p53 - Robuta Search

https://www.atlantis-press.com/proceedings/gdic-20/125960234 Identification of Apoptosis Marker in Preeclampsia: A Pre-Eliminary Study of P53 Gene Expression in... Preeclampsia still becomes a leading cause of maternal and perinatal mortality. The placenta is a critical subject in the pathogenesis of preeclampsia.... https://www.muni.cz/en/research/publications/2239430 Distinct p53 phosphorylation patterns in chronic lymphocytic leukemia patients are reflected in the... chronic lymphocytic leukemia https://www.wikidata.org/wiki/Q36222978 Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice. -... https://pmc.ncbi.nlm.nih.gov/articles/PMC11593115/ TMEM206 Contributes to Cancer Hallmark Functions in Colorectal Cancer Cells and Is Regulated by p53... Acid-induced ion flux plays a role in pathologies where tissue acidification is prevalent, including cancer. In 2019, TMEM206 was identified as the molecular... https://www.preprints.org/manuscript/202504.1298 miR-7-5p and Importin-7 Regulate the p53 Dynamics and Stability in Malignant and Benign Thyroid... Thyroid carcinogenesis has multiple hallmarks, including evasion of tumor suppressors. Reactivation of wild-type p53 function is an ultimate goal in cancer... https://www.jci.org/articles/view/33320/pdf JCI - Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19Arf/p53 pathway... https://www.vumc.org/chtn/publication/interaction-helicobacter-pylori-gastric-epithelial-cells-mediated-p53-protein-fami Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p53 protein... https://spinninrecords.com/talentpool/artist/p53/track/2022-04-maybe P53 - maybe | Spinnin' Records p53 maybe spinnin records https://www.biologyexperimentideas.net/ MDM2, MDMX and p53 in oncogenesis and cancer therapy mdm2 mdmx p53 oncogenesis cancer https://www.wikidata.org/wiki/Q41544440 Hemi- or homozygosity: a requirement for some but not other p53 mutant proteins to accumulate and... scientific article published on July 1993 https://www.wikidata.org/wiki/Q41742127 The p53 nuclear localisation signal is structurally linked to a p34cdc2 kinase motif - Wikidata scientific article published on March 1990 https://www.wikidata.org/wiki/Q35268497 Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study -... https://pmc.ncbi.nlm.nih.gov/articles/PMC5559307/ Analytic, Pre-analytic and Clinical Validation of p53 Immunohistochemistry for Detection of TP53... TP53 missense mutations may help to identify prostate cancer (PCa) with lethal potential. Here, we pre-analytically, analytically and clinically validated a... clinical validation analytic pre https://www.ncbi.nlm.nih.gov/Structure/pdb/5AOK 5AOK: Structure of the p53 cancer mutant Y220C with bound small molecule PhiKan7099 CELLULAR TUMOR ANTIGEN P535-[2-cyclopropyl-5-(1H-pyrrol-1-yl)-1,3-oxazol-4-yl]-1H-1,2,3,4-tetrazoleGLYCEROLZINC ION https://www.news-medical.net/news/20130722/p53-and-cancer-research-an-interview-with-Professor-Sir-David-Lane-Scientific-Director-of-the-Ludwig-Institute-for-Cancer-Research.aspx p53 and cancer research: an interview with Professor Sir David Lane, Scientific Director of the... Apr 8, 2023 - P53 is a tumor suppressor gene. The gene encodes for a protein that monitors the state of the cell. If something goes wrong, it stops the cell from dividing or... https://www.jci.org/articles/view/70355 JCI - p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes https://www.rcsb.org/structure/8QWK RCSB PDB - 8QWK: Structure of p53 cancer mutant Y126C Structure of p53 cancer mutant Y126C rcsb pdb structure p53 cancer mutant https://www.spandidos-publications.com/10.3892/ol.2011.267/abstract Protein expression status of p53 and epidermal growth factor receptor in thymoma Oncology Letters is an international journal devoted to Experimental and Clinical Oncology. epidermal growth factor protein expression https://www.jci.org/articles/view/174447 JCI - Transient p53/p21 activation selectively protects healthy human hair follicles and their stem... https://www.proquest.com/docview/304682923 p53-Dependent neural stem cell death regulation - ProQuest Explore millions of resources from scholarly journals, books, newspapers, videos and more, on the ProQuest Platform. neural stem cell p53 dependent death regulation https://elifesciences.org/reviewed-preprints/103904v1/reviews NOLC1 Suppresses Immuno-chemotherapy by Inhibiting p53-mediated Ferroptosis