Robuta

https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL41342 Compound: GERANYL DIPHOSPHATE (CHEMBL41342) - ChEMBL Report card for Compound GERANYL DIPHOSPHATE (CHEMBL41342). C10H20O7P2, Small molecule. geranyl diphosphatecompoundchembl https://www.ncbi.nlm.nih.gov/protein/3PYA_A Chain A, Ent-copalyl diphosphate synthase, chloroplastic - Protein - NCBI copalyl diphosphate synthasechainentproteinncbi https://www.rcsb.org/structure/1FI4 RCSB PDB - 1FI4: THE X-RAY CRYSTAL STRUCTURE OF MEVALONATE 5-DIPHOSPHATE DECARBOXYLASE AT 2.3... THE X-RAY CRYSTAL STRUCTURE OF MEVALONATE 5-DIPHOSPHATE DECARBOXYLASE AT 2.3 ANGSTROM RESOLUTION. https://www.rcsb.org/structure/4P0X RCSB PDB - 4P0X: Human farnesyl diphosphate synthase in complex with Taxodione Human farnesyl diphosphate synthase in complex with Taxodione farnesyl diphosphate synthasercsb pdbhuman https://www.ncbi.nlm.nih.gov/Structure/pdb/7XQ4 7XQ4: Drimenyl diphosphate synthase from Streptomyces showdoensis (apo) SQHop_cyclase_C domain-containing protein streptomyces showdoensisdiphosphatesynthaseapo https://www.ncbi.nlm.nih.gov/protein/3HF1_A Chain A, Ribonucleoside-diphosphate reductase subunit M2 B - Protein - NCBI b proteinchainribonucleosidediphosphatereductase https://www.wikidata.org/wiki/Q53748993 Biosynthesis of uridine diphosphate D-xylose. IV. Mechanism of action of uridine... scientific article published on 01 May 1970 uridine diphosphatebiosynthesisxyloseivmechanism https://pmc.ncbi.nlm.nih.gov/articles/PMC4319806/ Oritavancin Diphosphate - PMC Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3... oritavancin diphosphatepmc https://www.ncbi.nlm.nih.gov/Structure/pdb/4RXE 4RXE: T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-14 farnesyl diphosphate synthase https://www.ncbi.nlm.nih.gov/protein/514031568?report=GenPept putative nucleoside diphosphate kinase [Candidatus Tremblaya phenacola - Protein - NCBI nucleoside diphosphate kinaseputativecandidatusproteinncbi https://www.rcsb.org/structure/2B8Q RCSB PDB - 2B8Q: X-ray structure of Acanthamoeba ployphaga mimivirus nucleoside diphosphate kinase... X-ray structure of Acanthamoeba ployphaga mimivirus nucleoside diphosphate kinase complexed with TDP x ray structure https://www.ncbi.nlm.nih.gov/gene/936353 farP farnesyl diphosphate phosphatase [Bacillus subtilis subsp. subtilis str. 168] - Gene - NCBI farnesyl diphosphatebacillus subtilisfarpphosphatase https://www.semanticscholar.org/topic/motesanib-diphosphate/2433252 motesanib diphosphate | Semantic Scholar The orally bioavailable diphosphate salt of a multiple-receptor tyrosine kinase inhibitor with potential antineoplastic activity. Motesanib selectively targets... motesanib diphosphatesemanticscholar https://www.semanticscholar.org/topic/hydroxymethylbutenyl-diphosphate-reductase%2C-Vitis/11817675 hydroxymethylbutenyl diphosphate reductase, Vitis vinifera | Semantic Scholar vitis viniferadiphosphatereductasesemanticscholar https://www.rcsb.org/structure/1VHL RCSB PDB - 1VHL: Crystal structure of dephospho-CoA kinase with adenosine-5'-diphosphate Crystal structure of dephospho-CoA kinase with adenosine-5'-diphosphate dephospho coa kinase https://www.thermofisher.com/antibody/primary/panther/nucleoside%20diphosphate%20kinase%20activity nucleoside diphosphate kinase activity Antibodies | Invitrogen Antibodies