https://adisinsight.springer.com/trials/700374533?error=cookies_not_supported&code=3da7de1e-59a7-4fd4-972e-dde8587e7299
A Study of AK112 Monotherapy in Advanced/Metastatic Renal Cell Carcinoma - AdisInsight
This is an open-label, single arm , Ib/II phase trial to evaluate the efficacy and safety of AK112 ivonescimab monotherapy as first-line treatment for
renal cell carcinoma
https://pure.psu.edu/en/publications/management-of-renal-cell-carcinoma-presenting-during-teenage-preg/
Management of renal cell carcinoma presenting during teenage pregnancy - Penn State
renal cell carcinomateenage pregnancymanagement
https://pubmed.ncbi.nlm.nih.gov/29568504/
Renal cell carcinoma: a review of biology and pathophysiology
Over the past decade, our understanding of the biology and pathophysiology of renal cell carcinoma (RCC) has improved significantly. Insight into the disease...
renal cell carcinomareviewbiologypathophysiology
https://portal.fis.tum.de/de/publications/expression-of-nectin-4-in-chromophobe-renal-cell-carcinoma-in-a-m/
Expression of Nectin-4 in Chromophobe Renal Cell Carcinoma in a Multicenter Cohort: Early...
renal cell carcinoma
https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1112343/full
Frontiers | Renal cell carcinoma of different pathological types in bilateral native kidneys of a...
Patients after kidney transplantation have a much higher risk of developing malignant tumors than the general population. And the native kidney is an organ r...
renal cell carcinoma
https://health.economictimes.indiatimes.com/tag/renal+cell+carcinoma
Renal cell carcinoma - Latest renal cell carcinoma , Information & Updates - Health -ET HealthWorld
ETHealthworld.com brings latest renal cell carcinoma news, views and updates from all top sources for the Indian Health industry.
renal cell carcinomalatest informationupdateshealthet
https://pure.psu.edu/en/publications/renal-cell-carcinoma-with-sarcomatoid-transformation-presenting-a/
Renal cell carcinoma with sarcomatoid transformation, presenting as skin rashes - Penn State
renal cell carcinoma
https://pubmed.ncbi.nlm.nih.gov/17953739/
Basal cytokines profile in metastatic renal cell carcinoma patients treated with subcutaneous...
Higher cytokines levels characterize patients population with respect to healthy donors. Moreover, higher basal level of some immunosuppressive cytokines (CRP,...
renal cell carcinoma
https://pmc.ncbi.nlm.nih.gov/articles/PMC12536162/
Orthopedic interventions and outcomes in patients with metastatic renal cell carcinoma: a...
Despite advanced in systemic therapy for renal cell carcinoma (RCC), bone metastasis remains an adverse prognostic factor and major cause of mortality and...
renal cell carcinoma
https://hsrc.himmelfarb.gwu.edu/smhs_uro_facpubs/78/
"Managing Renal Cell Carcinoma Associated Paraneoplastic Syndrome with " by John M DiBianco, Julie...
A patient with germline von Hippel-Lindau (VHL) gene alteration and history of multiple tumors present with classical paraneoplastic syndrome (PNS) associated...
renal cell carcinoma
https://cordis.europa.eu/project/id/710938/results/es
A breakthrough in Renal Cell Carcinoma: Personalized RCC-Test | RCC-TEST | Proyecto | Resultados |...
Deliverables, publications, datasets, software, exploitable results
renal cell carcinomabreakthrough
https://pubmed.ncbi.nlm.nih.gov/32041500/
Nivolumab efficacy in leptomeningeal metastasis of renal cell carcinoma: a case report
Meningeal carcinomatosis metastasis from renal cancer is a rare condition. Diagnosis is often challenging: the onset of nonspecific presenting symptoms could...
renal cell carcinoma
https://pubmed.ncbi.nlm.nih.gov/29482572/
Wilms' tumor 1-associating protein promotes renal cell carcinoma proliferation by regulating CDK2...
These findings suggest that WTAP may have an oncogenic role in RCC through physically binding to CDK2 transcript and enhancing its transcript stability which...
renal cell carcinoma
https://adisinsight.springer.com/drugsafety/803914486?error=cookies_not_supported&code=f5ae6ad7-5d8c-46c9-9ab4-da1414046510
ICI therapy in renal cell carcinoma: endocrine immune-related AEs, favourable clinical outcomes -...
