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https://www.frontiersin.org/research-topics/51448/design-of-novel-inhibitors-for-ischemiareperfusion-injury-targeting-ferroptosis/magazine Design of novel inhibitors for Ischemia/Reperfusion Injury targeting Ferroptosis | Frontiers... Ischemic cardiovascular disease (CVD) is a leading cause of mortality worldwide. An estimated 18 million people died from CVDs in 2019, representing 32% of all... ischemia reperfusion injury design of novel inhibitors https://www.ncbi.nlm.nih.gov/Structure/pdb/4Z7M 4Z7M: Novel Inhibitors of Bacterial Methionine Aminopeptidase with Broad-Spectrum Biochemical... Methionine aminopeptidaseMANGANESE (II) IONN~2~-[(3,5-difluorophenyl)acetyl]-N-[(3S,7R)-1-methyl-2-oxo-7-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-yl]-L-alaninamide novel inhibitors methionine aminopeptidase broad spectrum bacterial https://www.imperial.ac.uk/for-business/commercialisation/imperial-tech/technology-search/-novel-inhibitors-of-nora-efflux-pump-for-combating-antimicrobial-resistance/ Novel inhibitors of NorA efflux pump for combating antimicrobial resistance | Imperial for business... Novel inhibitors of NorA efflux pump for combating antimicrobial resistance novel inhibitors efflux pump https://www.miragenews.com/novel-dual-hif-inhibitors-eradicate-tumors-in-1649831/ Novel Dual HIF Inhibitors Eradicate Tumors in Mice | Mirage News Researchers at Johns Hopkins University and the University of Maryland School of Pharmacy have developed a set of novel, first-in-class drugs that novel dual hif inhibitors eradicate https://www.mdpi.com/1999-4915/2/8/1621 Cyclophilin Inhibitors as a Novel HCV Therapy A critical role of Cyclophilins, mostly Cyclophilin A (CyPA), in the replication of HCV is supported by a growing body of in vitro and in vivo evidence. CyPA... as a cyclophilin inhibitors novel hcv https://www.mdpi.com/1999-4915/13/9/1852 A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity... Human noroviruses (HuNoVs) are the most common cause of viral gastroenteritis resulting annually in ~219,000 deaths and a societal cost of ~USD 60 billion, and... https://www.muni.cz/en/research/publications/2481479 Novel casein kinase 1 alpha inhibitors for the treatment of resistant AML and solid tumors |... https://www.acc.org/latest-in-cardiology/clinical-trials/2015/11/11/12/27/annexa-r Andexanet Alfa, a Novel Antidote to the Anticoagulation Effects of FXA Inhibitors Apixaban and... https://www.rcsb.org/structure/1TNJ RCSB PDB - 1TNJ: PREDICTION OF NOVEL SERINE PROTEASE INHIBITORS PREDICTION OF NOVEL SERINE PROTEASE INHIBITORS rcsb pdb serine protease prediction novel inhibitors https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2020.00105/full Frontiers | Novel Quinazolin-2,4-Dione Hybrid Molecules as Possible Inhibitors Against Malaria:... The research explores the synthesis of a series of novel hybrid quinazolin-2,4-dione analogues bearing acetyl/amide bridged-Nitrogen heterocyclic moieties s... https://www.rcsb.org/structure/1WBV RCSB PDB - 1WBV: Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead... Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation. https://www.mdpi.com/1420-3049/26/9/2742 Computational Design of Novel Allosteric Inhibitors for Plasmodium falciparum DegP The serine protease, DegP exhibits proteolytic and chaperone activities, essential for cellular protein quality control and normal cell development in... computational design allosteric inhibitors plasmodium falciparum novel degp https://sciencedaily.com/releases/2024/10/241008150239.htm Scientists discover novel series of SARS-CoV-2 mpro inhibitors for potential new COVID-19... New research has identified a novel series of SARS-CoV-2 Mpro inhibitors that may lead to potential new COVID-19 treatments that, according to preclinical... https://www.ebi.ac.uk/chembl/explore/document/CHEMBL1147276 Document: Novel Acetylenic Acids from the Root Bark of Paramacrolobium caeruleum: Inhibitors of... Report card for Document Novel Acetylenic Acids from the Root Bark of Paramacrolobium caeruleum: Inhibitors of 3-Hydroxy-3-methyl-glutaryl Coenzyme A Reductase... from the https://www.rcsb.org/structure/3R00 RCSB PDB - 3R00: The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1209060/full Frontiers | Discovery of novel benzylquinazoline molecules as p97/VCP inhibitors Protein p97 is an extensively investigated AAA ATPase with various cellular activities, including cell cycle control, ubiquitin-proteasome system, autophagy,... discovery of frontiers novel molecules p97 https://pmc.ncbi.nlm.nih.gov/articles/PMC3403534/ Identification and Characterization of Novel Tissue-Nonspecific Alkaline Phosphatase Inhibitors... Tissue-nonspecific alkaline phosphatase (TNAP) plays a major role in maintaining a ratio of phosphate to inorganic pyrophosphate (Pi/PPi) in biological fluids... alkaline phosphatase identification characterization novel tissue https://www.acc.org/Latest-in-Cardiology/Articles/2023/08/15/16/45/CV-Adverse-Effects-of-Novel-Bruton-Tyrosine-Kinase-Inhibitors Cardiovascular Adverse Effects of Novel Bruton Tyrosine Kinase Inhibitors: What All Cardiologists... bruton tyrosine kinase adverse effects https://www.ncbi.nlm.nih.gov/Structure/pdb/3SKA 3SKA: I. Novel Hcv Ns5b Polymerase Inhibitors: Discovery Of Indole 2- Carboxylic Acids With... HCV NS5B RNA_DEPENDENT RNA POLYMERASE1-[(2-Aminopyridin-4-Yl)methyl]-3-(2-Oxo-1,2-Dihydropyridin-3-Yl)-5-(Trifluoromethyl)-1h-Indole-2-Carboxylic