https://elifesciences.org/articles/52067/figures
The examination of the ultra-structure and in vivo dynamics of endocytosis in plants reveal plants unique actin-independent, clathrin-mediated endocytosis...
figuresdataevolutionarilyuniquemechanistic
https://pubmed.ncbi.nlm.nih.gov/30202036/
Despite the availability of multiple therapeutic agents, the search for novel pain management of neuropathic pain is still a challenge. Oxidative stress and...
toxicodendron pubescensultradilutedproinflammatory
https://www.grk2633.uni-luebeck.de/projects/1st-generation/md-projects/md-a17-autoantibody-mediated-effects-on-endothelial-and-immune-cell-signaling-in-systemic-sclerosis
immune cellmdautoantibodymediatedeffects
https://elifesciences.org/articles/71198?fbclid=IwAR0XA9NBusk8eNkAi-Aq49C-_2G6-y2OpXd4gCmY-WCPCzXDKY8cgJHpJiw
At mammalian synapses the clathrin adaptor AP-2 plays a crucial role in the endocytic retrieval of a subset of synaptic vesicle proteins from the presynaptic...
clathrinindependentendocyticretrievalsv
https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2020.586014/full
Brassinosteroid (BR) signaling has long been reported to have an effect on xylem development, but the detailed mechanism remains unclear, especially in tree ...
frontiersbrassinosteroidsignalingconvergesauxin
https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2022.1079442/full
The fall armyworm (FAW) Spodoptera frugiperda is a destructive and polyphagous pest of many essential food crops including maize and rice. The FAW is challen...
functional analysisfrontiersmolecularcharacterizationcytochrome
https://pubmed.ncbi.nlm.nih.gov/37075125/
Mixed-lineage leukemia 1 (MLL1) is a transcription activator of the HOX family, which binds to specific epigenetic marks on histone H3 through its third plant...
rnabindinginducesallostericswitch
https://www.osti.gov/pages/biblio/1845359-role-plasma-instabilities-relativistic-radiation-mediated-shocks-stability-analysis-particle-cell-simulations
The U.S. Department of Energy's Office of Scientific and Technical Information
the roleplasma instabilitiesrelativisticradiationmediated
https://www.technologynetworks.com/genomics/news/horizon-establishes-three-new-coe-in-raavmediated-cellular-genome-editing-197108
Dana-Farber Cancer Institute, University of Liverpool, and Babraham Institute join CoE network.
horizonestablishesthreenewcoe
https://elifesciences.org/articles/44353/figures
Two phosphorylation sites on 53BP1 are found to mediate interaction with TOPBP1-RAD9 and shown to be essential for assembling the G1 DNA damage checkpoint...
figuresdataphosphorylationmediatedinteractions
https://elifesciences.org/articles/79258/peer-reviews
Genomic imprinting in the bryophyte Marchantia polymorpha by Polycomb results in maternal dominance of embryonic gene expression.
peer reviewpolycombmediatedrepressionpaternal
https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1266641/full
In the culture of crustaceans, most species show sexual dimorphism. Monosex culture is an effective approach to achieve high yield and economic value, especi...
gene mutationleads tofrontierscrisprmediated
https://pubmed.ncbi.nlm.nih.gov/40877522/
Small interfering RNAs (siRNAs) hold significant promise as therapeutic agents for treating human diseases. However, their use is often limited by unintended...
antisense strandchemicalstrategiesenhanceselection
https://johannesfeist.eu/news/2024/05/unconventional-magnetism
Our paper on Unconventional magnetism mediated by spin-phonon-photon coupling has been published in Nature Communications! Magnetic order typically emerges...
in natureunconventionalmagnetismmediatedspin
https://www.mdpi.com/2073-4409/9/10/2213
Lipid exchange among biological membranes, lipoprotein particles, micelles, and liposomes is an important yet underrated phenomenon with repercussions...