The development of endocrine immune-related adverse events in patients with renal cell carcinoma treated with immune checkpoint inhibitors (ICIs) is associated
renal cell carcinoma
https://pure.psu.edu/en/publications/renal-cell-carcinoma-metastatic-to-the-orbit-a-clinicopathologic-/
Renal cell carcinoma metastatic to the orbit: a clinicopathologic report. - Penn State
renal cell carcinomato the
https://pure.psu.edu/en/publications/the-epidemiology-of-renal-cell-carcinoma-a-second-look/
The epidemiology of renal cell carcinoma. A second look - Penn State
renal cell carcinomasecond lookepidemiology
https://pubmed.ncbi.nlm.nih.gov/31656773/
Liquid biopsies in renal cell carcinoma with focus on epigenome analysis
Liquid biopsies in renal cell carcinoma with focus on epigenome analysis
renal cell carcinomafocus onliquidbiopsies
https://www.nice.org.uk/guidance/ta417/chapter/5-Implementation
5 Implementation | Nivolumab for previously treated advanced renal cell carcinoma | Guidance | NICE
Evidence-based recommendations on nivolumab (Opdivo) for previously treated advanced renal cell carcinoma in adults
renal cell carcinoma
https://adisinsight.springer.com/trials/700241851?error=cookies_not_supported&code=db394b49-0133-4490-9f75-f5fdd823a6d4
Everolimus (Afinitor) in Patients With Metastatic Renal Cell Carcinoma Following Progression on...
This trial evaluated the efficacy of everolimus [Afinitor] in metastatic renal cell carcinoma patients following progression on bevacizumab (with or without
renal cell carcinoma
https://medicine.buffalo.edu/departments/ortho/education/resources/tumor-unknown/matrix/renalcellhisto.html
Renal Cell Carcinoma Metastasis - Jacobs School of Medicine and Biomedical Sciences - University at...
renal cell carcinomaschool of medicine
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1271669/full
Frontiers | Advances in the research of exosomes in renal cell carcinoma: from mechanisms to...
Renal cell carcinoma (RCC) is one of the most malignant urological tumors. Currently, there is a lack of molecular markers for early diagnosis of RCC. The 5-...
renal cell carcinoma
https://www.wikidata.org/wiki/Q35977713
Molecular genetic investigation of sporadic renal cell carcinoma: analysis of allele loss on...
renal cell carcinomamolecular genetic
https://cdas.cancer.gov/approved-projects/386/
2007-0253: Genome-wide association study of renal cell carcinoma: replication scan - Approved...
CDAS allows the research community to submit research projects to request data, biospecimens, or images from cancer trials and other studies. Approved projects...
renal cell carcinoma
https://pure.psu.edu/en/publications/complications-and-outcomes-associated-with-surgical-management-of/
Complications and Outcomes Associated With Surgical Management of Renal Cell Carcinoma Involving...
renal cell carcinomaassociated withsurgical management
https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1111706/full
Frontiers | Case Report: Disease progression of renal cell carcinoma containing a novel putative...
Renal cell carcinoma still carries a poor prognosis despite therapeutic advancements. Detection of genetic mutations is vital in improving our understanding ...
renal cell carcinoma
https://umu.diva-portal.org/smash/record.jsf?faces-redirect=true&language=sv&searchType=SIMPLE&query=&af=%5B%5D&aq=%5B%5B%5D%5D&aq2=%5B%5B%5D%5D&aqe=%5B%5D&pid=diva2%3A2039429&noOfRows=50&sortOrder=author_sort_asc&sortOrder2=title_sort_asc&onlyFullText=false&sf=all
Metastatic renal cell carcinoma: risk of rapid progression to pathological fractures and factors...
renal cell carcinoma
https://pubmed.ncbi.nlm.nih.gov/33466124/
Renal cell carcinoma in children and adolescents: Single-center experience and literature review
Renal cell carcinoma (RCC) is infrequent in the pediatric population. In addition, till date, only a few reports have summarized the characteristics of...
