https://pubmed.ncbi.nlm.nih.gov/28345297/
In response to DNA damage, a cell can be forced to permanently exit the cell cycle and become senescent. Senescence provides an early barrier against tumor...
dna damageresidualactivitysenescence
https://pubmed.ncbi.nlm.nih.gov/38977850/
Cellular senescence is a response to many stressful insults. DNA damage is a consistent feature of senescent cells, but in many cases its source remains...
cellular senescencecaspaseactivateddnase
https://pubmed.ncbi.nlm.nih.gov/27304681/
The function of macroautophagy/autophagy during tumor initiation or in established tumors can be highly distinct and context-dependent. To investigate the role...
suppressionautophagyglioblastomadevelopmentinduces
https://www.news-medical.net/health/Is-Cellular-Senescence-the-Real-Cause-of-Aging.aspx
The interplay between aging and cellular senescence reveals insights into chronic inflammation and potential strategies for enhancing healthspan and longevity.
cellular senescencethe realcauseaging
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/senescence
NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine.
definitionsenescencencidictionarycancer
https://pubmed.ncbi.nlm.nih.gov/29762168/
The cellular CIADIS-weighted score was independently associated with both multimorbidity at inclusion and the risk of new age-related comorbidity during a 3-...
multimorbidityagerelatedcomorbiditiesmortality
https://pubmed.ncbi.nlm.nih.gov/38462130/
Through an extensive literature survey, we have upgraded the Leaf Senescence Database (LSD v5.0; https://ngdc.cncb.ac.cn/lsd/), a curated repository of...
leafsenescencedatabasecomprehensiverepository
https://pubmed.ncbi.nlm.nih.gov/10757058/
Cell senescence limits cell divisions in normal somatic cells and may play a central role in age-related diseases. In this review, we examine the theory that...
human agingcellsenescencereviewtheory
https://pubmed.ncbi.nlm.nih.gov/41556260/?utm_source=SimplePie&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1VUFS2KU_hFnBUajs3hlb00hHBOGRVXZp7ZhDB0wD6N0LBD9Nk&fc=20250423082013&ff=20260120124739&v=2.18.0.post22+67771e2
Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) resets the epigenetic landscapes that mark the aging clock, and consequently cells...
induced pluripotent stemcellular senescenceintroducinghumancells
https://www.mdpi.com/2072-6694/14/6/1460
Radiotherapy (RT) is a key component of cancer treatment. Although improvements have been made over the years, radioresistance remains a challenge. For this...
taking advantagesenescencepromotingeffectolaparib
https://pubmed.ncbi.nlm.nih.gov/15374672/?dopt=Abstract
The human brain is uniquely powerful with respect to cognitive abilities, yet the hippocampal and neocortical circuits that mediate such complex functions are...
aging brainsenescencecorticalcircuits
https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2020.611170/full
As the last step of leaf development, senescence is a molecular process involving cell death mechanism. Leaf senescence is trigged by both internal age-depen...
cell deathfrontiersactsnaturalleaf
https://elifesciences.org/articles/63284
Knockout of the methyltransferase ICMT prevents progerin methylation and improves survival in mice with Hutchinson-Gilford progeria syndrome (HGPS) and an ICMT...
small moleculeicmtinhibitordelayssenescence