pleiotropy - Robuta Search

https://pubmed.ncbi.nlm.nih.gov/30524730/ Is antagonistic pleiotropy ubiquitous in aging biology? Lay Summary: An evolutionary mechanism of aging was hypothesized 60 years ago to be the genetic trade-off between early life fitness and late life mortality.... antagonistic pleiotropy ubiquitous aging biology https://pubmed.ncbi.nlm.nih.gov/20724817/ Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program A half century ago, the antagonistic pleiotropy (AP) theory had solved a mystery of aging, by postulating genes beneficial early in life at the cost of aging.... https://pubmed.ncbi.nlm.nih.gov/32637184/ A genome-wide scan for pleiotropy between bone mineral density and nonbone phenotypes Osteoporosis is the most common metabolic bone disorder globally and is characterized by skeletal fragility and microarchitectural deterioration. Genetic... bone mineral density https://pure.psu.edu/en/publications/enhanced-insights-into-the-genetic-architecture-of-3d-cranial-vau/ Enhanced insights into the genetic architecture of 3D cranial vault shape using pleiotropy-informed... https://dukespace.lib.duke.edu/items/e94d406e-5c46-4d9b-b482-8e1ec28101ce CPAG: software for leveraging pleiotropy in GWAS to reveal similarity between human traits links... Meta-analyses of genome-wide association studies (GWAS) have demonstrated that the same genetic variants can be associated with multiple diseases and other... https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113874 Genetic Pleiotropy Explains Associations between Musical Auditory Discrimination and Intelligence |... Musical aptitude is commonly measured using tasks that involve discrimination of different types of musical auditory stimuli. Performance on such different... genetic pleiotropy explains associations musical https://scholars.duke.edu/publication/1383846 Scholars@Duke publication: Pleiotropy in developmental regulation by flowering-pathway genes: is it... https://pmc.ncbi.nlm.nih.gov/articles/PMC3512146/ Gene Functional Trade-Offs and the Evolution of Pleiotropy - PMC Pleiotropy is the property of genes affecting multiple functions or characters of an organism. Genes vary widely in their degree of pleiotropy, but this... and the gene functional trade offs https://pure.psu.edu/en/publications/implicating-genes-pleiotropy-and-sexual-dimorphism-at-blood-lipid/ Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry... https://pure.psu.edu/en/publications/pleiotropy-guided-transcriptome-imputation-from-normal-and-tumor-/ Pleiotropy-guided transcriptome imputation from normal and tumor tissues identifies candidate... pleiotropy guided transcriptome imputation