Sponsor of the Day:
Jerkmate
https://pdb101.rcsb.org/motm/316
PDB-101: Molecule of the Month: Insect Odorant Receptors
Protein complexes that allow insects to detect a wide variety of volatile compounds
pdb 101 moleculemonthinsectodorantreceptors
https://pdb101.rcsb.org/motm/272
PDB-101: Molecule of the Month: Secretory Antibodies
Secretory immunoglobulins are our most abundant antibodies, providing a first line of defense against pathogens.
pdb 101 moleculemonthsecretoryantibodies
https://pdb101.rcsb.org/motm/302
PDB-101: Molecule of the Month: H5 Hemagglutinin
Sugar-binding protein on the surface of the H5N1 avian influenza virus
pdb 101 moleculemonthh5
https://pdb101.rcsb.org/motm/120
PDB-101: Molecule of the Month: Antifreeze Proteins
Small antifreeze proteins protect cells from damage by ice
pdb 101 moleculemonthantifreezeproteins
https://pdb101.rcsb.org/motm/254
PDB-101: Molecule of the Month: Cellulose Synthase
Plants build tough cellulose strands one sugar at a time.
pdb 101 moleculemonthcellulosesynthase
https://pdb101.rcsb.org/motm/155
PDB-101: Molecule of the Month: Vitamin D Receptor
Vitamin D helps regulate the use of calcium throughout the body
pdb 101 moleculemonthvitaminreceptor
https://pdb101.rcsb.org/motm/83
PDB-101: Molecule of the Month: Fibrin
Rod-shaped fibrin molecules link together to form blood clots
pdb 101 moleculemonthfibrin
https://pdb101.rcsb.org/motm/214
PDB-101: Molecule of the Month: Chimeric Antigen Receptors
T cells may be engineered with chimeric antigen receptors to attack cancer cells.
pdb 101 moleculechimeric antigenmonthreceptors
https://pdb101.rcsb.org/motm/motm-by-date
PDB-101: Molecule of the Month By Date
PDB-101: Training, Outreach, and Education portal of RCSB PDB
pdb 101 moleculemonthdate
https://pdb101.rcsb.org/motm/174
PDB-101: Molecule of the Month: GFP-like Proteins
GFP-like proteins found in nature or engineered in the laboratory now span every color of the rainbow
pdb 101 moleculemonthgfplikeproteins
https://pdb101.rcsb.org/motm/17
PDB-101: Molecule of the Month: Cyclooxygenase
Aspirin attacks an important enzyme in pain signaling and blood clotting
pdb 101 moleculemonth
https://pdb101.rcsb.org/motm/185
PDB-101: Molecule of the Month: Titin
The giant protein titin organizes the structure of muscle and gives them elasticity
pdb 101 moleculemonth
https://pdb101.rcsb.org/motm/77
PDB-101: Molecule of the Month: Glucose Oxidase
Glucose oxidase measures blood glucose level in biosensors
pdb 101 moleculemonthglucoseoxidase
https://pdb101.rcsb.org/motm/287
PDB-101: Molecule of the Month: ZAR1 Resistosome
Plants protect themselves from infection with immune system machines such as the resistosome
pdb 101 moleculemonth
https://pdb101.rcsb.org/motm/40
PDB-101: Molecule of the Month: RNA Polymerase
RNA polymerase transcribes genetic information from DNA into RNA
pdb 101 moleculerna polymerasemonth
https://pdb101.rcsb.org/motm/27
PDB-101: Molecule of the Month: Bacteriorhodopsin
Bacteriorhodopsin pumps protons powered by green sunlight
pdb 101 moleculemonth
https://pdb101.rcsb.org/motm/100
PDB-101: Molecule of the Month: Adrenergic Receptors
Adrenaline stimulates a G-protein-coupled receptor, priming us for action
pdb 101 moleculemonthadrenergicreceptors
https://pdb101.rcsb.org/motm/68
PDB-101: Molecule of the Month: Neurotrophins
Neurotrophins guide the development of the nervous system
pdb 101 moleculemonth
https://pdb101.rcsb.org/motm/39
PDB-101: Molecule of the Month: lac Repressor
A genetic circuit controls the production of lactose-utilizing enzymes in bacteria
pdb 101 moleculemonthlac
https://pdb101.rcsb.org/motm/123
PDB-101: Molecule of the Month: P-glycoprotein
P-glycoprotein pumps toxic molecules out of our cells
pdb 101 moleculemonthglycoprotein
https://pdb101.rcsb.org/motm/204
PDB-101: Molecule of the Month: PD-1 (Programmed Cell Death Protein 1)
PD-1 and its ligands are a new target for cancer therapy
pdb 101 moleculecell deathmonthprogrammedprotein
https://pdb101.rcsb.org/motm/240
PDB-101: Molecule of the Month: Hypoxia-Inducible Factors
HIF-α is a molecular switch that responds to changing oxygen levels.
