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Integrated epigenetic and genetic programming of primary human T cells – nChroma
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https://www.boxrallies.com/research/leveraging-stem-like-memory-t-cells-for-effective-anti-cancer-mrna-vaccines
Leveraging stem-like memory T cells for effective anti-cancer mRNA vaccines
Leveraging stem-like memory T cells for effective anti-cancer mRNA vaccines
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https://www.jci.org/articles/view/73174/figure/3
JCI - CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells
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https://pure.amsterdamumc.nl/en/publications/preclinical-activity-of-allogeneic-slamf7-specific-car-t-cells-uc/
Preclinical activity of allogeneic SLAMF7-specific CAR T-cells (UCARTCS1) in multiple myeloma -...
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Characterization of the role of regulatory T cells in a murine model of uveitis
This dissertation investigates the role of regulatory T cells (Tregs) in uveitis using a murine adoptive transfer model and intravital microscopy. Contrary to...
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https://www.geneediting.com/clinical-trials/NCT06481228/
NCT06481228: Efficacy and Safety of TKI Combined With Chemotherapy and Sequential CAR-T Cells in ND...
In recent years, immunotherapy (eg. blinatumomab, inotuzumab ozogamicin, CAR-T cells) has demonstrated a high safety and efficacy profile in...
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https://www.bioocus.com/hidden/the-first-hospital-of-hebei-medical-university/
How T Cells Fight Cancer: Revolutionizing Cancer Treatment
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CAR-T Cells and Autoimmune Diseases: A Glimpse into the Future of Targeted Immunotherapy
Autoimmune diseases occur when the immune system mistakenly attacks the body’s own tissues. While current treatments can manage symptoms, they often require...
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https://www.prelekara.sk/casopisy/plos-pathogens/2010-4/natural-regulatory-t-cells-in-malaria-host-or-parasite-allies-45812
Natural Regulatory T Cells in Malaria: Host or Para... | preLekára.sk
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https://www.neurologylive.com/view/emerging-therapies-future-ms-insights-btk-inhibitors-car-t-cells
Emerging Therapies and the Future of MS: Insights on BTK Inhibitors and CAR T-Cells | NeurologyLive...
Oct 7, 2026 - Experts discussed the promise and uncertainty surrounding BTK inhibitors and CAR T-cell therapy in addressing progressive multiple sclerosis. [WATCH TIME: 8...
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https://www.citedrive.com/en/discovery/t-cells-with-chimeric-antigen-receptors-have-potent-antitumor-effects-and-can-establish-memory-in-patients-with-advanced-leukemia/
[PDF] T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish...
Adoptively transferred gene-modified T cells expand in vivo, eliminate leukemic cells, and form functional memory cells in patients.
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https://www.wikidata.org/wiki/Q43968794
CTLA-4 suppresses proximal TCR signaling in resting human CD4(+) T cells by inhibiting ZAP-70...
scientific article published in May 2002
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https://insight.jci.org/articles/view/185581/figure/1
JCI Insight - Tregs epigenetically reprogrammed from autoreactive effector T cells mitigate...
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https://experts.umn.edu/en/publications/sepsis-leads-to-lasting-changes-in-phenotype-and-function-of-na%C3%AFv/
Sepsis leads to lasting changes in phenotype and function of naïve CD8 T cells - Experts@Minnesota
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https://experts.umn.edu/en/projects/regulation-and-function-of-oral-resident-memory-t-cells/fingerprints/
Regulation and Function of Oral Resident Memory T Cells - Fingerprint - Experts@Minnesota
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https://cris.biu.ac.il/en/publications/extrathymic-generation-of-tumor-specific-t-cells-from-genetically-4/
Extrathymic generation of tumor-specific T cells from genetically engineered human hematopoietic...
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https://bioengineer.org/reversing-t-cells-misunderstood-rep-in-responding-to-a-pediatric-leukemia/
Reversing t cells' misunderstood rep in responding to a pediatric
Jun 26, 2019 - Credit: Anthony Zamora A study of pediatric patients with leukemia demonstrates that they were able to generate T cells against tumor-associated mutations,...
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https://www.cgtlive.com/view/engineered-car-t-cells-show-promise-multiple-myeloma
Engineered CAR T Cells Show Promise in Multiple Myeloma | CGTlive®
Oct 16, 2026 - Chimeric antigen receptor T cells can eradicate large burdens of multiple myeloma, according to a new study presented at ASH.
