mdm2 - Robuta Search

https://www.ncbi.nlm.nih.gov/Structure/pdb/7AHZ 7AHZ: Crystal structure of Western clawed frog MDM2 RING domain homodimer bound to UbcH5B-Ub E3 ubiquitin-protein ligase Mdm2ZINC ION https://www.biologyexperimentideas.net/ MDM2, MDMX and p53 in oncogenesis and cancer therapy mdm2 mdmx p53 oncogenesis cancer https://www.wikidata.org/wiki/Q35268497 Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study -... https://www.rcsb.org/structure/4ZYI RCSB PDB - 4ZYI: Discovery of NVP-CGM097 - a highly potent and selective MDM2 inhibitor undergoing... Discovery of NVP-CGM097 - a highly potent and selective MDM2 inhibitor undergoing phase 1 clinical trials in p53wt tumors: Hdm2 (MDM2) complexed with cpd2 https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.972372/full Frontiers | Discovery of spirooxindole-derived small-molecule compounds as novel HDAC/MDM2 dual... Simultaneous inhibition of more than one target is considered to be a novel strategy in cancer therapy. Owing to the importance of histone deacetylases (HDAC... https://www.biospace.com/ascentage-pharma-s-mdm2-p53-inhibitor-apg-115-alrizomadlin-granted-an-orphan-drug-designation-by-the-fda-for-the-treatment-of-stage-iib-iv-melanoma-marking-the-twelfth-obtained-by-the-company Ascentage Pharma's MDM2-p53 Inhibitor APG-115 (Alrizomadlin) Granted an Orphan Drug Designation by... Jul 21, 2021 - Ascentage Pharma, a globally focused biotechnology company engaged in developing novel therapies for cancers, chronic hepatitis B, and age-related diseases,... https://www.rcsb.org/structure/6AAW RCSB PDB - 6AAW: Mdm2 in complex with a D amino Acid Containing Stapled Peptide Mdm2 in complex with a D amino Acid Containing Stapled Peptide https://www.spandidos-publications.com/10.3892/ijo.15.4.653/abstract MDM2 oncogene as a target for cancer therapy: An antisense approach. International Journal of Oncology is an international journal devoted to oncology research and cancer treatment. as a cancer therapy mdm2 oncogene target https://www.wikidata.org/wiki/Q41063629 Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo. - Wikidata https://www.preprints.org/manuscript/202406.0019 The Ubiquitination of arrestin3 within the Nucleus Triggers the Nuclear Export of Mdm2, Which, in... GRK2 and arrestin3, key players in the functional regulation of G protein-coupled receptors (GPCRs), are ubiquitinated by Mdm2, a nuclear protein. The... https://www.cancerdir.com/ High potency inhibitors of MDM2 pathway high potency inhibitors mdm2 pathway https://www.rcsb.org/structure/6SQS RCSB PDB - 6SQS: Crystal structure of cat phospho-Ser429 MDM2 RING domain bound to UbcH5B-Ub Crystal structure of cat phospho-Ser429 MDM2 RING domain bound to UbcH5B-Ub https://www.ncbi.nlm.nih.gov/protein/4UD7_D Chain D, MDM2 - Protein - NCBI chain mdm2 protein ncbi https://www.wolframalpha.com/input/?i=human+gene+MDM2+homologs human gene MDM2 homologs - Wolfram|Alpha human gene mdm2 homologs wolfram alpha https://www.ncbi.nlm.nih.gov/Structure/pdb/2MPS 2MPS: Structure of complex of MDM2(3-109) and P73 TAD(10-25) E3 ubiquitin-protein ligase Mdm2Tumor protein p73 3 109 https://www.rcsb.org/structure/4ERE RCSB PDB - 4ERE: crystal structure of MDM2 (17-111) in complex with compound 23 crystal structure of MDM2 (17-111) in complex with compound 23 https://www.rcsb.org/structure/4MDQ RCSB PDB - 4MDQ: Structure of a novel submicromolar MDM2 inhibitor Structure of a novel submicromolar MDM2 inhibitor rcsb pdb a novel structure mdm2 inhibitor https://www.wikidata.org/wiki/Q35036580 The p53-Mdm2 module and the ubiquitin system. - Wikidata p53 mdm2 module ubiquitin system https://www.rcsb.org/structure/5TRF RCSB PDB - 5TRF: MDM2 in complex with SAR405838 MDM2 in complex with SAR405838 rcsb pdb mdm2 complex https://www.ncbi.nlm.nih.gov/protein/5HMK_A Chain A, E3 ubiquitin-protein ligase Mdm2 - Protein - NCBI ubiquitin protein ligase chain e3 mdm2 ncbi https://pmc.ncbi.nlm.nih.gov/articles/PMC20969/ Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2 - PMC The INK4a-ARF locus encodes two proteins, p16INK4a and p19ARF, that restrain cell growth by affecting the functions of the retinoblastoma protein and p53,... arf tumor suppressor https://www.thermofisher.com/antibody/product/MDM2-Antibody-clone-2A6C9-Monoclonal/66511-1-IG MDM2 Monoclonal Antibody (2A6C9) | Invitrogen (66511-1-IG) Detect MDM2 in WB, IHC (P), ELISA, ICC/IF, IHC (PFA). Reacts with Mouse, Rabbit, Chicken, Goat. Cited in 14 publications. Catalog # 66511-1-IG monoclonal antibody mdm2 invitrogen 66511 ig https://www.wikidata.org/wiki/Q35646494 Inhibition of the p53-MDM2 interaction: targeting a protein-protein interface. - Wikidata scientific article published on January 2004 of the inhibition p53 mdm2 https://www.rcsb.org/structure/4UD7 RCSB PDB - 4UD7: Structure of the stapled peptide YS-02 bound to MDM2 Structure of the stapled peptide YS-02 bound to MDM2 https://www.rcsb.org/structure/4JV9 RCSB PDB - 4JV9: Co-crystal structure of MDM2 with inhibitor... Co-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one rcsb pdb co crystal structure mdm2 inhibitor https://www.spandidos-publications.com/10.3892/etm.2018.6588/abstract Potential use of compounds from sea cucumbers as MDM2 and CXCR4 inhibitors to control cancer cell... Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine. https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.973077/full Frontiers | Associations of MDM2 rs2279744 and TP53 rs1042522 polymorphisms with cervical cancer... ABSTRACT Background: Although the association between MDM2 rs2279744 and TP53 rs1042522 polymorphisms and cervical cancer has been reported, the results of i... https://www.spandidos-publications.com/10.3892/or.2012.2005/abstract TRIAD1 is negatively regulated by the MDM2 E3 ligase Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. by the negatively regulated mdm2 e3 https://www.ncbi.nlm.nih.gov/nuccore/NM_002392 Homo sapiens MDM2 proto-oncogene (MDM2), transcript variant 1, mRNA - Nucleotide - NCBI homo sapiens proto oncogene transcript variant mdm2 https://www.thermofisher.com/antibody/product/Phospho-MDM2-Ser166-Antibody-clone-14F8-Recombinant-Monoclonal/MA5-50176 Phospho-MDM2 (Ser166) Recombinant Rabbit Monoclonal Antibody (14F8) | Invitrogen (MA5-50176) Detect Phospho-MDM2 (Ser166) in WB, IHC (P), ELISA, ICC/IF, Flow. Reacts with Rabbit. Catalog # MA5-50176 rabbit monoclonal phospho mdm2 recombinant