in Gastric Cancer https://www.utmb.edu/bmb/seminars/academic-year/2023/03/21/default-calendar/genetic-approaches-to-the-p53-paradox Genetic approaches to the p53 paradox Speaker: Dr. Annika Wylie University of Texas Southwestern Host: Junji Iwahara, PhD to the genetic approaches p53 paradox https://www.rcsb.org/structure/4AGO RCSB PDB - 4AGO: Structure of the p53 core domain mutant Y220C bound to the stabilizing small... Structure of the p53 core domain mutant Y220C bound to the stabilizing small molecule PhiKan5174 https://www.wikidata.org/wiki/Q70872946 The p53 tumour suppressor gene and tumour prognosis: is there a relationship? - Wikidata scientific article published on 01 November 1995 tumour suppressor gene https://pmc.ncbi.nlm.nih.gov/articles/PMC5351382/ Apigenin enhances the cisplatin cytotoxic effect through p53-modulated apoptosis - PMC Epidemiological and experimental evidence suggests that dietary flavonoids, including apigenin, have anticancer roles. Apigenin has been reported to elevate... apigenin enhances cisplatin cytotoxic https://scienceblog.com/small-molecule-may-disarm-enemy-of-cancer-fighting-p53/ Small molecule may disarm enemy of cancer-fighting p53 - ScienceBlog.com Dec 7, 2010 - ORLANDO -- A pioneering clinical trial is testing the effectiveness in leukemia of a small molecule that shuts down MDM2, a protein that can disable the... small molecule enemy of may disarm https://www.rcsb.org/structure/8V15 RCSB PDB - 8V15: Human SIRT3 bound to p53-AMC peptide, Carba-NAD, and Honokiol Human SIRT3 bound to p53-AMC peptide, Carba-NAD, and Honokiol https://www.biospace.com/ascentage-pharma-s-mdm2-p53-inhibitor-apg-115-alrizomadlin-granted-an-orphan-drug-designation-by-the-fda-for-the-treatment-of-stage-iib-iv-melanoma-marking-the-twelfth-obtained-by-the-company Ascentage Pharma's MDM2-p53 Inhibitor APG-115 (Alrizomadlin) Granted an Orphan Drug Designation by... Jul 21, 2021 - Ascentage Pharma, a globally focused biotechnology company engaged in developing novel therapies for cancers, chronic hepatitis B, and age-related diseases,... https://pmc.ncbi.nlm.nih.gov/articles/PMC6393013/ Recombinant adenovirus-p53 enhances the therapeutic effect of surgery and chemoradiotherapy... The purpose of our study was to assess the safety and efficacy of recombinant adenovirus-p53 (rAd-p53) combined with surgery and chemoradiotherapy (CRT) for... therapeutic effect recombinant adenovirus p53 enhances https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.761080/full Frontiers | p53 Modulation of Autophagy Signaling in Cancer Therapies: Perspectives Mechanism and... The key tumor suppressor protein p53, additionally known as p53, represents an attractive target for the development and management of anti-cancer therapies.... https://www.jci.org/articles/view/143945 JCI - Targeting the mutant p53 secretome the mutant jci targeting p53 secretome https://www.wikidata.org/wiki/Q40023550 The CDK7-cycH-p36 Complex of Transcription Factor IIH Phosphorylates p53, Enhancing Its... scientific article published on October 1, 1997 https://www.wikidata.org/wiki/Q71644976 Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1 - Wikidata scientific article published on 01 September 1994 thrombospondin 1 control angiogenesis fibroblasts https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1057829/full Frontiers | The role of p53 in liver fibrosis The tumor suppressor p53 is the central hub of a molecular network, which controls cell proliferation and death, and also plays an important role in the occu... the role frontiers p53 liver fibrosis https://www.rcsb.org/structure/2YDR RCSB PDB - 2YDR: CpOGA D298N in complex with p53-derived O-GlcNAc peptide CpOGA D298N in complex with p53-derived O-GlcNAc peptide https://www.jci.org/articles/view/33320/figure/1 JCI - Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19Arf/p53 pathway... https://pmc.ncbi.nlm.nih.gov/articles/PMC7328920/ P53 in lung vascular barrier dysfunction - PMC Endothelial barrier dysfunction is the hallmark of inflammatory lung disease, including Acute Lung Injury and Acute Respiratory Distress Syndrome. The purpose... p53 lung vascular barrier dysfunction https://www.ifixit.com/it-it/products/lenovo-thinkpad-p53-battery Batteria Lenovo ThinkPad P53 - 02DL028 Replace a 7800 mAh battery compatible with Lenovo ThinkPad P53 laptops. lenovo thinkpad p53 batteria https://www.jci.org/articles/view/205966/pdf