for proteins involved in nucleoside diphosphate kinase activity pathways, according to their Panther/Gene Ontology Classification nucleoside diphosphate kinaseactivityantibodiesinvitrogen https://www.fishersci.com/shop/products/uridine-5-diphosphate-mp-biomedicals-4/ICN10120591 URIDINE-5'-DIPHOSPHATE, MP Biomedicals 1 g | Buy Online | MP Biomedicals, Inc | Fisher Scientific URIDINE-5'-DIPHOSPHATE, MP Biomedicals from MP Biomedicals, Inc. Disodium Salt Shop URIDINE-5'-DIPHOSPHATE, MP Biomedicals at Fishersci.com. Available in 1 g mp biomedicals1 g https://www.merriam-webster.com/dictionary/diphosphate DIPHOSPHATE Definition & Meaning - Merriam-Webster The meaning of DIPHOSPHATE is a phosphate containing two phosphate groups. diphosphatedefinitionmeaningmerriamwebster https://www.ncbi.nlm.nih.gov/Structure/pdb/1B99 1B99: 3'-FLUORO-URIDINE DIPHOSPHATE BINDING TO NUCLEOSIDE DIPHOSPHATE KINASE PROTEIN (NUCLEOSIDE DIPHOSPHATE KINASE)2',3'-DIDEOXY-3'-FLUORO-URIDIDINE-5'-DIPHOSPHATEPYROPHOSPHATE 2- uridine diphosphate3fluorobindingnucleoside https://pmc.ncbi.nlm.nih.gov/articles/PMC35479/ Adenosine diphosphate sugar pyrophosphatase prevents glycogen biosynthesis in Escherichia coli - PMC An adenosine diphosphate sugar pyrophosphatase (ASPPase, EC 3.6.1.21) has been characterized by using Escherichia coli. This enzyme, whose activities in the... adenosine diphosphateescherichia colisugarpyrophosphataseprevents https://www.ncbi.nlm.nih.gov/protein/302831463?report=GenPept 4-hydroxy-3-methylbut-2-enyl diphosphate reductase chloroplast precurs - Protein - NCBI https://www.ncbi.nlm.nih.gov/protein/3HF1_B Chain B, Ribonucleoside-diphosphate reductase subunit M2 B - Protein - NCBI m2 proteinchainbdiphosphatereductase https://www.jci.org/articles/view/112436/pdf JCI - Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose... dna strand https://www.wikidata.org/wiki/Q54298585 Elongation factor 2. Amino acid sequence at the site of adenosine diphosphate ribosylation -... elongation factor 2amino acid sequence https://www.ncbi.nlm.nih.gov/gene/4062228 nrdF ribonucleotide-diphosphate reductase subunit beta [Streptococcus pyogenes MGAS9429] - Gene -... streptococcus pyogenesribonucleotidediphosphatereductasesubunit https://www.semanticscholar.org/topic/dimethylallyl-diphosphate-metabolic-process/7037410 dimethylallyl diphosphate metabolic process | Semantic Scholar The chemical reactions and pathways involving dimethylallyl diphosphate. [GOC:ai] dimethylallyl diphosphatemetabolic processsemanticscholar https://www.ncbi.nlm.nih.gov/protein/1V4E_A Chain A, octoprenyl-diphosphate synthase - Protein - NCBI chaindiphosphatesynthaseproteinncbi https://www.rcsb.org/structure/1N1B RCSB PDB - 1N1B: Crystal Structure of (+)-Bornyl Diphosphate Synthase from Sage Crystal Structure of (+)-Bornyl Diphosphate Synthase from Sage bornyl diphosphate synthasercsb pdbcrystal structure https://www.semanticscholar.org/topic/diphosphate-fructose-6-phosphate-activity/1745766 diphosphate-fructose-6-phosphate 1-phosphotransferase activity | Semantic Scholar Catalysis of the reaction: fructose-6-phosphate + diphosphate = phosphate + fructose-1,6-bisphosphate. [EC:2.7.1.90, MetaCyc:2.7.1.90-RXN] fructose 6 phosphatediphosphate1phosphotransferaseactivity https://www.wikidata.org/wiki/Q34217525 Enzymatic transfer of mannose from guanosine