pdb 101 moleculemonthhypoxiainduciblefactors
https://pdb101.rcsb.org/motm/253
PDB-101: Molecule of the Month: Expressome
In bacteria, ribosomes start building proteins as messenger RNA is being transcribed
pdb 101 moleculemonth
https://pdb101.rcsb.org/motm/243
PDB-101: Molecule of the Month: Voltage-gated Sodium Channels
Voltage-gated sodium channels transmit signals in a wave through the nervous system.
pdb 101 moleculemonthvoltagegatedsodium
https://pdb101.rcsb.org/motm/52
PDB-101: Molecule of the Month: Growth Hormone
Growth hormone brings together two copies of its cellular receptor
pdb 101 moleculemonth growthhormone
https://pdb101.rcsb.org/motm/46
PDB-101: Molecule of the Month: Trypsin
An activated serine amino acid in trypsin cleaves protein chains
pdb 101 moleculemonthtrypsin
https://pdb101.rcsb.org/motm/221
PDB-101: Molecule of the Month: Human Papillomavirus and Vaccines
The capsid protein of papillomavirus is used in vaccines that prevent cervical cancer.
pdb 101 moleculehuman papillomavirusmonthvaccines
https://pdb101.rcsb.org/motm/88
PDB-101: Molecule of the Month: Clathrin
Three-armed clathrin triskelions are used to build molecular cages involved in transport
pdb 101 moleculemonth
https://pdb101.rcsb.org/motm/252
PDB-101: Molecule of the Month: Hepatitis C Virus Protease/Helicase
Structures of hepatitis C viral proteins have led to the discovery of direct-acting antivirals.
pdb 101 moleculemonthhepatitisvirusprotease
https://pdb101.rcsb.org/motm/306
PDB-101: Molecule of the Month: Eastern Equine Encephalitis Virus
Infection by EEEV can cause severe neurological disease
pdb 101 moleculeequine encephalitismontheasternvirus
https://pdb101.rcsb.org/motm/134
PDB-101: Molecule of the Month: Integrin
Integrins forge flexible linkages between the infrastructure inside and outside of cells
pdb 101 moleculemonth
https://pdb101.rcsb.org/motm/motm-by-title
PDB-101: Molecule of the Month By Title
PDB-101: Training, Outreach, and Education portal of RCSB PDB
pdb 101 moleculemonthtitle
https://pdb101.rcsb.org/motm/198
PDB-101: Molecule of the Month: Beta-galactosidase
Beta-galactosidase is a powerful tool for genetic engineering of bacteria
pdb 101 moleculemonthbetagalactosidase
https://pdb101.rcsb.org/motm/139
PDB-101: Molecule of the Month: DNA Methyltransferases
Cells add methyl groups to their DNA to encode additional epigenetic information
pdb 101 moleculemonth dna
https://pdb101.rcsb.org/motm/127
PDB-101: Molecule of the Month: Crystallins
A concentrated solution of crystallins refracts light in our eye lens
pdb 101 moleculemonth
https://pdb101.rcsb.org/motm/106
PDB-101: Molecule of the Month: Poly(A) Polymerase
Poly(A) polymerase adds a long tail of adenine nucleotides at the end of messenger RNA
pdb 101 moleculemonthpoly
https://pdb101.rcsb.org/motm/motm-image-download
PDB-101: Molecule of the Month Image Download
PDB-101: Training, Outreach, and Education portal of RCSB PDB
pdb 101 moleculeimage downloadmonth
https://pdb101.rcsb.org/motm/315
PDB-101: Molecule of the Month: Lenacapavir
A potent and long-acting drug that targets the HIV capsid
pdb 101 moleculemonthlenacapavir
https://pdb101.rcsb.org/motm/55
PDB-101: Molecule of the Month: DNA Ligase
DNA ligase reconnects broken DNA strands, and is used to engineer recombinant DNA
pdb 101 moleculemonth dnaligase
https://pdb101.rcsb.org/motm/189
PDB-101: Molecule of the Month: Amyloids
Alzheimer's disease and prion diseases are linked to unnatural aggregation of proteins into amyloid fibrils.
