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https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2012.00035/full Frontiers | Using Drosophila melanogaster as a Model for Genotoxic Chemical Mutational Studies with... This paper describes a new program SnpSift for filtering differential DNA sequence variants between two or more experimental genomes after genotoxic chemical... https://www.wikidata.org/wiki/Q79256772 Determination of the order of mutational sites governing L-arabinose utilization in Escherichia... scientific article published on 01 November 1959 of the https://pmc.ncbi.nlm.nih.gov/articles/PMC12951377/ BCR::ABL1 Mutational Profiling in US Patients With Chronic-phase Chronic Myeloid Leukemia on... Widespread use of BCR::ABL1 tyrosine kinase inhibitors (TKIs) has transformed the clinical landscape of chronic myeloid leukemia (CML). However, BCR::ABL1... https://facts.net/earth-and-life-science/biology-earth-and-life-science/31-facts-about-mutational-meltdown/ 31 Facts About Mutational Meltdown - Facts.net Apr 24, 2025 - Mutational meltdown is a fascinating yet complex phenomenon in genetics. Ever wondered what happens when a population accumulates too many harmful mutations? Mu mutational meltdown 31 facts https://virmut.eimb.ru/ Virus Mutational Stability Pipeline Bioinformatic pipeline for NGS monitoring of mutational stability of viral drug targets virus mutational stability pipeline https://pmc.ncbi.nlm.nih.gov/articles/PMC10864773/ A Mutational Hotspot in The LAMP2 Gene: Unravelling Intrafamilial Phenotypic Variation and Global... Danon disease is defined by a clinical trio of cardiomyopathy, skeletal myopathy, and cognitive impairment. It results from the lysosomal-associated membrane... https://www.stjude.org/education-training/advanced-training/seminars-symposia/past-symposiums/2022-bringing-chemistry-to-medicine-symposium-transcription-therapy-cbt/videos/ciccarelli-2021-predictors-of-response-to-cancer-immunotherapy.html Predictors of Response to Cancer Immunotherapy: Beyond Tumor Mutational Burden - St. Jude... Listen to Francesca Ciccarelli, PhD speak on "Predictors of Response to Cancer Immunotherapy: Beyond Tumor Mutational Burden" from the 2021 Bringing Chemistry... tumor mutational burden cancer immunotherapy https://www.deutsche-digitale-bibliothek.de/item/OCHFWUN7RFJF2JBSN6GPOJK4KIMC3KRP Evolution of the Pseudomonas aeruginosa mutational resistome in an international Cystic Fibrosis... of the pseudomonas aeruginosa https://pmc.ncbi.nlm.nih.gov/articles/PMC17841/ Mutational analysis of a higher plant antenna protein provides identification of chromophores bound... The chromophore-binding properties of the higher plant light-harvesting protein CP29 have been studied by using site-directed mutagenesis of pigment-binding... higher plant https://elifesciences.org/reviewed-preprints/110149v1 Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease https://www.preprints.org/manuscript/202409.0406 G6PD Potenza: A Novel Pathogenic Variant Broadens the Mutational Landscape in the Italian... Background: G6PD is a rate-limiting enzyme of the pentose phosphate pathway. The loss of G6PD activity in red blood cells exposes to the risk of acute... a novel pathogenic variant https://www.mdanderson.org/research/research-resources/core-facilities/molecular-diagnostics-lab/services/flt3-mutational-analysis.html FLT3 Mutational Analysis (PCR) | UT MD Anderson flt3 mutational analysis pcr md https://elifesciences.org/articles/12125/figures Figures and data in Mutational scanning reveals the determinants of protein insertion and... Deep sequencing analysis quantifies the hydrophobicity of the plasma membrane and provides restraints for structure modeling of receptor homodimers to atomic... https://www.wikidata.org/wiki/Q38346504 Mutational analysis of the ligand binding domain of the low density lipoprotein receptor - Wikidata scientific article published on September 15, 1988 ligand binding domain low density lipoprotein of the https://www.spandidos-publications.com/10.3892/or.10.5.1497/abstract Mutational analysis of ras gene family in lung cancer in Thai Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. ras gene lung cancer mutational analysis family https://www.scirp.org/reference/ReferencesPapers?ReferenceID=1762061 Welander, J., Soderkvist, P. and Gimm, O. (2013) The NF1 Gene A Frequent Mutational Target in... Welander, J., Soderkvist, P. and Gimm, O. (2013) The NF1 Gene A Frequent Mutational Target in Sporadic Pheochromocytomas and Beyond. Endocrine-Related Cancer,... https://elifesciences.org/articles/12125v1 Mutational scanning reveals the determinants of protein insertion and association energetics in the... https://www.wikidata.org/wiki/Q64004926 Mutational spectrum of phenylalanine hydroxylase deficiency in Sicily: implications for diagnosis... scientific article published on 01 October 1993 phenylalanine hydroxylase mutational spectrum https://www.wikidata.org/wiki/Q45849967 Mutational analysis of barley stripe mosaic virus RNA beta - Wikidata scientific article published in December 1990 barley stripe mosaic virus mutational analysis rna beta https://www.mdpi.com/2072-6694/14/18/4370 The Impact of KRAS