https://www.mdpi.com/1999-4915/16/10/1509
Cannabis Use and Cannabidiol Modulate HIV-Induced Alterations in TREM2 Expression: Implications for...
Triggering receptor expressed on myeloid cells 2 (TREM2) is involved in neuroinflammation and HIV-associated neurocognitive impairment (NCI).
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1462508/full
Frontiers | The various roles of TREM2 in cardiovascular disease
Triggering receptor expressed on myeloid cells-2 (TREM2) is a transmembrane immune receptor that is expressed mainly on macrophages. As a pathology-induced i...
the variousin cardiovascularfrontiersrolestrem2
https://www.jax.org/strain/031942
031942 - Snx1*D465N/APOE4/Trem2*R47H Strain Details
snx1apoe4trem2straindetails
https://pmc.ncbi.nlm.nih.gov/articles/PMC9481739/
Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia - PMC
Using mouse models overexpressing human TREM2 in microglia, this study shows that WT TREM2 expression reduces amyloid deposition and suppresses...
elevatingmicrogliatrem2reducesamyloid
https://elifesciences.org/articles/20391
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct...
Structural, biophysical, and functional analyses reveal that mutations in TREM2 trigger either misfolding or reduced binding to cell-surface...
neurodegenerative diseasemutationstrem2
https://www.jci.org/articles/view/135197/pdf
JCI - TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver...
jcitrem2sustainsmacrophagehepatocyte
https://www.jax.org/strain/031880
031880 - BAC-TREM2 Strain Details
bactrem2straindetails
https://www.jax.org/strain/029853
029853 - Trem2 flox Strain Details
trem2floxstraindetails