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https://hsrc.himmelfarb.gwu.edu/gwhpubs/4310/
"Altered IL-7 signaling in CD4+ T cells from patients with visceral lei" by Shashi Kumar, Shashi...
BACKGROUND: CD4+ T cells play a central role in control of L. donovani infection, through IFN-γ production required for activation of macrophages and killing...
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CAR-T Cells and Autoimmune Diseases: A Glimpse into the Future of Targeted Immunotherapy
Autoimmune diseases occur when the immune system mistakenly attacks the body’s own tissues. While current treatments can manage symptoms, they often require...
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https://www.lji.org/news-events/news/post/family-resemblance-how-t-cells-could-fight-many-coronaviruses-at-once/embed/
Family resemblance: How T cells could fight many coronaviruses at once – La Jolla Institute for...
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https://www.jci.org/assets/289621/powerpoint
JCI - Control of inflammation by integration of environmental cues by regulatory T cells
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https://www.dm.univr.it/?ent=progetto&id=4808&lang=en
Role of CD4+ CD25+ regulatory T cells in the modulation of autoimmunity in the central nervous...
Dep.Medicine,University of Verona
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https://epub.ub.uni-muenchen.de/58725/
Major surgical trauma differentially affects T-cells and APC
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https://insight.jci.org/articles/view/179771
JCI Insight - Frequency of dengue virus–specific T cells is related to infection outcome in endemic...
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https://insight.jci.org/articles/view/90585
JCI Insight - Differential expression of GPR15 on T cells during ulcerative colitis
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CAR-T Cells and Autoimmune Diseases: A Glimpse into the Future of Targeted Immunotherapy
Autoimmune diseases occur when the immune system mistakenly attacks the body’s own tissues. While current treatments can manage symptoms, they often require...
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https://atcmeetingabstracts.com/abstract/evaluation-of-the-differentiation-program-of-endogenous-antigen-specific-cd8t-cells-following-transplantation/
Evaluation of the Differentiation Program of Endogenous Antigen-specific CD8+T Cells Following...
*Purpose: Despite advances in the survival of transplanted organs, acute T cell mediated rejection remains a significant clinical problem with few effective or...
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https://refubium.fu-berlin.de/handle/fub188/14355?show=full
Refubium - Transfer of regulatory T cells into abortion-prone mice promotes the expansion of...
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https://openaccess.bezmialem.edu.tr/entities/publication/aa02e4cc-bd6a-42a1-bfa3-0c058da3e389
Real-time tracking, retrieval and gene expression analysis of migrating human T cells
Dynamical analysis of single-cells allows assessment of the extent and role of cell-to-cell variability, however traditional dish-and-pipette techniques have...
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https://researchinformation.umcutrecht.nl/en/activities/make-car-t-cells-feel-at-home/
Make CAR-T cells feel at home - University Medical Center Utrecht
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https://insight.jci.org/assets/1118/powerpoint
JCI Insight - Induced regulatory T cells in allograft tolerance via transient mixed chimerism
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https://msg.ucsf.edu/content/abstract-6114-engineering-novel-synnotch-car-t-cells-to-precisely-and-effectively-target
Abstract 6114: Engineering novel synNotch CAR T cells to precisely and effectively target...
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https://clinicaltrials.ucsf.edu/trial/NCT04960579
UCSF Multiple Myeloma Trial → P-BCMA-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With...
This Multiple Myeloma study at UCSF ends March 2042.
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https://pure.ecnu.edu.cn/zh/publications/ancestral-t-cells-in-fish-require-mtorc1-coupled-immune-signals-a/
Ancestral T cells in fish require mTORC1-Coupled immune signals and metabolic programming for...
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Proteomics of human cancer-associated T cells identifies regulators of T cell functionality | Sciety
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CAR-T Cells and Autoimmune Diseases: A Glimpse into the Future of Targeted Immunotherapy
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https://scitechdaily.com/reviving-exhausted-t-cells-sparks-powerful-cancer-tumor-elimination/
Reviving Exhausted T Cells Sparks Powerful Cancer Tumor Elimination
Researchers found a hidden signal that makes T cells shut down during cancer fights. Turning off this signal reawakens the cells and helps them attack tumors...
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https://www.cancer.gov/publications/dictionaries/cancer-drug/def/autologous-anti-cd1a-car-t-cells-oc-1
Definition of autologous anti-CD1a CAR T cells OC-1 - NCI Drug Dictionary - NCI
Find technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. Each entry includes...
