Robuta

Sigma-2 receptors have been implicated in both tumor proliferation and neurodegenerative diseases. Recently the sigma-2 receptor was identified as...

Mutations in Connexin-31 (Cx31) are associated with multiple human diseases including erythrokeratodermia variabilis (EKV). The molecular action of Cx31...

Glioblastoma multiforme (GBM) is the most aggressive type of glioma, displaying atypical glycosylation pattern that may modulate signaling pathways involved in...

A new study shows that CaM kinase II enzyme activity triggers heart cell death by making the cells' energy-producing mitochondria leaky. Inhibiting the enzyme...

Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the developed world.

It is important to prevent cell death during fluorescence microscopy, as dying cells may skew experimental results and introduce artifacts.

Buffett battled a rare form of cancer for years before his death, his website said in a statement on Sunday.

Robust successes have been achieved in recent years in conquering the acutely lethal manifestations of heart disease. Many patients who previously would have...

Oxidative stress is a primary villain in a host of diseases that range from cancer and heart failure to Alzheimer's disease, amyotrophic lateral sclerosis and...

Two molecules with the power of life and death over cells also play a key role in protecting the genome and preventing cancer, a major new study reveals.

Src, an oncogene, promotes both cell proliferation and cell death simultaneously, which can be regulated by dietary methionine.

Demonstration of features of a programmed cell death (PCD) pathway in protozoan parasites initiated a great deal of interest and debate in the field of molec...

Phytoplankton are responsible for half of the global photosynthesis and form vast blooms in aquatic ecosystems. Bloom demise fuels marine microbial life and is...

Autophagy, a normal process by which cells eat their own proteins to provide needed resources to the body in times of stress, may paradoxically cause harm to...

Find out more about the research of Dr. Sjoerd van Wijk on ubiquitination, autophagy and programmed cell death in Frankfurt

Introduction. Fetal alcohol spectrum disorders (FASD) are the leading preventable cause of intellectual disability, providing the impetus for evaluating vari...

Programmed cell death, or apoptosis, has in the past few years undoubtedly become one of the most intensively investigated biological processes. However,...

The influenza A virus (IAV) 2009 H1N1 pandemic was associated with an increased risk of maternal mortality, preterm birth, and stillbirth. The underlying mec...

TRPM2 is a Ca(2+)-permeable channel that is activated by oxidative stress and confers susceptibility to cell death. Here, an isoform of TRPM2 was identified in...

Immune responses induced by natural infection and vaccination are known to be initiated by the recognition of microbial patterns by cognate receptors, since...

Cell-death-inducing proteins (CDIPs) play important roles in the infection of Botrytis cinerea, a broad-host-range necrotrophic phytopathogen. Here, we show ...

Cancer cells are characterized as highly proliferative at the expense of enhancement of metabolic rate. Consequently, cancer cells rely on antioxidant defenc...

As the last step of leaf development, senescence is a molecular process involving cell death mechanism. Leaf senescence is trigged by both internal age-depen...

Do you know about cell injury death and adaptation? If yes, take this cell injury death and adaptation quiz and find how well you know about this. The...

BRD-810 inhibits the MCL1 protein and reactivates apoptosis in tumor cells, displaying therapeutic potential in animal models.

Tuberculosis is a deadly, contagious respiratory disease that is caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb). Mtb is adept at manipul...

Imeglimin is the first in a new class of oral glucose-lowering agents, having recently completed its phase 2b trial. As Imeglimin did show a full prevention of...

We have investigated Amblyomin-X-treated horse melanomas to better understand its mode of action through transcriptome analysis and the in vivo model....