alkyl chainstabilitymediatedlipidanchoring
https://pubmed.ncbi.nlm.nih.gov/30038017/
Seventy percent of people infected with hepatitis C virus (HCV) will suffer chronic infection, putting them at risk for liver disease, including hepatocellular...
rna triphosphataseexonucleasexrnmediatedrestriction
https://pubmed.ncbi.nlm.nih.gov/29882317/?from_term=Fitzsimons+C&from_sort=date&from_page=2&from_pos=7
Microglia dynamically adapt their morphology and function during increasing age. However, the mechanisms behind these changes are to date poorly understood....
glucocorticoidmediatedmodulationmorphologicalchanges
https://pubmed.ncbi.nlm.nih.gov/12626560/
NK cells express Fc gamma RIII (CD16), which is responsible for IgG-dependent cell cytotoxicity and for production of several cytokines and chemokines. Whereas...
nk cellsigemediatedactivationfc
https://gdb.unibe.ch/untitled-5/
The paper Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds has just been accepted by...
mechanisticbasisinhibitionmediatedmetal
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.624746/full
Mesenchymal stem cells (MSCs) are multipotent adult stromal cells widely studied for their regenerative and immunomodulatory properties. They are capable of ...
mesenchymal stem cellfrontiersmacrophageresponsedriven
https://elifesciences.org/articles/00757
The receptor EBI2 is essential for correctly positioning CD4+ dendritic cells in the spleen so that they can present blood-borne antigens to T cells and...
dendritic cellmediatedbridgingchannelpositioning
https://pubmed.ncbi.nlm.nih.gov/39241004/
Strenuous physical training increases total blood volume (BV) through expansion of plasma volume (PV) and red cell volume (RCV). In contrast, exogenous...
red cellvolume expansionstrenuoustrainingcombined
https://pubmed.ncbi.nlm.nih.gov/41372808/
Our findings demonstrate that RPL7A promotes LUAD progression through circRANBP17-UPF1-mediated SIRT6 degradation, positioning RPL7A as a potential therapeutic...
ribosomal proteinlung adenocarcinomaprogressionvia
https://www.academia.edu/11503791/IL_17_mediated_M1_M2_Macrophage_Alteration_Contributes_to_Pathogenesis_of_Bisphosphonate_related_Osteonecrosis_of_the_Jaws
Nov 28, 2024 - Purpose: Osteonecrosis of the jaw (ONJ) is emerging as one of the important complications in cancer patients treated with antiresorptive agents. This study...
pdfilmediatedmacrophagealteration
https://www.nist.gov/publications/role-intramolecular-energy-fow-and-nonadiabaticity-vibrationally-mediated-chemistry
Time-dependent and time-independent quantum scattering methods are used to investigate state-to-state inelastic and reactive collision dynamicsfor a three-dimen
the roleenergyfow
https://pubmed.ncbi.nlm.nih.gov/37739344/
The fragile X messenger ribonucleoprotein 1 (FMRP) is a multifunctional RNA-binding protein implicated in human neurodevelopmental and neurodegenerative...
long rangefmrptransportdegradationmediated
https://www.timesnownews.com/videos/news-plus/saudi-officials-hold-oman-mediated-peace-talks-with-arch-rival-houthis-will-this-end-yemen-war-video-99457196
Delegations from Saudi Arabia along with Omani officials held talks with Houthi officials in the Yemeni capital Sanaa on April 9, Houthi-run media SABA...
peace talksarch rivalsaudiofficialshold
https://pubmed.ncbi.nlm.nih.gov/33268483/
Activating NK cell receptors represent promising target structures to elicit potent antitumor immune responses. In this study, novel immunoligands were...
affinity maturationnk celltranslatesenhanced
https://pubmed.ncbi.nlm.nih.gov/21199260/
NOD2 of the NLRs and TLR4 of the TLRs are major pattern-recognition receptors, which sense different microbial pathogens and have important roles in innate...
