Robuta

https://openreview.net/forum?id=7w1YGBPDMw Mechanistic PDE Networks for Discovery of Governing Equations | OpenReview We present Mechanistic PDE Networks -- a model for discovery of governing *partial differential equations* from data. Mechanistic PDE Networks represent... discovery ofgoverning equationsmechanisticpdenetworks https://pmc.ncbi.nlm.nih.gov/articles/PMC4112849/ The potential mechanistic link between allergy and obesity development and infant formula feeding -... This article provides a new view of the cellular mechanisms that have been proposed to explain the links between infant formula feeding and the development of... the potential https://pmc.ncbi.nlm.nih.gov/articles/PMC11637322/ Decoding the brain: from neural representations to mechanistic models - PMC A central principle in neuroscience is that neurons within the brain act in concert to produce perception, cognition, and adaptive behavior. Neurons are... the braindecodingneuralrepresentationsmechanistic https://www.omicsonline.org/peer-reviewed/mechanistic-evaluation-of-matrix-effect-on-three-different-model-of-mass-spectrometer-by-using-a-model-drug-73096.html Mechanistic Evaluation of Matrix Effect on Three Different Model of Mass Spectrometer by Using a... Mechanistic Evaluation of Matrix Effect on Three Different Model of Mass Spectrometer by Using a Model Drug Abstract. https://www.osti.gov/pages/biblio/1813634-new-mechanistic-reaction-pathway-insights-oxidative-coupling-methane-ocm-over-supported-na-wo-sio-catalysts New Mechanistic and Reaction Pathway Insights for Oxidative Coupling of Methane (OCM) over... The U.S. Department of Energy's Office of Scientific and Technical Information oxidative coupling of methane https://openreview.net/forum?id=QBCxWpOt5w Iteration Head: A Mechanistic Study of Chain-of-Thought | OpenReview Chain-of-Thought (CoT) reasoning is known to improve Large Language Models both empirically and in terms of theoretical approximation power. However, our... iterationheadmechanisticstudychain https://pmc.ncbi.nlm.nih.gov/articles/PMC10390488/ Knowledge-based mechanistic modeling accurately predicts disease progression with gefitinib in... Lung adenocarcinoma (LUAD) is associated with a low survival rate at advanced stages. Although the development of targeted therapies has improved outcomes in... knowledge basedmechanistic modelingdisease progressionaccurately https://www.bnl.gov/chemistry/ap/ka_ruivo_woc.php BNL | Chemistry | Artificial Photosynthesis | Research Highlights | Mechanistic understanding of... artificial photosynthesisresearch highlightsbnlchemistrymechanistic https://elifesciences.org/reviewed-preprints/90992/figures Mechanistic target of rapamycin (mTOR) pathway in Sertoli cells regulates age-dependent changes in... target of rapamycin https://pmc.ncbi.nlm.nih.gov/articles/PMC10602048/ Using Data Science for Mechanistic Insights and Selectivity Predictions in a Non-Natural... The study of non-natural biocatalytic transformations relies heavily on empirical methods, such as directed evolution, for identifying improved variants.... https://arxiv.org/abs/2601.21996 [2601.21996] Mechanistic Data Attribution: Tracing the Training Origins of Interpretable LLM Units Abstract page for arXiv paper 2601.21996: Mechanistic Data Attribution: Tracing the Training Origins of Interpretable LLM Units https://elifesciences.org/articles/75427 Modelling the response to vaccine in non-human primates to define SARS-CoV-2 mechanistic correlates... A model-based approach for modelling the immune control of viral dynamics is applied to quantify the effect of several SARS-CoV-2 vaccine platforms and to... https://www.globenewswire.com/fr/news-release/2025/03/19/3045269/18362/en/new-research-exploring-mechanistic-benefits-of-eicosapentaenoic-acid-epa-in-vitro-on-lipoprotein-a-lp-a-oxidation-and-on-protein-expression-in-endothelial-cells-in-combination-with.html New Research Exploring Mechanistic Benefits of DUBLIN and BRIDGEWATER, N.J., March 19, 2025 (GLOBE NEWSWIRE) -- Amarin Corporation plc (NASDAQ:AMRN) today announced that additional in vitro... new researchexploringmechanisticbenefits https://www.utmb.edu/bmb/seminars/academic-year/2018/11/15/default-calendar/balancing-x-chromosome-dosage--mechanistic-insights-and-impact-on-cancer Balancing X chromosome Dosage: Mechanistic Insights and Impact on Cancer Speaker: Dr. Eda Yildirim Host: Dr. Muge Kuyumcu-Martinez x chromosomebalancingdosagemechanisticinsights https://www.data.gov.uk/dataset/4f3ef70c-40b7-48bf-97db-d4fee8322085/water-and-carbon-balance-outputs-of-a-mechanistic-ecosystem-model-for-a-caatinga-dryland-forest Water and carbon balance outputs of a mechanistic ecosystem model for a Caatinga dryland forest in... https://arxiv.org/html/2510.01232v1 Benchmark Profiling: Mechanistic Diagnosis of LLM Benchmarks benchmarkprofilingmechanisticdiagnosisllm https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2020.01237/full Frontiers | Key Mechanistic Principles and Considerations Concerning RNA Interference Canonical RNAi, one of the so-called RNA-silencing mechanisms, is defined as sequence-specific RNA degradation induced by long double-stranded RNA (dsRNA). R... frontierskeymechanisticprinciplesconsiderations https://elifesciences.org/reviewed-preprints/88344/reviews A three filament mechanistic model of musculotendon force and impedance threefilamentmechanisticmodelforce https://elifesciences.org/reviewed-preprints/88344v3 A three filament mechanistic model of musculotendon force and impedance threefilamentmechanisticmodelforce https://www.uclahealth.org/programs/care-center/a5332-mechanistic-substudy-reprieve A5332 - Mechanistic Substudy of REPRIEVE - CARE Center | UCLA Health Currently, there are few strategies to prevent CVD in HIV-infected people, even though they are at high risk for developing CVD. Statin medications are used to... care centermechanisticreprieveuclahealth https://elifesciences.org/articles/17536v1 Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of... https://www.frontiersin.org/research-topics/69258/immunosenescence-and-metabolic-reprogramming-in-aging-mechanistic-insights-and-interventions/magazine Immunosenescence and Metabolic Reprogramming in Aging: Mechanistic Insights and Interventions |... Aging is marked by significant alterations in the immune system, known as immunosenescence, and in metabolic functions, termed metabolic reprogramming. These... immunosenescencemetabolicreprogrammingagingmechanistic https://www.frontiersin.org/research-topics/36213/towards-a-mechanistic-understanding-of-depression-anxiety-and-their-comorbidity-perspectives-from-cognitive-neuroscience/magazine Towards a Mechanistic Understanding of Depression, Anxiety, and Their Comorbidity: Perspectives... Depressive and anxiety disorders are among the most common and disabling mental disorders. Over and above that, these two disorders are often comorbid: over... depression anxietytowardsmechanisticunderstanding https://www.rug.nl/news/2013/03/09_roeser?lang=en Electrochemical oxidation and cleavage peptides in bioanalysis. Mechanistic aspects & method... Mar 13, 2020 - PhD ceremony: Mr. J. Roeser, 16.15 uur, Academiegebouw, Broerstraat 5, Groningen electrochemicaloxidationcleavagepeptidesbioanalysis https://pmc.ncbi.nlm.nih.gov/articles/PMC12985791/ Lipedema and Dynapenia: Inflammatory Myosteatosis as a Mechanistic Link Between Tissue Expansion... Lipedema is a chronic, progressive adipose tissue disorder characterized by disproportionate subcutaneous fat accumulation, pain, edema, and resistance to... as a https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2012.00183/full Frontiers | Mechanistic Insights into Aging, Cell-Cycle Progression, and Stress Response The longevity of an organism depends on the health of its cells. Throughout life cells are exposed to numerous intrinsic and extrinsic stresses, such as free... cell cycle progressionfrontiersmechanisticinsightsaging https://www.frontiersin.org/journals/energy-research/articles/10.3389/fenrg.2022.907505/full Frontiers | Mechanistic Kinetic Analysis of Fast Pyrolysis of Vanillin to Primary Phenols Vanillin is a major fine chemical in the flavoring industry and one of the pyrolysates from lignin. In order to understand the primary decomposition pathways... frontiersmechanistickineticanalysis