telomerase - Robuta Search

https://cordis.europa.eu/project/id/625821/results Towards the structural understanding of human telomerase | HTR | Project | Results | FP7 | CORDIS |... Deliverables, publications, datasets, software, exploitable results https://pubmed.ncbi.nlm.nih.gov/25320237/ An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or... Telomerase is a ribonucleoprotein complex that adds telomeric DNA to the ends of linear chromosomes. It contains two core canonical components: the essential... https://www.cruk.cam.ac.uk/publications/in-vivo-inhibition-of-lung-cancer-by-grn163l-a-novel-human-telomerase-inhibitor/ In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor. - Cancer Research... Authors: ZG Dikmen, GC Gellert, S Jackson, S Gryaznov, R Tressler, P Dogan, WE Wright, JW Shay Journal name: Cancer Res Citation info: 65(17):7866-7873... https://pubmed.ncbi.nlm.nih.gov/9454332/ Extension of life-span by introduction of telomerase into normal human cells Normal human cells undergo a finite number of cell divisions and ultimately enter a nondividing state called replicative senescence. It has been proposed that... life span extension https://scholars.lib.ntu.edu.tw/entities/project/71cb75e7-0e57-4c18-8655-1e9ad48ae532 Development of a New Anticancer Strategy---Combination of Topoisomerase Poisons and Telomerase... of a development new anticancer https://pure.psu.edu/en/publications/immortalized-mouse-mammary-cells-in-vivo-do-not-exhibit-increased/ Immortalized mouse mammary cells in vivo do not exhibit increased telomerase activity - Penn State https://scholars.duke.edu/publication/931328 Scholars@Duke publication: Telomerase activity in biopsied blastomeres of human day three embryos. https://www.ncbi.nlm.nih.gov/Structure/pdb/6ZD1 6ZD1: Structure of apo telomerase from Candida Tropicalis Telomerase reverse transcriptase structure apo telomerase candida https://microbiology.weill.cornell.edu/functional-analysis-c-terminal-extension-telomerase-reverse-transcriptase-putative-thumb-domain Functional analysis of the C-terminal extension of telomerase reverse transcriptase. A putative... functional analysis of the https://pubmed.ncbi.nlm.nih.gov/21730353/ Prolonged self-renewal activity unmasks telomerase control of telomere homeostasis and function of... Strategies for expanding hematopoietic stem cells (HSCs) could have significant utility for transplantation-based therapies. However, deleterious consequences... https://edrn.cancer.gov/data-and-resources/publications/15269291-1198-analytical-validation-of-telomerase-activity-for-cancer-early-detection-trappcr-ce-and-htert-mrna-quantification-assay-for-high-throughput-screening-of-tumor-cells/ Analytical validation of telomerase activity for cancer early detection: TRAP/PCR-CE and hTERT mRNA... This is a publication by a member of the Early Detection Research Network. https://scholars.lib.ntu.edu.tw/entities/publication/ddfe0fa7-e70c-46a1-ad17-4b4da44f0eb2 Pif1p helicase, a catalytic inhibitor of telomerase in yeast. Mutations in the yeast Saccharomyces cerevisiae PIF1 gene, which encodes a 5'-to-3' DNA helicase, cause telomere lengthening and a large increase in the... helicase catalytic inhibitor telomerase yeast https://collections.nlm.nih.gov/catalog/nlm:nlmuid-101584926X276-doc Telomerase Activation in Mouse Mammary Tumors: Lack of Detectable Telomere Shortening and Evidence... https://www.thermofisher.com/antibody/primary/panther/regulation%20of%20telomere%20maintenance%20via%20telomerase regulation of telomere maintenance via telomerase Antibodies | Invitrogen Antibodies for proteins involved in regulation of telomere maintenance via telomerase pathways, according to their Panther/Gene Ontology Classification regulation telomere maintenance via telomerase https://www.wikidata.org/wiki/Q40978424 Absence of cancer-associated changes in human fibroblasts immortalized with telomerase - Wikidata scientific article published on January 1999 in human https://www.mdpi.com/1422-0067/20/13/3186 Quantitative Biology of Human Shelterin and Telomerase: Searching for the Weakest Point The repetitive telomeric DNA at chromosome ends is protected from unwanted repair by telomere-associated proteins, which form the shelterin complex in mammals.... quantitative biology https://www.frontiersin.org/journals/analytical-science/articles/10.3389/frans.2022.994394/full Frontiers | An all-deoxyribonucleic acid circuit for detection of human telomerase activity in... We report on the design of a simple all-DNA circuit with dual functions of signal amplification and signal reporting and its use for detection of human