dual rolessignal transductionmediated
https://pubmed.ncbi.nlm.nih.gov/34044147/?utm_medium=email&_hsenc=p2ANqtz--wD6FtLKHedp0T82ZolwAvcTrQPKtNw4bsndGxw-jHqA-aq5sYlQLVM5H677gROYhjbPk6RSSTtmJ63f66b1ecT5vvaA&_hsmi=141845939&utm_content=141845939&utm_source=hs_email
Mutations in the beta-amyloid protein (APP) cause familial Alzheimer's disease. In hAPP-J20 mice expressing mutant APP, pharmacological inhibition or genetic...
tyrosine phosphatasenmda receptorpresynapticmediatedplasticity
https://www.petmd.com/dog/conditions/cardiovascular/imha-immune-mediated-hemolytic-anemia-dogs
Nov 6, 2025 - Dr. Veronica Higgs explains IMHA in dogs, including symptoms, diagnosis, and management options.
hemolytic anemiaimhaimmunemediateddogs
https://pubmed.ncbi.nlm.nih.gov/38310161/
CircDCBLD2 overexpression increased PARK7 ubiquitination degradation by upregulating STUB1 through its interaction with HuR, inhibiting HSC activation and...
liver fibrosisferroptosisviafacilitating
https://pubmed.ncbi.nlm.nih.gov/40669586/
Excessive osteogenesis in bone marrow mesenchymal stem cells (BMSCs) contributes to the ectopic ossification associated with ankylosing spondylitis (AS), yet...
integrinlinkedkinasemediatedpromotion
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2017.00976/full
Fibrosis reflects a progression to liver cancer or cirrhosis of the liver. Recent studies have shown that high-mobility group box-1 (HMGB1) plays a major rol...
carnosic acidliver fibrosisfrontiersbdlinduced
https://pubmed.ncbi.nlm.nih.gov/41527491/?utm_source=SimplePie&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1VUFS2KU_hFnBUajs3hlb00hHBOGRVXZp7ZhDB0wD6N0LBD9Nk&fc=20250423082013&ff=20260113113657&v=2.18.0.post22+67771e2
ALKBH5-modified UC-MSCs Exo reduced TRAF6 expression by demethylating its m6A sites, promoting M2 macrophage polarisation and alleviating DKD progression....
diabetic kidney diseaseprogressionmicemediated
https://pubmed.ncbi.nlm.nih.gov/21700835/
Free-living cells of the social amoebae Dictyostelium discoideum can aggregate and develop into multicellular fruiting bodies in which many die altruistically...
selfrecognitionsocialamoebaemediated
https://www.jmir.org/2016/8/e215/metrics
Background: Regular physical activity (PA) is recommended for persons with chronic obstructive pulmonary disease (COPD). Interventions that promote PA and...
internet researchlong termjournalmedicaleffects
https://www.post-gazette.com/ae/art-architecture/2011/07/12/let-s-talk-about-art-film-memory-and-the-mediated-image-olivia-ciummo/stories/201107120290
This is a biweekly series about art and artists in the region.
talk aboutart filmletmemorymediated
https://pubmed.ncbi.nlm.nih.gov/29155422/
High-grade gliomas (HGGs) include the most common and the most aggressive primary brain tumor of adults and children. Despite multimodality treatment, most...
secretionmediatedactivationselfrenewal
https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2022.1010719/full
Chinese hamster ovary (CHO) cells are the most important platform for producing biotherapeutics. Random integration of a transgene into epigenetically instab...
cho cellsfrontiersenhancingstabilityrecombinant
https://pubmed.ncbi.nlm.nih.gov/11775265/
IL-2 and IL-6 gene therapy can relieve the suppression of macrophages of the lymphoma-bearing mice, and efficiently activate the antitumor immune responses.
macrophage activationlymphomabearingmiceliposome
https://regenespine.com/sympathetically-mediated-pain/
Securing the expertise of a concierge regenerative medicine doctor elevates your health and overall quality of life. Distinct from conventional healthcare,...
