Robuta

https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2021.741946/full
The solute carrier family 10 member SLC10A7 is a negative regulator of intracellular calcium signaling (RCAS). In cell culture, SLC10A7 expression is negativ...
functional analysisgenetic variantsfrontiersrarenegative
https://pubmed.ncbi.nlm.nih.gov/27601774/
Frequent and regular physical activity has significant benefits for health, including improvement of body composition and help in weight control. Consequently,...
genetic variantstraining programmesinfluencingeffectivenessexercise
https://www.news-medical.net/news/20210217/People-with-ADHD-and-DBDs-share-genetic-variants-associated-with-risky-behaviors.aspx
People with attention-deficit / hyperactivity disorder (ADHD) combined with disruptive behaviour disorders (DBDs) share about the 80% of genetic variants...
genetic variantspeopleadhdshareassociated
https://www.acc.org/Latest-in-Cardiology/Journal-Scans/2021/09/08/18/49/Phenotypic-Expression-and-Outcomes
genetic variantsphenotypeoutcomesrarehcm
https://pubmed.ncbi.nlm.nih.gov/36068488/
The accuracy of RFI GEBV increased when international data were used or when selected sequence variants were combined with 50k SNP array data. This suggests...
genetic variantssharingeitherphenotypesincrease
https://pubmed.ncbi.nlm.nih.gov/23264444/
Genetic variants in the nicotinic acetylcholine receptor gene family jointly contribute to subclinical atherosclerosis in American Indians who participated in...
genetic variantsnicotinic acetylcholinejointassociations
https://www.news-medical.net/news/20220914/Study-explores-the-impact-of-genetic-risk-variants-on-overall-disease-burden-and-healthy-life-years.aspx
In a new study, researchers explored the genetic risk factors associated with various diseases to understand their impact on healthy life years.
genetic riskstudyexploresimpactvariants
https://www.mdpi.com/2072-6643/13/7/2189
Non-communicable diseases including type 2 diabetes mellitus, coronary heart disease, hepatic steatosis, and cancer are more prevalent in minority groups...
genetic variantshealth disparitieslifestylefactorsassociated
https://www.frontiersin.org/research-topics/26128/otitis-media-susceptibility-due-to-genetic-variants/magazine
Otitis media (OM) encompasses a spectrum of middle ear infections. Acute otitis media (AOM) is among the most common pediatric diseases, and the most frequent...
otitis mediagenetic variantssusceptibilityduefrontiers
https://www.mdpi.com/2076-393X/10/12/2021
Glycosylation of proteins is a post-translational process where oligosaccharides are attached to proteins, potentially altering their folding, epitope...
potentialnovelglycosylationpatternsassociated
https://www.psu.edu/news/eberly-college-science/story/background-genetic-variants-influence-clinical-features-complex
New research helps explain why disease-associated genetic variants can lead to variable clinical outcomes, influenced both by the patterns of secondary...
genetic variantsclinical featurescomplex disordersbackgroundinfluence
https://pubmed.ncbi.nlm.nih.gov/22490517/
Genotype data provide additional information that complements age, gender and FH as risk factors, but individualised genetic risk prediction is not currently...
cumulative impactgenetic variantsrisk factorscommon
https://scienceblogs.com/geneticfuture/2009/03/06/rare-genetic-variants-protect
Nejentsev et al. (2009).
genetic variantsrareprotecttypediabetes
https://pubmed.ncbi.nlm.nih.gov/33349701/
Expression quantitative trait loci (eQTLs) studies provide associations of genetic variants with gene expression but fall short of pinpointing functionally...
quantitative trait locipromoterinteractingexpressionenriched
https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.771312/full
Although 21 pancreatic cancer susceptibility loci have been identified in individuals of European ancestry through genome-wide association studies (GWAS), mu...
genetic variantsfrontiersidentificationrecessivelyinherited
https://pubmed.ncbi.nlm.nih.gov/33108341/
The selected pain-associated genetic variants were not associated with individual differences in experimental pain. Genetic variants well known for playing...
genetic variantsindividual differencesassociationselected
https://www.sri.com/publication/biosciences-health-pubs/lack-of-associations-of-chrna5-a3-b4-genetic-variants-with-smoking-cessation-treatment-outcomes-in-caucasian-smokers-despite-associations-with-baseline-smoking/
We observed no significant associations between CHRNA5-A3-B4 variants and smoking cessation, despite replicating previous associations with baseline tobacco...
genetic variantslackassociations
https://www.nist.gov/news-events/news/2022/02/new-benchmark-could-improve-detection-genetic-variants-linked-spinal
new benchmarkgenetic variantscouldimprovedetection
https://pubmed.ncbi.nlm.nih.gov/27939104/
Age-related macular degeneration (AMD) is a progressive retinal disease and the major cause of irreversible vision loss in the elderly. Numerous studies have...
complement systemmacular degenerationagerelatedreview
https://pubmed.ncbi.nlm.nih.gov/21292315/
Wellcome Trust, National Institute on Aging, and US Department of Defense.
imputationsequencevariantsidentificationgenetic
https://pubmed.ncbi.nlm.nih.gov/27199374/
Genome-wide association studies (GWAS) have boosted our knowledge of genetic risk variants in autoimmune diseases (AIDs). Most risk variants are located within...