https://pmc.ncbi.nlm.nih.gov/articles/PMC11336684/ Structured methods for parameter inference and uncertainty quantification for mechanistic models in... Parameter inference and uncertainty quantification are important steps when relating mathematical models to real-world observations and when estimating... uncertainty quantificationstructuredmethodsparameterinference https://www.sintef.no/en/publications/publication/350707/ Mechanistic study of the dry reforming of propane to synthesis gas over a Ni/Mg(Al)O catalyst -... https://www.osti.gov/pages/biblio/1576520-mechanistic-aspects-surface-organovanadium-iii-catalyst-hydrocarbon-hydrogenation-dehydrogenation Mechanistic Aspects of a Surface Organovanadium(III) Catalyst for Hydrocarbon Hydrogenation and... The U.S. Department of Energy's Office of Scientific and Technical Information https://elifesciences.org/articles/92063v1 Some mechanistic underpinnings of molecular adaptations of SARS-COV-2 spike protein by integrating... Insights from integrating evolutionary predictions and protein dynamics unveil how specific mutations in the SARS-CoV-2 spike protein epistatically interact in... sars cov 2 spike protein https://www.preprints.org/manuscript/202308.0137 Testing the Mechanistic-Universe Paradigm Using Chaotic Systems[v5] | Preprints.org We humans are natural-born engineers. As such, we model after machines not only isolated, naturally occurring systems, but also the basic laws of physics,... chaotic systemstestingmechanisticuniverseparadigm https://arxiv.org/html/2604.02838v1 Mechanistic insights into the spatial organization of RNA polymerase proteins and the chromosome in... https://www.frontiersin.org/research-topics/70146/fatigue-and-neuroplasticity-in-neurological-and-psychiatric-disorders-mechanistic-insights-and-biomarkers-discovery Frontiers | Fatigue and Neuroplasticity in Neurological and Psychiatric Disorders: Mechanistic... Fatigue is a prevalent yet often underrecognized symptom across neurological and psychiatric disorders, including depression, schizophrenia, multiple scleros... psychiatric disordersfrontiersfatigueneuroplasticityneurological https://openreview.net/forum?id=2J18i8T0oI Towards Universality: Studying Mechanistic Similarity Across Language Model Architectures |... language modeltowardsuniversalitystudyingmechanistic https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2023.1220376/full Frontiers | Application of CRISPR screen in mechanistic studies of tumor development, tumor drug... Tumor is one of the biggest threats to human health. Though tumor therapy has been dramatically advanced by the progress of technology and research in recent... frontiersapplicationcrisprscreen https://pmc.ncbi.nlm.nih.gov/articles/PMC10568569/ Propionate promotes gluconeogenesis by regulating mechanistic target of rapamycin (mTOR) pathway in... Enhancing hepatic gluconeogenesis is one of the main modes of meeting the glucose requirement of dairy cows. This study attempted to determine whether the... target of rapamycin https://pmc.ncbi.nlm.nih.gov/articles/PMC6032205/ Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights - PMC Inflammation is the principal response invoked by the body to address injuries. Despite inflammation constituting a crucial component of tissue repair, it is... anti inflammatoryeffectsresveratrolmechanisticinsights https://elifesciences.org/reviewed-preprints/88344v3/reviews A three filament mechanistic model of musculotendon force and impedance threefilamentmechanisticmodelforce https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.941839/full Frontiers | HLA-associated outcomes in peanut oral immunotherapy trials identify mechanistic and... Rationale: Previous studies identified an interaction between HLA and oral peanut exposure. 