JCI - Hitting pause on chemotherapy-induced alopecia: transient p53 activation as a guardian of the... https://p53.mshri.on.ca/ 20th International p53 Workshop | p53 Conference - April 27 - May 1, 2026 27 may 1 20th international p53 workshop https://www.rcsb.org/structure/5LAP RCSB PDB - 5LAP: p53 cancer mutant Y220C with Cys182 alkylation p53 cancer mutant Y220C with Cys182 alkylation rcsb pdb p53 cancer mutant alkylation https://www.wikidata.org/wiki/Q38339027 Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer... https://www.mdanderson.org/newsroom/archived-news/protein-disables-p53-drives-breast-cells-toward-cancer-transitio.h00-158598468.html ARCHIVED: Protein Disables p53, Drives Breast Cells Toward Cancer Transition | UT MD Anderson https://pmc.ncbi.nlm.nih.gov/articles/PMC25646/ Mechanisms of G2 Arrest in Response to Overexpression of p53 - PMC Overexpression of p53 causes G2 arrest, attributable in part to the loss of CDC2 activity. Transcription of cdc2 and cyclin B1, determined using reporter... in response mechanisms g2 arrest overexpression https://www.wikidata.org/wiki/Q74243929 c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a... scientific article published on 01 May 2002 https://www.wikidata.org/wiki/Q41063629 Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo. - Wikidata https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.00923/full Frontiers | The Stapled Peptide PM2 Stabilizes p53 Levels and Radiosensitizes Wild-Type p53 Cancer... The tumor suppressor p53 is a key mediator of cellular stress and DNA damage response cascades and is activated after exposure to ionizing radiation. Amplify... https://www.jci.org/articles/view/28920/figure/1 JCI - A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.728381/full Frontiers | p53 Activation Effect in the Balance of T Regulatory and Effector Cell Subsets in... Carcinomas evade the host immune system by negatively modulating CD4+ and CD8+ T effector lymphocytes through forkhead box protein 3 (FOXP3) positive T regul... https://www.uab.cat/ca/ibb/agenda/20250123/seminari-jerson-silva-2025 Seminari: "Phase Separation and Aggregation of Mutant p53 and Its Paralogs as Novel Targets in... Seminari Jerson L. Silva https://spinninrecords.com/talentpool/artist/p53/track/2022-06-new-york P53 - new york | Spinnin' Records new york p53 spinnin records https://www.preprints.org/manuscript/202507.0780 Mutation of p53 Acetylation Protects Against Angiotensin-II-Induced Cardiac Dysfunction and... Background: Hypertension is a major risk factor for heart failure. Acetylation of p53 is known to regulate its activities. We have previously identified that... https://www.ncbi.nlm.nih.gov/Structure/pdb/8V2N 8V2N: Human SIRT3 co-crystallized with ligands, including p53-AMC peptide and Carba-NAD GLN-PRO-LYS-FDLNAD-dependent protein deacetylase sirtuin-3, mitochondrialCARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDEZINC ION https://www.jci.org/articles/view/67315/figure/1 JCI - Retinal angiogenesis suppression through small molecule activation of p53 small molecule jci retinal angiogenesis suppression https://www.wikidata.org/wiki/Q40831456 A comparison of the biological activities of wild-type and mutant p53. - Wikidata a comparison of the biological activities https://www.wikidata.org/wiki/Q34619732 ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1... https://spinninrecords.com/talentpool/artist/p53/track/2022-04-farewell P53 - farewell | Spinnin' Records p53 farewell spinnin records https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1494110/full Frontiers | Corrigendum: Targeting p53 misfolding conundrum by stabilizing agents and their... Breast carcinoma is one of the most frequent malignancies diagnosed globally and the chief cause of mortality among females (Siegel et al., 2021;Mir and Qayo... stabilizing agents frontiers corrigendum targeting p53 https://www.jci.org/articles/view/205966/usage JCI - Usage information: Hitting pause on chemotherapy-induced alopecia: transient p53 activation... usage information https://pmc.ncbi.nlm.nih.gov/articles/PMC16540/ Identification and characterization of a p53 homologue in Drosophila melanogaster - PMC The tumor suppressor gene p53 in mammalian cells plays a critical role in safeguarding the integrity of genome. It functions as a sequence-specific... drosophila melanogaster identification characterization