stat3 - Robuta Search

https://www.jci.org/articles/view/73174/figure/1 JCI - CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells https://www.biospace.com/kymera-therapeutics-to-present-new-clinical-data-from-the-ongoing-phase-1-trial-of-stat3-degrader-kt-333-at-eha-annual-meeting Kymera Therapeutics to Present New Clinical Data from the Ongoing Phase 1 Trial of STAT3 Degrader... May 15, 2024 - Kymera Therapeutics, Inc. announced that new Phase 1 data for KT-333, a first-in-class degrader of STAT3, highlighting safety, pharmacokinetics,... https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1477122/full Frontiers | Calcium sensing receptor regulate claudin-14 via PKA-STAT3 pathway in rat model of... The calcium-sensitive receptor (CaSR) has been identified as a key factor in the formation of kidney stones. A substantial body of research has illuminated t... https://www.hyperige.de/ STAT3 Hyper-IgE Syndrom hyper ige stat3 syndrom https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2016.00626/full Frontiers | IL-15 Activates the Jak3/STAT3 Signaling Pathway to Mediate Glucose Uptake in Skeletal... Myokines are specialized cytokines that are secreted from skeletal muscle (SKM) in response to metabolic stimuli, such as exercise. Interleukin-15 (IL-15) i... https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1608612/full Frontiers | Unraveling the role of STAT3 in Cancer Cachexia: pathogenic mechanisms and therapeutic... Cancer cachexia is a complex, multifactorial syndrome characterized by severe weight loss, muscle wasting, and systemic inflammation, significantly contribut... https://www.semanticscholar.org/topic/STAT3-wt-Allele/1332398 STAT3 wt Allele | Semantic Scholar Human STAT3 wild-type allele is located in the vicinity of 17q21 and is approximately 75 kb in length. This allele, which encodes signal transducer and... stat3 wt allele semantic scholar https://elifesciences.org/articles/72837v1 STAT3-mediated allelic imbalance of novel genetic variant rs1047643 and B cell specific... https://www.preprints.org/manuscript/202310.1509 STAT3 Inhibitory Activities of Lignans Isolated from the Stems of Lindera obtusiloba Blume[v1] |... Lindera obtusiloba Blume has several activities, such as anti-inflammatory, anti-allergic, anti-tumor, anti-wrinkle, and antioxidant activities. Interleukin-6... https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/publications/2021/a-stat3-inhibitor-ameliorates-cns-autoimmunity-by-restoring-teff-treg- A STAT3 Inhibitor Ameliorates CNS Autoimmunity by Restoring Teff:Treg Balance | Quest Diagnostics A STAT3 inhibitor ameliorates CNS autoimmunity by restoring Teff:Treg balance https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.02031/full Frontiers | TLT2 Suppresses Th1 Response by Promoting IL-6 Production in Monocyte Through JAK/STAT3... The function of triggering receptor expressed on myeloid cell-like transcript 2 (TLT2) has not been characterized and their role in pulmonary tuberculosis (T... https://pmc.ncbi.nlm.nih.gov/articles/PMC43877/ Stat3 and Stat4: members of the family of signal transducers and activators of transcription - PMC The deduced amino acid sequence of two members of the signal transducers and activators of transcription (STAT) family from the mouse are described. Comparison... members of the family https://pmc.ncbi.nlm.nih.gov/articles/PMC5917091/ Phosphorylated Forms of STAT1, STAT3 and STAT5 Are Expressed in Proliferating but Not Involuted... We have recently demonstrated the expression of embryonic stem cell markers on the endothelium of infantile hemangioma, a functional hemogenic endothelium with... https://pmc.ncbi.nlm.nih.gov/articles/PMC20521/ Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality - PMC Signal transducer and activator of transcription (STAT) proteins have been shown to mediate biological actions in response to cytokines. Stat3, a member of the... https://pmc.ncbi.nlm.nih.gov/articles/PMC4718674/ Dihydroartemisinin as a Putative STAT3 Inhibitor, Suppresses the Growth of Head and Neck Squamous... Developing drugs that can effectively block STAT3 activation may serve as one of the most promising strategy for cancer treatment. Currently, there is no... https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.880787/full Frontiers | Resistance Training Attenuates Activation of STAT3 and Muscle Atrophy in Tumor-Bearing... Purpose: Although the role of signal transducers and activators of transcription (STAT3) in cachexia due to the association of circulating IL-6 and muscle wa... https://elifesciences.org/articles/63291 Ablation of STAT3 in Purkinje