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A New Model of SARS-CoV-2 Infection Based on (Hydroxy) Chloroquine Activity | bioRxiv
Chloroquine and hydroxychloroquine (H)CQ are well known anti-malarial drugs, while their use against COVID-19 is more controversial. (H)CQ activity was...
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The cockroach Blattella germanica possesses panoistic ovaries, in which oocytes lack nurse cells and therefore need to rely on their own transcriptional...
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Molecular structure and nickel binding capacity of Proteus mirabilis UreE | bioRxiv
UreE is a nickel chaperone required for the safe and efficient delivery of nickel to the active site of the metalloenzyme, urease; a key virulence factor of...
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Human Autosomal Nucleotide Positions Differing from Bonobo Instead Match Pig | bioRxiv
Overview To examine the hybrid hypothesis of human origins, a novel data mining program, BOOMSTICK, was used to scan the euchromatic portions of two target...
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https://www.biorxiv.org/content/10.1101/2020.08.02.232892v1
A New Model of SARS-CoV-2 Infection Based on (Hydroxy) Chloroquine Activity | bioRxiv
Chloroquine and hydroxychloroquine (H)CQ are well known anti-malarial drugs, while their use against COVID-19 is more controversial. (H)CQ activity was...
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Diversity and evolution of chromatin regulatory states across eukaryotes | bioRxiv
Histone post-translational modifications (hPTMs) are key regulators of chromatin states[1][1],[2][2], influencing gene expression, epigenetic memory, and...
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Reprogrammed Serine Integrases Enable Precise Integration of Synthetic DNA | bioRxiv
Despite recent progress in the ability to manipulate the genomes of eukaryotic cells[1][1]โ[3][2], there is still no effective and practical method to...
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Extreme disparity in the appendicular skeleton of domestic dogs (Canis familiaris) | bioRxiv
Domestic dogs ( Canis familiaris ) display more morphological variation than any other mammal. Cranial morphology has been extensively studied, as have the...
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Human Autosomal Nucleotide Positions Differing from Bonobo Instead Match Pig | bioRxiv
Overview To examine the hybrid hypothesis of human origins, a novel data mining program, BOOMSTICK, was used to scan the euchromatic portions of two target...
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Distributed control circuits across a brain-and-cord connectome | bioRxiv
Just as genomes revolutionized molecular genetics, connectomes (maps of neurons and synapses) are transforming neuroscience. To date, the only species with...
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PGP-UK: a research and citizen science hybrid project in support of personalized medicine | bioRxiv
Molecular analyses such as whole-genome sequencing have become routine and are expected to be transformational for future healthcare and lifestyle decisions....
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TCRi: Information theoretic metrics for single cell RNA and TCR sequencing in cancer | bioRxiv
Single-cell T cell repertoire sequencing can pair both T cell receptor (TCR) and gene expression sequence data, providing an enriched view of T cell behavior....
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Reprogrammed Serine Integrases Enable Precise Integration of Synthetic DNA | bioRxiv
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Persistent Neurological Deficits in Mouse PASC Reveal Antiviral Drug Limitations | bioRxiv
Post-Acute Sequelae of COVID-19 (PASC) encompasses persistent neurological symptoms, including olfactory and autonomic dysfunction. Here, we report chronic...
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Ten simple rules for structuring papers | bioRxiv
Good scientific writing is essential to career development and to the progress of science. A well-structured manuscript allows readers and reviewers to get...
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A connectomic study of a petascale fragment of human cerebral cortex | bioRxiv
We acquired a rapidly preserved human surgical sample from the temporal lobe of the cerebral cortex. We stained a 1 mm3 volume with heavy metals, embedded it...
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Autophagy acts as a spatial organizer of cell-type-specific plant immunity | bioRxiv
Plant immune responses must balance effective pathogen restriction to prevent excessive tissue damage and rely on potentiation between pattern-triggered...
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Potent Antiviral Activities of Type I Interferons to SARS-CoV-2 Infection | bioRxiv
The historical outbreak of COVID-19 disease not only constitutes a global public health crisis, but also has a devastating social and economic impact. The...
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Persistent Neurological Deficits in Mouse PASC Reveal Antiviral Drug Limitations | bioRxiv
Post-Acute Sequelae of COVID-19 (PASC) encompasses persistent neurological symptoms, including olfactory and autonomic dysfunction. Here, we report chronic...
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Reproducible Computational Workflows with Continuous Analysis | bioRxiv
Reproducing experiments is vital to science. Being able to replicate, validate and extend previous work also speeds new research projects. Reproducing...
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