https://pmc.ncbi.nlm.nih.gov/articles/PMC23579/ p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic... Loss of functional p53 paradoxically results in either increased or decreased resistance to chemotherapeutic drugs. The inconsistent relationship between p53... gene expression https://elifesciences.org/articles/02482v1 SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint... https://pmc.ncbi.nlm.nih.gov/articles/PMC11100565/ Ketogenic diet induces p53-dependent cellular senescence in multiple organs - PMC A ketogenic diet (KD) is a high-fat, low-carbohydrate diet that leads to the generation of ketones. While KDs improve certain health conditions and are popular... ketogenic diet cellular senescence induces p53 dependent https://www.spandidos-publications.com/10.3892/ol.2015.3624 Analysis of the correlation between P53 and Cox-2 expression and prognosis in esophageal cancer Oncology Letters is an international journal devoted to Experimental and Clinical Oncology. https://www.wikidata.org/wiki/Q40660065 Characterization of mutant p53-hsp72/73 protein-protein complexes by transient expression in monkey... scientific article published on September 1988 https://elifesciences.org/reviewed-preprints/88916/reviews Complex aneuploidy triggers autophagy and p53-mediated apoptosis and impairs the second lineage... https://www.jci.org/articles/view/205966 JCI - Hitting pause on chemotherapy-induced alopecia: transient p53 activation as a guardian of the... https://www.wikidata.org/wiki/Q34103258 p53: death star - Wikidata death star p53 wikidata https://www.wikidata.org/wiki/Q38338868 Evidence that p53 behaves as a tumour suppressor gene in sporadic breast tumours - Wikidata https://www.cancer.gov/research/participate/clinical-trials-search/v?id=NCI-2019-05417&r=1 Study of ASTX295 in Patients With Solid Tumors With Wild-Type p53 - NCI Study of ASTX295 in Patients With Solid Tumors With Wild-Type p53 in patients https://www.jci.org/articles/view/87724/figure/1 JCI - Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication jci mutant p53 establishes https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.583146/full Frontiers | The Nuclear Farnesoid X Receptor Reduces p53 Ubiquitination and Inhibits Cervical... The role of farnesoid X receptor (FXR) in cervical cancer and the underlying molecular mechanism remain largely unknown. Therefore, this study aimed to asses... farnesoid x receptor https://www.jci.org/articles/view/28920 JCI - A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo https://www.muni.cz/en/research/publications/1216619 Distinct in vitro sensitivity of p53-mutated and ATM-mutated chronic lymphocytic leukemia cells to... https://www.spandidos-publications.com/10.3892/etm.2013.1399/abstract Apoptosis and p53 expression in the placental villi of females with unexplained recurrent... Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine. https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2019.00282/full Frontiers | Corrigendum: A Novel Small Molecule p53 Stabilizer for Brain Cell Differentiation please introduce the same body text of the proof corrections a novel small molecule https://www.rcsb.org/structure/4IBQ RCSB PDB - 4IBQ: Human p53 core domain with hot spot mutation R273C Human p53 core domain with hot spot mutation R273C rcsb pdb https://elifesciences.org/reviewed-preprints/88256 PITAR, a DNA damage-inducible Cancer/Testis long noncoding RNA, inactivates p53 by binding and... https://pmc.ncbi.nlm.nih.gov/articles/PMC15761/ Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis -... Induction of wild-type p53 in mouse fibroblasts causes cell cycle arrest at the G1 phase, whereas coexpression of p53 and the protooncogene c-myc induces... https://elifesciences.org/articles/13446v1 Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma... https://elifesciences.org/articles/22477v1/peer-reviews Peer review in MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect |... https://pmc.ncbi.nlm.nih.gov/articles/PMC24879/ Specific interaction of mutant p53 with regions of matrix attachment region DNA elements (MARs)... Mutant, but not wild-type p53 binds with high affinity to a variety of MAR-DNA elements (MARs), suggesting that MAR-binding of mutant p53 relates to the... matrix attachment region https://www.preprints.org/manuscript/202105.0703 AML-related NPM Mutations Drive p53 Delocalization Into the