Robuta

https://pubmed.ncbi.nlm.nih.gov/30135653/ Rapamycin Upregulates Connective Tissue Growth Factor Expression in Hepatic Progenitor Cells... Rapamycin (sirolimus) is a mTOR kinase inhibitor and is widely used as an immunosuppressive drug to prevent graft rejection in organ transplantation currently.... connective tissuegrowth factorrapamycin https://research-portal.uu.nl/en/publications/targeting-rapamycin-to-podocytes-using-a-vascular-cell-adhesion-m/ Targeting Rapamycin to Podocytes Using a Vascular Cell Adhesion Molecule-1 (VCAM-1)-Harnessed... cell adhesion molecule https://hsbiblio.uni-tuebingen.de/xmlui/handle/10900/120130 Rapamycin delays allograft rejection in obese graft recipients through induction of myeloid-derived... https://scholars.uky.edu/es/publications/apoe-genotype-dependent-pharmacogenetic-responses-to-rapamycin-fo/ APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease - apoe genotype https://pubmed.ncbi.nlm.nih.gov/18295073/ Biological action of rapamycin in renal transplantation Biological action of rapamycin in renal transplantation biologicalactionrapamycinrenaltransplantation https://pubmed.ncbi.nlm.nih.gov/20804212/ Steady-state kinetic and inhibition studies of the mammalian target of rapamycin (mTOR) kinase... The mammalian target of rapamycin (mTOR) is a Ser/Thr protein kinase and a major controller of cell growth. In cells, mTOR forms two distinct multiprotein... https://www.wikidata.org/wiki/Q28257161 The Mammalian Target of Rapamycin Phosphorylates Sites Having a (Ser/Thr)-Pro Motif and Is... scientific article published on December 19, 1997 mammalian target of rapamycin https://pubmed.ncbi.nlm.nih.gov/23734717/ Late-life rapamycin treatment reverses age-related heart dysfunction Rapamycin has been shown to extend lifespan in numerous model organisms including mice, with the most dramatic longevity effects reported in females. However,... late liferapamycintreatmentreversesage https://vet.uga.edu/clinical-trial/study-to-assess-healthy-aging-in-dogs-the-dog-aging-project-and-test-of-rapamycin-in-aging-dogs-triad-study/ Study to assess healthy aging in dogs: the Dog Aging Project and Test of Rapamycin in Aging Dogs... Study to assess healthy aging in dogs: the Dog Aging Project and Test of Rapamycin in Aging Dogs (TRIAD study) https://scholars.uky.edu/es/publications/how-longevity-research-can-lead-to-therapies-for-alzheimers-disea/ How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story - https://scholarspace.manoa.hawaii.edu/items/9a3f3c0e-7ff0-4c80-96ed-1aa3e3247ac8 Muscle Hypertrophy Induced by Myostatin Inhibition is Suppressed by Rapamycin Administration muscle hypertrophyinducedmyostatininhibitionsuppressed https://naturalpet.health/ Rapamycin & Longevity Consults for Dogs | Natural Pet Health Mar 5, 2025 - Discover Rapamycin, NMN, and Longevity Consults for Dogs at Natural Pet Health. We're dedicated to extending your pet's happiness and life. for dogsnatural petrapamycinlongevityconsults https://cordis.europa.eu/project/id/101032175/pl Linking the Target of Rapamycin signalling to cell cycle progression during tuber initiation and... Potato tubers are nutrient storage organs that develop from underground stems called stolons through a process called tuberisation. This process is under the... https://pubmed.ncbi.nlm.nih.gov/24009623/ Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a... The mammalian target of rapamycin (mTOR) inhibitors, a set of promising potential anti-cancer agents, has shown response variability among individuals. This... https://adisinsight.springer.com/trials/700316764?error=cookies_not_supported&code=6498b6a7-4500-4fc5-8779-24e4f977bfaa Phase II Trial of Autologous Rapamycin-Resistant Th1/Tc1 (RAPA-201) Cell Therapy of Relapsed,... RAPA-201-RRMM is an open-label, single-arm, non-randomized multicenter phase II study of RAPA-201 autologous T cells in adults with relapsed, refractory