https://researchprofiles.ku.dk/en/publications/leptin-induced-mtor-activation-defines-a-specific-molecular-and-t/
Leptin-induced mTOR activation defines a specific molecular and transcriptional signature...
leptininducedmtoractivationdefines
https://www.thermofisher.com/antibody/product/Phospho-mTOR-Ser2454-Antibody-Polyclonal/PA5-105571
Phospho-mTOR (Ser2454) Polyclonal Antibody | Invitrogen (PA5-105571)
Detect Phospho-mTOR (Ser2454) in ICC/IF, IHC (P), WB. Reacts with Rabbit. Cited in 1 publication. Catalog # PA5-105571
polyclonal antibodyphosphomtorinvitrogen
https://www.cancer.gov/publications/dictionaries/cancer-drug/def/pan-pi3k-mtor-inhibitor-sf1126
Definition of pan-PI3K/mTOR inhibitor SF1126 - NCI Drug Dictionary - NCI
Find technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. Each entry includes...
definition ofmtor inhibitorpanncidrug
https://pubmed.ncbi.nlm.nih.gov/15718470/
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and diabetes. Akt/PKB activation requires the phosphorylation of Thr308...
by thephosphorylationregulationakt
https://pubmed.ncbi.nlm.nih.gov/33287453/
Prolidase Stimulates Proliferation and Migration through Activation of the PI3K/Akt/mTOR Signaling...
Recent reports have indicated prolidase (PEPD) as a ligand of the epidermal growth factor receptor (EGFR). Since this receptor is involved in the promotion of...
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2014.00409/full
Frontiers | Nutrient Sensing via mTOR in T Cells Maintains a Tolerogenic Microenvironment
We have proposed that tolerance can be maintained by the induction, by Treg cells, of a tolerogenic microenvironment within tolerated tissues that inhibits e...
in t
https://publikationen.uni-tuebingen.de/xmlui/handle/10900/98080
Haprolid inhibits tumor growth of hepatocellular carcinoma through Rb/E2F and Akt/mTOR inhibition
https://pubmed.ncbi.nlm.nih.gov/20804212/
Steady-state kinetic and inhibition studies of the mammalian target of rapamycin (mTOR) kinase...
The mammalian target of rapamycin (mTOR) is a Ser/Thr protein kinase and a major controller of cell growth. In cells, mTOR forms two distinct multiprotein...
https://pubmed.ncbi.nlm.nih.gov/39332412/
mTOR activity paces human blastocyst stage developmental progression
Many mammals can temporally uncouple conception from parturition by pacing down their development around the blastocyst stage. In mice, this dormant state is...
blastocyst stagemtoractivitypaceshuman
https://pubmed.ncbi.nlm.nih.gov/39593172/
YTHDF2 promotes anaplastic thyroid cancer progression by activating the DDIT4/AKT/mTOR signaling...
This study is the first to demonstrate that elevated YTHDF2 expression levels suppress DDIT4 expression in an m6A-dependent manner and activate the AKT/mTOR...
anaplastic thyroid cancer
https://cordis.europa.eu/project/id/224757/fr
THE ROLE OF THE MTOR SIGNALING PATHWAY IN NEUROGENESIS AND ITS IMPLICATIONS FOR THE REGULATION OF...
The major interest of my research activity is to understand the pathophysiological mechanisms leading to the development of obesity, particularly focusing on...
mtor signaling pathway
https://norngroup.substack.com/p/advancing-longevity-trials-lessons?triedRedirect=true&_src_ref=t.co
Advancing Longevity Trials: Lessons from mTOR-Targeting Interventions
What two decades of trials can teach us about translating rapamycin to human aging.
advancinglongevitytrialslessonsmtor
https://brainandmind.weill.cornell.edu/crosstalk-between-mtor-and-nrf2are-signaling-pathways-target-improvement-long-term-potentiation
Crosstalk between the mTOR and Nrf2/ARE signaling pathways as a target in the improvement of...