renal cell carcinomachildren and adolescents
https://pubmed.ncbi.nlm.nih.gov/28974985/
Cabozantinib in metastatic renal cell carcinoma: latest findings and clinical potential
Since the advent of immunotherapy revolutionized the treatment of metastatic renal cell carcinoma (mRCC), the attention of oncologists has been unavoidably...
renal cell carcinomalatest findingscabozantinibmetastatic
https://www.prnewswire.com/news-releases/global-renal-cell-carcinoma-drugs-market-2020-300220229.html
Global Renal Cell Carcinoma Drugs Market 2020
/PRNewswire/ -- Renal cell carcinoma, also called renal adenocarcinoma, is a disease in which malignant or cancerous cells are found in the lining of tubules...
renal cell carcinomadrugs marketglobal
https://scholars.duke.edu/publication/1527240
Scholars@Duke publication: mTOR Activation Initiates Renal Cell Carcinoma Development by...
renal cell carcinomascholarsdukepublicationmtor
https://researchconnect.buffalo.edu/en/publications/partial-adrenalectomy-for-renal-cell-carcinoma-with-bilateral-adr/
Partial Adrenalectomy for Renal Cell Carcinoma With Bilateral Adrenal Metastases - SUNY University...
renal cell carcinoma
https://scholars.duke.edu/publication/1428837
Scholars@Duke publication: Clinical Characteristics of Patients With Renal Cell Carcinoma and...
renal cell carcinoma
https://pubmed.ncbi.nlm.nih.gov/27462141/
Cabozantinib in the treatment of advanced renal cell carcinoma: design, development, and potential...
The treatment of metastatic renal cell carcinoma (mRCC) has markedly improved over the last few years with the introduction of several targeted agents in...
renal cell carcinoma
https://pubmed.ncbi.nlm.nih.gov/33588158/
Tumor mutational burden and immune infiltrates in renal cell carcinoma and matched brain metastases
The comparable immunological microenvironment of extra- and intracranial tumor samples in our study underscores the immunological activation also in BM from...
renal cell carcinoma
https://consultqd.clevelandclinic.org/neoadjuvant-and-adjuvant-combination-therapy-in-locally-advanced-renal-cell-carcinoma-raises-toxicity-concerns
Neoadjuvant and Adjuvant Combination Therapy in Locally Advanced Renal Cell Carcinoma Raises...
A new study finds neoadjuvant and adjuvant monotherapy using the checkpoint inhibitor durvalumab is well-tolerated by patients with locally advanced renal cell...
renal cell carcinomacombination therapy
https://pure.psu.edu/en/publications/handling-and-staging-of-renal-cell-carcinoma-the-international-so/
Handling and staging of renal cell carcinoma: The International Society of Urological Pathology...
renal cell carcinoma
https://www.urologynews.uk.com/features/features/post/sarcomatoid-renal-cell-carcinoma
Sarcomatoid renal cell carcinoma | Urology News
renal cell carcinomasarcomatoidurologynews
https://pmc.ncbi.nlm.nih.gov/articles/PMC8096365/
Serum Concentrations of Per- and Polyfluoroalkyl Substances and Risk of Renal Cell Carcinoma - PMC
Per- and polyfluoroalkyl substances (PFAS) are highly persistent chemicals that have been detected in the serum of over 98% of the US population. Studies among...
renal cell carcinoma
https://cordis.europa.eu/project/id/710938/results/pl
A breakthrough in Renal Cell Carcinoma: Personalized RCC-Test | RCC-TEST | Projekt | Wyniki | H2020...
Deliverables, publications, datasets, software, exploitable results
renal cell carcinoma
https://clarivate.com/life-sciences-healthcare/report/trsqon0007-2017-biopharma-renal-cell-carcinoma-treatment-sequencing-us-2017/
Renal Cell Carcinoma | Treatment Sequencing | US | 2017 | Clarivate
Treatment Sequencing provides disease-specific, sequential treatment patterns in market-relevant treatment scenarios and drug share mapped to treatment...
renal cell carcinomatreatmentsequencingusclarivate
https://pubmed.ncbi.nlm.nih.gov/31032317/
Adjuvant therapy in renal cell carcinoma-is pharmacogenomics assessment another element to select...