Cytoplasm With Possible Impact on... NPM interaction with tumor suppressor p53 is a part of a complex interaction network and considerably affects cellular stress response. An impact of... https://pmc.ncbi.nlm.nih.gov/articles/PMC9733976/ Mitogen Activated Protein Kinase (MAPK) Activation, p53, and Autophagy Inhibition Characterize the... The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and prions use common pathogenic pathways to induce toxicity in neurons.... mitogen activated protein https://pmc.ncbi.nlm.nih.gov/articles/PMC111528/ E1B 55-Kilodalton Oncoproteins of Adenovirus Types 5 and 12 Inactivate and Relocalize p53, but Not... The p53 tumor suppressor protein represents a target for viral and cellular oncoproteins, including adenovirus gene products. Recently, it was discovered that... https://www.mskcc.org/cancer-care/clinical-trials/21-162 A Phase I/II Study of PC14586 in People with Solid Tumors Containing a p53 Y220C Mutation |... Full Title A Phase 1/2 Open-label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of PC14586 in... https://www.spandidos-publications.com/10.3892/or.2015.3715/abstract p53-induced microRNA-1246 inhibits the cell growth of human hepatocellular carcinoma cells by... Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. https://spinninrecords.com/talentpool/artist/p53/track/2021-12-where-is-god P53 - where is god | Spinnin' Records where is p53 god spinnin records https://www.spandidos-publications.com/10.3892/or.10.5.1265/abstract P53-induced gene 11 (PIG11) involved in arsenic trioxide-induced apoptosis in human gastric cancer... Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. https://pmc.ncbi.nlm.nih.gov/articles/PMC21638/ The expression of the KAI1 gene, a tumor metastasis suppressor, is directly activated by p53 - PMC KAI1 is a tumor metastasis suppressor gene that is capable of inhibiting the metastatic process in animals. The expression of the KAI1 gene also is found to be... https://www.wikidata.org/wiki/Q53459620 p53 overexpression in the multistep process of esophageal carcinogenesis. - Wikidata in the p53 overexpression multistep process https://www.mdpi.com/2077-0383/9/2/598 p53 CRISPR Deletion Affects DNA Structure and Nuclear Architecture The TP53 gene is a key tumor suppressor. Although the tumor suppressor p53 was one of the first to be characterized as a transcription factor, with its main... dna structure p53 crispr deletion affects https://www.scirp.org/journal/paperinformation?paperid=5629 Preoperative evaluation of P53 and bcl-2 over expression in clinical stage 1 endometrial carcinoma... Discover the impact of P53 and bcl-2 overexpression on endometrial carcinoma prognosis. Study reveals adverse surgical criteria and increased mortality rate. https://www.ncbi.nlm.nih.gov/Structure/pdb/8UQR 8UQR: Crystal structure of the human p53 tetramerization domain Cellular tumor antigen p53 crystal structure of the human p53 domain https://pmc.ncbi.nlm.nih.gov/articles/PMC6276637/ Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action - PMC p53 is a tumor suppressor gene involved in various cellular mechanisms including DNA repair, apoptosis, and cell cycle arrest. More than 50% of human cancers... https://sciencedaily.com/releases/2022/07/220712102714.htm p53 in liver cancer: The ultimate betrayal? | ScienceDaily Researchers identified a novel mechanism by which expression of the tumor suppressor p53 paradoxically promotes liver cancer development in patients with... the ultimate betrayal liver cancer p53 sciencedaily https://elifesciences.org/articles/55325/peer-reviews Peer review in Parallel CRISPR-Cas9 screens clarify impacts of p53 on screen performance | eLife The protein p53 negatively impacts the ability of a CRISPR screen to discriminate between essential and non-essential genes, hence, p53 status should be... https://www.wikidata.org/wiki/Q41414258 Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the... scientific article published on December 1994 https://www.spandidos-publications.com/10.3892/ijmm.8.2.159/abstract Proliferating cell nuclear antigen labeling index and p53 expression predict outcome for breast... International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease. https://www.wikidata.org/wiki/Q37599465 A mutant p53 protein is required for maintenance of the transformed phenotype in cells transformed... scientific article published on May 1, 1992