https://pubmed.ncbi.nlm.nih.gov/34175443/
Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer
Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is one of the most frequently dysregulated signaling pathways observed in...
https://amsdottorato.unibo.it/id/eprint/4799/
The role of mitochondria in the regulation of gamma rays induced mTOR-dependent senescence
the role
https://pubmed.ncbi.nlm.nih.gov/29487226/
Emerging Perspectives on mTOR Inhibitor-Associated Pneumonitis in Breast Cancer
This article summarizes the pathogenesis, clinical presentation, incidence, detection, and optimal management of everolimus-related noninfectious pneumonitis...
mtor inhibitoremergingperspectivesassociatedbreast
https://pubmed.ncbi.nlm.nih.gov/23555892/
A polymorphism (rs2295080) in mTOR promoter region and its association with gastric cancer in a...
The mTOR promoter polymorphism rs2295080 was significantly associated with GC risk. This SNP, which effectively influenced the expression of mTOR, may be a new...
https://scholarsarchive.byu.edu/studentpub/447/
"A Case for mTOR Pathway Screening in Early Epilepsy Diagnosis" by David Seamons
Mutations in the mTOR pathway can give rise to epileptic seizures in patients. While a variety of antiepileptic drugs are available to treat epilepsy, a large...
a case for
https://pure.psu.edu/en/publications/therapeutic-approach-guided-by-genetic-alteration-use-of-mtor-inh/
Therapeutic approach guided by genetic alteration: Use of MTOR inhibitor in renal medullary...
https://portal.fis.tum.de/en/publications/multinuclear-nmr-and-mri-reveal-an-early-metabolic-response-to-mt/fingerprints/
Multinuclear NMR and MRI reveal an early metabolic response to mTOR inhibition in sarcoma -...
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2012.00401/full
Frontiers | AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV
As an obligate intracellular parasite, the Kaposi sarcoma-associated herpesvirus (KSHV) relies on host cell machinery to meet its needs for survival, viral r...
mtor signaling pathwayfrontiersakt
https://pubmed.ncbi.nlm.nih.gov/36274448/
Anal Cancer Prevention Through the Topical Use of Single or Dual PI3K/mTOR Inhibitors
Sapanisertib, the mTOR inhibitor, had the greatest effect, in terms of increasing tumor-free survival, regardless of starting time point or sex. Unlike the...
https://www.thermofisher.com/antibody/product/mTOR-Antibody-Polyclonal/28273-1-AP
mTOR Polyclonal Antibody | Invitrogen (28273-1-AP)
Detect mTOR in WB, IHC (P), IP, ICC/IF, ELISA. Reacts with Rabbit, Mouse, Goat. Cited in 49 publications. Catalog # 28273-1-AP
polyclonal antibodymtorinvitrogenap
https://www.mdpi.com/1422-0067/23/15/8747
mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity
Decreased content and activity of the mechanistic target of rapamycin (mTOR) signalling pathway, as well as the mTOR complex 1 (mTORC1) itself, are key traits...
mtorcomplexcontent
https://bio.as.uky.edu/bibcite/reference/28125
Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed...
https://iscrm.uw.edu/recent_research/metabolic-control-over-mtor-dependent-diapause-like-state/
Metabolic Control over mTOR-Dependent Diapause-like State - Institute for Stem Cell & Regenerative...
Apr 30, 2020 - Developmental Cell, January 2020
https://www.mdpi.com/1422-0067/22/1/173
PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects
Breast cancer is a serious health problem worldwide, representing the second cause of death through malignancies among women in developed countries....
https://pure.psu.edu/en/publications/ethanol-acutely-antagonizes-the-refeeding-induced-increase-in-mto/
Ethanol acutely antagonizes the refeeding-induced increase in mTOR-dependent protein synthesis and...
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1120996/full
Frontiers | ROS-AMPK/mTOR-dependent enterocyte autophagy is involved in the regulation of Giardia...