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CAR-T Cells and Autoimmune Diseases: A Glimpse into the Future of Targeted Immunotherapy
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https://www.cellgenetherapyreview.com/3975-Featured-Articles/619547-Unlocking-the-potential-of-unconventional-T-cells/
Unlocking the potential of unconventional T cells | Cellgenetherapyreview.com
Unlocking the potential of unconventional T cells
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https://utswmed.org/medblog/leukemia-car-t-cells/
CAR T-cells: A new frontier in children’s leukemia care | Cancer | UT Southwestern Medical Center
Learn how a breakthrough treatment trains children’s immune systems to fight back against leukemia.
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https://submit.jci.org/articles/view/202159/pdf
JCI Insight - Specificity, frequency, and phenotype of citrullinated-specific T cells vary with...
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https://www.jci.org/articles/view/153204/pdf
JCI - HIV-specific CAR T cells return to the clinic
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https://www.research.ed.ac.uk/en/publications/analysis-of-high-molecular-weight-rna-induced-silencing-complex-h/
Analysis of high molecular weight RNA-induced silencing complex (HMW-RISC) in CD8+ T cells...
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https://scholars.houstonmethodist.org/en/prizes/engineered-car-t-cells-for-the-treatment-of-diffuse-large-b-cell-/
“Engineered CAR-T cells for the treatment of diffuse large B cell lymphoma” - Houston Methodist...
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https://dzl.de/publication/10-1007-s00394-015-1100-1/
Zinc enhances the number of regulatory T cells in allergen-stimulated cells from atopic subjects -...
PURPOSE: The trace element zinc is essential for immune function and its regulation. Since zinc deficiency and allergic hyperresponsive reactions are often...
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https://hudson.org.au/news/t-cells-open-the-door-to-potential-immune-therapies/
T cells open the door to potential immune therapies - Hudson Institute of Medical Research
Jul 8, 2024 - Researchers are working on regulation of T cell activity to prevent excessive inflammation and damage to healthy tissue.
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CAR-T Cells and Autoimmune Diseases: A Glimpse into the Future of Targeted Immunotherapy
Autoimmune diseases occur when the immune system mistakenly attacks the body’s own tissues. While current treatments can manage symptoms, they often require...
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https://www.dm.univr.it/;jsessionid=abc6Wvm3YBUq3a3lmv0Uz?ent=progetto&lang=en&id=4808
Role of CD4+ CD25+ regulatory T cells in the modulation of autoimmunity in the central nervous...
Dep.Medicine,University of Verona
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https://esc365.escardio.org/journal/77762
ESC 365 - Exploring PD-1+ and tissue resident memory T cells in atherosclerotic diseases
Access Cardiovascular Research article on on ESC 365.
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https://idus.us.es/items/414ec410-a1a8-4493-8931-dedb503d823b
Immunomodulatory Effects of Cylindrospermopsin in Human T Cells and Monocytes
Cylindrospermopsin (CYN) is a cyanotoxin with an increasing occurrence, and therefore it is important to elucidate its toxicity profile. CYN has been...
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https://seek.synergy-munich.de/studies/94
Twin study identifies early immunological and metabolic dysregulation of CD8+ T cells in multiple...
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https://asoi.info/publication/glucagon-like-peptide-1-glp-1-and-the-regulation-of-human-invariant-natural-killer-t-cells-lessons-from-obesity-diabetes-and-psoriasis/
Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells:...
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https://inmuno.es/index.php/2024/12/10/identification-and-phenotypic-characterization-of-neoantigen-specific-cytotoxic-cd4-t-cells-in-endometrial-cancer/
Identification and phenotypic characterization of neoantigen-specific cytotoxic CD4+ T cells in...
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Peanut allergy oral immunotherapy drives single-cell multi-omic changes in peanut-reactive T cells...
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https://pure.psu.edu/en/publications/different-repertoires-of-mouse-t-cells-for-bovine-insulin-present/
Different repertoires of mouse T cells for bovine insulin presented by syngeneic and allogeneic...
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https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.773983/full
Frontiers | Multifunctional, TNF-α and IFN-γ-Secreting CD4 and CD8 T Cells and CD8High T Cells Are...
Visceral Leishmaniasis (VL) is a chronical and often fatal disease caused by protozoans of the genus Leishmania that affects millions of people worldwide. Pa...
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https://experts.umn.edu/en/publications/cd8supsup-t-cells-cause-disability-and-axon-loss-in-a-mouse-model/
CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis -...
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https://tus.elsevierpure.com/en/publications/a-protein-kinase-d-inhibitor-suppresses-akt-on-t-cells-and-antago/fingerprints/
A protein kinase D inhibitor suppresses AKT on T cells and antagonizes cancer immunotherapy by...
