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https://www.preprints.org/manuscript/202310.1159 Sialic Acid Mimetic Microglial SIGLEC Agonistic Nanoparticle: Potential to Restore Retinal... Age-related macular degeneration, a leading cause of visual loss and dysfunction in the devel-oped world, is a disease initiated by genetic polymorphisms that... sialic acid mimetic microglial siglec https://www.omicsonline.org/proceedings/prenatal-screening-of-maternal-immune-antigen-biomarkers-linked-to-microglial-regulation-of-brain-development-may-predic-63345.html Prenatal Screening Of Maternal Immune Antigen Biomarkers Linked To Microglial Regulation Of Brain... Recent discoveries of the connections between the maternal immune system (IS) and prenatal brain development suggest that routine prenatal screening for... prenatal screening https://pmc.ncbi.nlm.nih.gov/articles/PMC5960708/ Microglial Lectins in Health and Neurological Diseases - PMC Microglia are the innate sentinels of the central nervous system (CNS) and are responsible for the homeostasis and immune defense of the CNS. Under the... neurological diseases microglial lectins health pmc https://www.jci.org/articles/view/165523/ga JCI - Galectin-3 aggravates microglial activation and tau transmission in tauopathy galectin 3 microglial activation jci https://pmc.ncbi.nlm.nih.gov/articles/PMC6798794/ Activation of TRPV1 Contributes to Recurrent Febrile Seizures via Inhibiting the Microglial M2... Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel implicated in the nervous system as a key component of several... https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2025.1546848/full Frontiers | Enhancing autophagy mitigates LPS-induced neuroinflammation by inhibiting microglial M1... BackgroundAutophagy, a regulator of inflammation, has been implicated in various central nervous system pathologies. Despite this, the role and mechanisms of... frontiers enhancing autophagy mitigates lps https://elifesciences.org/articles/56502/peer-reviews Peer review in Microglial calcium signaling is attuned to neuronal activity in awake mice | eLife Microglial processes engage calcium signaling in response to hyper- or hypo-active shifts in neuronal activity. https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2023.1253192/full Frontiers | Morphological screens using aged primary adult neuronal, microglial, and astrocytic... The average age of a patient with neurotraumatic injuries or neurodegenerative diseases has been increasing worldwide. The preclinical live animal models use... frontiers morphological screens using aged https://www.spandidos-publications.com/10.3892/mmr.2019.10282 Callistephin enhances the protective effects of isoflurane on microglial injury through... Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery. callistephin enhances protective effects https://pmc.ncbi.nlm.nih.gov/articles/PMC12648178/ Bee venom-derived phospholipase A2 modulates microglial activity to promote antidepressant effects... Bee venom phospholipase A2 (bvPLA2) exhibits therapeutic potential in inflammatory disorders through the modulation of microglial activation, a mechanism... bee venom phospholipase a2 https://www.frontiersin.org/research-topics/28248/microglial-polarization-in-the-pathogenesis-and-therapeutics-of-neurodegenerative-diseases-volume-ii/magazine Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases, Volume... in the neurodegenerative diseases microglial polarization pathogenesis https://elifesciences.org/reviewed-preprints/87120 An acute microglial metabolic response controls metabolism and improves memory acute microglial metabolic response controls https://elifesciences.org/articles/51796/peer-reviews Peer review in A MAC2-positive progenitor-like microglial population is resistant to CSF1R... A hidden population of microglial progenitors with distinct transcriptomic signatures are among homeostatic microglia in adult mouse brain. https://www.news-medical.net/news/20251017/Study-reveals-how-a-microglial-mutation-increases-risk-for-Alzheimers-disease.aspx Study reveals how a microglial mutation increases risk for Alzheimer's disease Oct 18, 2025 - Dominika Pilat, PhD, and Ana Griciuc, PhD, of the Department of Neurology at Massachusetts General Hospital are the lead and senior authors of a paper... https://www.mdpi.com/1420-3049/27/9/2789 The Effects of Berry Extracts on Oxidative Stress in Cultured Cardiomyocytes and Microglial Cells:... Oxidative