Giardia duodenalis, a cosmopolitan noninvasive protozoan parasite of zoonotic concern and public health importance, infects the upper portions of the small i...
https://hsrc.himmelfarb.gwu.edu/gwhpubs/4380/
"PI3K/mTOR is a therapeutically targetable genetic dependency in diffus" by Ryan J. Duchatel,...
Diffuse midline glioma (DMG), including tumors diagnosed in the brainstem (diffuse intrinsic pontine glioma; DIPG), are uniformly fatal brain tumors that lack...
https://pmc.ncbi.nlm.nih.gov/articles/PMC4365758/
Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated...
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone; PLB), a naturally occurring naphthoquinone isolated from the roots of Plumbaginaceae plants, has been...
https://pubmed.ncbi.nlm.nih.gov/32198387/?dopt=Abstract
The potential role of the HCN1 ion channel and BDNF-mTOR signaling pathways and synaptic...
The function of the hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) and the expression of brain-derived neurotrophic factor (BDNF) may be...
https://pubmed.ncbi.nlm.nih.gov/24481314/
BMAL1-dependent regulation of the mTOR signaling pathway delays aging
The circadian clock, an internal time-keeping system, has been linked with control of aging, but molecular mechanisms of regulation are not known. BMAL1 is a...
mtor signaling pathwayof thedependentregulationdelays
https://edoc.ub.uni-muenchen.de/23791/
mTOR Inhibition durch Aspirin - antiproliferative Effekte auf neuroendokrine Tumorzellen in vitro
mtorinhibitiondurchaspirin
https://boris-portal.unibe.ch/entities/publication/91c87c34-03bc-4f15-ad87-83ad3911ca1a
Pulse mTOR inhibitor treatment effectively controls cyst growth but leads to severe parenchymal and...
The efficacy of mammalian target of rapamycin (mTOR) inhibitors is currently tested in patients affected by autosomal dominant polycystic kidney disease....
https://pmc.ncbi.nlm.nih.gov/articles/PMC4382265/
mTOR: a pharmacologic target for autophagy regulation - PMC
mTOR, a serine/threonine kinase, is a master regulator of cellular metabolism. mTOR regulates cell growth and proliferation in response to a wide range of...
autophagy regulationmtortargetpmc
https://pubchem.ncbi.nlm.nih.gov/bioassay/2054489
AID 2054489 - Selectivity interaction (Competition-binding assay (DiscoverX)) EUB0000092b MTOR -...
BioAssay record AID 2054489 submitted by ChEMBL: Selectivity interaction (Competition-binding assay (DiscoverX)) EUB0000092b MTOR.
aidselectivityinteractioncompetitionbinding
https://pmc.ncbi.nlm.nih.gov/articles/PMC4763238/
Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition - PMC
Resveratrol (RSV) is a natural polyphenol that has a beneficial effect on health, and resveratrol-induced autophagy has been suggested to be a key process in...
resveratrolautophagydirectly
https://boris-portal.unibe.ch/entities/publication/474f8152-fe96-4aad-afc3-c7fdbaccc078
MiRNAs and their interplay with PI3K/AKT/mTOR pathway in ovarian cancer cells: a potential role in...
Ovarian cancer is a leading cause of death among gynecologic malignancies. This disappointing prognosis is closely related to intrinsic or acquired resistance...
https://pubmed.ncbi.nlm.nih.gov/23272914/
Inhibition of PI3K/Akt/mTOR signaling by natural products
Inhibition of PI3K/Akt/mTOR signaling by natural products
inhibitionaktmtorsignalingnatural
https://pmc.ncbi.nlm.nih.gov/articles/PMC6900471/
Ivermectin induces autophagy-mediated cell death through the AKT/mTOR signaling pathway in glioma...
Glioma is one of the most common types of primary brain tumors. Ivermectin (IVM), a broad-spectrum antiparasitic drug, has been identified as a novel...
https://experts.mcmaster.ca/scholarly-works/210990
Combined mTOR inhibition and OX40 agonism enhances...