cells reorganizes cerebellar synaptic plasticity in long-term fear... Cerebellar STAT3 is indispensable for proper expression of fear memory network processing. https://www.mdpi.com/1422-0067/15/6/11013 Celecoxib Suppresses the Phosphorylation of STAT3 Protein and Can Enhance the Radiosensitivity of... Medulloblastoma (MB) is a malignant primary brain tumor with poor prognosis. MB-derived CD133/Nestin double-positive cells (MB-DPs) exhibit cancer stem-like... celecoxib phosphorylation https://elifesciences.org/articles/56666 Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes... Targeted SOCS3 null mice reveal that maturation of cortical bone comprises both pore closure and accumulation of high density bone, requiring local suppression... https://www.spandidos-publications.com/10.3892/or.2016.4822?text=fulltext STAT3 regulates hypoxia-induced epithelial mesenchymal transition in oesophageal squamous cell... Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. stat3 hypoxia induced epithelial https://pmc.ncbi.nlm.nih.gov/articles/PMC6356849/ Honokiol Eliminates Glioma/Glioblastoma Stem Cell-Like Cells via JAK-STAT3 Signaling and Inhibits... Malignant gliomas are the most aggressive forms of brain tumors; whose metastasis and recurrence contribute to high rates of morbidity and mortality. Glioma... https://pmc.ncbi.nlm.nih.gov/articles/PMC12905148/ SHP2 promotes osteosarcoma via regulating STAT3/TET3/HOXB2 signaling - PMC To investigate the effect of SHP2 on the STAT3/TET3/HOXB2 signaling pathway in osteosarcoma, and its role in the proliferation, migration and invasion of... shp2 osteosarcoma via regulating stat3 https://www.rcsb.org/structure/3CWG RCSB PDB - 3CWG: Unphosphorylated mouse STAT3 core fragment Unphosphorylated mouse STAT3 core fragment rcsb pdb mouse stat3 core fragment https://pmc.ncbi.nlm.nih.gov/articles/PMC8667935/ Synthesis and biological evaluation of celastrol derivatives as potent antitumor agents with STAT3... Using STAT3 inhibitors as a potential strategy in cancer therapy have attracted much attention. Recently, celastrol has been reported that it could directly... https://www.spandidos-publications.com/10.3892/or.2018.6890/abstract Erythropoietin promotes expression of survivin via STAT3 activation and reduces sensitivity to... Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. https://elifesciences.org/articles/72837 STAT3-mediated allelic imbalance of novel genetic variant Rs1047643 and B-cell-specific... Genetic analyses reveal biological insight of a novel risk locus into systemic lupus erythematosus susceptibility. https://www.spandidos-publications.com/10.3892/ijo.2012.1454/abstract PSK induces apoptosis through the inhibition of activated STAT3 in human esophageal carcinoma cells International Journal of Oncology is an international journal devoted to oncology research and cancer treatment. https://www.spandidos-publications.com/10.3892/or.2021.8088?text=fulltext Phlorizin from sweet tea inhibits the progress of esophageal cancer by antagonizing the JAK2/STAT3... Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. https://pmc.ncbi.nlm.nih.gov/articles/PMC9851268/ Curcumin analog WZ26 induces ROS and cell death via inhibition of STAT3 in cholangiocarcinoma - PMC Cholangiocarcinoma (CCA) is an aggressive biliary epithelial tumor with limited therapeutic options and poor prognosis. Curcumin is a promising active natural... https://www.spandidos-publications.com/10.3892/or.2021.8088/abstract Phlorizin from sweet tea inhibits the progress of esophageal cancer by antagonizing the JAK2/STAT3... Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. https://www.mdpi.com/1422-0067/24/8/7374 FTY720-P, a Biased S1PR Ligand, Increases Mitochondrial Function through STAT3 Activation in... FTY720 is an FDA-approved sphingosine derivative drug for the treatment of multiple sclerosis. This compound blocks lymphocyte egress from lymphoid organs and... https://pmc.ncbi.nlm.nih.gov/articles/PMC4026085/ Anti-EGFR therapeutic efficacy correlates directly with inhibition of STAT3 activity - PMC Several agents targeting the epidermal growth factor receptor (EGFR) have been FDA-approved to treat cancer patients with varying tumor types including... https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1538649/full Frontiers | OSMR induces M2 polarization of glioblastoma associated macrophages through JAK/STAT3... IntroductionVerify whether Onconstatin M receptor (OSMR) plays a regulatory role in the growth of glioblastoma (GBM) and explore its specific regulatory mech... https://www.spandidos-publications.com/10.3892/or.2016.4584 Xanthohumol inhibits STAT3 activation pathway leading to growth suppression and apoptosis induction... Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. https://www.fiercebiotech.com/biotech/tvardis-stat3-inhibitor-flunks-phase-2-ipf-trial-amid-high-dropout-rates Tvardi's STAT3 inhibitor flunks IPF trial amid high dropout rate Oct 13, 2025 - The biotech reported high dropout rates and placebolike efficacy in a phase 2 trial of its idiopathic pulmonary fibrosis prospect. stat3 inhibitor https://www.spandidos-publications.com/10.3892/ijo.2013.2195 STAT3 activation in HER2-overexpressing breast cancer promotes epithelial-mesenchymal transition... International Journal of Oncology is an international journal devoted to oncology research and cancer treatment. breast cancer stat3 activation her2 https://www.spandidos-publications.com/10.3892/or.2013.2858 Activation of the JAK-STAT3 pathway is associated with the growth of colorectal carcinoma cells Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. https://www.longdom.org/proceedings/stat3-as-a-molecular-target-for-prostate-cancer-prevention-and-therapy-11006.html STAT3 as a molecular target for prostate cancer prevention and th | 11006 Longdom Publishing SL is one of the leading international open access journals publishers, covering clinical, medical, and technology-oriented subjects as a molecular target https://pmc.ncbi.nlm.nih.gov/articles/PMC21603/ Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated... Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including... https://www.unh.edu/research/cibbr/modulation-stat3-activity-stat5-triple-negative-breast-cancer Modulation of STAT3 activity by STAT5 in triple negative breast cancer | Center of Integrated... Modulation of STAT3 activity by STAT5 in triple negative breast cancer Abstract. triple negative breast cancer https://pmc.ncbi.nlm.nih.gov/articles/PMC17660/ Two distinct signaling pathways in hair cycle induction: Stat3-dependent and -independent pathways... The hair follicle is an epidermal derivative that undergoes cycles of growth, involution, and rest. The hair cycle has well-orchestrated kinetics regulated by... signaling pathways hair cycle https://www.rti.org/publication/anti-myeloma-effects-icariin-mediated-attenuation-jak-stat3-dependent-signaling-cascade Anti-myeloma effects of icariin are mediated through the attenuation of JAK/STAT3-dependent... Because of the essential role of signal transducer and activator of transcription 3 (STAT3) in proliferation, anti-apoptosis, and chemoresistance of multiple... https://www.jci.org/articles/view/35344 JCI - What lurks beneath: IL-11, via Stat3, promotes inflammation-associated gastric tumorigenesis https://www.wikidata.org/wiki/Q42753357 STAT3 is required for the gp130-mediated full activation of the c-myc gene - Wikidata scientific article published on January 1999 https://www.sciencetimes.com/articles/640/20141011/an-unexpected-bonus-blocking-stat3-could-help-cancer-patients-in-two-ways.htm An unexpected bonus - blocking STAT3 could help cancer patients in two ways Oct 11, 2014 - The STAT transcription factors are involved in the development of many forms of cancer. STAT3 is frequently activated in tumour cells, so drugs targeting STAT3... https://www.spandidos-publications.com/10.3892/or.2026.9048/abstract [Corrigendum] Triptolide inhibits JAK2/STAT3 signaling and induces lethal autophagy through ROS... Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1132834/full Frontiers | Phosphorylated STAT3 as a potential diagnostic and predictive biomarker in ALK- ALCL... Aims: The differential diagnosis between ALK-negative anaplastic large cell lymphoma (ALK- ALCL) and peripheral T-cell lymphoma, not otherwise specified (PTC... https://pmc.ncbi.nlm.nih.gov/articles/PMC41035/ Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15... The cytokines interleukin 2 (IL-2) and IL-15 have similar biological effects on T cells and bind common hematopoietin receptor subunits. Pathways that involve... https://www.mendeley.com/catalogue/cea0e9c9-d493-3887-95ae-a578162ffabe/ Deciphering the impact of STAT3 a... preview & related info | Mendeley (2025) Cirauqui et al. Head and Neck. Background: Squamous cell carcinoma of the head and neck (SCCHN) is an aggressive disease with poor prognosis. It is... the impact related info deciphering stat3 preview https://www.spandidos-publications.com/10.3892/etm.2013.1008/abstract Qianliening capsule treats benign prostatic hyperplasia via suppression of the EGF/STAT3 signaling... Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine. benign prostatic hyperplasia suppression of the