telom... https://experts.umn.edu/en/publications/telomerase-mrna-transfected-dendritic-cells-stimulate-antigen-spe/ Telomerase mRNA-transfected dendritic cells stimulate antigen-specific CD8+ and CD4+ T cell... https://www.techtransfer.nih.gov/patent/e-195-1998-1-ca-03 RNase L Activators and Antisense Oligonucleotides Effective to Treat Telomerase-Expressing... antisense oligonucleotides rnase activators https://collaborate.princeton.edu/en/publications/the-saccharomyces-cerevisiae-telomerase-subunit-est3-binds-telome/ The saccharomyces cerevisiae telomerase subunit Est3 binds telomeres in a cell cycle- and... https://research.monash.edu/en/projects/identification-of-novel-telomerase-interacting-proteins/ Identification of novel telomerase interacting proteins - Monash University identification novel telomerase interacting proteins https://theses.gla.ac.uk/41113/ Telomere dynamics and telomerase expression in chronic myeloid leukaemia - Enlighten Theses chronic myeloid leukaemia telomere dynamics telomerase expression https://pure.psu.edu/en/publications/managing-telomerase-and-telomere-dysfunction-in-acral-melanoma/ Managing telomerase and telomere dysfunction in acral melanoma - Penn State managing telomerase telomere dysfunction melanoma https://experts.umn.edu/en/publications/expression-of-mutated-paramecium-telomerase-rnas-in-vivo-leads-to/ Expression of mutated Paramecium telomerase RNAs in vivo leads to templating error that resemble... https://microbiology.weill.cornell.edu/yeast-telomerase-capable-limited-repeat-addition-processivity Yeast telomerase is capable of limited repeat addition processivity. | Microbiology and Immunology https://pubchem.ncbi.nlm.nih.gov/bioassay/1259766 AID 1259766 - Growth inhibition of human NHBE cells immortalized with human telomerase and large-T... BioAssay record AID 1259766 submitted by ChEMBL: Growth inhibition of human NHBE cells immortalized with human telomerase and large-T antigen and transformed... https://www.thermofisher.com/antibody/primary/panther/positive%20regulation%20of%20telomerase%20activity positive regulation of telomerase activity Antibodies | Invitrogen Antibodies for proteins involved in positive regulation of telomerase activity pathways, according to their Panther/Gene Ontology Classification telomerase activity positive regulation antibodies invitrogen https://vivo.colorado.edu/display/pubid_30925 Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by... https://www.ta65.co.za/ Telomerase Activation - Advanced Age Management | TA65 Oct 5, 2022 - Anti-Aging Telomere Science and Cell Rejuvenation Supplements offering Ta65 - a Life Extension high Quality Vitamin and natural supplement to reduce aging in... age management telomerase activation advanced https://microbiology.weill.cornell.edu/contributions-recombination-and-repair-proteins-telomere-maintenance-telomerase-positive-and Contributions of recombination and repair proteins to telomere maintenance in telomerase-positive... https://www.prnewswire.com/news-releases/gemvaxs-highly-promising-phase-ii-alzheimers-disease-clinical-trial-results-targeting-telomerase-published-in-prestigious-alzheimers-research--therapy-journal-301258354.html GemVax's highly promising Phase II Alzheimer's disease clinical trial results targeting telomerase... https://www.news-medical.net/news/20180427/Telomerase-discovery-paves-way-for-drugs-to-combat-aging-and-cancer.aspx Telomerase discovery paves way for drug development Aug 23, 2018 - Researchers have published the first detailed image of the molecular structure of human telomerase, the enzyme that lengthens chromosomes and extends the... telomerase discovery paves way drug https://events.st-andrews.ac.uk/events/cellular-responses-and-adaptations-to-telomerase-insufficiency/ Cellular responses and adaptations to telomerase insufficiency | Events Research seminar by Dr Sveta Makovets, Institute of Cell Biology, University of Edinburgh, as part of the School of Biology's cellular responses adaptations telomerase insufficiency https://pmc.ncbi.nlm.nih.gov/articles/PMC6755196/ Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives -... Telomere length, a marker of cellular aging, decreases with age and it has been associated with aging-related diseases. Environmental factors, including diet... https://pubmed.ncbi.nlm.nih.gov/12452442/?dopt=Abstract&holding=idemdclib_fft&otool=idemdclib Real-time determination of telomerase activity in cell extracts using an optical biosensor A biosensoric approach has been developed to determine the activity of telomerase in tumor cell lysates. An optical sensor, the grating coupler, was used