Robuta

Feb 24, 2020 - Our body has a system, the Endocannabinoid System (ECS), which helps maintain homeostasis and also affects multiple functions of the human body and which...

Ribosome assembly is monitored to promote proteostatis through a system whereby unassembled ribosomal proteins lead to activation of heat shock factor 1 and...

Sex is a science of cutting edge but bathed in mystery. Coitus or sexual intercourse, which is at the core of sexual activities, requires healthy and...

The accumulation of ions due to increased salinity in the soil is one of the major abiotic stressors of cultivated plants that negatively affect their...

The effects of common polymorphisms influencing fasting glucose are apparent in healthy children, whereas the presence of multiple risk alleles amounts to a...

Genomic alterations of tumor suppressorsoften encompass collateral protein-coding genes that create therapeutic vulnerability to further inhibition of their...

Recent small-scale genomics analyses suggest that physiologic regulation of pro-inflammatory gene expression by endogenous glucocorticoids may be compromised...

Iron is an essential metal involved in several major cellular processes required to maintain life. Because of iron's ability to cause oxidative damage, its...

Slow-wave sleep (SWS) and rapid eye movement sleep are the two primary components of electrophysiological sleep (e-sleep) in mammals and birds. Slow waves in...

The receptor EBI2 is essential for correctly positioning CD4+ dendritic cells in the spleen so that they can present blood-borne antigens to T cells and...

Background: Suicide is a significant public health problem influenced by various risk factors, including dysregulation of the hypothalamus-pituitary-adrenal ...

Malat1 is a key skeletal regulator, unveiling how lncRNAs integrate cellular crosstalk and molecular networks to regulate bone remodeling and regeneration,...

Maintaining a balanced and functional proteome homeostasis, or proteostasis, is critical for viability and development of all cells and organisms. Proteome...

Abstract page for arXiv paper 2405.03861: Homeostasis in Input-Output Networks: Structure, Classification and Applications

Frozen shoulder is a condition of loss of active and passive motion as result of inflammatory contracture and fibrosis of the joint capsule. We hypothesize...

Homeostasis is the tendency of animals, including humans, to maintain relatively consistent internal environments by controlling temperature, metabolism, blood...

Chronic jet lag induces spontaneous hepatocellular carcinoma (HCC) in wild-type mice following a mechanism very similar to that observed in obese humans. The...

Little is known about amino acid (AA) and protein metabolism in lactating women. We hypothesized: 1) AA sources other than the plasma acid pool provide...

Disturbances of potassium homeostasis can cause either hyperkalemia or hypokalemia and result in serious consequences. Although the consequences of acute and...

Skin integrity and function depends to a large extent on the composition of the extracellular matrix, which regulates tissue organization. Collagen XII is a...

The human adrenal gland is a complex endocrine tissue. Studies on adrenal renewal have been limited to animal models or human foetuses. Enhancing our...

HH signaling regulates cholesterol homeostasis in chondrocytes, and intracellular cholesterol accumulation contributes to the severity of OA. Our findings have...

ABSTRACTRice (Oryza sativa; background Nipponbare) contains nine HKT (high-affinity K+ transport)-like genes encoding membrane proteins belonging to the supe...

The human body maintains a state of internal balance, called homeostasis, that is regulated at the cellular level. Even when the external environment fl...

Gata3 loss in prostate basal stem/progenitor cells upregulates BMP5 which is necessary and sufficient to sustain full self-renewal potential and its inhibition...

Damage-associated molecular patterns are signalling molecules involved in inflammatory responses and restoration of homeostasis. Chronic release of these...

Define homeostasis and provide examples of how different organ systems contribute to maintaining it in... Read more

The Rb tumor suppressor pathway is functionally inactivated in most human cancers. In human blood cancers, loss of Rb expression has been widely reported in...

The accumulation of toxic metals and metalloids, such as cadmium (Cd), mercury (Hg), or arsenic (As), as a consequence of various anthropogenic activities,...

Cholecystectomy (CCE) is a standard clinical treatment for conditions like gallstones and cholecystitis. However, its link to post-CCE syndrome, colorectal...

New horizons in Immune-medited homeostasis and diseases

As a main actor in humoral immunity, B cells participate in various antibody-related disorders. However, a deeper understanding of B-cell differentiation and...

Brown adipose tissue (BAT) is known to function in the dissipation of chemical energy in response to cold or excess feeding, and also has the capacity to...

HOMEOSTASIS HOMEOSTASIS Cells must preserve certain intracellular conditions in order to maintain the enzyme-catalysed metabolic reactions needed... Read more

The gut microbiota is essential for development and regulation of the immune system and the metabolism of the host. Germ-free animals have impaired immunity ...

Cysteine dioxygenase, a conserved and critical enzyme in sulfur amino acid metabolism, is activated by the hypoxia-inducible transcription factor.

A sine qua non is that environmental stressors exert a negative effect on animals via the hypothalamo-pituitary-adrenal axis including corticosterone and...

Tissues undergo a process of degeneration as the body ages. Mesenchymal stem cells (MSCs) have been found to have major potential in delaying the aging process...