pdb 101 moleculemonth
https://pdb101.rcsb.org/motm/223
PDB-101: Molecule of the Month: Piezo1 Mechanosensitive Channel
Mechanosensitive ion channels give our cells a sense of touch.
pdb 101 moleculemonthchannel
https://pdb101.rcsb.org/motm/137
PDB-101: Molecule of the Month: Cytochrome bc1
A flow of electrons powers proton pumps in cellular respiration and photosynthesis
pdb 101 moleculemonthcytochromebc1
https://pdb101.rcsb.org/motm/265
PDB-101: Molecule of the Month: Golgi Casein Kinase
Casein and many other secreted proteins are phosphorylated by Golgi casein kinase
pdb 101 moleculemonthgolgicaseinkinase
https://pdb101.rcsb.org/motm/235
PDB-101: Molecule of the Month: AMPA Receptor
Receptors for the neurotransmitter glutamate in our brain come in several shapes and sizes.
pdb 101 moleculemonthampareceptor
https://pdb101.rcsb.org/motm/178
PDB-101: Molecule of the Month: Ebola Virus Proteins
Structures of ebola virus proteins are giving new hope for fighting this deadly virus
pdb 101 moleculeebola virusmonthproteins
https://pdb101.rcsb.org/motm/135
PDB-101: Molecule of the Month: Integrase
HIV integrase allows HIV to insert itself into the genome of an infected cell
pdb 101 moleculemonthintegrase
https://pdb101.rcsb.org/motm/248
PDB-101: Molecule of the Month: Phytosulfokine Receptor
Phytosulfokine and other small peptides deliver signals about growth and development in plants.
pdb 101 moleculemonthreceptor
https://pdb101.rcsb.org/motm/161
PDB-101: Molecule of the Month: Ricin
The structure of ricin reveals how it kills cells and how vaccines can produce immunity against ricin poisoning
pdb 101 moleculemonth
https://pdb101.rcsb.org/motm/290
PDB-101: Molecule of the Month: Nanowires
Nanowires conduct electrons one at a time inside biological molecules.
pdb 101 moleculemonth
https://pdb101.rcsb.org/motm/199
PDB-101: Molecule of the Month: Monellin
Monellin and other supersweet proteins trick our taste receptors.
pdb 101 moleculemonth
https://pdb101.rcsb.org/motm/226
PDB-101: Molecule of the Month: Aminoglycoside Antibiotics and Resistance
Bacteria become resistant to aminoglycosides by destroying them or changing their target.
pdb 101 moleculemonthaminoglycosideantibioticsresistance
https://pdb101.rcsb.org/motm/113
PDB-101: Molecule of the Month: Influenza Neuraminidase
Neuraminidase is an important target for influenza drugs
pdb 101 moleculemonthinfluenzaneuraminidase
https://pdb101.rcsb.org/motm/222
PDB-101: Molecule of the Month: Proteins and Nanoparticles
Nanotech scientists are designing new ways to combine proteins and nanoparticles
pdb 101 moleculemonthproteinsnanoparticles
https://pdb101.rcsb.org/motm/299
PDB-101: Molecule of the Month: Malaria Parasite PTEX
The parasite that causes malaria exports hundreds of proteins to remodel the cells that it infects.