diphosphate mannose to dolichol phosphate in yeast... guanosine diphosphate https://www.wikidata.org/wiki/Q36819668 Cloning, characterization, and heterologous expression of cDNAs for farnesyl diphosphate synthase... scientific article published on August 1996 heterologous expressionfarnesyl diphosphatecloningcharacterization https://www.semanticscholar.org/topic/Uridine-Diphosphate-N-Acetylglucosamine/986047 Uridine Diphosphate N-Acetylglucosamine | Semantic Scholar Serves as the biological precursor of insect chitin, of muramic acid in bacterial cell walls, and of sialic acids in mammalian glycoproteins. uridine diphosphateacetylglucosaminesemanticscholar https://www.rcsb.org/structure/1NUE RCSB PDB - 1NUE: X-RAY STRUCTURE OF NM23 HUMAN NUCLEOSIDE DIPHOSPHATE KINASE B COMPLEXED WITH GDP... X-RAY STRUCTURE OF NM23 HUMAN NUCLEOSIDE DIPHOSPHATE KINASE B COMPLEXED WITH GDP AT 2 ANGSTROMS RESOLUTION https://www.ncbi.nlm.nih.gov/protein/302767946?report=GenPept 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic [Sel - Protein - NCBI https://www.ncbi.nlm.nih.gov/protein/7CPN_A Chain A, Trans,polycis-polyprenyl diphosphate synthase ((2Z,6E)-farnes - Protein - NCBI a trans https://www.ebi.ac.uk/chebi/CHEBI:73083 (7,8-dihydropterin-6-yl)methyl diphosphate (CHEBI:73083) 7 86yldiphosphatechebi https://www.ncbi.nlm.nih.gov/protein/3FCV_A Chain A, Nucleoside diphosphate kinase - Protein - NCBI nucleoside diphosphate kinasechainproteinncbi https://www.rcsb.org/structure/1S57 RCSB PDB - 1S57: crystal structure of nucleoside diphosphate kinase 2 from Arabidopsis crystal structure of nucleoside diphosphate kinase 2 from Arabidopsis nucleoside diphosphate kinasercsb pdbcrystal structure https://www.ncbi.nlm.nih.gov/protein/6QO9_A Chain A, Ribonucleoside-diphosphate reductase subunit beta - Protein - NCBI chainribonucleosidediphosphatereductasesubunit https://www.wikidata.org/wiki/Q34237604 Nicotinamide adenine dinucleotide glycohydrolases and poly adenosine diphosphate ribose synthesis... adenosine diphosphate ribosenicotinamideadeninedinucleotidepoly https://www.wikidata.org/wiki/Q24313033 nm23-H4, a new member of the family of human nm23/nucleoside diphosphate kinase genes localised on... https://www.ncbi.nlm.nih.gov/protein/5X00_A?report=GenPept Chain A, Nucleoside diphosphate kinase - Protein - NCBI nucleoside diphosphate kinasechainproteinncbi https://www.ncbi.nlm.nih.gov/protein/499459173?report=GenPept MULTISPECIES: nucleoside-diphosphate kinase [Photorhabdus] - Protein - NCBI nucleoside diphosphate kinasemultispeciesphotorhabdusproteinncbi https://www.ncbi.nlm.nih.gov/protein/4D8F_B Chain B, Ribonucleoside-diphosphate reductase subunit beta - Protein - NCBI chainbdiphosphatereductaseprotein https://www.ncbi.nlm.nih.gov/Structure/pdb/4N1Z 4N1Z: Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1222 Farnesyl pyrophosphate synthaseMAGNESIUM IONPHOSPHATE IONhydrogen [(1S)-1-hydroxy-2-(3-octyl-1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate farnesyl diphosphate synthase https://www.ncbi.nlm.nih.gov/Structure/pdb/7XRA 7XRA: Drimenyl diphosphate synthase D303A from Streptomyces showdoensis in complex with farnesyl... SQHop_cyclase_C domain-containing proteinFARNESYL DIPHOSPHATEMAGNESIUM ION https://www.ncbi.nlm.nih.gov/protein/505237460?report=GenPept nucleoside-diphosphate kinase [Candidatus Cloacimonas acidaminovorans] - Protein - NCBI nucleoside diphosphate kinasecandidatusproteinncbi https://www.ncbi.nlm.nih.gov/Structure/pdb/1UCN 1UCN: X-ray structure of human nucleoside diphosphate kinase A complexed with ADP at 2 A resolution nucleoside diphosphate kinase A2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOLADENOSINE-5'-DIPHOSPHATECALCIUM IONPHOSPHATE ION https://www.ebi.ac.uk/chebi/CHEBI:15442 presqualene diphosphate (CHEBI:15442) A triterpenyl phosphate that is presqualene in which the hydroxy hydrogen has been replaced by a diphosphate group. diphosphatechebi https://www.wikidata.org/wiki/Q78467680 THE INITIAL CHANGES IN PLATELET MORPHOLOGY FOLLOWING THE ADDITION OF ADENOSINE DIPHOSPHATE -... scientific article published on 01 July 1965 initialchangesplatelet https://www.ebi.ac.uk/chebi/CHEBI:14473 isopentenyl diphosphate (CHEBI:16584) isopentenyl diphosphatechebi https://www.semanticscholar.org/topic/Primaquine-Diphosphate/5552047 Primaquine Diphosphate | Semantic Scholar primaquinediphosphatesemanticscholar https://www.ncbi.nlm.nih.gov/Structure/pdb/5HXT 5HXT: Crystal Structure of Z,Z-Farnesyl Diphosphate Synthase (D71M, E75A and H103Y Mutants)... (2Z,6Z)-farnesyl diphosphate synthase, chloroplastic1,4,7,10,13,16-HEXAOXACYCLOOCTADECANEDIMETHYLALLYL S-THIOLODIPHOSPHATEISOPENTYL PYROPHOSPHATEMAGNESIUM ION farnesyl diphosphate synthase https://www.thermofisher.com/antibody/primary/panther/diphosphate%20metabolic%20process diphosphate metabolic process Antibodies | Invitrogen Antibodies for proteins involved in diphosphate metabolic process pathways, according to their Panther/Gene Ontology Classification metabolic processdiphosphateantibodiesinvitrogen https://www.ncbi.nlm.nih.gov/protein/3ETM_A Chain A, Nucleoside diphosphate kinase - Protein - NCBI nucleoside diphosphate kinasechainproteinncbi https://www.wikidata.org/wiki/Q72779905 Binding of Adenosine Triphosphate and Adenosine Diphosphate by Glutamine Synthetase* - Wikidata scientific article published on 01 March 1966 adenosine triphosphateglutamine synthetasebindingdiphosphatewikidata https://www.ncbi.nlm.nih.gov/protein/1V4E_B Chain B, octoprenyl-diphosphate synthase - Protein - NCBI chainbdiphosphatesynthaseprotein https://www.ncbi.nlm.nih.gov/protein/3ETM_B Chain B, Nucleoside diphosphate kinase - Protein - NCBI nucleoside diphosphate kinasechainbprotein https://www.ebi.ac.uk/chebi/CHEBI:15998 (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl trihydrogen diphosphate (CHEBI:15998) A 7,8-dihydropterin having a diphosphomethyl substituent at the 6-position. 2 amino 4 https://pmc.ncbi.nlm.nih.gov/articles/PMC5155509/ Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl... We synthesized a series of benzoic acids and phenylphosphonic acids and investigated their effects on the growth of Staphylococcus aureus and Bacillus... cell growthundecaprenyl diphosphatebacterialinhibitorstargeting https://www.ncbi.nlm.nih.gov/Structure/pdb/3HYQ 3HYQ: Crystal Structure Of Isopentenyl-Diphosphate Delta-Isomerase From Salmonella Entericase ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE crystal structureisopentenyl diphosphate https://www.ncbi.nlm.nih.gov/gene/939562 nrdIB SPbeta phage subunit of ribonucleoside diphosphate reductase [Bacillus subtilis subsp.... bacillus subtilisphagesubunit