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https://www.engineering.upenn.edu/stories/new-lipid-nanoparticles-improve-mrna-delivery-for-engineering-car-t-cells/
New Lipid Nanoparticles Improve mRNA Delivery for Engineering CAR T Cells | Penn Engineering
Inventing the Future
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https://www.lungcancerresearchfoundation.org/tag/car-t-cells/
CAR-T cells Archives - Lung Cancer Research Foundation
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Knocking out CD70 rescues CD70-specific nanoCAR T cells from antigen-induced exhaustion - Prinses...
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https://www.jci.org/articles/view/65722/usage
JCI - Usage information: Cross-presentation and genome-wide screening reveal candidate T cells...
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https://research.polyu.edu.hk/en/publications/role-of-nuclear-factor-of-activated-t-cells-5-in-regulating-hyper/
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https://research.manchester.ac.uk/en/publications/in-the-absence-of-reactive-oxygen-species-t-cells-default-to-a-th/
In the absence of reactive oxygen species, T cells default to a Th1 phenotype and mediate...
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https://digitalcommons.odu.edu/computerscience_fac_pubs/139/
"Dormant Pathogenic CD4(+) T Cells Are Prevalent in the Peripheral Repe" by Anna Cebula, Michal...
Thymic central tolerance eliminates most immature T cells with autoreactive T cell receptors (TCR) that recognize self MHC/peptide complexes. Regardless, an...
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Apototic Cell-Mediated Induction of Antigen-Specific Regulatory T Cells for the Therapy of...
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[Research Frontier] CRISPR screen decodes stimulatory responses of primary T cells – EDITGENE
[Research Frontier] CRISPR screen decodes stimulatory responses of primary T cells
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ScRNA-seq revealed targeting regulator of G protein signaling 1 to mediate regulatory T cells in...
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https://orbit.dtu.dk/en/publications/engineering-t-cells-with-lipid-nanoparticles-for-cancer-immunothe/
Engineering T cells with lipid nanoparticles for cancer immunotherapy - Welcome to DTU Research...
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https://eprints.ncl.ac.uk/100392
Light-directed activation of human T-Cells - ePrints - Newcastle University
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https://avesis.sdu.edu.tr/yayin/d9fdd37f-412f-4027-af9f-351eae44f1d1/reproducibility-of-cd8-positive-t-cells-density-using-digitized-whole-slides-in-tumor-areas
Reproducibility of CD8 Positive T Cells Density Using Digitized Whole Slides in Tumor Areas | AVESİS
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6.4 Limitations and Future Directions for CAR T Cells – Selected Topics in Health and Disease (Vol....
Limitations of CAR T Cells In the previous section, Liu and colleagues’ paper demonstrated that CAR T-cells could benefit both patients with PD-L1high tumours...
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T cells Archives - Gretchen LaSalle MD
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https://news.yale.edu/2020/03/12/how-t-cells-make-sure-they-have-quiet-time
How T cells make sure they have quiet time | Yale News
Oct 6, 2024 - Each T cell has a gas pedal and brakes that operate simultaneously. When T cells overwork, people can be more susceptible to overactive immune responses.
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Статьи | CAR-T Cells: прорыв в борьбе с раковыми клетками
Jan 8, 2025 - CAR-T cells лечение — инновационный подход в онкологии, основанный на модификации собственных иммунных клеток пациента для борьбы...
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https://www.spandidos-publications.com/10.3892/mmr.2017.7525
Thymic function in the regulation of T cells, and molecular mechanisms underlying the modulation of...
Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.
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https://dash.harvard.edu/entities/publication/950e026d-074e-47e8-8bd2-bd6d2d27cdde
Gut intraepithelial T cells calibrate dietary metabolism and contribute to the development of...
Tissue resident immune cells undergo phenotypic transformation to maintain the integrity and function of host tissues. Upon extravasation from circulation,...
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Dual chimeric antigen receptor T cells targeting CD38 and SLAMF7 with independent signalling...
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Induction of B Cell Aplasia with cGP130 Armored-CAR T Cells Without Lymphodepletion - ACR Meeting...
Background/Purpose: The clinical application of CAR-T therapy remains limited by its dependence on lymphodepleting chemotherapy. Although cytokine support can...