AcidPhosphate... https://pmc.ncbi.nlm.nih.gov/articles/PMC5846034/ Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant Staphylococcus... Diapophytoene desaturase (CrtN) is a potential novel target for intervening in the biosynthesis of the virulence factor staphyloxanthin. In this study, 38... multidrug resistant novel staphyloxanthin inhibitors improved https://www.ebi.ac.uk/chembl/explore/document/CHEMBL2434916 Document: Discovery of novel small-molecule inhibitors of BRD4 using structure-based virtual... Report card for Document Discovery of novel small-molecule inhibitors of BRD4 using structure-based virtual screening. (CHEMBL2434916). J Med Chem,... discovery of small molecule https://www.ncbi.nlm.nih.gov/Structure/pdb/3ARW 3ARW: Crystal Structure Analysis of Chitinase A from Vibrio harveyi with novel inhibitors - complex... Chitinase A1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-iumGLYCEROL https://www.rcsb.org/structure/5AEP RCSB PDB - 5AEP: Novel pyrrole carboxamide inhibitors of JAK2 as potential treatment of... Novel pyrrole carboxamide inhibitors of JAK2 as potential treatment of myeloproliferative disorders rcsb pdb https://www.rcsb.org/structure/2BXU RCSB PDB - 2BXU: Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing... Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-P2-Linker https://www.ncbi.nlm.nih.gov/Structure/pdb/8DIC 8DIC: Virtual screening for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors 3C-like proteinase nsp55-bromo-3-[(3-bromo-4-chlorophenyl)methoxy]pyridine-2-carbaldehyde sars cov 2 main protease https://www.rcsb.org/structure/3SHY RCSB PDB - 3SHY: Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors https://www.rcsb.org/structure/4O07 RCSB PDB - 4O07: Identification of novel HSP90/isoform selective inhibitors using structure-based... Identification of novel HSP90/isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such... https://pmc.ncbi.nlm.nih.gov/articles/PMC5733704/ A Novel Series of Enoyl Reductase Inhibitors Targeting the ESKAPE Pathogens, Staphylococcus aureus... S. aureus and A. baumannii are among the ESKAPE pathogens that are increasingly difficult to treat due to the rise in the number of drug resistant strains.... https://www.ebi.ac.uk/chembl/explore/document/CHEMBL1146955 Document: A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement... Report card for Document A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s. (CHEMBL1146955). Bioorg Med Chem... a novel series of document https://pmc.ncbi.nlm.nih.gov/articles/PMC11487423/ Design, synthesis, and evaluation of benzhydrylpiperazine-based novel dual COX-2/5-LOX inhibitors... Piperazine derivatives were screened using the ChEMBL database, paving the way for the design, synthesis, and evaluation of a novel series of dual COX-2/5-LOX... https://www.preprints.org/manuscript/202305.1103 Novel Wild Type and Mutate HIV-1 Protease Inhibitors Containing Heteroaryl Carboxamides in P2:... The Virus HIV-1 infection still represents a serious disease even if actually it is transformed in chronic pathology. Considering the crucial role of the... https://www.rcsb.org/structure/2X8E RCSB PDB - 2X8E: Discovery of a Novel Class of triazolones as Checkpoint Kinase Inhibitors - Hit to... Discovery of a Novel Class of triazolones as Checkpoint Kinase Inhibitors - Hit to Lead Exploration https://www.ornl.gov/publication/discovery-novel-rhizoctonia-solani-dhfr-inhibitors-fungicides-using-virtual-screening Discovery of Novel Rhizoctonia solani DHFR Inhibitors as Fungicides Using Virtual Screening | ORNL Dihydrofolate reductase (DHFR) is an essential enzyme in the folate pathway and has been recognized as a well-known target for antibacterial and antifungal... https://www.rcsb.org/structure/2BRM RCSB PDB - 2BRM: Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding... Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity https://www.rcsb.org/structure/2G01 RCSB PDB - 2G01: Pyrazoloquinolones as Novel, Selective JNK1 inhibitors Pyrazoloquinolones as Novel, Selective JNK1 inhibitors rcsb pdb novel selective jnk1 inhibitors https://www.rcsb.org/structure/1QHR RCSB PDB - 1QHR: NOVEL COVALENT ACTIVE SITE THROMBIN INHIBITORS NOVEL COVALENT ACTIVE SITE THROMBIN INHIBITORS rcsb pdb active site novel covalent thrombin https://www.rcsb.org/structure/4CRA RCSB PDB - 4CRA: Creating novel F1 inhibitors through fragment based lead generation and structure... Creating novel F1 inhibitors through fragment based lead generation and structure aided drug design https://www.spandidos-publications.com/ijmm/30/6/1281 RING-finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoid... International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease. https://www.rcsb.org/structure/5XSR RCSB PDB - 5XSR: novel orally efficacious inhibitors complexed with PARP1 novel orally efficacious inhibitors complexed with PARP1 rcsb pdb novel orally efficacious inhibitors https://www.rcsb.org/structure/4I12 RCSB PDB - 4I12: Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors https://www.wikidata.org/wiki/Q40694343 Novel actions of inhibitors of DNA topoisomerase II in drug-resistant tumor cells - Wikidata scientific article published on January 1994 dna topoisomerase ii https://www.rcsb.org/structure/4JBO RCSB PDB - 4JBO: Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of... Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules