Robuta

https://leads-study.medicine.iu.edu/ LEADS - Longitudinal Early-Onset Alzheimer's Disease Study Mar 9, 2026 - The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) is an observational study that will enroll and follow 500 cognitively impaired participants and... early onsetleadslongitudinalalzheimerdisease https://bbrfoundation.org/blog/diagnosing-early-onset-depression-young-children Diagnosing Early-Onset Depression in Young Children | Brain & Behavior Research Foundation There was a longstanding belief that pre-pubescent children were too developmentally and cognitively immature to experience the core aspects of depression. In... early onsetyoung childrenbrain behaviordiagnosingdepression https://icts.wustl.edu/red-flags-indicate-risk-for-early-onset-colorectal-cancer/ Red flags indicate risk for early-onset colorectal cancer | Clinical & Translational Sciences |... red flagsearly onset https://disorders.eyes.arizona.edu/references/tbce-mutations-cause-early-onset-progressive-encephalopathy-distal-spinal-muscular TBCE Mutations Cause Early-Onset Progressive Encephalopathy with Distal Spinal Muscular Atrophy |... early onset https://www.aafp.org/afp/2021/1200/p636 Neonatal Early-Onset Sepsis Calculator | AFP Can the neonatal early-onset sepsis calculator safely and accurately evaluate the risk of early-onset sepsis in neonates? early onsetneonatalsepsiscalculatorafp https://researchportalplus.anu.edu.au/en/publications/monogenic-early-onset-lymphoproliferation-and-autoimmunity-natura/ Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3... early onsetnatural historymonogenicautoimmunity https://www.cancer.gov/news-events/press-releases/2025/early-onset-cancer-rates NIH study investigates trends in early-onset cancers - NCI An analysis by NIH researchers finds that the incidence of 14 cancer types has risen among people under age 50, while 19 other cancer types have fallen. early onsetnihstudyinvestigatestrends https://news.cornell.edu/stories/2016/08/early-onset-spring-models-may-indicate-nightmare-ag Early-onset spring models may indicate 'nightmare' for ag | Cornell Chronicle early onsetspringmodelsmay https://events.diabetes.org/p/s/mechanisms-of-early-onset-prediabetes-in-women-after-pregnancy-5475 Mechanisms of Early-Onset Prediabetes in Women after Pregnancy - American Diabetes Association early onset https://www.livescience.com/health/cancer/some-early-onset-cancers-are-on-the-rise-why Some early-onset cancers are on the rise. Why? | Live Science Jun 24, 2025 - The rates of certain early-onset cancers are on the rise. on the riseearly onsetcancers https://pmc.ncbi.nlm.nih.gov/articles/PMC17958/ Deletion of Ku86 causes early onset of senescence in mice - PMC DNA double-strand breaks formed during the assembly of antigen receptors or after exposure to ionizing radiation are repaired by proteins important for... early onsetdeletioncausessenescencemice https://rarediseases.info.nih.gov/diseases/2600/early-onset-cerebellar-ataxia-with-retained-tendon-reflexes Early onset cerebellar ataxia with retained tendon reflexes | About the Disease | GARD Find symptoms and other information about Early onset cerebellar ataxia with retained tendon reflexes. about the diseaseearly onsetcerebellar ataxia https://pubmed.ncbi.nlm.nih.gov/41850249/ Early-Onset Digestive System Cancers: Risk Factors and Clinicopathological and Molecular Features... The incidence of early-onset cancers, commonly defined as cancers diagnosed before age 50 years, has been increasing globally over recent decades. In... early onsetdigestive systemrisk factorscancers https://www.buzzsprout.com/1589794/episodes/8410163 Early-Onset Alzheimer's: A Daughter's Story with Chelsea Cox In this episode, Virginia Naeve and Steve O'Leary interview Chelsea Cox, Associate Director of Education at UCI MIND, whose father was diagnosed with... early onsetalzheimerdaughterstorychelsea https://pmc.ncbi.nlm.nih.gov/articles/PMC10919688/ Factors associated with early-onset androgenetic alopecia: A scoping review - PMC Early-onset androgenetic alopecia (AGA) has been associated with various chronic conditions, including metabolic syndrome (MetS). Gaining a deep understanding... associated withearly onsetandrogenetic alopeciascoping reviewfactors https://eprints.ncl.ac.uk/236754 Alcohol Consumption, Early-Onset Drinking, and Health-Related Consequences in Adolescents... alcohol consumptionearly onsethealth relateddrinking https://ub01.uni-tuebingen.de/xmlui/handle/10900/104945 A clinical diagnostic algorithm for early onset cerebellar ataxia clinical diagnosticearly onsetalgorithmataxia https://www.cancer.columbia.edu/news/topics/early-onset-cancer Early Onset Cancer | Herbert Irving Comprehensive Cancer Center (HICCC) - New York Incidence of cancer in individuals under 50 are on the rise. Read how the HICCC is working to understand more on this trend through research in early detection. early onsetcancerherbertirvingcomprehensive https://tobias-lib.uni-tuebingen.de/xmlui/handle/10900/118615 Expanding the phenotype of PIGS-associated early onset epileptic developmental encephalopathy early onsetexpandingphenotypepigs https://www.mediafire.com/file_premium/15agivu30rw4u93/Early-onset_Bowel_Cancer_The_Facts_Bowel_Cancer_Australia.pdf/file Early-onset Bowel Cancer_The Facts_Bowel Cancer Australia MediaFire is a simple to use free service that lets you put all your photos, documents, music, and video in a single place so you can access them anywhere and... early onsetbowel cancerthe factsaustralia https://pubmed.ncbi.nlm.nih.gov/38451966/ Factors associated with early-onset androgenetic alopecia: A scoping review Early-onset AGA is a complex condition with various risk factors and etiology, associated comorbidities, and potential implications for treatment response and... associated withearly onsetandrogenetic alopeciafactorsscoping https://prism.northwestern.edu/records/qb3z2-wtg16 CDKL5 Mutations in Boys With Encephalopathy and Early-Onset Intractable Epilepsy early onsetmutationsboys https://pubmed.ncbi.nlm.nih.gov/22868939/ Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers These results highlight an increased genetic vulnerability to smoking in early-onset smokers. early onsetincreasedgeneticvulnerabilitysmoking https://researchconnect.buffalo.edu/en/publications/genomically-defined-hypervirulent-klebsiella-pneumoniae-contribut/ Genomically defined hypervirulent Klebsiella pneumoniae contributed to early-onset increased... klebsiella pneumoniaeearly onsetdefinedcontributedincreased https://pubmed.ncbi.nlm.nih.gov/27940705/ Epidemiology of Invasive Early-Onset Neonatal Sepsis, 2005 to 2014 GBS prevention efforts have not led to an increasing burden of early-onset E coli infections. However, the stable burden of E coli sepsis and associated... early onsetneonatal sepsisepidemiologyinvasive https://www.lenmeldyhcp.com/ For early onset MLD LENMELDY is a transformative treatment and the standard of care for patients with early onset MLD in the US. See full indication and Prescribing Information early onsetmld https://rarediseases.info.nih.gov/diseases/21656/nebulin-related-early-onset-distal-myopathy Nebulin-related early-onset distal myopathy | About the Disease | GARD Find symptoms and other information about Nebulin-related early-onset distal myopathy. about the diseaseearly onsetrelateddistalmyopathy https://www.zeffy.com/en-US/donation-form/donate-to-be-a-disrupter-of-early-onset-colon-cancer Donate to be a disrupter of Early Onset Colon Cancer Help Mike Check Yur Colon raise funds for Donate to be a disrupter of Early Onset Colon Cancer. Make a donation on Zeffy, and ensure 100% of your donation goes... donate toearly onsetdisruptercoloncancer https://cbic.weill.cornell.edu/publications/hypometabolism-exceeds-atrophy-presymptomatic-early-onset-familial-alzheimers-disease Hypometabolism exceeds atrophy in presymptomatic early-onset familial early onsetexceedsatrophyfamilial https://retail.economictimes.indiatimes.com/news/food-entertainment/personal-care-pet-supplies-liquor/early-onset-of-summer-increasing-health-awareness-and-easing-of-covid-restrictions-to-drive-sales-of-healthy-non-carbonated-drinks-this-summer/91252795 Healthy Beverages: Early onset of summer, increasing health awareness, and easing of COVID... Healthy Beverages: The last two summers, beverage makers witnessed muted demand due to the impact of pandemic on retail and HoReCa (Hotel, Restaurant,... healthy beveragesearly onset https://www.sydney.edu.au/news-opinion/news/2022/07/25/type-of-early-onset-dementia-now-more-detectible.html Type of early-onset dementia now more detectible - The University of Sydney early onset dementianow morethe universitytype https://bmcdev-e2b2a6gdfff3f6d0.uaenorth-01.azurewebsites.net/diseases/early-onset-scoliosis-congenital-or-idiopathic/ Early-onset scoliosis (congenital or idiopathic) - Burjeel Medical City early onset scoliosiscongenitalidiopathicmedicalcity https://research.monash.edu/en/publications/birthweight-and-early-onset-type-2-diabetes-in-american-indians-d/ Birthweight and early-onset type 2 diabetes in American Indians: differential effects in... early onset https://www.nice.org.uk/guidance/cg149 Neonatal infection (early onset): antibiotics for prevention and treatment | Guidance | NICE This guidance has been updated and replaced by neonatal infection: antibiotics for prevention and treatment prevention and treatmentearly onsetneonatalinfectionantibiotics https://prism.northwestern.edu/records/5ewpq-x1b11 Early Onset West Syndrome with Hypomyelination, Coloboma and SPTAN1 Mutation early onsetwest syndromecolobomamutation https://pure.psu.edu/en/publications/characteristics-of-early-onset-vs-late-onset-colorectal-cancer-a-/ Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review - Penn State early onset https://news.feinberg.northwestern.edu/2013/08/13/early_onset_dementia/ New Test May Help Reveal Early-Onset Dementia - News Center Aug 13, 2013 - Simple tests that measure the ability to recognize individuals such as Albert Einstein, Bill Gates, or Oprah Winfrey may help doctors identify early dementia... early onset dementianew testmay helprevealnews https://pmc.ncbi.nlm.nih.gov/articles/PMC10340669/ Could Microplastics Be a Driver for Early Onset Colorectal Cancer? - PMC The incidence of colorectal cancer has increasing dramatically in those under 50 years of age. These cancers are prominently in the sigmoid colon and rectum.... be a driverearly onsetcolorectal cancercouldmicroplastics https://bibliographie.uni-tuebingen.de/xmlui/handle/10900/83942 Early-onset familial hemiplegic migraine due to a novel SCN1A mutation familial hemiplegic migraineearly onsetdue to https://data.mendeley.com/datasets/swrwmfy6tg/1 Development of multisensory integration following prolonged early-onset visual deprivation. Senna... In the present study we investigated the development of multisensory integration in individuals who suffered from congenital bilateral cataract and got... early onsetdevelopmentmultisensoryintegrationfollowing https://vtbcfeed.blogspot.com/2026/05/can-pesticide-exposure-increase-early.html Can Pesticide Exposure Increase Early-Onset Colorectal Cancer Risk? VTBC current news, and updates relating life, agriculture, spirituality, science, technology, crypto, blockchains, space, metaverse, and on. pesticide exposureearly onsetcolorectal cancerincreaserisk https://cancer.pfizer.com/colorectal-cancer/early-onset Early Onset Colorectal Cancer | Let's Outdo Cancer by Pfizer Learn how early onset colorectal cancer can be treatable when caught early and see how innovations are changing care for patients. early onsetcolorectal cancerletoutdopfizer https://economictimes.indiatimes.com/topic/early-onset-puberty early onset puberty: Latest News & Videos, Photos about early onset puberty | The Economic Times -... early onset puberty Latest Breaking News, Pictures, Videos, and Special Reports from The Economic Times. early onset puberty Blogs, Comments and Archive News... latest news videosearly onsetabout thepuberty https://medicine.yale.edu/cancer/event/early-onset-cancer-support-group-26/ Early Onset Cancer Support Group | Yale Cancer Center 04/14/2026 event : Facilitated by licensed oncology social workers, this group offers a safe space for adults ages 18-49 to connect with others living with cancer support groupearly onsetyalecenter https://boris-portal.unibe.ch/entities/publication/34753513-b2fa-4af5-934f-84ab9ffc2584 Treatment of adolescents with early-onset schizophrenia spectrum disorders: in search of a... Purpose of review: We aimed to review literature on the efficacy and tolerability of psychosocial and psychopharmacological interventions in youth with... early onset https://podcasts.ox.ac.uk/causes-early-onset-psychosis The causes of early onset psychosis | University of Oxford Podcasts Produced by Wayne Davies at the University Department of Psychiatry the causesearly onsetpsychosisuniversityoxford https://blogs.bmj.com/jmg/2025/09/10/multiple-early-onset-atypical-cutaneous-fibrous-histiocytomas-in-multilocus-inherited-neoplasia-allele-syndrome-involving-tp53-and-flcn-genes/ Multiple early onset atypical cutaneous fibrous histiocytomas in multilocus inherited neoplasia... Feb 22, 2026 - A 16-year-old boy developed multiple rare skin tumours called atypical cutaneous fibrous histiocytomas (ACFHs). Genetic testing revealed he has two inherited... early onsetmultipleatypicalcutaneous https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.734612/full Frontiers | Treatment Guidelines for Rare, Early-Onset, Treatment-Resistant Epileptic Conditions: A... Background Dravet syndrome (DS), Lennox-Gastaut syndrome (LGS) and CDKL5 deficiency disorder (CDD) are rare epileptic conditions, characterised by drug-resis... treatment guidelinesearly onsetfrontiersrare https://www.mayoclinic.org/departments-centers/early-onset-colorectal-cancer-group/resources-medical-professionals/mpc-20584211 Early-Onset Colorectal Cancer Group - Referrals - Mayo Clinic early onsetcolorectal cancergroupreferralsmayo https://research.birmingham.ac.uk/en/publications/screening-and-management-of-early-onset-group-b-streptococcus-dur/ Screening and management of early onset group B streptococcus during labour. - University of... group b streptococcusearly onset https://medlineplus.gov/genetics/condition/early-onset-isolated-dystonia/ Early-onset isolated dystonia: MedlinePlus Genetics Early-onset isolated dystonia is one of many forms of dystonia, Explore symptoms, inheritance, genetics of this condition. early onsetisolateddystoniamedlineplusgenetics https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2023.1101006/full Frontiers | The role of thrombin in early-onset seizures Clinical observations and studies on different animal models of temporal lobe epilepsy (TLE) reveal dysfunction of blood-brain barrier (BBB) during seizures.... the roleearly onsetfrontiersthrombinseizures https://scholars.duke.edu/publication/1258852 Scholars@Duke publication: Early-Onset Psychotic Disorders early onsetscholarsdukepublicationpsychotic https://experts.umn.edu/en/publications/white-matter-potholes-in-early-onset-schizophrenia-a-new-approach/ White matter 'potholes' in early-onset schizophrenia: A new approach to evaluate white matter... a new approachwhite matterearly onset https://pubmed.ncbi.nlm.nih.gov/40013172/?otool=flbhsflib&holding=flbhsflib Atypical Early Onset Alzheimer's Disease in a Young Female: A Case Report Early-onset Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the development of amyloid plaques and neurofibrillary tangles at an... early onset https://pmc.ncbi.nlm.nih.gov/articles/PMC9458941/ Early-onset scoliosis: a narrative review - PMC Early-onset scoliosis (EOS) is defined as any spinal deformity that is present before 10 years old, regardless of etiology. Deformity must be evaluated based... early onset scoliosisnarrative reviewpmc https://scholars.duke.edu/grant/13022 Scholars@Duke grant: New Animal Model For Early Onset Nonimmune Diabetes new animalearly onsetscholarsdukegrant https://research-portal.uu.nl/en/publications/fbxo7-mutations-cause-autosomal-recessive-early-onset-parkinsonia/ FBXO7 mutations cause autosomal recessive, early-onset parkinsonian-pyramidal syndrome - Utrecht... early onsetmutationscauseautosomalrecessive https://pmc.ncbi.nlm.nih.gov/articles/PMC10989383/ Early-onset gastrointestinal cancer: An epidemiological reality with great significance and... During the last few years, epidemiological data from many countries suggest that the incidence and prevalence of many cancers of the digestive system are... early onsetgastrointestinal cancer https://www.thestar.com.my/lifestyle/health/2024/09/25/losing-sleep-over-early-onset-hair-loss Losing sleep over early onset hair loss | The Star Sep 21, 2024 - Alopecia is a condition that causes premature hair loss and it can be temporary or permanent. losing sleepearly onsethair lossstar https://www.news-medical.net/news/20260504/Cellular-aging-in-immune-cells-signals-early-onset-of-cognitive-depression.aspx Cellular aging in immune cells signals early onset of cognitive depression May 4, 2026 - Blood tests measuring the aging of certain white blood cells can predict cognitive and mood-related symptoms of depression, rather than physical symptoms. cellular agingimmune cellsearly onset https://prism.northwestern.edu/records/xghbf-cs012 Early Onset Absence Epilepsy early onsetabsenceepilepsy https://pubmed.ncbi.nlm.nih.gov/11818374/ Nearwork in early-onset myopia Children aged 7 to 9 years with a greater current reading exposure were more likely to be myopic. This association of reading and myopia in a young age cohort... early onsetmyopia https://pubmed.ncbi.nlm.nih.gov/?term=(early-onset+glaucoma%5BTIAB%5D)+AND+english%5Bla%5D+AND+human%5Bmh%5D (early-onset glaucoma[TIAB]) AND english[la] AND human[mh] - Search Results - PubMed (early-onset glaucoma[TIAB]) AND english[la] AND human[mh] - Search Results - PubMed early onsetenglish la https://prism.northwestern.edu/records/d0858-4s488 Genetics of Early Onset Restless Legs Syndrome early onsetrestless legsgeneticssyndrome https://orthop.washington.edu/grand-rounds/management-of-early-onset-scoliosis.html Management of Early Onset Scoliosis | UW Orthopaedic Surgery and Sports Medicine December 3, 2014 Grand Rounds: Management of Early Onset ScoliosisDr. early onset scoliosisorthopaedic surgeryand sportsmanagement https://pubmed.ncbi.nlm.nih.gov/10441572/ Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation... To determine the prevalence of early-onset Alzheimer disease (EOAD) and of autosomal dominant forms of EOAD (ADEOAD), we performed a population-based study in... early onsetalzheimer diseaseautosomaldominant https://pubmed.ncbi.nlm.nih.gov/19664745/ Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney... Through linkage analysis and candidate gene sequencing, we identified three unrelated families with the autosomal-dominant inheritance of early onset anemia,... https://research.monash.edu/en/publications/strider-sildenafil-therapy-in-dismal-prognosis-early-onset-fetal-/ STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): An... https://pubmed.ncbi.nlm.nih.gov/22314128/ Germline DNA copy number variation in familial and early-onset breast cancer This study is the first to explore the contribution of germline CNVs to BRCA1/2-negative familial and early-onset breast cancer. The data suggest that rare... copy number variation https://www.ndph.ox.ac.uk/corectr/projects/elucidating-the-epidemiological-and-clinico-pathological-features-of-early-onset-colorectal-cancer-crc-to-optimise-prevention-screening-and-treatment?4216d444-4ce5-11f1-821b-e92dc95b75f5 Elucidating the epidemiological and clinico-pathological features of early onset colorectal Cancer... https://pubmed.ncbi.nlm.nih.gov/40977998/ COVID-19 Pandemic, Parental Protective Factors, and Substance Use Onset Among Early Adolescents in... The authors found that higher levels of COVID-19-related emotional impact were predictive of increased cigarette and E-cigarette onset but were only marginally... https://www.cbsnews.com/news/still-alice-novelist-movie-raises-awareness-early-onset-alzheimers/ "Still Alice" novelist Lisa Genova shines spotlight on early onset Alzheimer's - CBS News Julianne Moore won an Oscar for her role, based on a work of fiction by Lisa Genova that reflects the reality of 200,000 Americans