nlrp3 - Robuta Search

https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.967594/full Frontiers | Pharmacological effects of Chinese medicine modulating NLRP3 inflammasomes in fatty... Inflammation is a key contributing factor in the pathogenesis of fatty liver diseases (FLD), such as nonalcoholic fatty liver disease (NAFLD), and alcohol-as... chinese medicine frontiers pharmacological effects https://www.ncbi.nlm.nih.gov/Structure/pdb/9GU4 9GU4: Crystal structure of NLRP3 in complex with inhibitor NP3-253 NACHT, LRR and PYD domains-containing protein 3ADENOSINE-5'-DIPHOSPHATE crystal structure nlrp3 https://www.jci.org/articles/view/169986 JCI - UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis fatty acid synthase https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.02305/full Frontiers | Regulation of NLRP3 Inflammasome by Phosphorylation The cytosolic pattern recognition receptor (PRR) NOD-like receptor family, pyrin domain containing 3 (NLRP3) senses a wide range of pathogen-associated molec... nlrp3 inflammasome frontiers regulation phosphorylation https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01728/full Frontiers | Relevance of the NLRP3 Inflammasome in the Pathogenesis of Chronic Liver Disease Inflammation is a common characteristic of most chronic liver disease (CLD). Inflammasomes are multi-protein complexes that can sense and recognize various e... of the nlrp3 inflammasome frontiers relevance https://www.mdpi.com/1422-0067/22/22/12434 The Role of Cytokines Produced via the NLRP3 Inflammasome in Mouse Macrophages Stimulated with... Dental calculus (DC) is a common deposit in periodontitis patients. We have previously shown that DC contains both microbial components and calcium phosphate... https://pmc.ncbi.nlm.nih.gov/articles/PMC7878893/ Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3 - PMC Fulminant hepatitis (FH) is an incurable clinical syndrome where novel therapeutics are warranted. Withaferin A (WA), isolated from herb Withania Somnifera, is... withaferin a fulminant hepatitis https://www.bas.bg/?p=29866&lang=en New clinical evidence confirms the hypothesis of scientists of BAS for the role of NLRP3... Apr 29, 2020 - Studies launched in 2010 by scientists at the Institute of Biology and Immunology of Reproduction at the Bulgarian Academy of Sciences (IBIR-BAS) suggest that... clinical evidence https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1516120/full Frontiers | Caspase-11 and NLRP3 exacerbate systemic Klebsiella infection through reducing... IntroductionKlebsiella pneumoniae is a Gram-negative bacterium and the third most commonly isolated microorganism in blood cultures from septic patients. Des... caspase 11 klebsiella infection frontiers nlrp3 https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.812362/full Frontiers | Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via... Depression is a common and serious mental disorder. Data on its pathogenesis remain unclear and the options of drug treatments are limited. Here, we explored... frontiers salidroside depression nlrp3 mediated https://www.thermofisher.com/antibody/product/NLRP3-Antibody-clone-3H1A7-Monoclonal/68102-1-IG150UL NLRP3 Monoclonal Antibody (3H1A7) | Invitrogen (68102-1-IG150UL) Detect NLRP3 in WB, ICC/IF, IHC (P), Flow, ELISA. Reacts with Rabbit, Mouse, Goat, Rat. Catalog # 68102-1-IG150UL monoclonal antibody nlrp3 invitrogen 1 https://www.uibk.ac.at/events/2026/01/23/relevance-of-the-nlrp3-inflammasome-on-orthodontic-tooth-movement Relevance of the NLRP3 Inflammasome on Orthodontic Tooth Movement in a Mouse Model -... Veranstaltungstyp: Defensio; orthodontic tooth movement https://medlineplus.gov/genetics/gene/nlrp3/ NLRP3 gene: MedlinePlus Genetics The NLRP3 gene provides instructions for making a protein called cryopyrin. Learn about this gene and related health conditions. nlrp3 gene medlineplus https://elifesciences.org/articles/49248v1 ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in Cystic Fibrosis | eLife https://pmc.ncbi.nlm.nih.gov/articles/PMC6121934/ Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3... Circulating oxidized linoleic acid (LA) metabolites (OXLAMs) are increased in patients with nonalcoholic steatohepatitis (NASH) and their levels correlate with... linoleic acid mitochondrial dysfunction oxidized metabolites induce https://www.ebi.ac.uk/chembl/explore/document/CHEMBL5390258 Document: Recent Progress and Prospects of Small Molecules for NLRP3 Inflammasome Inhibition.... Report card for Document Recent Progress and Prospects of Small Molecules for NLRP3 Inflammasome Inhibition. (CHEMBL5390258). J Med Chem, NLRP3 inflammasome is... recent progress https://www.spandidos-publications.com/10.3892/mmr.2026.13901 [Retracted] Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3... Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery. traumatic brain injury https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1497984/full Frontiers | Apigenin inhibits NLRP3 inflammasome activation in monocytes and macrophages... IntroductionCD38, a regulator of intracellular calcium signalling, is highly expressed in immune cells. Mice lacking CD38 are very susceptible to acute bacte... nlrp3 inflammasome frontiers apigenin activation monocytes https://pmc.ncbi.nlm.nih.gov/articles/PMC11955958/ Biological and therapeutic significance of targeting NLRP3 inflammasome in the brain and the... NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, a pivotal regulator of the innate immune system, orchestrates inflammatory responses... nlrp3 inflammasome biological therapeutic significance https://elifesciences.org/articles/82766 Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors | eLife A horizontally shared type VI secretion system affects the interaction between vibrios and eukaryotic hosts. nlrp3 inflammasome https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2022.992769/full Frontiers | NLRP3 inflammasome activation contributes to the cognitive decline after cardiac surgery Background: Perioperative neurocognitive disorders (PND) are a common complication of cardiac surgery in elderly patients. The etiopathogenesis of PND is not... nlrp3 inflammasome to the https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1250918/full Frontiers | Advancements in research on the immune-inflammatory mechanisms mediated by NLRP3... Ischemic stroke (IS) is a major cause of mortality and disability among adults.Recanalization of blood vessels to facilitate timely reperfusion is the primar... in research on the https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2018.00709/full Frontiers | Association Analysis of NLRP3 Inflammation-Related Gene Promotor Methylation as Well as... Abstract Objective: To explore the association between the methylation levels in the promoter regions of the NLRP3, AIM2 and ASC genes and T2DM and its vascu... https://pmc.ncbi.nlm.nih.gov/articles/PMC8416146/ Oxymatrine attenuates oxidized low-density lipoprotein-induced HUVEC injury by inhibiting NLRP3... Oxymatrine, a quinolizidine alkaloid isolated from the traditional Chinese herb Sophora flavescens Aiton, has been demonstrated to exert anti-inflammatory and... low density lipoprotein https://www.jci.org/articles/view/83260/figure/4 JCI - Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects https://elifesciences.org/articles/49248/figures Figures and data in ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic... Dysfunction and overexpression of ENaC-mediated sodium influx exacerbates activation of NLRP3-inflammasome mediated inflammation in cells with CF-associated... https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2020.00155/full Frontiers | Inhibition of NLRP3 Inflammasome: A Prospective Target for the Treatment of Ischemic... Stroke is one of the major devastating diseases with no effective medical therapeutics. Because of the high rate of disability and mortality among stroke pat... nlrp3 inflammasome https://www.muni.cz/en/research/publications/1416044 Association of the NOD-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis... https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.727474/full Frontiers | MCC950, a Selective NLRP3 Inhibitor, Attenuates Adverse Cardiac Remodeling Following... Obesity is often accompanied by hypertension. Although a large number of studies have confirmed that NLRP3 inhibitors can improve cardiac remodeling in mice ... cardiac remodeling frontiers mcc950 selective nlrp3 https://elifesciences.org/articles/73675 Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon |... Cellular, genetic, and biochemical assays shows that the application of a specific type of currents in mouse tendons induces an inflammatory response that... https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1105973/full Frontiers | PHLDA1 modulates microglial response and NLRP3 inflammasome signaling following... Balancing microglia M1/M2 polarization is an effective therapeutic strategy for neuroinflammation after subarachnoid hemorrhage (SAH). Pleckstrin homology-li... nlrp3 inflammasome frontiers phlda1 microglial response https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1407721/full Frontiers | Current research status and future prospects of NLRP3 inflammasome in cardiovascular... Background: Cardiovascular disease (CVD) is a leading cause of global mortality, with atherosclerosis (AS) contributing to its pathological basis. Inflammati... current research future prospects