https://experts.arizona.edu/en/publications/rapamycin-blocks-fibrocyte-migration-and-attenuates-bronchiolitis/ Rapamycin blocks fibrocyte migration and attenuates bronchiolitis obliterans in a murine model -... https://profiles.uchicago.edu/profiles/display/33661776 Mechanistic Target of Rapamycin Complex 2 | Profiles RNS targetrapamycincomplexprofilesrns https://publikationen.uni-tuebingen.de/xmlui/handle/10900/39214 Balloon Coating with Rapamycin Using an On-site Coating Device on siteballooncoatingrapamycinusing https://researchdiscovery.drexel.edu/esploro/outputs/journalArticle/Characterization-of-the-metabolic-phenotype-of/991014878120504721 Characterization of the metabolic phenotype of rapamycin-treated CD8+ T cells with augmented... Cellular metabolism plays a critical role in regulating T cell responses and the development of memory T cells with long-term protections. However, the... of the https://nrc-publications.canada.ca/eng/view/object/?id=7b5db050-ebf8-4ff7-869d-d802b3de07c9 Ectopic expression of Arabidopsis Target of Rapamycin (AtTOR) improves water-use efficiency and... Ectopic expression of Arabidopsis Target of Rapamycin (AtTOR) improves water-use efficiency and yield potential in rice water use efficiency https://www.age.mpg.de/392233/240228_pm_rapamycin_endolysosomes?c=211370 Anti-ageing drug rapamycin improves immune function through endolysosomes | Max Planck Institute... Rapamycin is considered a promising anti-ageing drug that improves health in old age and alleviates the age-related decline in immune function. A research... anti ageingimmune function https://pubmed.ncbi.nlm.nih.gov/28971953/?dopt=Abstract Rapamycin and CHIR99021 Coordinate Robust Cardiomyocyte Differentiation From Human Pluripotent Stem... We have demonstrated that mammalian target of rapamycin exerts a stage-specific and multifaceted regulation over cardiac differentiation and provides an... rapamycincoordinaterobust https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.649475/full Frontiers | Genome-Wide Gene Expression Analysis of Mtb-Infected DC Highlights the Rapamycin-Driven... In human primary dendritic cells (DC) rapamycin - an autophagy inducer and protein synthesis inhibitor - overcomes the autophagy block induced by Mycobacteri... https://pmc.ncbi.nlm.nih.gov/articles/PMC6613906/ Rapamycin and Alzheimer disease: a double-edged sword? - PMC Numerous studies have reported that inhibition of MTOR (mechanistic target of rapamycin kinase) clearly reduces Alzheimer disease neuropathological hallmarks... alzheimer diseasedouble edgedrapamycinswordpmc https://research.monash.edu/en/publications/target-of-rapamycin-signalling-mediates-the-lifespan-extending-ef/ Target of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by... https://pubmed.ncbi.nlm.nih.gov/31401286/ Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing... Our findings reveal a critical metabolic signaling relay of barrier formation in which epidermal mTORC2 activity controls FLG processing and de novo epidermal... mammalian target of rapamycin https://boris-portal.unibe.ch/entities/publication/4899d8db-9859-4ba2-81f0-6cfef3823456 Corrigendum to: Mechanistic target of rapamycin (mTOR) protein expression in the tumor and its... https://pubmed.ncbi.nlm.nih.gov/19190131/ Marked activity of irinotecan and rapamycin combination toward colon cancer cells in vivo and in... These results identify HIF-1alpha as a promising target and provide a rationale for clinical trials of low-dose irinotecan and rapamycin combination toward... https://sciencedaily.com/releases/2021/06/210601165041.htm Modulating rapamycin target protein promotes autophagy, lowering toxic Huntingtin protein |... Recent failed clinical trials of a drug designed to clear the mutant Huntingtin protein that causes Huntington's disease (HD) heightens the need for new... rapamycintargetproteinpromotesautophagy https://pubmed.ncbi.nlm.nih.gov/23443503/ Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at... Males, who