genetic riskautoimmune diseasesvariantsinfluenceexpression
https://www.rti.org/publication/genetic-variants-associated-with-severe-retinopathy-of-prematurity-in-extremely-low-birth-weight-infants
Purpose To determine genetic variants associated with severe retinopathy of prematurity (ROP) in a candidate gene cohort study of US preterm infants. Methods...
genetic variantsassociatedsevereretinopathyprematurity
https://pubmed.ncbi.nlm.nih.gov/19533685/
We evaluated whether risk of non-Hodgkin lymphoma (NHL), particularly adult T-cell leukemia/lymphoma (ATL) related to human T-lymphotropic virus (HTLV)...
non hodgkin lymphomagenetic variantscommonrisk
https://pubmed.ncbi.nlm.nih.gov/30691483/
Most variants associated with complex phenotypes in genome-wide association studies (GWAS) do not directly index coding changes affecting protein structure....
genetic riskbrain disordersvariantsenrichedcortical
https://pubmed.ncbi.nlm.nih.gov/18591388/
Currently, common risk variants for type 2 diabetes do not provide strong predictive value at a population level. However, the joint effect of risk variants...
genetic variantsassessingcombinedimpactcommon
https://pubmed.ncbi.nlm.nih.gov/23588304/
Cisplatin is a widely used chemotherapeutic agent for the treatment of solid tumors. A serious complication of cisplatin treatment is permanent hearing loss....
genetic variantsreplicationtpmthighlyassociated
https://pubmed.ncbi.nlm.nih.gov/24897020/
Chronic hepatitis C is a serious liver disease that often results in cirrhosis or hepatocellular carcinoma. The aim of this study was to assess the association...
human leukocyte antigengenetic variantsdpinfluencehepatitis
https://pubmed.ncbi.nlm.nih.gov/33478553/
The purpose of this article is to stimulate discussion about whether a phenome-wide association study is a suitable tool for uncovering late-onset risks in...
learncommonvariantsassociatedunexpected
https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2021.782419/full
Objective: Childhood epilepsy is a considerably heterogeneous neurological condition with a high worldwide incidence. Genetic diagnosis of childhood epilepsy...
genetic diagnosisfrontiersspectrumburdenexome
https://pubmed.ncbi.nlm.nih.gov/28205274/
This is the first report of the relationship between PAD and ADAMTS7 expression and the effects of the rs1994016 and rs3825807 variants on PAD development....
genetic variantsaffectmrna
https://pubmed.ncbi.nlm.nih.gov/39843573/
Hip pain is a common musculoskeletal complaint that leads many people to seek medical attention. We conducted a primary genome-wide association study (GWAS) on...
genome wide associationgenetic variantsstudyidentifiesassociated
https://github.com/jamesware/denovolyzer
An R package for statistical analyses of de novo genetic variants - jamesware/denovolyzeR
r packagestatistical analysesgithub
https://pubmed.ncbi.nlm.nih.gov/31055994/
Ischemic stroke (IS) is the leading cause of disability. Researchers have demonstrated that IS is more a multifactorial disorder than a single-factor disease....
genetic variantscerebral infarctionchromosomeconferrisks
https://pubmed.ncbi.nlm.nih.gov/29439855/
Our findings suggest that the high-COMT activity haplotype is associated with cognitive decline in patients with PD.
genetic variantscatecholmethyltransferasecomtassociated
https://pubmed.ncbi.nlm.nih.gov/31166609/
The long-term consumption of a MedDiet modulates ppHTG through APOE genetic variants in CHD patients. This gene-diet interaction may contribute to a more...
apolipoprotein egenetic variantsmediterranean dietinteractmodulate
https://pubmed.ncbi.nlm.nih.gov/40968290/
geneticscreensprimaryhumancells
https://pubmed.ncbi.nlm.nih.gov/34182385/
Bisphenol A (BPA) may induce oxidative stress as well as the toxicity of colon cancer cells. We hypothesized that BPA exposure and interactions with genetic...
genetic variantscolorectal cancerbisphenolexposureinteraction
https://pubmed.ncbi.nlm.nih.gov/30667085/
Frozen shoulder is a condition of loss of active and passive motion as result of inflammatory contracture and fibrosis of the joint capsule. We hypothesize...
genetic variantsextracellular matrixinvolvedhomeostasisplay
https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2023.1059447/full
Background: Influenza is a global public health problem for its detrimental impact on human health. Annual vaccination is the most effective prevention of in...
genetic variantsfrontiersassociatedimmuneresponsiveness
https://pubmed.ncbi.nlm.nih.gov/28566218/
Seventh Framework Programme for Research and Technical Development (AtheroRemo and RiskyCAD), INTERREG IV Oberrhein Programme, Deutsche Nierenstiftung,...
genetic variantsrelationslipoproteinconcentrationslpa
https://www.mdpi.com/2077-0383/12/13/4288
The pathophysiology of body weight control involves complex interactions between hormonal, environmental, behavioral and genetic factors. The purpose of this...
genetic variantslong termcombinedeffectweight
https://www.cbsnews.com/news/worlds-oldest-person-study-genetic-yogurt-habit-maria-branyas-morera/
Sep 25, 2025 - Maria Branyas Morera once posted on social media about her love for yogurt, saying it "gives life," and hers was a long one.
oldest personlivedworld