to... https://scholarshare.temple.edu/entities/publication/e40b008d-1384-45ab-997e-0367d893e2e8 An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1 Ribonucleoprotein enzymes require dynamic conformations of their RNA constituents for regulated catalysis. Human telomerase employs a non-coding RNA (hTR) with... https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1462953/full Frontiers | Evaluating the prognostic potential of telomerase signature in breast cancer through... BackgroundBreast cancer prognosis remains a significant challenge due to the disease's molecular heterogeneity and complexity. Accurate predictive models are... https://pubmed.ncbi.nlm.nih.gov/40638752/ Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization Telomerase ribonucleoprotein (RNP) synthesizes telomeric repeats at chromosome ends using a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR... https://openresearch.surrey.ac.uk/esploro/outputs/journalArticle/Differences-in-telomerase-expression-by-the/99514359602346 Differences in telomerase expression by the CD1a(+) cells in Langerhans cell histiocytosis reflect... Jun 1, 2007 - Differences in telomerase expression by the CD1a(+) cells in Langerhans cell histiocytosis reflect the diverse clinical presentation of the disease -... langerhans cell histiocytosis by the https://collaborate.princeton.edu/en/publications/structural-basis-of-human-telomerase-recruitment-by-tpp1-pot1/ Structural basis of human telomerase recruitment by TPP1-POT1 - Princeton University structural basis human telomerase https://scholarshare.temple.edu/entities/publication/32a28d1a-acbf-4c44-92f3-8b2db95b2782 Clonal inactivation of telomerase promotes accelerated stem cell differentiation Telomerase is intimately associated with stem cells and upregulated in cancer, where it serves essential roles through its catalytic action in elongating... stem cell telomerase promotes accelerated differentiation https://pubmed.ncbi.nlm.nih.gov/11274400/ Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase... Recent evidence suggests that the Myc and Mad1 proteins are implicated in the regulation of the gene encoding the human telomerase reverse transcriptase... https://www.wikidata.org/wiki/Q41108271 The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the... scientific article published on June 1997 https://portal.fis.tum.de/en/publications/differential-transcriptional-regulation-of-human-telomerase-in-a-/ Differential transcriptional regulation of human telomerase in a cellular model representing... in a differential regulation human https://portal.fis.tum.de/en/publications/ribozyme-cleavage-of-telomerase-mrna-sensitizes-breast-epithelial-2/ Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of... epithelial cells ribozyme cleavage telomerase mrna https://pubmed.ncbi.nlm.nih.gov/18073191/ The telomerase database Telomerase is a ribonucleoprotein enzyme that extends DNA at the chromosome ends in most eukaryotes. Since 1985, telomerase has been studied intensively and... telomerase database https://iris.cnr.it/handle/20.500.14243/285095 The finger subdomain of yeast telomerase cooperates with Pif1p to limit telomere elongation https://pubmed.ncbi.nlm.nih.gov/9528864/?dopt=Abstract Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the... The expression of telomerase, the enzyme that synthesizes telomeric DNA de novo, is suppressed in normal somatic human cells but is reactivated during... https://pubmed.ncbi.nlm.nih.gov/31921617/ Spheroid-Derived Cells From Renal Adenocarcinoma Have Low Telomerase Activity and High Stem-Like... Cancer stem cells (CSCs) are a theorized small subpopulation of cells within tumors thought to be responsible for metastasis, tumor development, disease... https://pure.psu.edu/en/publications/robust-activation-of-the-human-but-not-mouse-telomerase-gene-duri/ Robust activation of the human but not mouse telomerase gene during the induction of pluripotency -... https://pubmed.ncbi.nlm.nih.gov/18718525/ Telomerase deficiency promotes oxidative stress by reducing catalase activity Telomere shortening and redox imbalance have been related to the aging process. We used cultured mouse embryonic fibroblasts (MEF) isolated from mice lacking... oxidative stress telomerase deficiency promotes reducing https://pubmed.ncbi.nlm.nih.gov/18799986/ Relationship between physical activity level, telomere length, and telomerase activity These results indicate that moderate physical activity levels may provide a protective effect on PBMC telomere length compared with both low and high EEE... physical activity telomere length relationship level telomerase https://vivo.colorado.edu/display/pubid_103334 Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere... https://pmc.ncbi.nlm.nih.gov/articles/PMC10122201/ Activation of telomerase by TA-65 enhances immunity and reduces inflammation post myocardial... Myocardial infarction (MI) accelerates immune ageing characterised by lymphopenia, expansion of terminally differentiated CD8+ T-lymphocytes (CD8+ TEMRA) and... https://www.ncbi.nlm.nih.gov/Structure/pdb/5UGW 5UGW: STRUCTURE OF THE HUMAN TELOMERASE THUMB DOMAIN Telomerase reverse transcriptaseGLUTATHIONE of the structure human telomerase thumb https://cordis.europa.eu/project/id/625821/results/it Towards the structural understanding of human telomerase | HTR | Progetto | Risultati | FP7 |... Deliverables, publications, datasets, software, exploitable results towards structural understanding https://pubchem.ncbi.nlm.nih.gov/protein/Q4KTA7 Telomerase reverse transcriptase (torafugu) | Protein Target - PubChem Protein target information for Telomerase reverse transcriptase (torafugu). Find diseases associated with this biological target and compounds tested against... reverse transcriptase telomerase protein target pubchem https://pmc.ncbi.nlm.nih.gov/articles/PMC14995/ Polymerization Defects within Human Telomerase Are Distinct from Telomerase RNA and TEP1 Binding -... The minimal, active core of human telomerase is postulated to contain two components, the telomerase RNA hTER and the telomerase reverse transcriptase hTERT.... https://scholars.uky.edu/es/publications/telomerase-activity-in-pancreatic-endocrine-tumors/ Telomerase activity in pancreatic endocrine tumors - telomerase activity pancreatic endocrine tumors https://www.thermofisher.com/antibody/primary/panther/positive%20regulation%20of%20telomerase%20RNA%20localization%20to%20Cajal%20body positive regulation of telomerase RNA localization to Cajal body Antibodies | Invitrogen Antibodies for proteins involved in positive regulation of telomerase RNA localization to Cajal body pathways, according to their Panther/Gene Ontology... positive regulation telomerase rna https://scholarworks.iu.edu/dspace/items/d580c101-0621-4433-8c14-315bff4655dc The Saccharomyces cerevisiae Hrq1 and Pif1 DNA helicases synergistically modulate telomerase... Telomere length homeostasis is vital for maintaining genomic stability and is regulated by multiple factors, including telomerase activity and DNA helicases.... saccharomyces cerevisiae https://publikationen.uni-tuebingen.de/xmlui/handle/10900/52016?show=full Treatment of lung cancer via telomerase inhibition: Self-assembled nanoplexes versus polymeric... lung cancer https://pmc.ncbi.nlm.nih.gov/articles/PMC12411320/ Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT... Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells. This happens through the induction of telomerase enzyme... human cell lines https://researchconnect.buffalo.edu/en/publications/the-predictive-role-of-circulating-telomerase-and-vitamin-d-for-l/ The predictive role of circulating telomerase and vitamin D for long-term survival in patients... https://scholarshare.temple.edu/entities/publication/3a7e2fa8-3b70-4ac1-99db-504d647280b1 Mitochondrial Telomerase Reverse Transcriptase, a Target for Cardiovascular Disease? reverse transcriptase mitochondrial telomerase target cardiovascular https://pmc.ncbi.nlm.nih.gov/articles/PMC5042389/ Telomeres and Telomerase in Cardiovascular Diseases - PMC Telomeres are tandem repeat DNA sequences present at the ends of each eukaryotic chromosome to stabilize the genome structure integrity. Telomere lengths... cardiovascular diseases telomeres telomerase pmc https://www.news-medical.net/news/20180426/Researchers-target-telomerase-for-killing-NRAS-mutant-melanoma-cells.aspx Researchers target telomerase for killing NRAS-mutant melanoma cells Jun 19, 2019 - Targeting telomerase was effective at killing NRAS-mutant melanoma cells, and the impact was further enhanced when the strategy was paired with an inhibitor of... researchers target telomerase killing nras https://microbiology.weill.cornell.edu/analysis-yeast-telomerase-primer-extension-assays-0 Analysis of yeast telomerase by primer extension assays. | Microbiology and Immunology analysis yeast telomerase https://pubchem.ncbi.nlm.nih.gov/bioassay/1159963 AID 1159963 - Inhibition of telomerase (unknown origin) by TRAP assay - PubChem BioAssay record AID 1159963 submitted by ChEMBL: Inhibition of telomerase (unknown origin) by TRAP assay. aid inhibition telomerase https://theses.gla.ac.uk/76131/ Characterisation of Transcriptional Regulation of the Human Telomerase RNA Gene - Enlighten Theses the human characterisation regulation