are bigger and stronger than females, live shorter in most species from flies to mammals including humans. Cellular mass growth is driven in part by... mammalian target of rapamycin https://pubmed.ncbi.nlm.nih.gov/15772072/ The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role... The target of rapamycin (TOR) is a highly conserved Ser/Thr kinase that plays a central role in the control of cellular growth. TOR has a characteristic... https://pure.psu.edu/en/publications/rapamycin-inhibits-human-laryngotracheal-stenosis-derived-fibrobl/ Rapamycin inhibits human laryngotracheal stenosis-derived fibroblast proliferation, metabolism, and... rapamycinhumanstenosisderivedfibroblast https://research.monash.edu/en/publications/cyclosporin-a-fk506-and-rapamycin-produce-multiple-temporally-dis/ Cyclosporin A, FK506 and rapamycin produce multiple, temporally distinct, effects on memory... cyclosporin a https://pubmed.ncbi.nlm.nih.gov/31955578/ Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin... Recent clinical evaluation of everolimus for seizure reduction in patients with tuberous sclerosis complex (TSC), a disease with overactivated mechanistic... of a https://pmc.ncbi.nlm.nih.gov/articles/PMC12181551/ Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective,... Companion dogs are a powerful model for aging research given their morphologic and genetic variability, risk for age-related disease, and habitation of the... https://data.mendeley.com/datasets/tkgms4pmdz/1 Clinical Trial_Rapamycin_Functional study_Paper 2 - Mendeley Data The raw data for Rapamycin trial utilizing a compounded version of rapamycin to alleviate clinical symptoms of PEM in ME/CFS. clinical trialrapamycinfunctionalstudypaper https://rapamycin.io/ Rapamycin rapamycin https://pubmed.ncbi.nlm.nih.gov/30082562/ Surendra Nath Sehgal: A pioneer in rapamycin discovery Surendra Nath Sehgal: A pioneer in rapamycin discovery surendra nathpioneerrapamycindiscovery https://scholars.uky.edu/en/publications/how-longevity-research-can-lead-to-therapies-for-alzheimers-disea/ How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story -... https://www.bcp.fu-berlin.de/en/chemie/chemie/forschung/OrgChem/haag/publications/haag2021045/index.html 576. Topical Delivery of Rapamycin by Means of Microenvironment-Sensitive Core-Multi-Shell... https://www.ideals.illinois.edu/items/86073 Investigation of the Function and Regulatory Mechanisms of the Mammalian Target of Rapamycin |... of theinvestigationfunctionregulatorymechanisms https://research.birmingham.ac.uk/en/publications/mammalian-target-of-rapamycin-independent-s6k1-and-4e-bp1-phospho/fingerprints/ Mammalian target of rapamycin-independent S6K1 and 4E-BP1 phosphorylation during contraction in rat... mammalian target of rapamycin https://pubmed.ncbi.nlm.nih.gov/26381051/ Regulation of cardiac miR-208a, an inducer of obesity, by rapamycin and nebivolol Rap and Neb suppressed cardiac miR-208a. Suppression of miR-208a and increase in MED13 correlated with attenuated weight gain despite leptin resistance. https://pubmed.ncbi.nlm.nih.gov/10330150/ Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs... Cryptococcus neoformans is a fungal pathogen that causes meningitis in patients immunocompromised by AIDS, chemotherapy, organ transplantation, or high-dose... https://brainandmind.weill.cornell.edu/multiple-critical-periods-rapamycin-treatment-correct-structural-defects-suppressed-brain Multiple Critical Periods for Rapamycin Treatment to Correct Structural Defects in -Suppressed... critical periods https://pubmed.ncbi.nlm.nih.gov/41573946/ Rapamycin Differentially Impacts Germline Stem Cell Quiescence Across Diverse Genetic Backgrounds... In response to ionizing radiation, stem cells enter a state of temporary quiescence, safeguarding the stem cell pool for tissue regeneration. Quiescence... stem cellrapamycinimpactsgermline