Mutational Status on Long-Term Survival following Liver Resection for Hilar... KRAS mutation is reportedly associated with poor prognosis in patients with different cancer types. However, mutational data on hilar cholangiocarcinoma are... https://elifesciences.org/reviewed-preprints/110491 Design and experimental characterization of specificity-switching mutational paths of WW domains design experimental characterization https://pmc.ncbi.nlm.nih.gov/articles/PMC41758/ Adaptive mutations in Escherichia coli as a model for the multiple mutational origins of tumors -... The cells in most tumors are found to carry multiple mutations; however, based upon mutation rates determined by fluctuation tests, the frequency of such... https://signal.mutationalsignatures.com/ Signal - The Homepage of Mutational Signatures signal the homepage mutational signatures https://www.wikidata.org/wiki/Q36719681 Biochemical and functional characterization of glycosylation-associated mutational landscapes in... scientific article published on 23 March 2016 biochemical functional characterization glycosylation associated https://www.wikidata.org/wiki/Q36790548 Mutational analysis of centromere DNA from chromosome VI of Saccharomyces cerevisiae - Wikidata scientific article published on June 1988 saccharomyces cerevisiae mutational analysis centromere dna https://www.gu.se/en/event/markus-lindberg-computational-studies-of-mutational-sequence-signatures-in-cancer-genomes Markus Lindberg - Computational studies of mutational sequence signatures in cancer genomes |... Opponent Inigo Martincorena, Wellcome Sanger Institute, Cambridge, United Kingdom Examining committee Frida Abel, Department of Laboratory Medicine, University... markus lindberg computational studies https://www.fredhutch.org/en/news/spotlight/2020/12/hb_garrett_iscience.html Phage display libraries and deep mutational scanning to map antibody epitopes in HIV-1 - Fred Hutch https://github.com/getzlab/SignatureAnalyzer GitHub - getzlab/SignatureAnalyzer: Updated SignatureAnalyzer-GPU with mutational spectra & RNA... github updated gpu mutational spectra https://pmc.ncbi.nlm.nih.gov/articles/PMC51688/ A systematic mutational analysis of hormone-binding determinants in the human growth hormone... A mutational strategy is presented that allowed us to identify hormone-binding determinants in the extracellular portion of the human growth hormone receptor... https://pmc.ncbi.nlm.nih.gov/articles/PMC48720/ DNA helical stability accounts for mutational defects in a yeast replication origin - PMC Earlier studies on the H4 autonomously replicating sequence (ARS) identified a DNA unwinding element (DUE), a required sequence that is hypersensitive to... https://openreview.net/forum?id=lzdFImKK8w&referrer=%5Bthe%20profile%20of%20Xiaoran%20Jiao%5D(%2Fprofile%3Fid%3D~Xiaoran_Jiao1) Boltzmann-Aligned Inverse Folding Model as a Predictor of Mutational Effects on Protein-Protein... Predicting the change in binding free energy ($\Delta \Delta G$) is crucial for understanding and modulating protein-protein interactions, which are critical... https://elifesciences.org/articles/46267 Structural and mutational analysis of the ribosome-arresting human XBP1u | eLife Two integrated approaches shed light on how XBP1 arrest peptide induces intermediate level of translational pausing and identify hotspot positions to make it... of the structural mutational analysis https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.745796/full Frontiers | Germline Mutational Landscape in Chinese Patients With Advanced Breast Cancer Background Genetic testing for breast cancer (BC) patients may shift the paradigm towards more personalized management and treatment strategies. While gene a... in chinese frontiers germline mutational landscape https://elifesciences.org/articles/12125/peer-reviews Peer review in Mutational scanning reveals the determinants of protein insertion and association... Deep sequencing analysis quantifies the hydrophobicity of the plasma membrane and provides restraints for structure modeling of receptor homodimers to atomic... https://pmc.ncbi.nlm.nih.gov/articles/PMC38227/ Potential use of additivity of mutational effects in simplifying protein engineering - PMC The problem of rationally engineering protein molecules can be simplified where effects of mutations on protein function are additive. Crystal structures of... protein engineering potential use additivity mutational https://www.ncbi.nlm.nih.gov/research/mutagene/ MutaGene: Explore and analyze context-dependent mutational signatures in cancer - Home page explore and analyze context dependent https://www.scirp.org/journal/papercitationdetails?paperid=7308&journalid=613 iPAH/i mutational spectrum: still expanding Phenylketonuria (PKU, MIM 261600) is the most common inborn error of amino acid metabolism. To date, a total of more than 500 mutations have been associated... mutational spectrum still expanding https://pmc.ncbi.nlm.nih.gov/articles/PMC18878/ Mutational studies on HslU and its docking mode with HslV - PMC HslVU is an ATP-dependent prokaryotic protease complex. Despite detailed crystal and molecular structure determinations of free HslV and HslU, the