Adjuvant therapy in renal cell carcinoma-is pharmacogenomics assessment another element to select our patients?
renal cell carcinoma
https://eipm.weill.cornell.edu/publications/interferon-signaling-restrains-renal-cell-carcinoma-heterogeneity
Interferon signaling restrains renal cell carcinoma heterogeneity. | Englander Institute for...
renal cell carcinomainterferonsignalingrestrainsheterogeneity
https://openresearch.surrey.ac.uk/esploro/outputs/journalArticle/The-dysfunctional-immune-response-in-renal/99829668202346
The dysfunctional immune response in renal cell carcinoma correlates with changes in the metabolic...
Nov 8, 2023 - Renal cell carcinoma is an immunogenic tumour with a prominent dysfunctional immune cell infiltrate, unable to control tumour growth. Although tyrosine kinase...
renal cell carcinomaimmune response
https://cordis.europa.eu/project/id/710938/results/de
A breakthrough in Renal Cell Carcinoma: Personalized RCC-Test | RCC-TEST | Projekt | Ergebnisse |...
Deliverables, publications, datasets, software, exploitable results
renal cell carcinomabreakthrough
https://researchportalplus.anu.edu.au/en/publications/new-systemic-treatment-options-for-metastatic-renal-cell-carcinom/
New systemic treatment options for metastatic renal-cell carcinoma in the era of targeted therapies...
https://pubmed.ncbi.nlm.nih.gov/30988818/
The potential role of miR-126, miR-21 and miR-10b as prognostic biomarkers in renal cell carcinoma
Renal cell carcinoma (RCC) is the most commonly diagnosed renal tumor, consisting of ~3% of all malignancies worldwide. The prognosis of RCC can vary widely,...
https://researchconnect.buffalo.edu/en/publications/everolimus-versus-sunitinib-for-patients-with-metastatic-non-clea/
Everolimus versus sunitinib for patients with metastatic non-clear cell renal cell carcinoma...
for patients
https://www.wikidata.org/wiki/Q45880509
Targeted exome sequencing in clear cell renal cell carcinoma tumors suggests aberrant chromatin...
exome sequencingclear cell
https://pubmed.ncbi.nlm.nih.gov/23205057/
Experience with sorafenib in the treatment of advanced renal cell carcinoma
The molecular-targeted agent sorafenib is the first anticancer agent able to slow the progression of advanced/metastatic renal cell carcinoma, a tumor that was...
in theexperiencesorafenib
https://connect.mayoclinic.org/discussion/lung-cancer-7/
Renal small cell carcinoma has spread to the lungs | Mayo Clinic Connect
Small cell carcinoma in left kidney in 2018. Removed, then chemo. Fortunately lung was clear then. Now, showing growing spots in lungs. Follow up Cat...
small cell
https://adisinsight.springer.com/trials/700042847?error=cookies_not_supported&code=8a8615ea-559d-4717-8ee9-a8cc2b06c23d
A Phase II Study of Sorafenib in Patients With Metastatic Renal Cell Carcinoma (RCC) Refractory to...
This trial investigated the efficacy and tolerability of sorafenib [BAY 43-9006] in patients with metastatic renal cell carcinoma refractory to sunitinib or
https://www.ncbi.nlm.nih.gov/clinvar/RCV002847211/
NM_000245.4(MET):c.1971TC (p.Pro657=) AND Renal cell carcinoma - ClinVar - NCBI
ClinVar archives and aggregates information about relationships among variation and human health.
https://experts.arizona.edu/en/publications/pd-1pd-l1-in-renal-cell-carcinoma-projecting-the-way-forward/
PD-1/PD-L1 in Renal Cell Carcinoma: Projecting the Way Forward - University of Arizona
https://adisinsight.springer.com/trials/700259726?error=cookies_not_supported&code=1fedc199-d708-43a7-ad9b-49311fe49bfa
Tumour biomarkers for sunitinib response in patients with advanced renal cell carcinoma -...
This retrospective study investigated tumour biomarkers for sunitinib response in patients with advanced renal cell carcinoma. Patients identified from the
in patients
https://www.mdpi.com/2311-553X/7/2/25
Long Non-Coding PROX1-AS1 Expression Correlates with Renal Cell Carcinoma Metastasis and...
