https://singularityhub.com/2019/06/19/the-prickly-debate-on-germline-gene-therapy-and-moving-it-forward/
Germline gene therapy has the ability to prevent diseases from being passed on not only to one child, but to all future generations.
germline gene therapypricklydebatemoving
https://www.geneticsandsociety.org/biopolitical-times/growing-chorus-objections-loosened-rules-embryo-and-germline-research
On May 26, the International Society of Stem Cell Research (
growingchorusobjectionsloosenedrules
https://www.statnews.com/2025/05/13/scientific-societies-call-for-ten-year-moratorium-on-germline-gene-editing-crispr/
May 14, 2025 - The move is intended to signal that altering the genomes of eggs, sperm, or embryos destined for live births remains unacceptable for now.
ban onscientistscallyearcrispr
https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.1020543/full
Background. Colorectal cancer (CRC) is the third most common cancer in Estonia in both women and men. According to the Estonian National Institute for Health...
frontiersprevalencegermlinepathogenicvariants
https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1467882/full
Multiple Endocrine Neoplasia type 1 (MEN1) is a rare genetic disease, characterized by co-occurrence of several lesions of the endocrine system.In MEN1, the ...
case reportpathogenic variantfrontiersnovelgermline
https://pubmed.ncbi.nlm.nih.gov/41493635/
BRCA1/2 carriers exhibit a 2- to 3-fold higher risk of second primary cancer than non-carriers. Ovarian cancer represents the majority of second primary...
primary cancerin chineserisksecondnon
https://www.sciencedaily.com/releases/2019/06/190603151709.htm
An internationally known embryologist and his son make the case for using gene-editing tools to prevent inherited disease, in a new editorial. The authors push...
germline gene therapysafetysciencedaily
https://pubmed.ncbi.nlm.nih.gov/20555324/
The plasticity of ageing suggests that longevity may be controlled epigenetically by specific alterations in chromatin state. The link between chromatin and...
members ofin acomplexregulatelifespan
https://sdbcore.org/topic?TopicID=8
The Germline: Specification of the germline is critical to ensure genetic information is transmitted to the next generation. Germ cells not only produce the...
sdbcoregermline
https://www.mdpi.com/2072-6694/13/24/6283
Copy-number variations (CNVs) have important clinical implications for several diseases and cancers. Relevant CNVs are hard to detect because common structural...
copy number variationcomparisontoolsdetection
https://www.nationalacademies.org/projects/PGA-PGA%20EO-19-01/event/33281
This will be a conference call of the international commission developing a framework for considering technical, scientific, medical, regulatory, and ethical...
on theclinical useinternationalcommissionhuman
https://www.ajmc.com/view/nccn-prostate-cancer-update-emphasizes-germline-testing
Germline testing at diagnosis, along with tumor testing, have the potential to identify candidates for investigational poly (ADP-ribose) polymerase (PARP)...
prostate cancernccnupdategermlinetesting