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Oct 28, 2025 - Targeting the key APOBEC enzymes that are a principle cause of cancer development, evolution, spread and cancer treatment resistance.
discovery
https://pubmed.ncbi.nlm.nih.gov/39868801/
APOBEC-1 cofactors regulate APOBEC3-induced mutations in hepatitis B virus
As human host restriction factors, A3s play an important role against viral infections. A3s are also major mutagenic drivers of cancer. However, why A3-induced...
hepatitis bcofactorsregulate
https://www.mdpi.com/1999-4915/13/3/497
Insights into the Structures and Multimeric Status of APOBEC Proteins Involved in Viral Restriction...
Apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) proteins belong to a family of deaminase proteins that can catalyze the deamination of...
https://medicine.yale.edu/cancer/research/excellence/handn/projects/apobec/
PROJECT 3: Demethylation of HPV-associated head and neck cancer to trigger APOBEC synthetic...
Human papillomavirus (HPV)-associated neck squamous cell carcinoma (HNSCC) represents an increasing proportion of HNSCC. The incidence of HPV+ HNSCC has
head and neck cancer
https://profiles.wustl.edu/en/publications/isolation-characterization-and-developmental-regulation-of-the-hu/fingerprints/?sortBy=alphabetically
Isolation, characterization and developmental regulation of the human apobec-1 complementation...
of theisolationcharacterizationdevelopmentalregulation
https://www.urmc.rochester.edu/labs/chu/projects/aid-apobec-lymphoid-malignancies
Role of AID/APOBEC mutagenesis in evolution of aggressive lymphoid malignancies - Research Projects...
https://data.mendeley.com/datasets/kdpch25vt9/1
Data for: APOBEC and ADAR deaminases may cause many single nucleotide polymorphisms curated in the...
Targeted Somatic Mutation (TSM) analysis for disease-associated SNPs on all genes that are: I X Chromosome OMIM SNPs; and, II All chromosome OMIM SNPs in...
https://cordis.europa.eu/project/id/101055134/fr
APOBEC Mutagenesis: a novel Achilles heel of Breast cancer | AMBER | Projet | Fiche descriptive |...
APOBEC mutagenesis is a cellular mechanism by which genetic alterations are acquired somatically, driven by APOBEC enzyme family members. This mechanism is...