mtorc1 - Robuta Search

https://pmc.ncbi.nlm.nih.gov/articles/PMC5545101/ mTORC1 signaling and the metabolic control of cell growth - PMC mTOR [mechanistic target of rapamycin] is a serine/threonine protein kinase that, as part of mTORC1 (mTOR complex 1), acts as an important molecular connection... cell growth mtorc1 signaling metabolic control https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2019.00228/full Frontiers | Transient Inhibition of mTORC1 Signaling Ameliorates Irradiation-Induced Liver Damage Despite radiotherapy is often used to treat liver cancer with recurrence after surgery, irradiation-induced liver damage cannot be ignored. It has documented... frontiers transient inhibition mtorc1 https://www.jci.org/articles/view/44771/figure/5 JCI - mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy... https://www.jci.org/articles/view/61248/figure/1 JCI - Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice https://www.jci.org/articles/view/44771/figure/7 JCI - mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy... https://www.jci.org/articles/view/126859/pdf JCI - Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation https://pmc.ncbi.nlm.nih.gov/articles/PMC4835982/ The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and... ULK1 (unc-51 like autophagy activating kinase 1), the key mediator of MTORC1 signaling to autophagy, regulates early stages of autophagosome formation in... https://sabanciuniv.edu/en/events/detail/28331 SEMINAR: Metabolic Stress Signaling and mTORC1 Dysregulation in Tissue Injury and Tumorigenesis... seminar metabolic stress signaling https://elifesciences.org/articles/74903v1 Continuous sensing of nutrients and growth factors by the mTORC1-TFEB axis | eLife https://www.jci.org/articles/view/44771/usage JCI - Usage information: mTORC1 activation in podocytes is a critical step in the development of... https://elifesciences.org/articles/66278 Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial... mTORC1 and c-Jun are implicated in a possible mechanism causing myelin loss downstream of mitochondrial dysfunction in Schwann cells. https://pmc.ncbi.nlm.nih.gov/articles/PMC6953079/ mTORC1 Mediates Lysine-Induced Satellite Cell Activation to Promote Skeletal Muscle Growth - PMC As the first limiting amino acid, lysine (Lys) has been thought to promote muscle fiber hypertrophy by increasing protein synthesis. However, the functions of... https://pmc.ncbi.nlm.nih.gov/articles/PMC3359502/ Reconstitution of leucine-mediated autophagy via the mTORC1-Barkor pathway in vitro - PMC Supplementation of branched chain amino acids, especially leucine, is critical to improve malnutrition by regulating protein synthesis and degradation.... https://www.mdpi.com/1422-0067/24/11/9171 Genetic Ablation of LAT1 Inhibits Growth of Liver Cancer Cells and Downregulates mTORC1 Signaling Through a comprehensive analysis of the gene expression and dependency in HCC patients and cell lines, LAT1 was identified as the top amino acid transporter... https://www.jci.org/articles/view/199108/pdf JCI - DYRK1A enhances antitumor immunity in type 1 conventional dendritic cells via mTORC1... https://pmc.ncbi.nlm.nih.gov/articles/PMC11881726/ Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system - PMC central nervous system ampk mtorc1 balance https://www.jci.org/articles/view/44771/figure/2 JCI - mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy... https://elifesciences.org/articles/19960 Dynamics of mTORC1 activation in response to amino acids | eLife Activation by amino acids causes mTORC1 to translocate transiently to the lysosomal surface. in response amino acids dynamics mtorc1 activation https://elifesciences.org/articles/79782 Correction: mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking | eLife in the orbitofrontal cortex correction mtorc1 https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2021.761333/full Frontiers | mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a master regulator of metabolism and aging. A complex signaling network converges on mTORC1 ... stress granules https://www.jci.org/articles/view/44771/figure/8 JCI - mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy... https://www.jci.org/articles/view/44771/sd/1 JCI - mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy... https://www.rcsb.org/structure/7YRJ RCSB PDB - 7YRJ: S-adenosylmethionine sensor upstream of mTORC1 S-adenosylmethionine sensor upstream of mTORC1 rcsb pdb adenosylmethionine sensor upstream mtorc1 https://elifesciences.org/articles/51333v1/figures Figures and data in mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking | eLife https://elifesciences.org/articles/19360v1 Regulation of mTORC1 by lysosomal calcium and calmodulin | eLife regulation mtorc1 lysosomal calcium calmodulin https://www.preprints.org/manuscript/202106.0309 Evaluation of the Binding Kinetics of RHEB with mTORC1 by In-cell and In vitro Assays[v1] |... The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) is activated by the small G-protein, RHEB-GTPase. On lysosome, RHEB activates mTORC1 by... https://elifesciences.org/articles/19360/figures Figures and data in Regulation of mTORC1 by lysosomal calcium and calmodulin | eLife The multipronged chemical biology approach unraveled a novel mechanism by which mTOR is regulated by the second messenger calcium. https://elifesciences.org/articles/25237 LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of... LARP1 turns off and on the translation of an essential class of mRNAs by acting as a key effecter and regulator for mTORC1. https://elifesciences.org/articles/51333v1/peer-reviews Peer review in mTORC1 in the orbitofrontal cortex promotes habitual alcohol seeking | eLife peer review orbitofrontal cortex https://www.jci.org/articles/view/77746 JCI - mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation cd8 t cell jci mtorc1 mtorc2 regulate https://pmc.ncbi.nlm.nih.gov/articles/PMC3408989/ Dietary intervention in acne: Attenuation of increased mTORC1 signaling promoted by Western diet -... The purpose of this paper is to highlight the endocrine signaling of Western diet, a fundamental environmental factor involved in the pathogenesis of epidemic... https://pmc.ncbi.nlm.nih.gov/articles/PMC8226784/ Dihydroartemisinin Inhibits mTORC1 Signaling by Activating the AMPK Pathway in Rhabdomyosarcoma... Dihydroartemisinin (DHA), an anti-malarial drug, has been shown to possess potent anticancer activity, partly by inhibiting the mammalian target of rapamycin... dihydroartemisinin mtorc1 signaling https://elifesciences.org/articles/51440 Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic... The crucial regulator of brain function, mTOR, signals through distinct macromolecular complexes to control how synaptic vesicles are released from the... https://www.prnewswire.com/news-releases/tsc-alliance-endowment-fund-invests-in-aeovian-pharmaceuticals-to-advance-development-of-an-mtorc1-selective-inhibitor-for-tuberous-sclerosis-complex-302642001.html?tc=eml_cleartime TSC Alliance Endowment Fund Invests in Aeovian Pharmaceuticals to Advance Development of an mTORC1... /PRNewswire/ -- The TSC Alliance Endowment Fund, a supporting organization of the TSC Alliance, has invested in Aeovian Pharmaceuticals as part of their... https://www.jci.org/articles/view/44771/figure/9 JCI - mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy... https://www.jci.org/assets/330358/powerpoint JCI - mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing... lysosomal storage disorders bone growth https://www.ncbi.nlm.nih.gov/protein/7YRJ_B Chain B, S-adenosylmethionine sensor upstream of mTORC1 - Protein - NCBI b s chain adenosylmethionine sensor upstream https://www.proquest.com/docview/1868419011 ATP6v1c1 enhances breast cancer growth by activating V-ATPase mediated mtorc1 signaling and... Explore millions of resources from scholarly journals, books, newspapers, videos and more, on the ProQuest Platform. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.00684/full Frontiers | mTORC1 Activation in Osteoclasts Prevents Bone Loss in a Mouse Model of Osteoporosis The mechanistic/mammalian target of rapamycin (mTOR) is widely implicated in the pathogenesis of various diseases, including cancer, obesity, and cardiovascu... https://www.preprints.org/manuscript/202407.2536 Interplay between mTORC1 and mTORC2 in Regulating cAMP Signaling and Cell Adhesion in Dictyostelium... The mechanistic Target of Rapamycin Complex 1 (mTORC1) regulates ribosome biogenesis and the transcription of ribosomal genes. Its inactivation impacts protein... https://sabanciuniv.edu/tr/events/detail/28331 SEMINAR: Metabolic Stress Signaling and mTORC1 Dysregulation in Tissue Injury and Tumorigenesis... seminar metabolic stress signaling https://pmc.ncbi.nlm.nih.gov/articles/PMC4698017/ Sestrin2 is a leucine sensor for the mTORC1 pathway - PMC Leucine is a proteogenic amino acid that also regulates many aspects of mammalian physiology, in large part by activating the mTOR complex 1 (mTORC1) protein... is a sensor for sestrin2 leucine mtorc1 https://racetab.org/ Structure-Based Design of mTORC1 Inhibitors in Cancer Therapy – mTORC1 inhibitor design of cancer therapy structure based mtorc1