mechanism of... mutational studies hslu https://www.acsh.org/tags/dna-mutational-signatures DNA mutational signatures | American Council on Science and Health mutational signatures american council dna science health https://openreview.net/forum?id=0wrovwz9dG&referrer=%5Bthe%20profile%20of%20Jixian%20Zhang%5D(%2Fprofile%3Fid%3D~Jixian_Zhang1) AlphaFold3, a secret sauce for predicting mutational effects on protein-protein interactions |... AlphaFold3 has set the new state-of-the-art in predicting protein-protein complex structures. However, the complete picture of biomolecular interactions cannot... a secret alphafold3 sauce https://www.wikidata.org/wiki/Q37411997 Mutational analysis of the immunoglobulin heavy chain promoter region - Wikidata scientific article published on December 1986 immunoglobulin heavy chain of the promoter region mutational analysis https://www.uhhospitals.org/for-clinicians/specialties/pathology/genomic-and-molecular-pathology/tests-offered/ighv-mutational-status-analysis Chronic Lymphocytic Leukemia | IGHV Mutational Status Analysis in Cleveland, Ohio | University... chronic lymphocytic leukemia cleveland ohio ighv mutational https://www.wikidata.org/wiki/Q45129646 The mutational alteration of the primary structure of yeast iso-1-cytochrome c. - Wikidata scientific article published in October 1968 primary structure https://openreview.net/forum?id=lzdFImKK8w&referrer=%5Bthe%20profile%20of%20Weian%20Mao%5D(%2Fprofile%3Fid%3D~Weian_Mao2) Boltzmann-Aligned Inverse Folding Model as a Predictor of Mutational Effects on Protein-Protein... Predicting the change in binding free energy ($\Delta \Delta G$) is crucial for understanding and modulating protein-protein interactions, which are critical... https://elifesciences.org/articles/34420/figures Figures and data in Mapping mutational effects along the evolutionary landscape of HIV envelope |... Deep mutational scanning of Env proteins from two transmitted-founder strains of HIV shows how the accessible evolutionary space changes as the virus evolves. https://pmc.ncbi.nlm.nih.gov/articles/PMC20331/ A common mutational pattern in Cockayne syndrome patients from xeroderma pigmentosum group G:... Xeroderma pigmentosum (XP) patients have defects in nucleotide excision repair (NER), the versatile repair pathway that removes UV-induced damage and other... https://elifesciences.org/articles/34420/peer-reviews Peer review in Mapping mutational effects along the evolutionary landscape of HIV envelope | eLife Deep mutational scanning of Env proteins from two transmitted-founder strains of HIV shows how the accessible evolutionary space changes as the virus evolves. https://elifesciences.org/reviewed-preprints/104725v1 High resolution deep mutational scanning of the melanocortin-4 receptor enables target... melanocortin 4 receptor high resolution of the https://pmc.ncbi.nlm.nih.gov/articles/PMC148585/ Structural analysis of a mutational hot-spot in the EcoRV restriction endonuclease: a catalytic... Following random mutagenesis of the Eco RV endonuclease, a high proportion of the null mutants carry substitutions at Gln69. Such mutants display reduced rates... https://pmc.ncbi.nlm.nih.gov/articles/PMC38904/ Mutational analysis of NM23-H2/NDP kinase identifies the structural domains critical to recognition... NM23-H2, a presumed regulator of tumor metastasis in humans, is a hexameric protein with both enzymatic (NDP kinase) and regulatory (transcriptional... https://pmc.ncbi.nlm.nih.gov/articles/PMC20104/ Mutational studies of yeast transcription factor IIB in vivo reveal a functional surface important... Recent experiments in yeast (Saccharomyces cerevisiae) cells have identified a species-specific region of yeast transcription factor IIB (TFIIB) located at... https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/conference-presentations/2022/validation-and-adoption-of-an-igvh-mutational-status-assay-in-chronic-lymphocytic-leukemia--cll--using-next-generation-sequencing--ngs--in-a-clinical-laboratory Validation and adoption of an IGVH mutational status assay in chronic lymphocytic leukemia (CLL)... Poster presentation at the Association for Molecular Pathology Annual Meeting (AMP 2022) conference, with the title "Validation and adoption of an IGVH... https://pmc.ncbi.nlm.nih.gov/articles/PMC11899081/ Longitudinal CSF Tumor Cell Enumeration and Mutational Analysis as a Driver for Leptomeningeal... This research focuses on better diagnosing and monitoring of leptomeningeal disease (LMD), a condition hard to detect with current methods. We use a new... https://www.rti.org/publication/repertoire-mutational-signatures-human-cancer The repertoire of mutational signatures in human cancer | RTI Somatic mutations in cancer genomes are caused by multiple mutational processes, each of which generates a characteristic mutational signature1. Here, as part... mutational signatures repertoire human cancer rti https://www.preprints.org/manuscript/202407.0536 Mechanistic Insights into the Mutational Landscape of the Main Protease/3CLPro and Its Impact on... The main proteinase (Mpro), or 3CLpro, is a critical enzyme in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lifecycle and is responsible...