https://pubmed.ncbi.nlm.nih.gov/23900731/ The diagnostic utility of EEG in early-onset dementia: a systematic review of the literature with... Early-onset dementia (EOD) is characterized by functionally impairing deterioration in memory, language, personality or visuospatial skills emerging under the... https://pubmed.ncbi.nlm.nih.gov/22531231/ Use of the complete blood cell count in early-onset neonatal sepsis Low white blood cell count, absolute neutrophil count and high immature-to-total neutrophil ratio were associated with increasing odds of infection, but no... of theblood cell https://www.ncbi.nlm.nih.gov/clinvar/RCV000327411/ NM_001267550.2(TTN):c.69231TC (p.Leu23077=) AND Early-onset myopathy with fatal cardiomyopathy -... ClinVar archives and aggregates information about relationships among variation and human health. https://eprints.ncl.ac.uk/252004 A multinational study on motor function in early-onset FSHD - ePrints - Newcastle University https://pubmed.ncbi.nlm.nih.gov/27742809/ A frameshift deletion in the sarcomere gene MYL4 causes early-onset familial atrial fibrillation Through a population approach we found a loss of function mutation in the myosin gene MYL4 that, in the homozygous state, is completely penetrant for... https://pmc.ncbi.nlm.nih.gov/articles/PMC8021204/ Pubertal Timing During Early Adolescence: Advanced Pubertal Onset in Females with Autism Spectrum... Autism spectrum disorder (ASD) is characterized by impaired social communication and poor adaptation to change; thus, the onset of puberty may be a pivotal... https://scholars.lib.ntu.edu.tw/entities/publication/d4196b0e-d700-436f-97c1-3ff97243980e Analysis of Parkin Co-Regulated Gene in a Taiwanese-Ethnic Chinese Cohort with Early-Onset... PArkin Co-Regulated Gene (PACRG) is a novel gene which is transcriptionally co-regulated with the parkin gene (PRKN) by a shared bi- directional promoter. To... https://pmc.ncbi.nlm.nih.gov/articles/PMC11259789/ Haploinsufficiency in PTPN2 leads to early-onset systemic autoimmunity from Evans syndrome to lupus... Exome sequencing in pediatric systemic lupus and Evans syndrome identified six novel monoallelic PTPN2 mutations, impairing its regulatory function. This... https://blogs.bmj.com/jmg/2024/06/18/de-novo-variants-in-kcnj3-are-associated-with-early-onset-epilepsy/ De novo variants in KCNJ3 are associated with early-onset epilepsy (Contributed by Dr Lili Long) -... Feb 22, 2026 - Epilepsy is a common chronic neurological disorder characterized by recurring spontaneous seizures with cognitive and psychosocial comorbidities. Genetic... https://pmc.ncbi.nlm.nih.gov/articles/PMC7047210/ Rare Variants in Genes Linked to Appetite Control and Hypothalamic Development in Early-Onset... Context: The hypothalamic circuit has an essential role in the regulation of appetite and energy expenditure. Pathogenic variants in genes involved in the... https://pubmed.ncbi.nlm.nih.gov/33958435/ Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal... Higher SSB intake in adulthood and adolescence was associated with a higher risk of EO-CRC among women. Reduction of SSB consumption among adolescents and... https://scholars.duke.edu/publication/1702778 Scholars@Duke publication: Corrigendum to "Early-onset cancer incidence in the United States by... in the united states https://pubmed.ncbi.nlm.nih.gov/40003962/?dopt=Abstract Non-Invasive Assessment of Neurogenesis Dysfunction in Fetuses with Early-Onset Growth Restriction... The vector of modern obstetrics is aimed at finding ways to predict various placenta-associated complications, including those associated with neuronal... https://profiles.wustl.edu/en/publications/early-onset-and-severe-clinical-course-associated-with-the-m5540g/fingerprints/ Early onset and severe clinical course associated with the m.5540GA mutation in MT-TW -... https://pubmed.ncbi.nlm.nih.gov/31269749/ A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via... Aurora A kinase (AURKA) is an important regulator in mitotic progression and is overexpressed frequently in human cancers, including hepatocellular carcinoma...