Robuta

Thyroid function has a widespread effect on the cardiometabolic system. However, the causal association between either subclinical hyper- or hypothyroidism and...

Sandra Laing's extraordinary story examines being born black to white parents, raising questions about ancestry and genetic tests.

Growing evidence indicates that variations in the composition of the gut microbiota are linked to the onset and progression of chronic respiratory diseases (...

Our study suggests lower BW within the normal range is causally associated with a more myopic refractive error. However, the impact of the causal effect was...

Background: We aimed to determine whether the plasma cystatin C is a causal risk factor for cardiovascular events, stroke, myocardial infarction (MI), and ca...

The causation of Glycemic Traits and risks of Melanoma remains unknown. We used Mendelian Randomization (MR) to assess the links between Glycemic Traits and ...

Online Mendelian Inheritance in Animals (OMIA) provides up-to-date information on inherited disorders and other familial traits in non-laboratory animals. It...

Background: Previous observational studies have investigated the association between sleep-related traits and male fertility; however, conclusive evidence of...

The feasibility of well-powered, unbiased MR studies will depend upon the amount of variance in the exposure that can be explained by known genetic factors and...

: Care must be taken to assess the NOME assumption via the IGX2 statistic before implementing standard MR-Egger regression in the two-sample summary data...

Mendelian Randomization

Applied and computational results show how dimensionality reduction approaches can help in grouping correlated genetic variant-exposure associations and...

With the use of a Mendelian randomization approach, we observed associations between FADS variants and gestation duration. This suggests a potential role of...

These results provide strong evidence that low serum 25(OH)D concentration is a cause of MS, independent of established risk factors.

Mendelian susceptibility to mycobacterial diseases (MSMD) refers to a group of genetic conditions predisposing an individual to environmental mycobacteria and...

Scores of the GRCh38 genome build are highly correlated to the prior release with a performance increase due to the better coverage of features. For...

Harmful genetic variants at mendelian disease genes slow down adaptation, by interfering with the spread of adaptive variants in a population.

Our results demonstrate the potential power gain of aggregating bioinformatics variant scores into gene-level scores and the general utility of bioinformatics...