pdb 101 moleculemonthmalariaparasite
https://pdb101.rcsb.org/motm/34
PDB-101: Molecule of the Month: Dihydrofolate Reductase
DHFR is a target for cancer chemotherapy and bacterial infection
pdb 101 moleculemonthreductase
https://pdb101.rcsb.org/motm/229
PDB-101: Molecule of the Month: Fluorescent RNA Aptamers
RNA aptamers are being engineered to track molecules inside living cells
pdb 101 moleculemonthfluorescentrna
https://pdb101.rcsb.org/motm/138
PDB-101: Molecule of the Month: Glucansucrase
Bacteria adhere to our teeth by building sticky sugar chains
pdb 101 moleculemonth
https://pdb101.rcsb.org/motm/57
PDB-101: Molecule of the Month: Catalase
Catalase protects us from dangerous reactive oxidizing molecules
pdb 101 moleculemonth
https://pdb101.rcsb.org/motm/305
PDB-101: Molecule of the Month: TOC-TIC Translocon
The large TOC-TIC supercomplex transports proteins into the chloroplast
pdb 101 moleculemonthtoctic
https://pdb101.rcsb.org/motm/295
PDB-101: Molecule of the Month: Ribosome Diversity
By comparing the structures of ribosomes from different organisms, we can explore the evolution of life.
pdb 101 moleculemonthribosomediversity
https://pdb101.rcsb.org/motm/95
PDB-101: Molecule of the Month: Multidrug Resistance Transporters
Many bacteria use multidrug resistance transporters to pump drugs and poisons out of the cell
pdb 101 moleculemonthmultidrugresistancetransporters
https://pdb101.rcsb.org/motm/motm-by-category
PDB-101: Molecule of the Month By Category
PDB-101: Training, Outreach, and Education portal of RCSB PDB
pdb 101 moleculemonthcategory
https://pdb101.rcsb.org/motm/201
PDB-101: Molecule of the Month: Isoprene Synthase
Plants release a billion metric tons of isoprene and other organic gases every year.
pdb 101 moleculemonthsynthase
https://pdb101.rcsb.org/motm/205
PDB-101: Molecule of the Month: Nuclear Pore Complex
The nuclear pore complex is the gateway between the nucleus and cytoplasm.
pdb 101 moleculemonthnuclearporecomplex
https://pdb101.rcsb.org/motm/289
PDB-101: Molecule of the Month: Mediator
Mediator integrates regulatory information to decide when genes need to be transcribed.
pdb 101 moleculemonthmediator
https://pdb101.rcsb.org/motm/23
PDB-101: Molecule of the Month: DNA
Atomic structures reveal how the iconic double helix encodes genomic information
pdb 101 moleculemonth dna
https://pdb101.rcsb.org/motm/162
PDB-101: Molecule of the Month: Dermcidin
Small toxic peptides help protect us from bacterial infection
pdb 101 moleculemonth
https://pdb101.rcsb.org/motm/249
PDB-101: Molecule of the Month: SARS-CoV-2 RNA-dependent RNA Polymerase
Coronaviruses duplicate their RNA genome using a specialized polymerase
pdb 101 moleculesars cov 2monthrnadependent
https://pdb101.rcsb.org/motm/246
PDB-101: Molecule of the Month: SARS-CoV-2 Spike
Coronavirus spike protein binds to receptors on cell surfaces, and is a target for vaccine development.
pdb 101 moleculesars cov 2monthspike
https://pdb101.rcsb.org/motm/146
PDB-101: Molecule of the Month: Aminoglycoside Antibiotics
Antibiotic-resistant bacteria build enzymes that destroy drugs like streptomycin
pdb 101 moleculemonthaminoglycosideantibiotics
https://pdb101.rcsb.org/motm/260
PDB-101: Molecule of the Month: Ribonuclease P
The ribozyme ribonuclease P cleaves pre-tRNA to form functional tRNA.
pdb 101 moleculemonthribonuclease