https://pubmed.ncbi.nlm.nih.gov/24508508/?dopt=Abstract Rapamycin: one drug, many effects The mammalian target of rapamycin (mTOR) signaling pathway is a master regulator of cell growth and metabolism. Deregulation of the mTOR pathway has been... rapamycinonedrugmanyeffects https://pubmed.ncbi.nlm.nih.gov/20436272/ Rapamycin and quasi-programmed aging: four years later In 2006, Cell Cycle featured the concept that aging is not caused by molecular damage (nor by free radicals) but instead is a purposeless quasi-program... four yearsrapamycinquasiprogrammedaging https://pubmed.ncbi.nlm.nih.gov/25505613/ Metabolomic evaluation of Mitomycin C and rapamycin in a personalized treatment of pancreatic cancer In a personalized treatment designed for a patient with pancreatic cancer resistant to other treatments, the success of Mitomycin C (MMC) has been highlighted.... https://www.cirm.ca.gov/cirm-trial/a-phase-1-study-of-ub-vv111-with-and-without-rapamycin-in-relapsed-refractory-cd19-b-cell-malignancies-2/ A Phase 1 Study of UB-VV111 With and Without Rapamycin in Relapsed/Refractory CD19+ B-cell... https://pubmed.ncbi.nlm.nih.gov/38741464/ The ion channel TRPM8 is a direct target of the immunosuppressant rapamycin in primary sensory... These results identify TRPM8 cationic channels in sensory neurons as novel molecular targets of the immunosuppressant rapamycin. These findings may help... https://www.techtransfer.nih.gov/patent/e-063-2003-0-us-05 Rapamycin-Resistant T Cells and Therapeutics Uses Thereof | Technology Transfer t cellsrapamycinresistanttherapeuticsuses https://www.pharmacy.arizona.edu/news/2026/can-drug-slow-aging-rapamycin-story Can a Drug Slow Aging? The Rapamycin Story | R. Ken Coit College of Pharmacy https://iris.cnr.it/handle/20.500.14243/745 Altered Centrosomes in Ataxia-Telangiectasia Cells and Rapamycin-Treated Chinese Hamster Cells ataxia telangiectasiaaltered https://www.news-medical.net/news/20120330/Study-explains-how-rapamycin-also-causes-insulin-resistance.aspx Study explains how rapamycin also causes insulin resistance Jun 19, 2019 - A Penn- and MIT-led team explained how rapamycin, a drug that extends mouse lifespan, also causes insulin resistance. The researchers showed in an animal model... studyexplainsrapamycinalsocauses https://pmc.ncbi.nlm.nih.gov/articles/PMC20323/ Target of rapamycin proteins and their kinase activities are required for meiosis - PMC The phosphatidylinositol kinase-related kinases, including Tor1p, Tor2p, FRAP/RAFT, FRP/ATR, ATM, Mec1p, Rad3, and Tel1p, function in signal transduction... https://pmc.ncbi.nlm.nih.gov/articles/PMC2786175/ Rapamycin fed late in life extends lifespan in genetically heterogeneous mice - PMC Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends lifespan in invertebrates, including yeast, nematodes and fruit... in liferapamycinfedlate https://pubmed.ncbi.nlm.nih.gov/21339643/ Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated... LEOPARD syndrome (LS) is an autosomal dominant "RASopathy" that manifests with congenital heart disease. Nearly all cases of LS are caused by catalytically... hypertrophic cardiomyopathy https://www.wikidata.org/wiki/Q41608842 Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase - Wikidata scientific article published on August 14, 1992 of theprotein kinaserapamycininducedinhibition https://www.news-medical.net/news/20230418/Rapamycin-and-other-rapalogs-have-potential-to-delay-cancer.aspx Rapamycin and other rapalogs have potential to delay cancer Apr 18, 2023 - A new research perspective was published in Oncotarget's Volume 14 on April 14, 2023, entitled, "Cancer prevention with rapamycin." and otherrapamycinpotentialdelaycancer https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.783884/full Frontiers | Rapamycin Ameliorates Radiation-Induced Testis Damage in Mice Male infertility is an important problem in human and animal reproduction. The testis is the core of male reproduction, which