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Feb 24, 2026 - Type 1 diabetes, which is the most common metabolic disease in children and adolescents, begins with a pre-clinical phase which is defined by the presence of... https://dukespace.lib.duke.edu/items/7f93a744-7e91-45ea-a60f-8306f68c7f51 Immunity and Autoimmunity: Host Mimicry by HIV-1 immunityhostmimicryhiv https://pubmed.ncbi.nlm.nih.gov/9200926/?dopt=Abstract [Costimulatory molecules in autoimmunity: role of CD28/CTLA4-CD80/CD86] Optimal T cell activation requires at least two signals. 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