its AAV9 https://www.mdpi.com/1422-0067/24/3/2030 Impact of Enniatin B and Beauvericin on Lysosomal Cathepsin B Secretion and Apoptosis Induction Enniatin B (ENN B) and Beauvericin (BEA) are cyclohexadepsipeptides that can be isolated from Fusarium and Beauveria bassiana, respectively. Both compounds are... b and https://www.bcm.edu/research/research-centers/center-for-lysosome-regulation-and-signaling-research-in-aging-and-alzheimers-disease/projects-and-cores/tfeb-and-v-atpase-mediated-lysosomal-stress-sensing-pathway-in-tauopathy TFEB and V-ATPase-mediated Lysosomal Stress Sensing Pathway in Tauopathy | BCM Early work revealed that TFEB is highly effective in ameliorating tau/NFT pathology and rescuing cognitive impairment and neurodegeneration. TFEB targets... and v lysosomal stress https://www.ncbi.nlm.nih.gov/protein/1SZV_A Chain A, Late endosomal/lysosomal Mp1 interacting protein - Protein - NCBI chain late endosomal lysosomal mp1 https://www.semanticscholar.org/topic/positive-regulation-of-lysosomal-protein-catabolic/7632986 positive regulation of lysosomal protein catabolic process | Semantic Scholar Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] positive regulation lysosomal protein catabolic process https://worldsymposia.org/ WORLDSymposium - We're Organizing Research on Lysosomal Diseases Jul 9, 2026 - WORLDSymposium™ is an annual research conference dedicated to lysosomal diseases, presenting the latest information from basic science, translational research,... we re research on organizing lysosomal diseases https://elifesciences.org/articles/07366 VCP-dependent muscle degeneration is linked to defects in a dynamic tubular lysosomal network in... The AAA-ATPase VCP sustains sarcoplasmic proteostasis, in part, by controlling autophagosome-lysosome fusion and the integrity of a dynamic tubular lysosomal... https://www.researchandmarkets.com/reports/6164493/lysosomal-storage-disease-treatment-market Lysosomal Storage Disease Treatment Market - Global Industry Size, Share, Trends, Opportunity, and... The Lysosomal Storage Disease Treatment Market, valued at USD 4.61B in 2024, is projected to reach USD 6.03B by 2030, growing at a 4.5% CAGR. lysosomal storage disease global industry https://www.jci.org/assets/330358/powerpoint JCI - mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing... lysosomal storage disorders bone growth https://www.wikidata.org/wiki/Q40340293 At least three human neutrophil lysosomal proteases are capable of degrading joint connective... scientific article published on June 13, 1975 https://www.ncbi.nlm.nih.gov/gene/100071855 HPS5 HPS5 biogenesis of lysosomal organelles complex 2 subunit 2 [Equus caballus (horse)] - Gene -... complex 2 https://elifesciences.org/reviewed-preprints/92243 Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to... https://elifesciences.org/articles/92243/peer-reviews Peer review in Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and... MBOAT7 loss of function in hepatocytes contributes to ethanol-induced liver injury, offering crucial insights into the dysregulated lipid metabolism and... https://elifesciences.org/articles/30543 Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak | eLife Molecular pathways controlling autophagic cell death are regulated at the level of the lysosome through the activity of the pro-death Bcl-2 family member... autophagic cell death https://www.downtoearth.org.in/topic/lysosomal-storage-disorder-support-society Lysosomal Storage Disorder Support Society Read stories listed under on Lysosomal Storage Disorder Support Society lysosomal storage disorder support society https://pmc.ncbi.nlm.nih.gov/articles/PMC7178086/ Lysosomal Exocytosis, Exosome Release and Secretory Autophagy: The Autophagic- and Endo-Lysosomal... Beyond the consolidated role in degrading and recycling cellular waste, the autophagic- and endo-lysosomal systems play a crucial role in extracellular release... lysosomal exocytosis exosome release secretory https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1375498/full Frontiers | Targeting of lysosomal-bound protein mEAK-7 for cancer therapy mEAK-7 (mammalian EAK-7 or MTOR-associated protein, eak-7 homolog), is an evolutionarily conserved lysosomal membrane protein that is highly expressed in sev... 7 for frontiers targeting lysosomal bound https://www.ncbi.nlm.nih.gov/gene/3988 LIPA lipase A, lysosomal acid type [Homo sapiens (human)] - Gene - NCBI lipase a lysosomal acid type homo sapiens human gene https://pmc.ncbi.nlm.nih.gov/articles/PMC12350760/ Lysosomal free sialic acid storage disorder iPSC-derived neural cells display altered... Lysosomal free sialic acid storage disorder (FSASD) is a rare neurodegenerative disease caused by biallelic mutations in SLC17A5, encoding the lysosomal sialic... sialic acid storage disorder https://www.mdpi.com/1420-3049/25/20/4618 N-Alkylated Iminosugar Based Ligands: Synthesis and Inhibition of Human Lysosomal... The scope of a series of N-alkylated iminosugar based inhibitors in the d-gluco as well as d-xylo configuration towards their interaction with human lysosomal... n alkylated based https://www.mdpi.com/2073-4409/11/11/1840 Lysosomal Proteomics Links Disturbances in Lipid Homeostasis and Sphingolipid Metabolism to CLN5... CLN5 disease (MIM: 256731) represents a rare late-infantile form of neuronal ceroid lipofuscinosis (NCL), caused by mutations in the CLN5 gene that encodes the... https://www.ncbi.nlm.nih.gov/gene/101099749 HPS5 HPS5 biogenesis of lysosomal organelles complex 2 subunit 2 [Felis catus (domestic cat)] -... complex 2 https://www.biospace.com/avrobio-posts-positive-data-in-ongoing-gene-therapy-trials-of-rare-lysomal-diseases Avrobio Gene Therapy Shows Early Promise in Fabry, Other Rare Lysosomal Diseases - BioSpace Mar 31, 2021 - Shares of Avrobio were up nearly 20% in premarket trading after the company posted positive clinical data from its gene therapy trials in three different rare... https://www.wikidata.org/wiki/Q36417995 Phosphorylated oligosaccharides in lysosomal enzymes: identification of... lysosomal enzymes phosphorylated oligosaccharides identification https://pmc.ncbi.nlm.nih.gov/articles/PMC10893887/ Withaferin A inhibits lysosomal activity to block autophagic flux and induces apoptosis via... Withaferin A (WFA), a steroidal lactone, negatively regulates breast cancer growth however, its mechanisms of action remain largely elusive. We found that WFA...