https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01518/full Frontiers | Targeting the NLRP3 Inflammasome in Severe COVID-19 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus Betacoronavirus within the family Coronaviridae. It is an enveloped sin... nlrp3 inflammasome frontiers targeting severe covid https://www.muni.cz/en/research/publications/1423235 Association of NOD-like receptor (NLRP3) gene variability with chronic periodontitis and type 2... https://www.mdpi.com/1999-4915/15/12/2419 Altered Ex Vivo NLRP3 Inflammasome Activation Is Associated with 28-Day Mortality in Septic Patients Sepsis is a life-threatening organ dysfunction caused by a dysregulated response to infection. In this context, the aberrant activation of the NLRP3... https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1526616/full Frontiers | Cordycepin attenuates NLRP3/Caspase-1/GSDMD-mediated LPS-induced macrophage pyroptosis Pyroptosis, a form of programmed cell death driven by the NLRP3 inflammasome, is a key contributor to inflammation in various diseases. This study aimed to i... caspase 1 https://www.thermofisher.com/antibody/product/NLRP3-Antibody-clone-1O9U2-Recombinant-Monoclonal/MA5-51539 NLRP3 Recombinant Rabbit Monoclonal Antibody (1O9U2) | Invitrogen (MA5-51539) Detect NLRP3 in WB, ICC/IF, IHC (P), Flow, ELISA. Reacts with Rabbit, Mouse, Goat, Rat. Catalog # MA5-51539 rabbit monoclonal nlrp3 recombinant antibody invitrogen https://www.jci.org/articles/view/78253/figure/1 JCI - UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis fatty acid synthase https://elifesciences.org/articles/49248/peer-reviews Peer review in ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic... Dysfunction and overexpression of ENaC-mediated sodium influx exacerbates activation of NLRP3-inflammasome mediated inflammation in cells with CF-associated... peer review https://www.mdpi.com/2072-6643/13/7/2409 Caffeine Has Different Immunomodulatory Effect on the Cytokine Expression and NLRP3 Inflammasome... Besides its well-known psychoactive effects, caffeine has a broad range of actions. It regulates several physiological mechanisms as well as modulates both... on the https://pmc.ncbi.nlm.nih.gov/articles/PMC3218743/ The role of the NLRP3 inflammasome in gout - PMC Gout is an inflammatory arthritis characterized by abrupt self-limiting attacks of inflammation caused by precipitation of monosodium urate crystals (MSU) in... the role nlrp3 inflammasome gout pmc https://elifesciences.org/articles/75166/peer-reviews Peer review in Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in... Mutated NLRP3 forms cryo-sensitive aggregates that induce inflammasome assembly distinct from the canonical NLRP3 inflammasome. peer review nlrp3 inflammasome cryo sensitive aggregation https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2022.956079/full Frontiers | Microglial activation in the motor cortex mediated NLRP3-related neuroinflammation and... Spinal cord injury (SCI) is a traumatic event that can lead to neurodegeneration. Neuronal damage in primary motor cortex (M1) can hinder the recovery of mot... microglial activation in the motor cortex https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1190219/full Frontiers | Divergent functional outcomes of NLRP3 blockade downstream of multi-inflammasome... NOD-Like Receptor Family Pyrin Domain Containing (NLRP3) inflammasome modulation has emerged as a potential therapeutic approach targeting inflammation ampli... functional outcomes frontiers divergent nlrp3 blockade https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.966279/full Frontiers | NLRP3 neuroinflammatory factors may be involved in atopic dermatitis mental disorders:... AbstractBackground: Numerous clinical studies have shown that atopic dermatitis (AD) is often associated with mental disorders. This could contribute to the ... may be https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1364161/full Frontiers | Corilagin alleviates atherosclerosis by inhibiting NLRP3 inflammasome activation via... Atherosclerosis, a leading cause of global cardiovascular mortality, is characterized by chronic inflammation. Central to this process is the NOD-like recept... nlrp3 inflammasome frontiers corilagin atherosclerosis inhibiting https://elifesciences.org/articles/75166 Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic... Mutated NLRP3 forms cryo-sensitive aggregates that induce inflammasome assembly distinct from the canonical NLRP3 inflammasome. nlrp3 inflammasome cryo sensitive aggregation triggers https://elifesciences.org/articles/59704 LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation |... Depletion of LRRC8A provides genetic evidence for the importance of Cl- channels in NLRP3 activation.