Learn about the scholarly work entitled Combined mTOR inhibition and OX40 agonism enhances...
combinedmtorinhibitionenhances
https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2020.01028/full
Frontiers | Tuberous Sclerosis Complex as Disease Model for Investigating mTOR-Related Gliopathy...
Tuberous sclerosis complex (TSC) represents the prototypic monogenic disorder of the mammalian target of rapamycin (mTOR) pathway dysregulation. It provides ...
tuberous sclerosis complexdisease model
https://pubmed.ncbi.nlm.nih.gov/31213776/
Salvianolic acid A attenuates CCl4-induced liver fibrosis by regulating the PI3K/AKT/mTOR,...
https://www.mdpi.com/2077-0383/8/2/232
Investigating the Role of Everolimus in mTOR Inhibition and Autophagy Promotion as a Potential...
Tuberculosis (TB) is a serious infectious disease caused by the pathogen Mycobacterium tuberculosis (Mtb). The current therapy consists of a combination of...
https://pmc.ncbi.nlm.nih.gov/articles/PMC11785570/
Baicalein induces apoptosis by inhibiting the glutamine-mTOR metabolic pathway in lung cancer - PMC
Keywords: Baicalein, Non-small-cell lung cancer, Apoptosis, Metabonomics, Glutamine-mTOR metabolic pathway
https://scholarworks.indianapolis.iu.edu/items/f8d56bef-4aa6-4fcb-9fa8-5bbff4617432
mTOR SIGNALING MEDIATES TBI-ENHANCED NEURAL STEM CELL PROLIFERAION
Traumatic Brain Injury (TBI) induced neuron death was once thought to be irreversible. However, the identification of neural stem cells (NSCs) in the adult...
stem cellmtorsignalingtbienhanced
https://digital.library.adelaide.edu.au/items/7bb21414-7559-4dfe-b426-4b65180dfac2
Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated...
Published under the terms of the CC BY 4.0 license.Pancreatic ductal adenocarcinoma (PDAC) is extremely stroma-rich. Cancer-associated fibroblasts (CAFs)...
https://research.vu.nl/en/publications/mtor-plays-an-important-role-in-cows-milk-allergy-associated-beha/
MTOR plays an important role in cow's milk allergy-associated behavioral and immunological deficits...
https://jornal.fmrp.usp.br/bdnf-activates-mtor-to-regulate-glur1-expression-required-for-memory-formation/
"BDNF Activates mTOR to Regulate GluR1 Expression Required for Memory Formation" | Jornal...
https://pure.psu.edu/en/publications/delayed-recovery-of-skeletal-muscle-mass-following-hindlimb-immob/
Delayed recovery of skeletal muscle mass following hindlimb immobilization in mTOR heterozygous...
delayed recoveryskeletal muscle
https://ub01.uni-tuebingen.de/xmlui/handle/10900/109121
Low-dose cidofovir and conversion to mTOR-based immunosuppression in polyomavirus-associated...
low dose
https://boris-portal.unibe.ch/entities/publication/4899d8db-9859-4ba2-81f0-6cfef3823456
Corrigendum to: Mechanistic target of rapamycin (mTOR) protein expression in the tumor and its...
https://scholars.lib.ntu.edu.tw/entities/project/c51e7a86-c775-4b8a-87b7-f063cdcf38f4
Exploration of the Regulation of Mtor Inhibitors on the Functions of Antigen Presenting Cells and...
antigen presenting cellsof themtor inhibitors
https://dash.harvard.edu/entities/publication/73120378-9a76-6bd4-e053-0100007fdf3b
PI3 K/Akt/mTOR-Mediated Translational Control Regulates Proliferation and Differentiation of...
Background: We have previously derived highly similar lineage-restricted stem cell lines, RoSH and E-RoSH cell lines from mouse embryos and CD9hi SSEA-1-...
https://open.library.emory.edu/concern/publications/2bd75eb1-841d-4f47-b196-6432418e0982
High urea induces depression and LTP impairment through mTOR signalling suppression caused by...