sympatheticallymediatedpain
https://pubmed.ncbi.nlm.nih.gov/41389613/
Periodontitis-induced periodontal bone defect is a key clinical challenge, and the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) is...
gatadrivenmediatedmitophagyosteogenesis
https://www.mdpi.com/1420-3049/26/14/4365
We have previously clarified that the strongly electron-withdrawing CF3 group nicely affected the base-mediated proton shift of CF3-containing propargylic or...
claisen rearrangementbasemediatedcontainingethers
https://intellectdiscover.com/content/journals/10.1386/peet.8.1.19_1
Abstract This article reads Many Moons (2011), by British playwright Alice Birch, from the point of view of the ‘affective turn’ that has recently taken place...
for aheartknowsbriefmediated
https://www.mdpi.com/2076-393X/9/10/1054
The Herpes Simplex Virus (HSV-1) immediate-early protein ICP22 interacts with cellular proteins to inhibit host cell gene expression and promote viral gene...
is ahsvselectiveviralrepressor
https://elifesciences.org/articles/79966/peer-reviews
In vivo evaluation of mineralized skeleton in the regenerating axolotl limb reveals a significant osteoclast-driven resorption as an early event with...
peer reviewosteoclastmediatedresorptionprimes
https://www.mdpi.com/2077-0383/12/13/4516
Objective: To determine the prevalence of positive antiphospholipid (aPL) antibodies among pregnant women with placenta-mediated complications delivered at...
antiphospholipidwomenplacentamediated
https://healthsojo-africa.org/kisumu-leverages-on-drone-technology-to-defeat-dog-mediated-rabies/
Jul 30, 2024 - “It was devastating!” This was Jackline Akinyi’s description of the loss of her daughter to rabies. The daughter’s death in January 2019 formed part of...
kisumudronetechnologydefeatdog
https://pubmed.ncbi.nlm.nih.gov/24488098/
Restoration of p53 tumor suppressor function through inhibition of its interaction and/or enzymatic activity of its E3 ligase, MDM2, is a promising therapeutic...
restrainsestrogenmediatedaktactivation
https://elifesciences.org/articles/59177?utm_source=Unknown+List&utm_campaign=7a5785d58d-EMAIL_CAMPAIGN_2020_07_27_02_37&utm_medium=email&utm_term=0_-7a5785d58d-
Gene expression analysis reveals a novel, integrated molecular mechanism for much of the pathogenesis of COVID-19 that provides therapeutic intervention points...
mechanisticmodeltherapeuticinterventionscovid
https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1375068/full
Objective: Whether the role of post-traumatic stress disorder (PTSD) on type 2 diabetes (T2D) is mediated by obesity or other mediating factors is controvers...
post traumatic stressfrontierseffectdisordertype
https://www.scirp.org/journal/paperinforcitation?paperid=53476
The research examines the field of Computer Mediated Communications and religion from an evolutionary perspective by tracing five subjectively selected...
open journalcomputermediatedcommunicationsreligion
https://chicagoreader.com/visual-arts/sixtywrd-art-review/amo-zeng/
Nov 26, 2025 - Beijing artist Amo (Mengying) Zeng, living and working in Chicago, uses technology to render complex situations more legible.
chicago readerarttechmediatedhuman
https://pubmed.ncbi.nlm.nih.gov/32259060/?dopt=Abstract
Oxycodone is a potent medicinal opioid analgesic to treat pain. It is also addictive and a main cause for the current opioid crisis. At present, the impact of...
mu opioid receptoroxycodonemediatedactivationreduces
https://www.mdpi.com/1420-3049/29/1/31
Chitosan nanoparticles (NPs) serve as useful multidrug delivery carriers in cancer chemotherapy. Chitosan has considerable potential in drug delivery systems...
optimizeddoxdrugviachitosan
https://impact.economist.com/health/innovative-medicine-for-immune-diseases/
By focusing on underlying pathways and collaboration between R&D and commercial groups, Johnson & Johnson plans to get more patients into remission
breaking new groundimmunemediateddiseases