is very sensitive to radiation.... frontiersrapamycinradiationinducedtestis https://conservancy.umn.edu/items/7bc84458-7c64-42f0-87ea-6ac0c65b9ef1 Identification and characterization of novel positive regulators of the Target of Rapamycin (TOR)... Target of Rapamycin (TOR) is an evolutionary conserved pathway in eukaryotes for growth and proliferation. TOR pathway plays an important role for growth... the targetidentificationcharacterizationnovel https://www.wikidata.org/wiki/Q41666761 Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing... scientific article published on September 1995 and therapamycin https://pubmed.ncbi.nlm.nih.gov/23715582/ Results of an international randomized phase III trial of the mammalian target of rapamycin... Ridaforolimus delayed tumor progression to a small statistically significant degree in patients with metastatic sarcoma who experienced benefit with prior... phase iii https://researchdiscovery.drexel.edu/esploro/outputs/journalArticle/Topical-rapamycin-reduces-markers-of-senescence/991019168157004721 Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory,... Dec 1, 2019 - Aging is a major risk factor for the majority of human diseases, and the development of interventions to reduce the intrinsic rate of aging is expected to... https://www.techtransfer.nih.gov/patent/e-063-2003-0-ca-04 Rapamycin-Resistant T Cells and Therapeutic Uses Thereof | Technology Transfer t cellsrapamycinresistanttherapeuticuses https://pubmed.ncbi.nlm.nih.gov/15612989/ Dosing of rapamycin is critical to achieve an optimal antiangiogenic effect against cancer Rapamycin has antiangiogenic activity against tumors. This has been discussed while addressing the problem of cancer in organ transplantation. Here we... https://lod.nal.usda.gov/nalt/en/page/?uri=https%3A//lod.nal.usda.gov/nalt/291300 NAL Agricultural Thesaurus: NALT: rapamycin nalagriculturalthesaurusrapamycin https://tobias-lib.ub.uni-tuebingen.de/xmlui/handle/10900/118648?show=full A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets... https://scholars.uky.edu/en/publications/aging-and-the-contractile-regulation-of-human-skeletal-muscle-mam/ Aging and the contractile regulation of human skeletal muscle mammalian target of rapamycin complex... https://pubmed.ncbi.nlm.nih.gov/37057884/ Cancer prevention with rapamycin Rapamycin (sirolimus) and other rapalogs (everolimus) are anti-cancer and anti-aging drugs, which delay cancer by directly targeting pre-cancerous cells and,... cancer preventionrapamycin https://ub01.uni-tuebingen.de/xmlui/handle/10900/149384 SNF1-RELATED KINASE 1 and TARGET OF RAPAMYCIN control light-responsive splicing events and... https://pubmed.ncbi.nlm.nih.gov/36943069/ Cross-Talk and Multiple Control of Target of Rapamycin (TOR) in Sclerotinia sclerotiorum cross talk https://kohane.tch.harvard.edu/2026/04/22/polymeric-rapamycin-nanoparticles-encapsulating-ponatinib-cause-regression-of-venous-malformations-in-mice/ Polymeric Rapamycin Nanoparticles Encapsulating Ponatinib Cause Regression of Venous Malformations... Apr 22, 2026 - Tang W, Li Y, Boscolo E, Kohane DS*, Cullion K*: Polymeric Rapamycin Nanoparticles Encapsulating Ponatinib Cause Regression of Venous Malformations in Mice.... polymericrapamycinnanoparticlesencapsulatingponatinib https://mindandmatter.substack.com/p/early-access-aging-mtor-sirtuins Aging, mTOR, Sirtuins, Rapamycin, Metformin, the Truth of Resveratrol & Longevity Supplements,... About the guest: Matt Kaeberlein, PhD is a Professor of at the University of Washington and CEO of OptiSpan. the truthagingmtorsirtuinsrapamycin https://journals.plos.org/plosone/article/comments?id=10.1371/journal.pone.0064078 Rapamycin Attenuates the Development of Posttraumatic Epilepsy in a Mouse Model of Traumatic Brain... Posttraumatic epilepsy is a major source of disability following traumatic brain injury (TBI) and a common cause of medically-intractable epilepsy. Previous...