High urea induces depression and LTP impairment through mTOR signalling suppression caused by carbamylation
https://pubmed.ncbi.nlm.nih.gov/23443503/
Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at...
Males, who are bigger and stronger than females, live shorter in most species from flies to mammals including humans. Cellular mass growth is driven in part by...
mammalian target of rapamycin
https://www.thermofisher.com/antibody/product/mTOR-Antibody-Polyclonal/PA1-518
mTOR Polyclonal Antibody | Invitrogen (PA1-518)
Detect mTOR in WB, IHC (P), IP, ICC/IF, ELISA. Reacts with Rabbit, Mouse, Goat. Cited in 5 publications. Catalog # PA1-518
polyclonal antibodymtorinvitrogen
https://pubchem.ncbi.nlm.nih.gov/bioassay/1341953
AID 1341953 - Inhibition of mTOR in human U87 cells assessed as reduction in pAKT phosphorylation...
BioAssay record AID 1341953 submitted by ChEMBL: Inhibition of mTOR in human U87 cells assessed as reduction in pAKT phosphorylation at residue 47 by Western...
https://data.mendeley.com/datasets/27432g3zhs/1
Mitochondrial Integrity Modulates mTOR Signaling and Podocyte Function - Mendeley Data
Immunoblots Figure 6 and S2
mitochondrialintegritymtorsignalingfunction
https://pubmed.ncbi.nlm.nih.gov/37545094/
Seizure reduction in TSC2-mutant mouse model by an mTOR catalytic inhibitor
Novel mTOR catalytic inhibitor TC1 exhibits a promising therapeutic option in the treatment of TSC.
mouse model
https://infoscience.epfl.ch/entities/publication/761fbb95-f016-40a3-93e4-6f4bb81ed410/statistics
Study of mTOR palmitoylation
studymtor
https://odysee.com/%24/embed/%40jroseland%3Af%2FMetformin-Longevity-Hack%3Af?r=DFvuTzNDSzGaWhbtoMWiqWPBhnCwi3qx
Metformin: This AMPK/mTOR Longevity Hack Stinks! What to take instead to hack insulin...
This pharmaceutical is an insulin hack and the most studied diabetes drug, yet it remains highly controversial as an anti-aging and longevity tool for...
what to take
https://pubmed.ncbi.nlm.nih.gov/30061532/
mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders
The mammalian target of rapamycin (mTOR) is an ubiquitously expressed serine-threonine kinase, which senses and integrates several intracellular and...
mtorrelatedbraindysfunctionsneuropsychiatric
https://ub01.uni-tuebingen.de/xmlui/handle/10900/98080?show=full
Haprolid inhibits tumor growth of hepatocellular carcinoma through Rb/E2F and Akt/mTOR inhibition
https://pubmed.ncbi.nlm.nih.gov/29204551/
mTOR, metabolism, and the immune response in HPV-positive head and neck squamous cell cancer
Extensive preclinical studies have identified mammalian target of rapamycin (mTOR) activation as a frequent molecular signature underlying head and neck...
https://www.gasyblog.com/
Outlook on PI3K/AKT/mTOR inhibition – PI3K/AKT/mTOR Signaling
outlookaktmtorinhibitionsignaling
https://cordis.europa.eu/project/id/224757/pl
THE ROLE OF THE MTOR SIGNALING PATHWAY IN NEUROGENESIS AND ITS IMPLICATIONS FOR THE REGULATION OF...
The major interest of my research activity is to understand the pathophysiological mechanisms leading to the development of obesity, particularly focusing on...
mtor signaling pathway
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1007264
Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated...
Author summary Dysregulated mRNA translation occurs frequently in tumours due to elevated eIF4E expression or a hyperactive mTOR complex 1 (mTORC1) signaling...
https://pubmed.ncbi.nlm.nih.gov/34831441/?dopt=Abstract
PI3K/AKT/mTOR Signaling Pathway Is Required for JCPyV Infection in Primary Astrocytes
Astrocytes are a main target of JC polyomavirus (JCPyV) in the central nervous system (CNS), where the destruction of these cells, along with oligodendrocytes,...
mtor signaling pathway
https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2023.1217127/full
Frontiers | Impact of e-cigarette vaping aerosol exposure in pregnancy on mTOR signaling in rat...