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Teprotumumab has shown significant efficacy in treating Thyroid Eye Disease (TED), but its adverse effects require careful management. Key reactions include... https://pmc.ncbi.nlm.nih.gov/articles/PMC5976976/ Ayurvedic Medicine for the Treatment of Dementia: Mechanistic Aspects - PMC Ayurvedic medicine is a personalized system of traditional medicine native to India and the Indian subcontinent. It is based on a holistic view of treatment... treatment of dementiaayurvedic medicinefor themechanisticaspects https://openreview.net/forum?id=FP7_Q6Np8w A mechanistic multi-area recurrent network model of decision-making | OpenReview Recurrent neural networks (RNNs) trained on neuroscience-based tasks have been widely used as models for cortical areas performing analogous tasks. However,... network modeldecision makingmechanisticmultiarea https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.857563/full Frontiers | Mechanistic Clues Provided by Concurrent Changes in the Expression of Genes Encoding... Muscarinic receptors (MRs) in the G protein-coupled receptor superfamily are recipients and mediators of parasympathetic neural transmission within the centr... https://openreview.net/forum?id=JEflV4nRlH What Makes and Breaks Safety Fine-tuning? A Mechanistic Study | OpenReview Safety fine-tuning helps align Large Language Models (LLMs) with human preferences for their safe deployment. To better understand the underlying factors that... fine tuningmakesbreakssafety https://pmc.ncbi.nlm.nih.gov/articles/PMC11100965/ Advancements in Dermatological Applications of Curcumin: Clinical Efficacy and Mechanistic Insights... Curcumin, derived from Curcuma longa (turmeric), exhibits significant potential in dermatology, addressing conditions like atopic dermatitis, psoriasis,... clinical efficacyadvancementsdermatologicalapplications https://arxiv.org/abs/2504.13151v1 [2504.13151v1] MIB: A Mechanistic Interpretability Benchmark Abstract page for arXiv paper 2504.13151v1: MIB: A Mechanistic Interpretability Benchmark mechanistic interpretability2504mibbenchmark https://elifesciences.org/articles/101885v1 Mechanistic insight for T-cell exclusion by cancer-associated fibroblasts in human lung cancer |... The crosstalk between cancerous lesions and the immune system in the lungs demonstrates the complex role of fibroblasts. cancer associated fibroblasts https://www.preprints.org/manuscript/202404.0176 Mechanistic Sequence of Histone Deacetylase Inhibitors and Radiation Treatment: An Overview[v1] |... Histone deacetylases inhibitors (HDACi) have shown promising therapeutic outcomes in haematological malignancies such as leu-kaemia, multiple myeloma and... histone deacetylase https://finviz.com/news/201869/bioatla-presents-compelling-mechanistic-rationale-for-targeting-ror2-with-ozuriftamab-vedotin-oz-v-in-oropharyngeal-squamous-cell-carcinoma-opscc-at-the-annual-conference-of-the-international-papillomavirus-society BioAtla Presents Compelling Mechanistic Rationale for Targeting ROR2 with Ozuriftamab Vedotin... Stock screener for investors and traders, financial visualizations. presentscompellingmechanisticrationale https://arxiv.org/abs/2512.05794 [2512.05794] Mechanistic Interpretability of Antibody Language Models Using SAEs Abstract page for arXiv paper 2512.05794: Mechanistic Interpretability of Antibody Language Models Using SAEs mechanistic interpretabilitylanguage models251205794antibody https://www.ebi.ac.uk/chembl/explore/document/CHEMBL1129730 Document: Mechanistic studies on the inactivation of papain by epoxysuccinyl inhibitors.... Report card for Document Mechanistic studies on the inactivation of papain by epoxysuccinyl inhibitors. (CHEMBL1129730). J Med Chem, Analogs of the... on thedocumentmechanisticstudies https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2019.02644/full Frontiers | Proteomics-Based Mechanistic Investigation of Escherichia coli Inactivation by Pulsed... The pulsed electric field (PEF) technology has been widely applied to inactivate pathogenic bacteria in food products. Though irreversible pore formation and... escherichia colifrontiersproteomicsbasedmechanistic https://www.preprints.org/manuscript/202504.2163 Inflammation in Asthma: Mechanistic Insights and the Role of Biologics in Therapeutic Frontiers[v1]... Asthma is a chronic and multifaceted respiratory condition that affects over 300 million individuals across the globe. It is characterized by persistent... https://pmc.ncbi.nlm.nih.gov/articles/PMC7401704/ Making sense out of missense mutations: Mechanistic dissection of Notch receptors through... Notch signaling is involved in the development of almost all organ systems and required post-developmentally to modulate tissue homeostasis. Rare variants in... making senseout ofmissense mutations https://pmc.ncbi.nlm.nih.gov/articles/PMC11381892/ O-GlcNAc transferase congenital disorder of glycosylation (OGT-CDG): Potential mechanistic targets... O-GlcNAc transferase (OGT) is the sole enzyme responsible for the post-translational modification of O-GlcNAc on thousands of target nucleocytoplasmic... o glcnac transferasecongenital disorder https://pmc.ncbi.nlm.nih.gov/articles/PMC9089307/ Mechanistic study of 1,1-dimethylhydrazine transformation over Pt/SiO2 catalyst - PMC Catalytic oxidation of 1,1-dimethylhydrazine (UDMH) with molecular oxygen over Pt/SiO2 was studied by in situ FTIR spectroscopy coupled with online MS... of 1mechanisticstudydimethylhydrazine https://www.mskcc.org/apply How To Apply to the Mechanistic Biology Summer Program | Memorial Sloan Kettering Cancer Center Students can apply online for our Mechanistic Biology Summer Program. how to apply https://www.mdpi.com/1422-0067/22/7/3751 Modeling Rett Syndrome with Human Pluripotent Stem Cells: Mechanistic Outcomes and Future Clinical... Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the gene encoding the methyl-CpG-binding protein 2 (MeCP2). Among many different... pluripotent stem cells https://www.usgs.gov/publications/linking-spring-phenology-mechanistic-models-host-movement-predict-disease-transmission Linking spring phenology with mechanistic models of host movement to predict disease transmission... Disease models typically focus on temporal dynamics of infection, while often neglecting environmental processes that determine host movement. In many systems,... https://www.rcsb.org/structure/1YR2 RCSB PDB - 1YR2: Structural and Mechanistic Analysis of Two Prolyl Endopeptidases: Role of... Structural and Mechanistic Analysis of Two Prolyl Endopeptidases: Role of Inter-Domain Dynamics in Catalysis and Specificity rcsb pdb https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.632284/full Frontiers | Mechanistic Targets and Nutritionally Relevant Intervention Strategies to Break... The worldwide prevalence of obesity and overweight status has tripled since 1975. More than 40% of adults and nearly 13% of the population were overweight an... frontiersmechanistictargetsrelevantintervention https://www.mdpi.com/1422-0067/23/11/6330 Mechanistic Insight into Permeation of Plasma-Generated Species from Vacuum into Water Bulk Due to their potential benefits, cold atmospheric plasmas (CAPs), as biotechnological tools, have been used for various purposes, especially in medical and... insight into https://elifesciences.org/articles/51913/peer-reviews Peer review in Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by... 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Insights from integrating evolutionary predictions and protein dynamics unveil how specific mutations in the SARS-CoV-2 spike protein epistatically interact in... https://openreview.net/forum?id=wpzRkAW2Sy Group Equivariance Meets Mechanistic Interpretability: Equivariant Sparse Autoencoders | OpenReview Sparse autoencoders (SAEs) have proven useful in disentangling the opaque activations of neural networks, primarily large language models, into sets of... mechanistic interpretabilitygroupequivariancemeetsequivariant https://huggingface.co/papers/2604.11661 Paper page - Towards Autonomous Mechanistic Reasoning in Virtual Cells Join the discussion on this paper page papertowardsautonomousmechanisticreasoning https://www.frontiersin.org/research-topics/58502/natural-products-and-immune-inflammation-mechanistic-understanding-based-on-systems-biology/magazine Natural Products and Immune Inflammation: Mechanistic Understanding Based on Systems Biology |... 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Isotactic poly(1-butene) (iPB) is an interesting semi-crystalline thermoplastic material characterized by notable physical and mechanical attributes encompas... on 1