https://www.mdpi.com/1422-0067/22/13/6727
Monosomy 3 Is Linked to Resistance to MEK Inhibitors in Uveal Melanoma
The use of MEK inhibitors in the therapy of uveal melanoma (UM) has been investigated widely but has failed to show benefits in clinical trials due to fast...
mek inhibitorslinked
https://digitalcommons.usf.edu/etd/8094/
"A Novel Cytokine Response Modulatory Function of MEK Inhibitors Mediat" by Mengyu Xie
Despite the recent success of immune-checkpoint blockade therapy for late-stage non-small cell lung cancer (NSCLC), lung cancer is still the leading cause of...
https://pubmed.ncbi.nlm.nih.gov/36398965/
Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors
Transcriptional adaptation to MEK inhibition is mediated by CDK8 and can be blocked by the addition of CDK8 inhibitors to improve response to MEK inhibitors in...
antagonisminhibition