Electronic cigarette (e-cig) use during pregnancy has become a major health concern in recent years and many view them as less harmful and may help quit or r...
https://pubmed.ncbi.nlm.nih.gov/28400999/
mTOR function and therapeutic targeting in breast cancer
mtorfunctiontherapeutictargetingbreast
https://openresearch-repository.anu.edu.au/items/81a59121-6145-429b-8971-b9ccb9f3eab0
Pathological actions of STAT4, MTOR and STAT3 in human T cell differentiation
There is an expanding catalogue of immune deficiency diseases with inflammatory and autoimmune manifestations. Understanding the genetic basis of this...
https://pubmed.ncbi.nlm.nih.gov/27753196/
Smith-Kingsmore syndrome: A third family with the MTOR mutation c.5395GA p.(Glu1799Lys) and...
Heterozygous germline mutations in MTOR have been shown to underlie Smith-Kingsmore syndrome, a rare autosomal dominant syndrome characterized by macrocephaly,...
https://pubmed.ncbi.nlm.nih.gov/35388773/
Streptococcus agalactiae-induced autophagy of bovine mammary epithelial cell via PI3K/AKT/mTOR...
Streptococcus agalactiae (S. agalactiae) infection is a significant cause of mastitis, resulting in loss of cellular homeostasis and tissue damage. Autophagy...
https://pubmed.ncbi.nlm.nih.gov/29490194/
Abnormal mTOR Activation in Autism
The mechanistic target of rapamycin (mTOR) is an important signaling hub that integrates environmental information regarding energy availability and stimulates...
abnormalmtoractivationautism
https://pubmed.ncbi.nlm.nih.gov/34001131/?dopt=Abstract
CCL21 activation of the MALAT1/SRSF1/mTOR axis underpins the development of gastric carcinoma
Taken together, the key observations of our study provide evidence that CCL21 enhances the progression of GC via the MALAT1/SRSF1/mTOR axis, providing a novel...
of the
https://pubmed.ncbi.nlm.nih.gov/16109716/
mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival...
A critical aspect of tumor progression is the generation of survival signals that overcome default apoptotic programs. Recent studies have revealed that...
https://pubmed.ncbi.nlm.nih.gov/20606252/
The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway
Transient induction of p53 can cause reversible quiescence and irreversible senescence. Using nutlin-3a (a small molecule that activates p53 without causing...
https://pubmed.ncbi.nlm.nih.gov/39755581/
SIGLEC11 promotes M2 macrophage polarization through AKT-mTOR signaling and facilitates the...
https://pubmed.ncbi.nlm.nih.gov/32039915/
Chronic mTOR activation induces a degradative smooth muscle cell phenotype
Smooth muscle cell (SMC) proliferation has been thought to limit the progression of thoracic aortic aneurysm and dissection (TAAD) because loss of medial cells...
smooth musclechronicmtoractivationcell
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.647540/full
Frontiers | TOX Acts as a Tumor Suppressor by Inhibiting mTOR Signaling in Colorectal Cancer
The treatment and prognosis of advanced colorectal cancer (CRC) remain challenging clinical research focus. Here, we describe a new CRC tumor suppressor and ...
https://pubmed.ncbi.nlm.nih.gov/41825157/
Autophagy-centered regulation of PI3K/Akt/mTOR and MAPK signaling by traditional Chinese medicine...