Long non-coding RNAs (lncRNAs) can be specifically expressed in different tissues and cancers. By controlling the gene expression at the transcriptional and...
https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.985641/full
Frontiers | Sarcomatoid-associated gene risk index for clear cell renal cell carcinoma
Sarcomatoid renal cell carcinoma is a de-differentiated form of kidney cancer with an extremely poor prognosis. Genes associated with sarcomatoid differentia...
risk indexclear cellfrontierssarcomatoidassociated
https://blogs.bmj.com/jmg/2026/02/05/mitf-p-e318k-and-renal-cell-carcinoma-current-evidence-does-not-support-an-effect/
MITF (p.E318K) and renal cell carcinoma: current evidence does not support an effect (Contributed...
Feb 22, 2026 - Variants in the human genome are known to predispose to disease. The E318K variant in the MITF transcription factor increases the likelyhood of melanoma...
https://www.mdpi.com/2077-0383/12/12/3888
Cellular and Molecular Players in the Tumor Microenvironment of Renal Cell Carcinoma
Globally, clear-cell renal cell carcinoma (ccRCC) represents the most prevalent type of kidney cancer. Surgery plays a key role in the treatment of this...
in the
https://pure.psu.edu/en/publications/lead-calcium-uptake-and-related-genetic-variants-in-association-w/
Lead, calcium uptake, and related genetic variants in association with renal cell carcinoma risk in...
https://pubmed.ncbi.nlm.nih.gov/15941683/
The sensitivity of renal cell carcinoma cells to interferon alpha correlates with p53-induction and...
Interferon alpha (IFN-alpha) is an approved treatment in metastatic renal cell carcinoma (RCC). The underlying mechanisms are far from being clear, but are...
https://pubmed.ncbi.nlm.nih.gov/26425143/
Clinical experience with everolimus in the second-line treatment of advanced renal cell carcinoma
Everolimus is an oral inhibitor of mammalian target of rapamycin (mTOR-I) and is currently approved for the treatment of metastatic renal cell carcinoma (mRCC)...
https://pubmed.ncbi.nlm.nih.gov/31480348/
The Evaluation of Response to Immunotherapy in Metastatic Renal Cell Carcinoma: Open Challenges in...
Immunotherapy has changed the therapeutic scenario of metastatic renal cell carcinoma (mRCC), however the evaluation of disease response to immune-checkpoint...
https://pubmed.ncbi.nlm.nih.gov/24093097/
Progress of molecular targeted therapies for advanced renal cell carcinoma
Vascular endothelial growth factor (VEGF) plays a crucial role in tumor angiogenesis. VEGF expression in metastatic renal cell carcinoma (mRCC) is mostly...
targeted therapiesfor advancedprogressmolecularrenal
https://pubmed.ncbi.nlm.nih.gov/19804430/
Cost-effectiveness of temsirolimus for first line treatment of advanced renal cell carcinoma
Temsirolimus has been shown to be clinically effective compared to interferon-alpha offering additional health benefits, however, with a cost per QALY in...
cost effectivenessfor first
https://pubmed.ncbi.nlm.nih.gov/31961766/
Phase IB/II Trial of Lenvatinib Plus Pembrolizumab in Patients With Advanced Renal Cell Carcinoma,...
Lenvatinib plus pembrolizumab demonstrated a manageable safety profile and promising antitumor activity in patients with selected solid tumor types.
https://hsbiblio.uni-tuebingen.de/xmlui/handle/10900/76040
Long-term survival correlates with immunological responses in renal cell carcinoma patients treated...
https://anesthesiology.weill.cornell.edu/publications/identifying-clear-cell-renal-cell-carcinoma-coexpression-networks-associated-with
Identifying Clear Cell Renal Cell Carcinoma Coexpression Networks Associated with Opioid Signaling...
clear cellassociated withidentifyingrenalcarcinoma
https://www.scirp.org/journal/paperinformation?paperid=80350
Thyroid Metastases from Clear Cell Renal Carcinoma: Presentation of an Unusual Case and Literature...
