Robuta

https://pmc.ncbi.nlm.nih.gov/articles/PMC9420920/ Daridorexant: A New Dual Orexin Receptor Antagonist for Insomnia - PMC Objective: To review the safety, efficacy, and tolerability of daridorexant in treating insomnia characterized by difficulties with sleep onset and/or sleep... a neworexin receptorfor insomniadaridorexantdual https://www.semanticscholar.org/topic/orexin-receptor-type-2/3375608 orexin receptor type 2 | Semantic Scholar orexin receptortypesemanticscholar https://pubmed.ncbi.nlm.nih.gov/24262606/?dopt=Abstract An investigation of interactions between hypocretin/orexin signaling and glutamate receptor surface... Hypocretin peptides are critical for the effects of cocaine on excitatory synaptic strength in the ventral tegmental area (VTA). However, little is known about... an investigation https://pmc.ncbi.nlm.nih.gov/articles/PMC10325868/ Daridorexant, a Recently Approved Dual Orexin Receptor Antagonists (DORA) in Treatment of Insomnia... Insomnia is one of the major challenges in medical science nowadays as it leads to great socio-economic burden by impairing daytime function as well as the... https://pubchem.ncbi.nlm.nih.gov/bioassay/1806176 AID 1806176 - Human Orexin 1 Receptor Radioligand Binding Studies from US Patent USRE48841:... BioAssay record AID 1806176 submitted by BindingDB: Human Orexin 1 Receptor Radioligand Binding Studies from US Patent USRE48841: https://open.library.emory.edu/concern/publications/8c06a47a-99ad-47ca-9e8c-78fb17b16852 Development of Novel 11C-Labeled Selective Orexin-2 Receptor Radioligands for Positron Emission... Development of Novel 11C-Labeled Selective Orexin-2 Receptor Radioligands for Positron Emission Tomography Imaging https://pubchem.ncbi.nlm.nih.gov/bioassay/1263647 AID 1263647 - Insurmountable antagonist activity against rat orexin-2 receptor expressed in CHO... BioAssay record AID 1263647 submitted by ChEMBL: Insurmountable antagonist activity against rat orexin-2 receptor expressed in CHO cells assessed as calcium... https://www.ncbi.nlm.nih.gov/Structure/pdb/6TP4 6TP4: Crystal structure of the Orexin-1 receptor in complex with ACT-462206 https://teams.semel.ucla.edu/sleep-research/publication/role-hypocretin-orexin-receptor-2-hcrt-r2-regulation-hypocretin-level-and Role of the hypocretin (orexin) receptor 2 (Hcrt-r2) in the regulation of hypocretin level and... https://pubchem.ncbi.nlm.nih.gov/bioassay/1263646 AID 1263646 - Insurmountable antagonist activity against rat orexin-1 receptor expressed in CHO... BioAssay record AID 1263646 submitted by ChEMBL: Insurmountable antagonist activity against rat orexin-1 receptor expressed in CHO cells assessed as calcium... https://pubmed.ncbi.nlm.nih.gov/41139604/ Successful Methods for Switching from a Benzodiazepine Receptor Agonist to a Dual Orexin Receptor... These findings suggest that in efforts to switch a patient's insomnia medication to a DORA, the tapering of ultra-short/short-acting BZRAs can lead to the... https://www.businesswire.com/news/home/20250508841747/en/The-New-England-Journal-of-Medicine-Publishes-Data-from-Phase-2b-Trial-of-Oral-Orexin-Receptor-2-Agonist-Oveporexton-TAK-861-in-People-with-Narcolepsy-Type-1 The New England Journal of Medicine Publishes Data from Phase 2b Trial of Oral Orexin Receptor 2... Takeda (TSE: 4502/NYSE:TAK) today announced that the New England Journal of Medicine published data from the Phase 2b trial of oveporexton (TAK-861) in peopl... https://pubmed.ncbi.nlm.nih.gov/14643355/?dopt=Abstract N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective... The identification of potent and selective orexin-2 receptor (OX(2)R) antagonists is described based on the modification of N-acyl... https://experts.umn.edu/en/publications/elevated-sleep-quality-and-orexin-receptor-mrna-in-obesity-resist/ Elevated sleep quality and orexin receptor mRNA in obesity-resistant rats - Experts@Minnesota https://www.ncbi.nlm.nih.gov/Structure/pdb/6TPN 6TPN: Crystal structure of the Orexin-2 receptor in complex with HTL6641 at 2.61 A resolution Orexin receptor type 2,GlgA glycogen synthase,Orexin receptor type...