https://www.spandidos-publications.com/10.3892/ol.2023.13731/abstract Farnesyl diphosphate synthase promotes cell proliferation by regulating gene expression and... Oncology Letters is an international journal devoted to Experimental and Clinical Oncology. farnesyl diphosphate synthasecell proliferationgene expression https://www.ncbi.nlm.nih.gov/Structure/pdb/1N20 1N20: (+)-Bornyl Diphosphate Synthase: Complex with Mg and 3-aza-2,3-dihydrogeranyl diphosphate (+)-bornyl diphosphate synthase2-[METHYL-(4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATEMAGNESIUM ION bornyl diphosphate synthase https://www.wikidata.org/wiki/Q67367141 Action of glycosidases on the saccharide moiety of the glucose--containing dolichyl diphosphate... scientific article published on 01 July 1978 on theactionglycosidases https://www.ncbi.nlm.nih.gov/protein/6QO9_B Chain B, Ribonucleoside-diphosphate reductase subunit beta - Protein - NCBI chainbdiphosphatereductaseprotein https://www.omicsonline.org/proceedings/expression-of-nuclear-polyadenosine-diphosphateribose-polymerase-in-brca-1-and-brca-2-deficient-breast-cancer-3122.html Expression Of Nuclear Poly(Adenosine Diphosphate-Ribose) Polymerase In BRCA 1 And BRCA 2 Deficient... Molecular mechanisms of DNA damage and repair and factors interfering with it have been subject of numerous studies in the last decades. BRCA1 and BRCA2... https://www.semanticscholar.org/topic/1%2CN%286%29-ethenoadenosine-diphosphate/2729066 1,N(6)-ethenoadenosine diphosphate | Semantic Scholar 1 n6diphosphatesemanticscholar https://www.ncbi.nlm.nih.gov/protein/1PIU_B Chain B, Ribonucleoside-diphosphate reductase 1 beta chain - Protein - NCBI chainbdiphosphatereductase1 https://www.ncbi.nlm.nih.gov/Structure/pdb/3Q8U 3Q8U: Crystal structure of Staphylococcus aureus nucleoside diphosphate kinase complexed with ADP Nucleoside diphosphate kinaseADENOSINE-5'-DIPHOSPHATEMAGNESIUM ION nucleoside diphosphate kinasecrystal structurestaphylococcus aureus https://www.ncbi.nlm.nih.gov/protein/1W68_A Chain A, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE M2 CHAIN - Protein - NCBI m2 proteinchainribonucleosidediphosphatereductase https://www.ncbi.nlm.nih.gov/Structure/pdb/4RXD 4RXD: T. Brucei Farnesyl Diphosphate Synthase Complexed with Risedronate Farnesyl pyrophosphate synthase1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACIDMAGNESIUM ION farnesyl diphosphate synthaserisedronate https://www.ncbi.nlm.nih.gov/protein/152997008?report=GenPept Record removed: ribonucleotide-diphosphate reductase subunit beta [Marinomonas sp. MWY - Protein -... recordremovedribonucleotidediphosphatereductase https://www.ncbi.nlm.nih.gov/protein/1S57_D Chain D, Nucleoside diphosphate kinase II - Protein - NCBI nucleoside diphosphate kinasechainiiproteinncbi https://www.ncbi.nlm.nih.gov/protein/18466786?report=GenPept Record removed: ribonucleotide-diphosphate reductase subunit beta (plasmid) [Salmonell - Protein -... recordremovedribonucleotidediphosphatereductase https://www.semanticscholar.org/topic/nucleoside-diphosphate-kinase-A/224098 nucleoside diphosphate kinase A | Semantic Scholar Nucleoside diphosphate kinase A (152 aa, ~17 kDa) is encoded by the human NME1 gene. This protein plays a role in nucleoside triphosphate synthesis, lipid and... nucleoside diphosphate kinasesemanticscholar