Clear cell type renal cell carcinoma is a malignant tumor that can metastasize to many locations, but unusually spreads to thyroid. Therefore it is important...
https://pmc.ncbi.nlm.nih.gov/articles/PMC5189272/
Treatment of Metastatic Renal Cell Carcinoma With CAIX CAR-engineered T cells: Clinical Evaluation...
Autologous T cells genetically modified to express a chimeric antibody receptor (CAR) against carboxy-anhydrase-IX (CAIX) were administered to 12 patients with...
https://oru.diva-portal.org/smash/record.jsf?pid=diva2:1583948
Rate of incisional hernia after minimally invasive and open surgery for renal cell carcinoma : a...
https://www.mdpi.com/1970-6790/1/2/e16
Clear Cell Renal Cell Carcinoma with Vaginal and Brain Metastases: A Case Report and Literature...
There are very few cases of clear cell renal cell carcinoma with metastases to the vagina and brain reported in the literature. Our case study highlights this...
https://pmc.ncbi.nlm.nih.gov/articles/PMC4148549/
Long term survival in a case of concurrent retroperitoneal liposarcoma and renal cell carcinoma: a...
Liposarcoma is one of the most common soft tissue sarcomas found in adults. It has a predilection for retroperitoneal space. Renal cell carcinoma is the most...
https://bibliographie.uni-tuebingen.de/xmlui/handle/10900/83284
Mass spectrometry-based analysis of the HLA-ligandomes of renal cell carcinoma and benign renal...
https://researchconnect.buffalo.edu/en/publications/combination-strategy-targeting-vegf-and-hgfc-met-in-human-renal-c/
Combination strategy targeting VEGF and HGF/c-met in human renal cell carcinoma models - SUNY...
https://www.cancer.gov/research/participate/clinical-trials-search/v?id=NCI-2025-05251&r=1
Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With...
Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy...
https://pubmed.ncbi.nlm.nih.gov/24282987/
Collision renal cell papillary and medullary carcinoma in a 66-year-old man
Collision renal cell papillary and medullary carcinoma in a 66-year-old man
https://pubmed.ncbi.nlm.nih.gov/37393162/
Multimodal recurrence scoring system for prediction of clear cell renal cell carcinoma outcome: a...
National Natural Science Foundation of China, and National Key Research and Development Program of China.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6340265/
A Case of Stage IV Chromophobe Renal Cell Carcinoma Treated with the Oncolytic ECHO-7 Virus,...
Patient: Male, 59 Final Diagnosis: Chromophobe renal cell carcinoma, stage IV Symptoms: Discomfort in the right hypochondrium Medication: Oncolytic virus...
https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.657318/full
Frontiers | Prognostic Value of Tumor-Associated Macrophages in Clear Cell Renal Cell Carcinoma: A...
Background: Tumor-associated macrophages (TAMs) are the major immune cells in tumor microenvironment. The prognostic significance of TAMs has been confirmed ...
https://scholars.duke.edu/publication/1344743
Scholars@Duke publication: Incidence and presentation of squamous cell carcinoma in renal...
squamous cell carcinoma
https://pure.psu.edu/en/publications/prospective-clinical-trial-of-preoperative-sunitinib-in-patients-/
Prospective clinical trial of preoperative sunitinib in patients with renal cell carcinoma - Penn...
https://portal.fis.tum.de/en/publications/trophoblast-cell-surface-antigen-2-trop2-in-chromophobe-renal-cel/
Trophoblast Cell Surface Antigen 2 (Trop2) in Chromophobe Renal Cell Carcinoma - Technical...
cellsurfaceantigen
https://scholars.uky.edu/en/publications/local-recurrence-following-resection-of-intermediate-high-risk-no/
Local Recurrence Following Resection of Intermediate-High Risk Nonmetastatic Renal Cell Carcinoma:...
local recurrence
https://medicine.yale.edu/cancer/trial/a032201-testing-the-addition-of-the-anti-cancer-drug-tivozanib-to-immunotherapy-pembrolizumab-aft/
Short TeRm Intensified Pembrolizumab (KEytruda) and Tivozanib for High-Risk Renal Cell Carcinoma -...
This phase III trial compares the effect of adding tivozanib to standard therapy pembrolizumab versus pembrolizumab alone for the treatment of patients with