stress is a key underlying factor in cognitive decline and atherosclerosis. Oxidative stress occurs at the cellular level with an imbalance between... https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.1059364/full Frontiers | Microglial Pten safeguards postnatal integrity of the cortex and sociability Microglial abnormalities may contribute to neurodevelopmental disorders. PTEN is implicated as a susceptibility gene for autism spectrum disorders and its ge... of the frontiers microglial pten safeguards https://www.miragenews.com/low-sodium-levels-impact-brain-microglial-cells-1319216/ Low Sodium Levels Impact Brain Microglial Cells | Mirage News Low serum sodium concentrations in blood are called hyponatremia, a prevalent clinical electrolyte disorder. In contrast to acute hyponatremia low sodium microglial cells levels impact brain https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.00683/full Frontiers | Antidepressant-Like Activity of Myelophil via Attenuation of Microglial-Mediated... Myelophil, a 30% ethanol extract that has an equal rate in both Astragali Radix and Salviae Radix, is a remedy for the treatment of fatigue-linked disorders ... frontiers antidepressant like activity via https://pmc.ncbi.nlm.nih.gov/articles/PMC12637658/ Epigenetic control of microglial developmental milestones from proliferative progenitors to... Early immune perturbations increase the risk of neurodegenerative and neurodevelopmental disorders, yet the mechanisms underlying the maturation of microglia,... developmental milestones epigenetic control microglial proliferative https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.660164/full Frontiers | Microglial Activation Is Associated With Vasoprotection in a Rat Model of Inflammatory... Vascular dysfunction and vasoregression are hallmarks of a variety of inflammatory central nervous system disorders and inflammation related retinal diseases... https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.998397/full Frontiers | Peripheral interleukin-6-associated microglial QUIN elevation in basolateral amygdala... Background: Developing effective approaches for postoperative delirium has been hampered due to the lack of a pathophysiologically similar animal model to of... interleukin 6 frontiers peripheral associated https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1509370/full Frontiers | ATP5J regulates microglial activation via mitochondrial dysfunction, exacerbating... Microglial-mediated neuroinflammation is crucial in the pathophysiological mechanisms of secondary brain injury (SBI) following intracerebral hemorrhage (ICH... microglial activation mitochondrial dysfunction frontiers atp5j via https://www.preprints.org/manuscript/202404.1620/v3 Microglial Replacement and COURIER or SPIT for Neuronal Gene Editing[v3] | Preprints.org Adeno-associated viral (AAV) vectors can be used for gene delivery. AAV.CAP-Mac was recently developed; it can cross the blood-brain barrier and transduce... https://pmc.ncbi.nlm.nih.gov/articles/PMC11829307/ Astragalus polysaccharide attenuates retinal ischemia reperfusion-induced microglial activation... Microglial activation is a hallmark of pathogenic retinal conditions such as retinal ischemia-reperfusion (RIR). While sortilin-related vacuolar protein... retinal ischemia astragalus polysaccharide induced microglial https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2025.1572431/full Frontiers | Distinct reduction in relative microglial glucose uptake compared to astrocytes and... IntroductionMicroglial energy metabolism has gained attention for the treatment of neurodegenerative diseases. In vitro methods provide important insights; h... reduction in https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2023.1120400/full Frontiers | LPS-stimulated microglial cells promote ganglion cell death in organotypic cultures of... During development microglia colonize the central nervous system (CNS) and play an important role in programmed cell death, not only because of their ability... https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1105973/full Frontiers | PHLDA1 modulates microglial response and NLRP3 inflammasome signaling following... Balancing microglia M1/M2 polarization is an effective therapeutic strategy for neuroinflammation after subarachnoid hemorrhage (SAH). Pleckstrin homology-li... nlrp3 inflammasome frontiers phlda1 microglial response https://pmc.ncbi.nlm.nih.gov/articles/PMC10682836/ Neuropsychiatric Symptoms and Microglial Activation in Patients with Alzheimer Disease - PMC Is microglial activation, a proxy for neuroinflammation, associated with neuropsychiatric symptoms in patients with Alzheimer disease? In this cross-sectional... neuropsychiatric symptoms microglial activation in patients alzheimer disease https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1172334/full Frontiers | Pterostilbene attenuates microglial inflammation and brain injury after intracerebral... Microglial activation and subsequent inflammatory responses are critical processes in aggravating secondary brain injury after intracerebral hemorrhage (ICH)... brain injury frontiers pterostilbene microglial inflammation https://www.preprints.org/manuscript/202301.0021 Traumatic Brain Injury Induced Microglial and Caspase3 Activation in the Retina[v1] | Preprints.org A Traumatic brain injury (TBI) is among the main causes of sudden death after head trauma. These injuries can result in severe degeneration and neuronal cell... traumatic brain injury https://elifesciences.org/articles/33385 Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in... A combined approach of unbiased proteomics, biochemistry, genetics, and transgenic animal models reveals that GPR56/ADGRG1 regulates myelin formation and... transglutaminase 2 https://pmc.ncbi.nlm.nih.gov/articles/PMC8906187/ Baseline Microglial Activation Correlates With Brain Amyloidosis and Longitudinal Cognitive Decline... This study aims to quantify microglial activation in individuals with Alzheimer disease (AD) using the 18-kDa translocator protein (TSPO) PET imaging in the... microglial activation baseline https://www.spandidos-publications.com/10.3892/etm.2013.1397/abstract Pyrrolidine dithiocarbamate (PDTC) inhibits the overexpression of MCP-1 and attenuates microglial... Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine. pyrrolidine dithiocarbamate https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2021.727899/full Frontiers | New Insights Into the Roles of Microglial Regulation in Brain Plasticity-Dependent... ABSTRACT Stroke remains the leading cause of long-term disability worldwide with significant long-term sequalae. However, there is no highly effective treatm... https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2013.00006/full Frontiers | Janus-faced microglia: beneficial and detrimental consequences of microglial... Microglia are the resident brain macrophages and they have been traditionally studied as orchestrators of the brain inflammatory response during infections a... frontiers janus faced microglia beneficial https://elifesciences.org/articles/56502/figures Figures and data in Microglial calcium signaling is attuned to neuronal activity in awake mice |... Microglial processes engage calcium signaling in response to hyper- or hypo-active shifts in neuronal activity. https://elifesciences.org/articles/82031 T cells modulate the microglial response to brain ischemia | eLife Transcriptional signature and cell morphology of the stroke-associated microglia are reprogrammed by distinct T cell subpopulations. t cells brain ischemia modulate microglial response https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2022.956079/full Frontiers | Microglial activation in the motor cortex mediated NLRP3-related neuroinflammation and... Spinal cord injury (SCI) is a traumatic event that can lead to neurodegeneration. Neuronal damage in primary motor cortex (M1) can hinder the recovery of mot... microglial activation in the motor cortex https://neurosciencenews.com/microglia-brain-aging-sexes-23946/ Aging in the Brain: Microglial Changes Differ Between Sexes - Neuroscience News Sep 19, 2023 - This pivotal research seeks to unravel the microglial aging process, potentially offering insights for human brain health. in the brain aging microglial https://www.mdpi.com/1420-3049/19/7/8820 Regulatory Effects of Fisetin on Microglial Activation Increasing evidence suggests that inflammatory processes in the central nervous system that are mediated by microglial activation play a key role in... regulatory effects fisetin microglial activation https://pmc.ncbi.nlm.nih.gov/articles/PMC50641/ Human T-cell leukemia virus type I infection of monocytes and microglial cells in primary human... The pathogenesis of progressive spastic paraparesis [HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)], a serious consequence of human... human t cell leukemia virus