https://www.ncbi.nlm.nih.gov/gene/884627 nrdB ribonucleoside-diphosphate reductase subunit beta [Chlamydia trachomatis D/UW-3/CX] - Gene -... https://www.ncbi.nlm.nih.gov/Structure/pdb/1U8W 1U8W: Crystal structure of Arabidopsis thaliana nucleoside diphosphate kinase 1 Nucleoside diphosphate kinase I nucleoside diphosphate kinasecrystal structurearabidopsis thaliana1 https://www.wikidata.org/wiki/Q72139287 Trehalose 6-phosphate synthetase (uridine diphosphate glucose: d-glucose 6-phosphate... scientific article published on 01 October 1968 uridine diphosphate glucosetrehalose6synthetase https://www.ncbi.nlm.nih.gov/protein/302753790?report=GenPept 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic [Sel - Protein - NCBI https://www.ebi.ac.uk/chebi/CHEBI:632 (2E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate (CHEBI:15664) 3 methylbut 2 en 1 yl https://www.ncbi.nlm.nih.gov/protein/433642644 Record removed: Putative nucleoside diphosphate kinase NdkA (NDK) (NDP kinase) (nucleo - Protein -... nucleoside diphosphate kinaserecordremovedputative https://www.ebi.ac.uk/chebi/CHEBI:978 2-(1-hydroxyethyl)thiamine diphosphate (CHEBI:978) 2 1thiamine diphosphatehydroxyethylchebi978 https://www.ncbi.nlm.nih.gov/protein/3FCV_B Chain B, Nucleoside diphosphate kinase - Protein - NCBI nucleoside diphosphate kinasechainbprotein https://pmc.ncbi.nlm.nih.gov/articles/PMC5012948/ Structure, Function and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase - PMC We report the first structure of heptaprenyl diphosphate synthase from Staphylococcus aureus (SaHepPPS), together with an investigation of its mechanism of... structure functionstaphylococcus aureusinhibition https://www.ncbi.nlm.nih.gov/Structure/pdb/4FKY 4FKY: Crystal structure of nucleoside diphosphate kinase B from Trypanosoma brucei bound to GTP Nucleoside diphosphate kinase(4S)-2-METHYL-2,4-PENTANEDIOLGUANOSINE-5'-DIPHOSPHATE https://www.researchandmarkets.com/reports/4175235/fructose-16-diphosphate-disodium-salt-cas Fructose-1,6-Diphosphate Disodium Salt (CAS 26177-85-5) Industry Research 2025: Global and Regional... Fructose-1,6-Diphosphate Disodium Salt (CAS 26177-85-5) Industry Research 2025: Global and Regional Market Trends 2019-2024 and Forecast to 2029 https://elifesciences.org/articles/15159v1/figures Figures and data in Adenosine diphosphate restricts the protein remodeling activity of Hsp104... https://www.ncbi.nlm.nih.gov/protein/2F7M_F Chain F, Farnesyl Diphosphate Synthase - Protein - NCBI farnesyl diphosphate synthasechainproteinncbi https://www.ncbi.nlm.nih.gov/Structure/pdb/1NGS 1NGS: COMPLEX OF TRANSKETOLASE WITH THIAMIN DIPHOSPHATE, CA2+ AND ACCEPTOR SUBSTRATE... TRANSKETOLASECALCIUM IONERYTHOSE-4-PHOSPHATETHIAMINE DIPHOSPHATE thiamin diphosphatecomplextransketolase https://www.ncbi.nlm.nih.gov/protein/7CPN_B Chain B, Trans,polycis-polyprenyl diphosphate synthase ((2Z,6E)-farnes - Protein - NCBI https://www.wikidata.org/wiki/Q28568195 Cloning and subcellular localization of hamster and rat isopentenyl diphosphate dimethylallyl... scientific journal article subcellular localizationisopentenyl diphosphatecloninghamsterrat https://www.semanticscholar.org/topic/polyadenosine-diphosphate-ribose-polymerase/7439965 polyadenosine diphosphate ribose polymerase | Semantic Scholar polyadenosinediphosphateribosepolymerasesemantic