Gastric cancer (GC) remains a major global health burden, with high incidence and mortality rates, particularly in East Asia, driven by factors such as...
https://pubmed.ncbi.nlm.nih.gov/26139536/
mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival
Lysosomes are essential organelles that function to degrade and recycle unwanted, damaged and toxic biological components. Lysosomes also act as signalling...
https://pubmed.ncbi.nlm.nih.gov/24508774/
Targeting bone metastatic cancer: Role of the mTOR pathway
One of the great challenges of cancer medicine is to develop effective treatments for bone metastatic cancer. Most patients with advanced solid tumors will...
metastatic cancerof thetargetingbonerole
https://dshb.biology.uiowa.edu/12F10-5F11
Mtor Antibody (12F10-5F11) - DSHB
Catalog FieldsClone ID/Product Name: 12F10-5F11Available to For-Profits: YesAlternate Antibody Name: Gene Symbol: MtorAb Isotype: MIgG1Gene Name: Antibody...
mtorantibody
https://pubmed.ncbi.nlm.nih.gov/26927950/
The Role of mTOR Inhibitors in the Treatment of Patients with Tuberous Sclerosis Complex:...
Tuberous sclerosis complex (TSC) is a genetic disorder arising from mutations in the TSC1 or TSC2 genes. The resulting over-activation of the mammalian target...
the rolemtor inhibitors
https://pure.psu.edu/en/publications/alcohol-and-pras40-knockdown-decrease-mtor-activity-and-protein-s/
Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and...
https://pubs.rsc.org/en/Content/ArticleLanding/2016/MD/C5MD00493D
eCF309: a potent, selective and cell-permeable mTOR inhibitor - MedChemComm (RSC Publishing)
Kinase inhibitors capable of blocking the phosphorylation of protein substrates with high selectivity are essential to probe and elucidate the etiological role...
https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2019.00236/full
Frontiers | Novel 4-Acrylamido-Quinoline Derivatives as Potent PI3K/mTOR Dual Inhibitors: The...
A novel structural series of quinoline derivatives were designed, synthesized and biologically evaluated as PI3K/mTOR dual inhibitors upon incorporation of C...
https://bibliographie.uni-tuebingen.de/xmlui/handle/10900/163018
The non-canonical impact of complement factor H on mTOR signaling and cellular metabolism in...
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2012.00312/full
Frontiers | All PI3Kinase signaling is not mTOR: dissecting mTOR-dependent and independent...
The mechanistic target of rapamycin (mTOR) is emerging as playing a central role in regulating T cell activation, differentiation, and function. mTOR integr...
frontierssignaling
https://researchdiscovery.drexel.edu/esploro/outputs/graduate/Enhancing-bone-marrow-derived-mesenchymal-stem-cell/991018528711104721
Enhancing bone marrow-derived mesenchymal stem cell therapeutic potential through mTOR inhibition -...
Despite our best efforts to avoid growing older, aging is an inevitable phenomenon that affects all living organisms. The aging process results from normal...
mesenchymal stem cellbone marrow
https://groupleaders.mpdl.mpg.de/tag/mtor/
mTOR Archives - MPRGL
mtorarchives
https://scholars.duke.edu/publication/1527240
Scholars@Duke publication: mTOR Activation Initiates Renal Cell Carcinoma Development by...
renal cell carcinomascholarsdukepublicationmtor
https://pmc.ncbi.nlm.nih.gov/articles/PMC8225252/
mTOR: A possible therapeutic target against SARS-CoV-2 infection - PMC
therapeutic targetsars covmtorpossible
https://researchconnect.buffalo.edu/en/publications/the-choice-between-p53-induced-senescence-and-quiescence-is-deter/
The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway...
https://theses.gla.ac.uk/83311/
Investigating PI3K/AKT/mTOR signalling in pancreatobiliary cancer - Enlighten Theses
investigatingaktmtorsignallingpancreatobiliary
https://mindandmatter.substack.com/p/linoleic-acid-seed-oils-mtor-and
Linoleic Acid, Seed Oils, mTOR & Breast Cancer | Nikos Koundouros & John Blenis | 229
How dietary fats influence breast cancer progression.
linoleic acidseed oilsbreast cancer
https://bibliographie.uni-tuebingen.de/xmlui/handle/10900/98080?show=full
Haprolid inhibits tumor growth of hepatocellular carcinoma through Rb/E2F and Akt/mTOR inhibition