https://pmc.ncbi.nlm.nih.gov/articles/PMC5768569/
Regulation of epithelial barrier function by the inflammatory bowel disease candidate gene, PTPN2 -...
Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) has been identified as an inflammatory bowel disease (IBD) candidate gene. However, the mechanism...
epithelial barrier functioninflammatory bowel disease
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1124633/full
Frontiers | PTPN2 targets TAK1 for dephosphorylation to improve cellular senescence and promote...
The energy imbalance when energy intake exceeds expenditure acts as an essential factor in the development of insulin resistance (IR). The activity of brown ...
https://pmc.ncbi.nlm.nih.gov/articles/PMC11259789/
Haploinsufficiency in PTPN2 leads to early-onset systemic autoimmunity from Evans syndrome to lupus...
Exome sequencing in pediatric systemic lupus and Evans syndrome identified six novel monoallelic PTPN2 mutations, impairing its regulatory function. This...
https://www.mondegobio.com/
PTPN2 Inhibitors for Cancer Immunotherapy | Mondego Bio
May 7, 2026 - Mondego Bio is developing best-in-class PTPN2 inhibitors to advance breakthrough cancer immunotherapies with improved safety, tolerability, and efficacy.
cancer immunotherapyptpn2inhibitorsmondegobio
https://www.jci.org/articles/view/123267
JCI - Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in...
jcireducedexpressionphosphatase