https://www.sciencedaily.com/releases/2018/04/180425131846.htm Long-sought structure of telomerase paves way for new drugs for aging, cancer | ScienceDaily Telomerase, because of its role in cancer and aging, has long been a target of drug companies who want to block it to stop the uncontrolled cell growth... https://pmc.ncbi.nlm.nih.gov/articles/PMC19463/ Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomerase - PMC Current models of telomere replication predict that due to the properties of the polymerases implicated in semiconservative replication of linear DNA, the two... https://pubmed.ncbi.nlm.nih.gov/21933855/ Telomere length and telomerase levels delineate subgroups of B-cell chronic lymphocytic leukemia... Comprehensive analyses of telomeres, telomerase, chromosomal aberrations, and IGVH mutational status delineate groups of chronic lymphocytic leukemias with... https://pmc.ncbi.nlm.nih.gov/articles/PMC35454/ A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell... The ribonucleoprotein telomerase synthesizes telomeric DNA by copying an intrinsic RNA template. In most cancer cells, telomerase is highly activated. Here we... https://pubmed.ncbi.nlm.nih.gov/32515354/ Assessment of telomerase as drug target in breast cancer Telomerase is a specialized enzyme which maintains telomere length at the extreme end of the chromosome. Over 90% of all cases of cancer show high expression... assessment telomerase drug target breast https://www.wikidata.org/wiki/Q46265180 Telomerase in yeast - Wikidata telomerase yeast wikidata https://www.ncbi.nlm.nih.gov/Structure/pdb/8GAP 8GAP: Structure of LARP7 protein p65-telomerase RNA complex in telomerase Telomerase La-related protein p65Telomerase RNATelomerase associated protein p50Telomerase holoenzyme Teb1 subunitTelomerase holoenzyme Teb2 subunitTelomerase... structure protein telomerase rna complex https://collaborate.princeton.edu/en/publications/sensitivity-of-yeast-strains-with-long-g-tails-to-levels-of-telom-2/ Sensitivity of yeast strains with long G-tails to levels of telomere-bound telomerase - Princeton... https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1542930/full Frontiers | The role of telomere and telomerase in cancer and novel therapeutic target: narrative... Telomeres are dynamic complexes at the ends of chromosomes that are made up of protective proteins and tandem repeating DNA sequences. In the large majority ... https://pubmed.ncbi.nlm.nih.gov/34059744/ A genetic variant in telomerase reverse transcriptase (TERT) modifies cancer risk in Lynch syndrome... Individuals with Lynch syndrome (LS), have an increased risk of developing cancer. Common genetic variants of telomerase reverse transcriptase (TERT) have been... https://pubchem.ncbi.nlm.nih.gov/bioassay/1159969 AID 1159969 - Inhibition of telomerase (unknown origin) - PubChem BioAssay record AID 1159969 submitted by ChEMBL: Inhibition of telomerase (unknown origin). aid inhibition telomerase unknown origin https://pubmed.ncbi.nlm.nih.gov/18574244/ A flexible template boundary element in the RNA subunit of fission yeast telomerase Telomerase adds telomeric repeat sequences to chromosome ends using a short region of its RNA subunit as a template. Telomerase RNA subunits are... https://www.techtransfer.nih.gov/patent/e-195-1998-1-pct-01 RNase L Activators and Antisense Oligonucleotides Effective to Treat Telomerase-Expressing... antisense oligonucleotides rnase activators https://scholars.uky.edu/en/projects/gizard-post-doc-fellowship-role-of-telomerase-in-macrophage-infla-2/ Gizard Post-Doc Fellowship: Role of Telomerase in Macrophage Inflammation and Atherosclerosis -... post doc https://vivo.colorado.edu/display/pubid_30865 Mutually Exclusive Binding of Telomerase RNA and DNA by Ku Alters Telomerase Recruitment Model | CU... https://microbiology.weill.cornell.edu/conserved-n-terminal-motifs-telomerase-reverse-transcriptase-required-ribonucleoprotein-assembly Conserved N-terminal motifs of telomerase reverse transcriptase required for ribonucleoprotein... reverse transcriptase terminal motifs https://open.library.ubc.ca/soa/cIRcle/collections/ubctheses/24/items/1.0071358 Combination chemotherapy with telomerase inhibitors and genotoxic compounds against breast and... Learning, knowledge, research, insight: welcome to the world of UBC Library, the second-largest academic research library in Canada. combination chemotherapy telomerase inhibitors compounds https://lifelength.com/ Life Length – World Leader in Telomere & Telomerase Diagnostics world leader life length telomere telomerase https://eprints.ncl.ac.uk/206428 Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with...