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https://healthtost.com/scientists-aim-to-understand-why-t-cells-do-not-conserve-energy-in-tumors/
Scientists aim to understand why T cells do not conserve energy in tumors – Healthtost
Mar 17, 2024 - T cells are often called "killers" or "killers" because they can orchestrate and carry out missions to hunt down bacteria, viruses and cancer cells throughout t
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T Cells Crucial in Avoiding Symptoms of COVID-19 | Contagion Live
Oct 11, 2026 - Cells reactive to SARS-CoV-2 peptide pools were found in all anti-NP IgG–positive individuals.
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Depletion of KLRG1+ T cells in a First-in-Human Clinical Trial of ABC008 in Inclusion Body Myositis...
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Selective immunotargeting of diabetogenic CD4 T cells by genetically redirected T cells | MIGAL -...
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KMT2D regulates activation, localization, and integrin expression by T-cells
Individuals with Kabuki syndrome present with immunodeficiency; however, how pathogenic variants in the gene encoding the histone-modifying enzyme lysine...
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https://pmc.ncbi.nlm.nih.gov/articles/PMC9339908/
Vitamin A, systemic T-cells, and the eye: Focus on degenerative retinal disease - PMC
The first discovered vitamin, vitamin A, exists in a range of forms, primarily retinoids and provitamin carotenoids. The bioactive forms of vitamin A, retinol...
vitamin athe eyefocus onretinal diseasesystemic
https://pubchem.ncbi.nlm.nih.gov/bioassay/209814
AID 209814 - In vitro inhibition of proliferation of PMA and ionomycin stimulated murine T cells;...
BioAssay record AID 209814 submitted by ChEMBL: In vitro inhibition of proliferation of PMA and ionomycin stimulated murine T cells; Antagonist.
in vitroaidinhibitionproliferationpma
https://bsgct.org/crispr-engineered-t-cells-in-patients-with-refractory-cancer/
CRISPR-engineered T cells in patients with refractory cancer - BSGCT
Jan 28, 2025 - Author: Dr Mustafa M. Munye, 6th May 2020 A recent paper from Carl June’s lab published in the journal Science¹ described results of a University of Pennsylvani
t cellsrefractory cancercrisprengineeredpatients
https://research.itg.be/en/publications/interleukin-2-receptor-subunit-expression-and-function-on-human-p/
Interleukin-2 receptor subunit expression and function on human peripheral T cells is not dependent...
t cellsis notinterleukinreceptorsubunit
https://pure.lib.cgu.edu.tw/en/publications/lag-3-expressing-antigen-specific-cd4t-cells-attenuate-lung-infla/
LAG-3 expressing antigen-specific CD4+T cells attenuate lung inflammation during acute influenza...
t cellslagexpressingantigenspecific
https://www.progenitorcelltherapy.com/product/885376/melanoma-marker-hmb45-a103-t311-cf488a-conjugate-01mgml
CAR-T Cells and Autoimmune Diseases: A Glimpse into the Future of Targeted Immunotherapy
Autoimmune diseases occur when the immune system mistakenly attacks the body’s own tissues. While current treatments can manage symptoms, they often require...
car t cellsinto the futureautoimmune diseasesglimpsetargeted
https://insight.jci.org/articles/view/166076
JCI Insight - HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease
cytotoxic t cellsjci insightskin diseasehifregulates
https://foliabiologica.lf1.cuni.cz/59/4/0146/
Selective Depletion of Alloreactive Donor T Cells Leads to Elimination of Graft-Versus-Host...
graft versus hostleads toselectivedepletionalloreactive
https://pure.fujita-hu.ac.jp/ja/publications/therapy-of-relapsed-leukemia-after-allogeneic-hematopoietic-cell-/
Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells...
hematopoietic celltherapyrelapsedleukemiaallogeneic
https://scholars.uky.edu/es/publications/west-nile-virus-specific-cd4-t-cells-exhibit-direct-antiviral-cyt/
West Nile virus-specific CD4 T cells exhibit direct antiviral cytokine secretion and cytotoxicity...
west nile virusspecificcellsexhibitdirect
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.951143/full
Frontiers | CAR T cells targeting the ganglioside NGcGM3 control ovarian tumors in the absence of...
Chimeric antigen receptor (CAR) T cells have emerged as a powerful immunotherapeutic tool against certain hematological malignancies but a significant propor...
car t cellsovarian tumorsfrontierstargetingganglioside
https://dspace.mit.edu/entities/publication/30c0ac7f-a2a1-4f30-a622-372196d26b3c
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis
© 2021 Elsevier Inc. T cells are critical effectors of cancer immunotherapies, but little is known about their gene expression programs in diffuse gliomas....
single cell analysist cellsinhibitoryreceptoridentified